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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Drug-Induced Dyskinesia
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Accession:DOID:9008394 term browser browse the term
Definition:Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Synonyms:exact_synonym: Drug-Induced Dyskinesias;   Medication Induced Dyskinesia;   Medication-Induced Dyskinesias
 primary_id: MESH:D004409
 xref: EFO:1000904



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Drug-Induced Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:7740056 PMID:6445277 RGD:1598524, RGD:10047091 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IMP RGD PMID:18947822 RGD:6906919 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19109989 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: therapeutic CTD PMID:2320253 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Comt catechol-O-methyltransferase IMP RGD PMID:16437585 RGD:2289781 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO RGD PMID:1673290 RGD:1358547 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dbn1 drebrin 1 IEP levodopainduced; protein:increased expression:striatum: RGD PMID:23241013 RGD:10398811 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Ddc dopa decarboxylase IEP associated with Parkinson Disease; protein:decreased expression:striatum (rat) RGD PMID:20232137 RGD:5128860 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7845605 PMID:10858612 PMID:16982285 PMID:19520364 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:7845605 PMID:10534246 PMID:14629710 PMID:18707801 RGD:2311579 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20945430 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Egr1 early growth response 1 IEP RGD PMID:22153973 RGD:10395307 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17219962 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9767399 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:11168568 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Glul glutamate-ammonia ligase IDA RGD PMID:6445277 RGD:10047091 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IMP associated with Parkinson Disease RGD PMID:20410529 RGD:5684919 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IMP associated with Parkinsonian Disorders RGD PMID:26997328 RGD:13792768 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Homer1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24126708 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IMP RGD PMID:21352823 RGD:5683628 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Mapt microtubule-associated protein tau treatment IDA associated with Parkinsonian Disorders RGD PMID:25511986 RGD:13800920 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IMP associated with Parkinsonian Disorders RGD PMID:23938307 RGD:10040953 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Pdyn prodynorphin severity
treatment
ISO
HEP
IEP
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;protein:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:21737418 PMID:21737418 PMID:17884291 PMID:10869049 RGD:401850563, RGD:401851046, RGD:401900134 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin disease_progression
treatment
IEP
ISO
mRNA:increased expression:brain:striatum:
CTD Direct Evidence: marker/mechanism
associated with Parkinsonism;mRNA:increased expression:striatum
CTD
RGD
PMID:9767399 PMID:20456008 PMID:26113400 PMID:10869049 RGD:10003039, RGD:401851054, RGD:401900134 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B treatment IDA associated with Parkinsonian Disorders RGD PMID:27771532 RGD:13514053 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21115823 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP protein:increased expression:nucleus, brain RGD PMID:18590723 RGD:2298778 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment IMP associated with Parkinsonian Disorders RGD PMID:24969021 RGD:13524515 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18160641 PMID:24663062 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892
JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: therapeutic CTD PMID:15659429 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
Tardive Dyskinesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 treatment ISO associated with schizophrenia RGD PMID:10889552 RGD:1358545 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Drd3 dopamine receptor D3 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Sod2 superoxide dismutase 2 ISO associated with schizophrenia RGD PMID:12960753 RGD:1581250 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    syndrome 10832
      toxic encephalopathy 237
        Drug-Induced Dyskinesia 33
          Tardive Dyskinesia 3
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      nervous system disease 14060
        central nervous system disease 12399
          brain disease 11634
            movement disease 2576
              Dyskinesias 2190
                Drug-Induced Dyskinesia 33
                  Tardive Dyskinesia 3
paths to the root