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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:G protein mediated signaling pathway
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Accession:PW:0000125 term browser browse the term
Definition:G-proteins act as signal transducers between activated receptors or other incoming signals and downstream effectors. They comprise the heterotrimeric G proteins downstream of G protein-coupled receptors (GPCRs) and the Ras superfamily of small, monomeric G proteins. They function as molecular switches, alternating between the GDP-inactive and GTP-active bound state.
Synonyms:related_synonym: G protein-coupled receptor signaling pathway;   Signaling by GPCR;   heterotrimeric G protein mediated signaling pathway


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G protein mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A IDA RGD PMID:11257446 RGD:6907050 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G F2r coagulation factor II (thrombin) receptor IMP RGD PMID:15145074 RGD:1582290 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Gnao1 G protein subunit alpha o1 IMP RGD PMID:18162464 RGD:2301999 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:29081032 RGD:13506833 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:29081032 RGD:13506833 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Ltb4r leukotriene B4 receptor ISO RGD PMID:16043658 RGD:1581956 NCBI chr15:29,263,199...29,265,716 JBrowse link
G Plcd1 phospholipase C, delta 1 IDA RGD PMID:8663582 RGD:2301018 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
Arf family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 ISO PID PID:200195 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 ISO PID PID:200195 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Arf1 ADP-ribosylation factor 1 ISO PID PID:200195 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Arfgap1 ADP-ribosylation factor GTPase activating protein 1 ISO PID PID:200195 NCBI chr 3:168,084,560...168,099,948
Ensembl chr 3:168,084,614...168,099,933 		JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 ISO PID PID:200195 NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336 		JBrowse link
G Arl6 ADP-ribosylation factor like GTPase 6 ISO RGD PMID:15314642 RGD:1578724 NCBI chr11:40,711,878...40,738,254
Ensembl chr11:40,712,022...40,737,937 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO PID PID:200195 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754 		JBrowse link
G Cd4 Cd4 molecule ISO PID PID:200195 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Clta clathrin, light chain A ISO PID PID:200195 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472 		JBrowse link
G Cltb clathrin, light chain B ISO PID PID:200195 NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169 		JBrowse link
G Copa COPI coat complex subunit alpha ISO PID PID:200195 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874 		JBrowse link
G Cyth2 cytohesin 2 ISO PID PID:200195 NCBI chr 1:96,283,182...96,291,094
Ensembl chr 1:96,284,252...96,291,092 		JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 ISO PID PID:200195 NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 ISO PID PID:200195 NCBI chr10:100,825,427...100,843,422
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Git1 GIT ArfGAP 1 IDA RGD PMID:9826657 RGD:68782 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373 		JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 ISO PID PID:200195 NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625 		JBrowse link
G Kdelr1 KDEL endoplasmic reticulum protein retention receptor 1 ISO PID PID:200195 NCBI chr 1:96,347,258...96,358,145
Ensembl chr 1:96,347,150...96,358,157 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha ISO PID PID:200195 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598 		JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200195 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200195 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Uso1 USO1 vesicle transport factor ISO PID PID:200195 NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171 		JBrowse link
G protein mediated signaling pathway via Galpha12/Galpha13 family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:9092554 RGD:1582440 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Casr calcium-sensing receptor ISO RGD PMID:22192592 RGD:7207059 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Gna13 G protein subunit alpha 13 IMP RGD PMID:9092554 RGD:1582440 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gnb1 G protein subunit beta 1 IMP RGD PMID:9092554 RGD:1582440 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
G Gng3 G protein subunit gamma 3 IMP RGD PMID:9092554 RGD:1582440 NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603 		JBrowse link
G Rgs12 regulator of G-protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr14:75,715,925...75,824,012
Ensembl chr14:75,715,934...75,794,596 		JBrowse link
G protein mediated signaling pathway via Galphai family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 ISO RGD PMID:26468202 RGD:11041137 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adrb2 adrenoceptor beta 2 IMP RGD PMID:10577992 RGD:1559319 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO		 RGD PMID:14657020 PMID:22949090 RGD:1566502, RGD:7401256 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22192592 RGD:7207059 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:12121979 PMID:21303898 RGD:1581445, RGD:11041134 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Gnai1 G protein subunit alpha i1 IMP
ISO		 RGD PMID:12890892 PMID:23759942 RGD:1642020, RGD:8549590 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 PMID:24831693 PMID:23759942 RGD:7401256, RGD:11041136, RGD:8549590 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gnao1 G protein subunit alpha o1 ISO RGD PMID:24831693 RGD:11041136 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
G Oxtr oxytocin receptor ISO
IMP		 RGD PMID:12826328 PMID:9575824 RGD:1579893, RGD:2304227 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094 PMID:21303898 RGD:7207227, RGD:11041134 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888 		JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IMP RGD PMID:11557736 RGD:1581747 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G protein mediated signaling pathway via Galphaq family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISS RGD PMID:11454900 RGD:1559318 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B ISS RGD PMID:11454900 RGD:1559318 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D ISS RGD PMID:11454900 RGD:1559318 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11906170 PMID:12446719 RGD:70819, RGD:629553 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO
IDA		 RGD PMID:14624682 PMID:19047484 RGD:1579891, RGD:2312649 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22192592 PMID:12239094 RGD:7207059, RGD:7207227 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 ISO RGD PMID:23841840 RGD:8549585 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Drd1 dopamine receptor D1 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:25671228 RGD:11041142 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Ghsr growth hormone secretagogue receptor TAS RGD PMID:15788704 RGD:1642818 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 PMID:23759942 PMID:11395409 RGD:1579891, RGD:8549590, RGD:5131495 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna14 G protein subunit alpha 14 ISO RGD PMID:11395409 PMID:23759942 RGD:5131495, RGD:8549590 NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423 		JBrowse link
G Gna15 G protein subunit alpha 15 IMP
ISO		 RGD PMID:9685675 PMID:11395409 RGD:728647, RGD:5131495 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508 		JBrowse link
G Gnaq G protein subunit alpha q IMP
ISO		 RGD PMID:12890892 PMID:23759942 PMID:11395409 PMID:14624682 RGD:1642020, RGD:8549590, RGD:5131495, RGD:1579891 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Hcrtr1 hypocretin receptor 1 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357 		JBrowse link
G Oxtr oxytocin receptor ISO
IMP		 RGD PMID:14624682 PMID:9575824 RGD:1579891, RGD:2304227 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Pth1r parathyroid hormone 1 receptor IDA
ISO		 RGD PMID:9054374 PMID:19395963 PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207465 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 PMID:12239094 RGD:5133418, RGD:7207227 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G protein mediated signaling pathway via Galphas family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy3 adenylate cyclase 3 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adcy5 adenylate cyclase 5 ISO
IDA		 RGD PMID:18948702 PMID:26468202 PMID:17010343 RGD:2312469, RGD:11041137, RGD:2315004 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA		 RGD PMID:18948702 PMID:15579502 PMID:17010343 RGD:2312469, RGD:2313211, RGD:2315004 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adcy9 adenylate cyclase 9 ISO RGD PMID:18948702 RGD:2312469 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Adrb1 adrenoceptor beta 1 TAS RGD PMID:10577992 RGD:1559319 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 TAS RGD PMID:10577992 RGD:1559319 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO RGD PMID:8011597 RGD:1559323 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B IDA RGD PMID:19047484 RGD:2312649 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 ISO RGD PMID:14624682 RGD:1579891 NCBI chr  X:151,633,501...151,636,155
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:16484629 RGD:5147387 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:21303898 RGD:11041134 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Gcgr glucagon receptor IDA RGD PMID:17010343 RGD:2315004 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Gnal G protein subunit alpha L ISO RGD PMID:24144882 RGD:11041135 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gnas GNAS complex locus IDA
IMP
ISO		 RGD PMID:15297467 PMID:17010343 PMID:15687107 PMID:15579502 PMID:14624682 More... RGD:1580407, RGD:2315004, RGD:1625210, RGD:2313211, RGD:1579891, RGD:2312469 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:19767412 RGD:5128698 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 TAS RGD PMID:1403099 RGD:632163 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 TAS RGD PMID:1403099 RGD:632163 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor IDA RGD PMID:8440169 RGD:2292602 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mc2r melanocortin 2 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488 		JBrowse link
G Mc3r melanocortin 3 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444 		JBrowse link
G Mc4r melanocortin 4 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc5r melanocortin 5 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:61,915,188...61,920,229
Ensembl chr18:61,915,188...61,920,229 		JBrowse link
G Pth1r parathyroid hormone 1 receptor ISO RGD PMID:21777186 PMID:19395963 RGD:7207465, RGD:7207470 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888 		JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892 		JBrowse link
G Snx13 sorting nexin 13 ISO RGD PMID:17173929 RGD:4140388 NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224 		JBrowse link
Rab family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IMP RGD PMID:20739464 RGD:10054052 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 IMP RGD PMID:20739464 RGD:10054052 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 IMP RGD PMID:20739464 RGD:10054052 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 ISO RGD PMID:20739464 RGD:10054052 NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 ISO RGD PMID:20739464 RGD:10054052 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410 		JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Dennd1c DENN domain containing 1C ISO RGD PMID:24598362 RGD:10053653 NCBI chr 9:1,904,040...1,916,329
Ensembl chr 9:1,904,045...1,916,187 		JBrowse link
G Dennd4a DENN domain containing 4A ISO RGD PMID:24598362 RGD:10053653 NCBI chr 8:65,322,920...65,436,331
Ensembl chr 8:65,322,941...65,436,330 		JBrowse link
G Dennd4b DENN domain containing 4B ISO RGD PMID:24598362 RGD:10053653 NCBI chr 2:175,720,473...175,736,425
Ensembl chr 2:175,709,610...175,736,426 		JBrowse link
G Dennd4c DENN domain containing 4C ISO RGD PMID:24598362 RGD:10053653 NCBI chr 5:101,272,298...101,369,529
Ensembl chr 5:101,272,005...101,368,118 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 TAS RGD PMID:8188702 RGD:61604 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Limk1 LIM domain kinase 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606 		JBrowse link
G Rab10 RAB10, member RAS oncogene family ISO RGD PMID:17629673 PMID:24598362 PMID:18171431 PMID:18570632 RGD:2302395, RGD:10053653, RGD:2306494, RGD:2302397 NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab13 RAB13, member RAS oncogene family TAS RGD PMID:24598362 RGD:10053653 NCBI chr 2:175,674,894...175,680,043
Ensembl chr 2:175,675,005...175,680,036 		JBrowse link
G Rab14 RAB14, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172 		JBrowse link
G Rab2a RAB2A, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899 		JBrowse link
G Rab3ip RAB3A interacting protein ISO RGD PMID:24598362 RGD:10053653 NCBI chr 7:52,531,461...52,575,295
Ensembl chr 7:52,532,401...52,561,043 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 RGD:2302395, RGD:2306494 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873 		JBrowse link
G Rab8a RAB8A, member RAS oncogene family ISO RGD PMID:17629673 PMID:18171431 PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678 		JBrowse link
G Rab8b RAB8B, member RAS oncogene family ISO RGD PMID:18570632 RGD:2302397 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384 		JBrowse link
G Ssh1 slingshot protein phosphatase 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274 		JBrowse link
G Tbc1d1 TBC1 domain family member 1 TAS RGD PMID:24598362 RGD:10053653 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 ISO RGD PMID:17629673 PMID:18570632 PMID:18171431 RGD:2302395, RGD:2302397, RGD:2306494 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265 		JBrowse link
Ras family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
Ras mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:9211935 RGD:1625352 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IMP RGD PMID:9271418 RGD:1582133 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Hmga2 high mobility group AT-hook 2 IMP RGD PMID:11390395 RGD:1601592 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Tp73 tumor protein p73 IMP RGD PMID:17353261 RGD:2291838 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
Rheb mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rheb Ras homolog, mTORC1 binding TAS RGD PMID:15240005 RGD:1625609 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160 		JBrowse link
Rho/Rac/Cdc42 mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18306009 RGD:5129131 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134 		JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:24613967 RGD:10053654 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cdc42 cell division cycle 42 IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein IDA RGD PMID:7835339 RGD:68218 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:16543720 RGD:4892323 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Limk2 LIM domain kinase 2 ISS RGD PMID:10613909 RGD:1549432 NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:9487126 RGD:2293350 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IMP RGD PMID:9487126 RGD:2293350 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Plekhg4 pleckstrin homology and RhoGEF domain containing G4 ISO RGD PMID:24613967 RGD:10053654 NCBI chr19:33,251,788...33,266,490
Ensembl chr19:33,249,706...33,266,357 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit IMP RGD PMID:16549782 RGD:8693756 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15158121 RGD:1642626 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rac1 Rac family small GTPase 1 IMP
ISO		 RGD PMID:9487126 PMID:24613967 RGD:2293350, RGD:10053654 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rhoa ras homolog family member A TAS
ISO		 RGD PMID:12782387 PMID:12239094 RGD:1299238, RGD:7207227 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhoq ras homolog family member Q ISO RGD PMID:24613967 RGD:10053654 NCBI chr 6:7,613,632...7,652,047 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      G protein mediated signaling pathway 160
        Ras superfamily mediated signaling pathway + 79
        altered G protein mediated signaling pathway + 0
        heterotrimeric G protein mediated signaling pathway + 78
paths to the root