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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Liver Neoplasms
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Accession:DOID:9001586 term browser browse the term
Definition:Experimentally induced tumors of the LIVER.
Synonyms:exact_synonym: Experimental Hepatomas;   Experimental Liver Neoplasm;   Morris Hepatoma;   Novikoff hepatoma;   experimental hepatoma
 primary_id: MESH:D008114
 alt_id: RDO:0006023
For additional species annotation, visit the Alliance of Genome Resources.



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Experimental Liver Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 IDA RGD PMID:15853769 RGD:1598580 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IEP RGD PMID:8104413 RGD:5684351 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Adsl adenylosuccinate lyase IEP protein:increased activity:liver (rat) RGD PMID:2937404 RGD:1598766 NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760
JBrowse link
G Afp alpha-fetoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24012840 PMID:32961231 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agps alkylglycerone phosphate synthase IDA RGD PMID:7407223 RGD:1598794 NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Apoa4 apolipoprotein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoc2 apolipoprotein C2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
JBrowse link
G Arid1a AT-rich interaction domain 1A disease_progression ISO RGD PMID:26569409 RGD:11344640 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Arrb2 arrestin, beta 2 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:21167192 RGD:5509890 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp7b ATPase copper transporting beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:10426811 PMID:28100771 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10426811 PMID:28100771 PMID:22414765 RGD:11353865 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 IEP mRNA, protein:increased expression:liver RGD PMID:18246794 RGD:2293125 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IEP protein:increased activity:liver (rat) RGD PMID:13618893 RGD:5132586 NCBI chr 6:25,292,133...25,315,176
Ensembl chr 6:25,292,133...25,319,861
JBrowse link
G Car3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30603057 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccnb1 cyclin B1 IEP mRNA:increased expression:liver RGD PMID:17342310 RGD:2315991 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:28100771 PMID:17055752 RGD:2289139 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccndbp1 cyclin D1 binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16501603 NCBI chr 3:107,962,402...107,974,234
Ensembl chr 3:107,962,261...107,974,233
JBrowse link
G Ccng1 cyclin G1 ISO RGD PMID:27982046 RGD:151361200 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccng2 cyclin G2 ISO RGD PMID:27982046 RGD:151361200 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:19035311 RGD:5491179 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd63 Cd63 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20118494 PMID:25319454 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP protein:decreased expression:liver: RGD PMID:8640740 RGD:8662309 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B disease_progression IEP mRNA:increased expression:liver (rat) RGD PMID:19533683 RGD:2315050 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C disease_progression IEP protein:decreased expression:liver (rat)
mRNA:increased expression:liver (rat)
protein:increased expression:liver (rat)
RGD PMID:26606000 PMID:19533683 PMID:3965145 RGD:11354707, RGD:2315050, RGD:152998958 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cops5 COP9 signalosome subunit 5 IEP protein:increased expression:liver (rat) RGD PMID:26606000 RGD:11354707 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 severity IEP mRNA:decreased expression:liver RGD PMID:3387993 RGD:2303406 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11280770 PMID:20118494 PMID:21147764 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:increased expression:liver RGD PMID:22687991 RGD:7296954 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11376689 PMID:21147764 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18056438 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IEP protein:increased activity:liver (rat) RGD PMID:6331524 RGD:5132618 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Dtymk deoxythymidylate kinase IEP protein:increased activity:tumor (rat) RGD PMID:6244089 RGD:5133686 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Eno2 enolase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2910524 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ephx1 epoxide hydrolase 1 IEP RGD PMID:7260898 RGD:11252158 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G F12 coagulation factor XII ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30737368 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Foxm1 forkhead box M1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15082532 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Gjb1 gap junction protein, beta 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18308698 PMID:1336494 RGD:7349398 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gjb2 gap junction protein, beta 2 IEP RGD PMID:1336494 RGD:7349398 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Glul glutamate-ammonia ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20118494 PMID:21147764 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Grp gastrin releasing peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:2910524 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEP
ISO
CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (rat)
CTD
RGD
PMID:2563599 PMID:3124819 PMID:7585603 PMID:20188851 PMID:12016164 More... RGD:2317823, RGD:152998958 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H19 H19 imprinted maternally expressed transcript IDA
ISO
DNA:hypomethylation:promoter
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11420682 PMID:15352122 RGD:1342455 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Hat1 histone acetyltransferase 1 IEP protein:increased expression:liver RGD PMID:17182829 RGD:2316578 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
JBrowse link
G Hgf hepatocyte growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11896611 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:7955063 PMID:20118494 PMID:21147764 PMID:27517622 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IEP protein:increased expression:brainstem, cerebral cortex RGD PMID:17258772 RGD:1624998 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Igf2 insulin-like growth factor 2 treatment IEP RGD PMID:22425635 RGD:10402567 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igf2r insulin-like growth factor 2 receptor IAGP RGD PMID:15057872 PMID:9652747 RGD:2311623, RGD:2311630 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:30737368 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il6 interleukin 6 disease_progression ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (mouse)
CTD
RGD
PMID:26297436 PMID:26569409 RGD:11344640 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor disease_progression IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:cytoplasm,liver (rat) RGD PMID:15520221 RGD:2306052 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Jak2 Janus kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kat6a lysine acetyltransferase 6A IEP protein:increased expression:liver (rat) RGD PMID:17083329 RGD:2312274 NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606
JBrowse link
G Kdr kinase insert domain receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kras KRAS proto-oncogene, GTPase disease_progression ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)
CTD
RGD
PMID:8603461 PMID:19533683 RGD:2315050 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:liver RGD PMID:15520221 RGD:2306052 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073
JBrowse link
G Mir10a microRNA 10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280
JBrowse link
G Mir125a microRNA 125a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
JBrowse link
G Mir145 microRNA 145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Mir151 microRNA 151 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:105,172,377...105,172,473 JBrowse link
G Mir181c microRNA 181c ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628
JBrowse link
G Mir181d microRNA 181d ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788
JBrowse link
G Mir183 microRNA 183 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
JBrowse link
G Mir186 microRNA 186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
JBrowse link
G Mir18a microRNA 18a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir195 microRNA 195 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924
JBrowse link
G Mir196b microRNA 196b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
JBrowse link
G Mir200b microRNA 200b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
JBrowse link
G Mir206 microRNA 206 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir212 microRNA 212 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513
JBrowse link
G Mir221 microRNA 221 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir26a microRNA 26a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Mir26b microRNA 26b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
JBrowse link
G Mir290 microRNA 290 EXP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728
JBrowse link
G Mir300 microRNA 300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594
JBrowse link
G Mir301a microRNA 301a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435
JBrowse link
G Mir30a microRNA 30a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
JBrowse link
G Mir30b microRNA 30b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675
JBrowse link
G Mir30d microRNA 30d ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472
JBrowse link
G Mir30e microRNA 30e ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323
JBrowse link
G Mir324 microRNA 324 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
JBrowse link
G Mir331 microRNA 331 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485
JBrowse link
G Mir336 microRNA 336 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:34,185,579...34,185,674
Ensembl chr10:34,185,579...34,185,674
JBrowse link
G Mir339 microRNA 339 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641
JBrowse link
G Mir340-1 microRNA mir-340-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665
JBrowse link
G Mir347 microRNA mir-347 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526
G Mir349 microRNA 349 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:120,243,311...120,243,407
Ensembl chr 7:120,243,311...120,243,407
JBrowse link
G Mir34a microRNA 34a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mir352 microRNA mir-352 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526
G Mir383 microRNA 383 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr16:54,040,340...54,040,413
Ensembl chr16:54,040,340...54,040,413
JBrowse link
G Mir409 microRNA 409 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858
JBrowse link
G Mir429 microRNA 429 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
JBrowse link
G Mir598 microRNA 598 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr15:37,962,692...37,962,770
Ensembl chr15:37,962,692...37,962,771
JBrowse link
G Mir652 microRNA 652 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:106,343,293...106,343,373
Ensembl chr  X:106,343,293...106,343,373
JBrowse link
G Mir671 microRNA 671 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835
JBrowse link
G Mir708 microRNA 708 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:150,599,876...150,599,963
Ensembl chr 1:150,599,876...150,599,963
JBrowse link
G Mir760 microRNA 760 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695
JBrowse link
G Mir92b microRNA 92b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 2:174,633,890...174,633,972
Ensembl chr 2:174,633,890...174,633,972
JBrowse link
G Mir98 microRNA 98 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mir99b microRNA 99b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
JBrowse link
G Mirlet7b microRNA let-7b ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mirlet7d microRNA let-7d ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
JBrowse link
G Mirlet7i microRNA let-7i ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP
ISO
mRNA, protein:increased expression, increased activity:liver
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:30603057 PMID:19528495 PMID:19539802 RGD:2325736, RGD:2325734 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP mRNA, protein:increased expression, increased activity:liver RGD PMID:19528495 PMID:19539802 RGD:2325736, RGD:2325734 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpeg1 macrophage expressed 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP
ISO
mRNA:increased expression:liver (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9079223 PMID:11280770 PMID:18560566 PMID:3335218 RGD:10059623 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:liver RGD PMID:10383909 RGD:2325277 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 IEP protein:increased expression:liver RGD PMID:18942116 RGD:2325310 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:27867096 RGD:13442478 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 susceptibility ISO RGD PMID:17283114 RGD:14701032 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17172636 PMID:24769335 PMID:25656644 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO human gene in mouse model RGD PMID:16286660 RGD:14975105 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase IEP protein:decreased expression:liver RGD PMID:7929120 RGD:1642378 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
JBrowse link
G Plcl1 phospholipase C-like 1 disease_progression IEP mRNA:increased expression:liver (rat) RGD PMID:19533683 RGD:2315050 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
JBrowse link
G Pml PML nuclear body scaffold ISO CTD Direct Evidence: therapeutic CTD PMID:20377131 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppat phosphoribosyl pyrophosphate amidotransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:761203 NCBI chr14:31,215,741...31,250,144
Ensembl chr14:31,216,165...31,250,144
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IEP mRNA:increased expression:liver (rat) RGD PMID:2562181 RGD:8693574 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Prdx1 peroxiredoxin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27517622 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Ptgr1 prostaglandin reductase 1 IEP protein:increased expression:liver RGD PMID:24853774 RGD:14401713 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Rad51 RAD51 recombinase IEP protein:decreased expression:liver RGD PMID:17219426 RGD:2292638 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17854601 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rgn regucalcin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Rida reactive intermediate imine deaminase A homolog IEP protein:increased expression:liver (rat) RGD PMID:12939504 RGD:9685719 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716
JBrowse link
G Rras2 RAS related 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147764 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 IEP RGD PMID:15224347 RGD:2316863 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rxra retinoid X receptor alpha IEP mRNA, protein:decreased expression:liver RGD PMID:17786350 RGD:1643105 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Serpina1 serpin family A member 1 IEP RGD PMID:10569800 RGD:1626391 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc7a5 solute carrier family 7 member 5 IEP mRNA:increased expression:liver RGD PMID:17498859 RGD:151357003 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15197228 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Sox4 SRY-box transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21147764 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqle squalene epoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26297436 PMID:28100771 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tek TEK receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfa transforming growth factor alpha IEP
ISO
protein:increased expression:liver
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9079223 PMID:16734725 RGD:2317490 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tk1 thymidine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor treatment
disease_progression
ISO CTD Direct Evidence: marker/mechanism
Morris hepatoma
protein:increased expression:blood serum (mouse)
CTD
RGD
PMID:28100771 PMID:9063767 PMID:26569409 RGD:14696818, RGD:11344640 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10626228 PMID:28100771 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15833021 PMID:17533171 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Vim vimentin IDA RGD PMID:19199359 RGD:6480440 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xdh xanthine dehydrogenase IEP protein:decreased expression:liver RGD PMID:3460692 RGD:13210515 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18133
    disease of cellular proliferation 7304
      Experimental Neoplasms 627
        Experimental Liver Neoplasms 192
Path 2
Term Annotations click to browse term
  disease 18133
    disease of anatomical entity 17503
      gastrointestinal system disease 6558
        hepatobiliary disease 2732
          liver disease 2621
            Liver Neoplasms 1141
              Experimental Liver Neoplasms 192
paths to the root