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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:membranous glomerulonephritis
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Accession:DOID:10976 term browser browse the term
Definition:A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Synonyms:exact_synonym: CONGENITAL MEMBRANOUS NEPHROPATHY DUE TO FETOMATERNAL ANTI-NEUTRAL ENDOPEPTIDASE ALLOIMMUNIZATION;   Extramembranous Glomerulopathy;   Heymann Nephritis;   Idiopathic Membranous Glomerulonephritis;   Idiopathic Membranous Nephropathy;   MBNP;   Membranous Glomerulonephritides;   Membranous Glomerulonephropathy;   idiopathic membranous glomerulonephritides;   membranous glomerulopathy;   membranous nephropathy
 related_synonym: membranous nephropathy, susceptibility to
 primary_id: MESH:D015433
 alt_id: MIM:614692
 xref: EFO:0004254;   ICD10CM:N03.2;   NCI:C34645
For additional species annotation, visit the Alliance of Genome Resources.


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membranous glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP protein:increased expression:serum RGD PMID:9453001 RGD:10046046 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 IEP RGD PMID:12507911 RGD:1598547 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1342223 PMID:9794552 PMID:11938814 PMID:12776520 PMID:15385633 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7900854 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoe apolipoprotein E IEP protein:increased expression:serum (rat) RGD PMID:22785171 RGD:6903854 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G C3 complement C3 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:25954969 PMID:10729746 RGD:5129563 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C7 complement C7 IEP RGD PMID:6241952 RGD:1599528 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Cd40 CD40 molecule treatment IMP
ISO		 RGD PMID:23223173 PMID:23223173 RGD:8547786, RGD:8547786 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand treatment ISO associated with Lupus Erythematosus, Systemic RGD PMID:17911451 PMID:7564113 RGD:7248430, RGD:7248720 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B treatment IEP RGD PMID:24583340 RGD:10045363 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cfb complement factor B susceptibility ISO RGD PMID:3272818 RGD:7242764 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H IEP mRNA, protein:increased expression:glomerulus RGD PMID:12911541 RGD:1599888 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Gaa alpha glucosidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15466083 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:20588061 RGD:7175342 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Lrp2 LDL receptor related protein 2 IEP mRNA:decreased expression:glomerulus RGD PMID:10919857 RGD:1641827 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 IEP
IDA		 mRNA, protein:increased expression:glomerulus, epithelial cell RGD PMID:7778686 PMID:7723231 RGD:1641937, RGD:1641936 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP protein:increased activity,protein:renal glomerulus: RGD PMID:18178252 RGD:10412641 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mme membrane metallo-endopeptidase ISO antenatal membranous glomerulonephritis
ClinVar Annotator: match by term: Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization		 ClinVar
RGD		 PMID:15464186 PMID:24033266 PMID:25565308 PMID:25741868 PMID:26991897 More... RGD:1600817 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP RGD PMID:8613533 RGD:8547919 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin IEP RGD PMID:15882266 RGD:1598706 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin IDA RGD PMID:15882266 RGD:1598706 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IDA RGD PMID:28711658 RGD:13439719 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Plg plasminogen TAS RGD PMID:1645711 RGD:1299252 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP mRNA:increased expression:renal cortex (rat) RGD PMID:14636300 RGD:10043359 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptpru protein tyrosine phosphatase, receptor type, U IEP mRNA, protein:decreased expression:glomerulus RGD PMID:17457373 RGD:1642654 NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768 		JBrowse link
G Rhoa ras homolog family member A IMP protein:increased activity:epithelial cell RGD PMID:17376765 RGD:1642963 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:SNP: :rs2187668 (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11436868 PMID:21323541 RGD:5147785 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11436868 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Shh sonic hedgehog signaling molecule ISO RGD PMID:24744439 RGD:12859042 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP protein:increased expression:kidney RGD PMID:8943481 RGD:2300069 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:8982653 RGD:1601473 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tf transferrin ISO associated with Lupus Erythematosus, Systemic RGD PMID:22328173 RGD:7244198 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tslp thymic stromal lymphopoietin treatment ISO RGD PMID:11920357 RGD:38549592 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      immune system disease 4931
        autoimmune disease 2365
          membranous glomerulonephritis 33
Path 2
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      Urogenital Diseases 5272
        urinary system disease 2827
          kidney disease 2576
            Glomerular Diseases 434
              glomerulonephritis 427
                membranous glomerulonephritis 33
paths to the root