RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Vascular System Injuries
Accession: DOID:9000352
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Definition: Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Synonyms: exact_synonym: Vascular Injuries; Vascular Injury; Vascular System Injury
primary_id: MESH:D057772 ; RDO:0007794
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Ace
angiotensin I converting enzyme
susceptibility
IAGP ISO
DNA:repeat:intron:IVS13+40(CA)?-26 (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19258495 PMID:9484988
RGD:8157602
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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Agtr1a
angiotensin II receptor, type 1a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
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Agtr2
angiotensin II receptor, type 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057
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Apoe
apolipoprotein E
IEP ISO
protein:decreased expression:plasma (rat)
RGD
PMID:21416056 PMID:21163611
RGD:5509868 , RGD:6904145
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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Atp7a
ATPase copper transporting alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20671235
NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354
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Bdkrb1
bradykinin receptor B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747
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Bdkrb2
bradykinin receptor B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497
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Grk2
G protein-coupled receptor kinase 2
IEP
protein:increased expression:aorta (rat)
RGD
PMID:28653218
RGD:13513975
NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19234301
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Id2
inhibitor of DNA binding 2
IEP
protein:increased expression:carotid artery, blood vessel wall (rat)
RGD
PMID:11706002
RGD:619536
NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
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Iqgap1
IQ motif containing GTPase activating protein 1
IEP
RGD
PMID:15217908
RGD:11049588
NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:134,679,586...134,769,755
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19234301
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Pecam1
platelet and endothelial cell adhesion molecule 1
IDA
RGD
PMID:22552115
RGD:6484736
NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116
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Pf4
platelet factor 4
ISO
RGD
PMID:23568488
RGD:329901761
NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365
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S1pr1
sphingosine-1-phosphate receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29609002
NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
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Sell
selectin L
ameliorates
IMP
RGD
PMID:1717513
RGD:597015750
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456
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Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11868353
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19234301
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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