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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:limb ischemia
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Accession:DOID:0050852 term browser browse the term
Definition:An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply. (DO)


show annotations for term's descendants           Sort by:
limb ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:11877468 RGD:737810 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 ISO RGD PMID:26315408 RGD:14367880 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Cs citrate synthase IDA RGD PMID:571116 RGD:243049254 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:plasma: RGD PMID:16648859 RGD:10449511 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:23294128 PMID:16224058 RGD:10400895, RGD:11039414 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 exacerbates
ameliorates		 ISO RGD PMID:20508179 PMID:35301145 PMID:22252294 RGD:155641249, RGD:155663375, RGD:155663358 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23294128 RGD:10400895 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Etv2 ETS variant transcription factor 2 exacerbates
ameliorates		 ISO RGD PMID:26586661 PMID:28466428 PMID:32075417 PMID:28424975 PMID:28424975 RGD:11076207, RGD:192379484, RGD:192186227, RGD:156451664, RGD:156451664 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 treatment IEP RGD PMID:25388665 RGD:11568031 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IMP RGD PMID:26604244 RGD:13514042 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:15238569 RGD:8548639 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:skeletal muscle RGD PMID:17522350 RGD:1626332 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:12593860 RGD:1598394 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:monocyte (human) RGD PMID:20816321 RGD:329901827 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgav integrin subunit alpha V ISO RGD PMID:15750161 RGD:1582449 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Mir126a microRNA 126a ameliorates ISO associated with type 1 diabetes mellitus; RGD PMID:29242072 PMID:35151721 RGD:401851035, RGD:401851044 NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir210 microRNA 210 severity ISO RGD PMID:31878120 RGD:155882482 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IDA
ISO
IEP		 associated with Diabetes Mellitus, Experimental
human gene in rat model		 RGD PMID:19080171 PMID:12171788 PMID:28979692 RGD:7794710, RGD:7794776, RGD:13450931 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22369073 PMID:21940947 RGD:6767285, RGD:6906905 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:30638058 RGD:401794451 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment ISO
IMP		 human gene in a mouse model
rat gene in human cells in a mouse model		 RGD PMID:12586736 PMID:14568901 PMID:19344900 RGD:401959585, RGD:401960079, RGD:401960096 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO protein:increased expression, increased activity:hindlimb muscle (mouse) RGD PMID:18451337 RGD:401965417 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment IDA RGD PMID:23562340 RGD:7421600 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
limb reperfusion injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:36495512 RGD:401717522 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19065
    Pathological Conditions, Signs and Symptoms 13511
      Pathologic Processes 8221
        ischemia 1499
          limb ischemia 24
            limb reperfusion injury 1
Path 2
Term Annotations click to browse term
  disease 19065
    disease of anatomical entity 18355
      cardiovascular system disease 5559
        vascular disease 4072
          ischemia 1499
            limb ischemia 24
              limb reperfusion injury 1
paths to the root