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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Limb Ischemia
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Accession:DOID:0050852 term browser browse the term
Definition:A hypoperfusion of the blood through a limb caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation.
Synonyms:primary_id: RDO:9000011
For additional species annotation, visit the Alliance of Genome Resources.

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Limb Ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:11877468 RGD:737810 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 ISO RGD PMID:26315408 RGD:14367880 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:plasma: RGD PMID:16648859 RGD:10449511 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:23294128, PMID:16224058 RGD:10400895, RGD:11039414 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:23294128 RGD:10400895 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 treatment IEP RGD PMID:25388665 RGD:11568031 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IMP RGD PMID:26604244 RGD:13514042 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:15238569 RGD:8548639 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:skeletal muscle RGD PMID:17522350 RGD:1626332 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:12593860 RGD:1598394 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itgav integrin subunit alpha V ISO RGD PMID:15750161 RGD:1582449 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IDA
associated with Diabetes Mellitus, Experimental
human gene in rat model
RGD PMID:19080171, PMID:28979692, PMID:12171788 RGD:7794710, RGD:13450931, RGD:7794776 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22369073, PMID:21940947 RGD:6767285, RGD:6906905 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Vegfa vascular endothelial growth factor A treatment IDA RGD PMID:23562340 RGD:7421600 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    Pathological Conditions, Signs and Symptoms 8840
      Pathologic Processes 6201
        ischemia 1283
          Limb Ischemia 14
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      cardiovascular system disease 4371
        vascular disease 3309
          ischemia 1283
            Limb Ischemia 14
paths to the root