RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: impotence
Accession: DOID:1875
browse the term
Definition: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Synonyms: exact_synonym: Male Impotence; erectile dysfunction; male sexual impotence; sexual impotence
primary_id: MESH:D007172
alt_id: RDO:0005882
For additional species annotation, visit the
Alliance of Genome Resources .
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Ager
advanced glycosylation end product-specific receptor
treatment
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:23698784
RGD:7244246
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Agt
angiotensinogen
treatment
IDA
RGD
PMID:17616753
RGD:8548892
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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Akt1
AKT serine/threonine kinase 1
treatment
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Bad
BCL2-associated agonist of cell death
treatment
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
G
Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
treatment
IDA ISO IEP
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Experimental
CTD
PMID:12394778 , PMID:12394778 , PMID:21235725
RGD:1579980 , RGD:10053666
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bcl2l1
Bcl2-like 1
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12394778 , PMID:12394778
RGD:1579980
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
G
Casp3
caspase 3
treatment
IEP
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Ccnd1
cyclin D1
IEP
mRNA:decreased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
G
Ccnd2
cyclin D2
IEP
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis
RGD
PMID:18068478
RGD:2289159
NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
G
Cfl1
cofilin 1
treatment
IEP
protein:increased phosphorylation:corpus cavernosum penis (rat)
RGD
PMID:25923835 , PMID:25444982
RGD:11568706 , RGD:11570410
NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
G
Cnr1
cannabinoid receptor 1
IMP
associated with Diabetes Mellitus, Experimental
RGD
PMID:17850365
RGD:2314634
NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
G
Dynll1
dynein light chain LC8-type 1
treatment
IMP
RGD
PMID:17433082
RGD:13207433
NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
G
Edn1
endothelin 1
IEP ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441 , PMID:17420087
RGD:2292142
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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Ednra
endothelin receptor type A
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18823320 , PMID:17420087
RGD:2292142
NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
G
Fabp4
fatty acid binding protein 4
IEP
associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
G
Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:15758817
RGD:2315866
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Gja1
gap junction protein, alpha 1
IEP
mRNA, protein:decreased expression:corpus cavernosum penis
RGD
PMID:17146929
RGD:8662385
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19295509
NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012
G
Grk2
G protein-coupled receptor kinase 2
IMP
associated with Diabetes Mellitus, Experimental
RGD
PMID:30226217
RGD:13792691
NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
G
Hdac3
histone deacetylase 3
IEP
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
G
Hdac4
histone deacetylase 4
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
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Igfbp3
insulin-like growth factor binding protein 3
treatment
IMP IEP
mRNA, protein:increased expression:penis
RGD
PMID:24576658 , PMID:21595839
RGD:10402763 , RGD:10402765
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
G
Il6
interleukin 6
treatment
IMP IEP
associated with Diabetes Mellitus, Type 2
RGD
PMID:21492407 , PMID:24467772
RGD:10402827 , RGD:9495931
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Kdr
kinase insert domain receptor
IEP
RGD
PMID:16422887
RGD:5684417
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Mcam
melanoma cell adhesion molecule
IEP
protein:decreased expression:penis erectile tissue
RGD
PMID:24023647
RGD:7364777
NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
G
Nos1
nitric oxide synthase 1
treatment
IDA IEP
associated with Diabetes Mellitus, Experimental associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD
PMID:23698784 , PMID:23522997 , PMID:23535456
RGD:7244246 , RGD:7257657 , RGD:7257656
NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
G
Nos2
nitric oxide synthase 2
IEP
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:19554009
RGD:2313212
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nos3
nitric oxide synthase 3
treatment
IEP ISO
associated with Cocaine-Related Disorders;protein:decreased expression:penis CTD Direct Evidence: marker/mechanism|therapeutic associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD
PMID:12002441 PMID:17071732 , PMID:17420087 , PMID:29260891 , PMID:20807325
RGD:2292142 , RGD:13504711 , RGD:4891999
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
G
P2ry1
purinergic receptor P2Y1
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
G
P2ry2
purinergic receptor P2Y2
IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
G
Pde5a
phosphodiesterase 5A
IMP
associated with Hypercholesterolemia associated with Diabetes Mellitus, Experimental
RGD
PMID:15920460 , PMID:15578039 , PMID:15667904
RGD:2314519 , RGD:2314521 , RGD:2314520
NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
G
Prkg1
protein kinase cGMP-dependent 1
IEP
associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue
RGD
PMID:17355372
RGD:7775062
NCBI chr 1:248,982,039...250,300,952
G
Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
G
Shbg
sex hormone binding globulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17961146
NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
G
Sirt1
sirtuin 1
treatment
IEP
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
G
Tgfb1
transforming growth factor, beta 1
IEP
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:18778311 , PMID:27051243
RGD:2306738 , RGD:14995446
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:11596671
RGD:2312459
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
G
Tnf
tumor necrosis factor
treatment
IEP
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
G
Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10233493
NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
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Xrcc1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H
RGD
PMID:18582155
RGD:2302570
NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
G
Angpt2
angiopoietin 2
IEP
associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat)
RGD
PMID:16750245
RGD:2314210
NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
G
Apod
apolipoprotein D
IEP
mRNA:increased expression:penis erectile tissue
RGD
PMID:11444882
RGD:2311196
NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
G
Pde5a
phosphodiesterase 5A
IMP
RGD
PMID:17287493
RGD:2314469
NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
G
Tgfbr2
transforming growth factor, beta receptor 2
ISO
protein:increased expression:penis erectile tissue
RGD
PMID:14718046
RGD:1601627
NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
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