Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hyperalgesia
go back to main search page
Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Mechanical;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesia, Tactile;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Hyperalgesia;   Tactile Allodynia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930;   RDO:0005827
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
Hyperalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:24890317 RGD:9588557 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Adk adenosine kinase IMP associated with diabetic neuropathies; RGD PMID:11423084 PMID:9932716 RGD:6482662, RGD:6482666 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adm adrenomedullin IDA
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17043245 PMID:17043245 RGD:1625316 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora1 adenosine A1 receptor IDA associated with Spinal Cord Injuries RGD PMID:20065990 RGD:5129094 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adra1a adrenoceptor alpha 1A IEP associated with Diabetes Mellitus, Experimental; mRNA:increased expression:dorsal root ganglion RGD PMID:10841349 RGD:5688377 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:17959985 RGD:6480488 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2c adrenoceptor alpha 2C IMP RGD PMID:20007733 RGD:6893568 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IMP
ISO
IEP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:25014009 PMID:25014009 PMID:24077211 RGD:8695980, RGD:7364865 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP
ISO
associated with Alcohol-Induced Disorders, Nervous System; protein:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:27093858 PMID:17284346 RGD:2313035 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B IDA associated with Hyperglycemia RGD PMID:12505670 RGD:1626082 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ano3 anoctamin 3 IMP RGD PMID:23872594 RGD:9681745 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa1 annexin A1 IMP
IEP
protein:increased expression:dorsal root ganglion RGD PMID:9222544 PMID:21990306 RGD:2306950, RGD:7421656 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Aqp4 aquaporin 4 IEP associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord: RGD PMID:16219025 RGD:8695957 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bace1 beta-secretase 1 IMP RGD PMID:28012171 RGD:13782150 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bdkrb1 bradykinin receptor B1 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17989505 PMID:19300402 PMID:19815945 PMID:12927641 PMID:12637034 RGD:1579989, RGD:7241581 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP
ISO
CTD Direct Evidence: marker/mechanism
associated with Diabetic Neuropathy
CTD
RGD
PMID:17989505 PMID:19300402 PMID:19815945 PMID:10188975 PMID:19300402 RGD:4891040, RGD:2313332 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
IEP
IDA
ISO
associated with Peripheral Nerve Injuries;
associated with inflammation;protein:increased expression:dorsal root ganglion:
associated with Sciatic Neuropathy;
associated with Pancreatitis, Chronic;
RGD PMID:11425916 PMID:21958434 PMID:10779676 PMID:12435470 PMID:21864655 More... RGD:8657088, RGD:8657122, RGD:8657114, RGD:8657101, RGD:8657099, RGD:8657093, RGD:8657091 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 IEP RGD PMID:23665054 RGD:11560531 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G C3 complement C3 IEP associated with Sciatic Neuropathy;mRNA, protein:increased expression:spinal cord RGD PMID:23588254 RGD:7401259 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B IDA RGD PMID:17567797 RGD:1626313 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO CTD Direct Evidence: marker/mechanism CTD PMID:19577366 PMID:30552955 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IMP RGD PMID:17112407 RGD:15003199 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11245671 PMID:17881535 PMID:24133248 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Calca calcitonin-related polypeptide alpha IEP
ISO
associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
RGD
PMID:12787826 PMID:12855330 PMID:15265675 PMID:27093858 PMID:21958434 RGD:8657122 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
IMP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:20053885 PMID:18042863 RGD:7240711 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Capn2 calpain 2 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:25150005 RGD:13792585 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:21167239 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Cat catalase treatment IEP
IMP
RGD PMID:23952340 PMID:23658840 RGD:9479063, RGD:9479069 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin IDA RGD PMID:15647484 RGD:1626108 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cckbr cholecystokinin B receptor IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11880531 PMID:15647484 RGD:1626108 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IDA
ISO
IEP
IMP
CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal root ganglion, spinal cord (rat)
CTD
RGD
PMID:17881535 PMID:18419759 PMID:21712071 PMID:20737477 PMID:22531750 RGD:2307043, RGD:8548873, RGD:8548848, RGD:8548845 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP
IDA
mRNA:increased expression:dorsal root ganglion (rat) RGD PMID:18076762 PMID:18656466 RGD:4890034, RGD:2303121 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP
ISO
IEP
associated with Intervertebral disc disease;
associated with Demyelinating Diseases;
associated with Sciatic Neuropathy;
protein:increased expression:dorsal horn of spinal cord:
associated with Bone Neoplasms;protein:increased expression:spinal cord:
RGD PMID:18419759 PMID:24462503 PMID:18076762 PMID:24907405 PMID:22721162 More... RGD:2307043, RGD:8661788, RGD:4890034, RGD:8661781, RGD:8548831, RGD:8661772 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP
ISO
IMP
mRNA:increased expression:dorsal root ganglion (rat)
associated with Spinal Cord Injuries
RGD PMID:18076762 PMID:22033364 PMID:23147416 PMID:24589480 RGD:4890034, RGD:8551820, RGD:8551809, RGD:8551795 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cfl1 cofilin 1 IEP protein:increased phosphorylation:dorsal root ganglion (rat) RGD PMID:24962708 RGD:11570412 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17572696 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:17572696 PMID:18664590 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:28195063 PMID:20726980 RGD:8662326 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Crcp CGRP receptor component IEP RGD PMID:12895509 RGD:727768 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO associated with Sciatic Neuropathy; RGD PMID:24253780 RGD:11039470 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Csk C-terminal Src kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Ctss cathepsin S IMP
ISO
associated with Arthritis, Experimental
associated with Colitis
RGD PMID:22213084 PMID:21802389 RGD:5686870, RGD:5686873 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment IDA
IEP
associated with Arthritis, Experimental RGD PMID:19249394 PMID:22647647 RGD:2304251, RGD:9491779 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO
IEP
IMP
associated with Arthritis, Experimental;protein:increased expression:lumbar spinal cord
associated with Inflammation
associated with Bone Neoplasms
associated with Sciatic Neuropathy
RGD PMID:20609517 PMID:22647647 PMID:16324111 PMID:20524966 PMID:20736819 More... RGD:4891885, RGD:9491779, RGD:9387859, RGD:9354422, RGD:4892020, RGD:4891942 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IDA RGD PMID:28638088 RGD:13838657 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment IMP RGD PMID:28638088 PMID:30142543 RGD:13838657, RGD:13838658 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cybb cytochrome b-245 beta chain ISO associated with Spinal Cord Injuries; RGD PMID:20679217 RGD:11040629 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IDA associated with Diabetic neuropathies; RGD PMID:20531396 RGD:7257680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dnmt1 DNA methyltransferase 1 IMP RGD PMID:21682946 RGD:9588311 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20433900 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP
IDA
associated with Sciatic Neuropathy RGD PMID:22901764 PMID:22540262 RGD:7771531, RGD:7771574 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 treatment IEP associated with Sciatic Neuropathy RGD PMID:22901764 RGD:7771531 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Edn1 endothelin 1 susceptibility ISO mRNA:increased expression:paw skin (mouse)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:19429182 PMID:23347081 PMID:15664691 RGD:8661716, RGD:8661735 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 treatment IMP RGD PMID:20392816 RGD:9685429 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:25263804 RGD:9588307 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epha4 Eph receptor A4 IMP associated with spinal cord injuries; RGD PMID:16959251 RGD:5688783 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephx2 epoxide hydrolase 2 IMP RGD PMID:16962614 RGD:5688387 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:19285805 RGD:8553066 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 IDA
ISO
RGD PMID:17056036 PMID:19285805 RGD:5508846, RGD:8553066 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F2 coagulation factor II ISO associated with Sciatic Neuropathy RGD PMID:16251448 RGD:7387272 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor severity ISO
IDA
RGD PMID:19674841 PMID:11877315 PMID:12717003 RGD:7387269, RGD:7387271, RGD:7387270 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia ameliorates IMP RGD PMID:32510872 RGD:127338469 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP
ISO
protein:increased expression:dorsal horn of spinal cord, neuron
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:27093858 PMID:22160634 RGD:9999169 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gal galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20457222 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein IEP
ISO
associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord:
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:27093858 PMID:16219025 RGD:8695957 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gfra1 GDNF family receptor alpha 1 IDA RGD PMID:16464682 RGD:6218969 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IMP
IEP
associated with Sciatic Neuropathy RGD PMID:24631560 PMID:23374942 RGD:8662447, RGD:8662456 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IDA RGD PMID:29758384 RGD:13792698 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B treatment ISO
IMP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:20042082 PMID:24204988 RGD:13210755 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment
severity
IDA
IMP
IEP
associated with bone cancer
associated with Complex Regional Pain Syndromes
RGD PMID:26935064 PMID:22796071 PMID:25466829 PMID:26064176 RGD:13513996, RGD:13792780, RGD:13514049, RGD:13514046 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP associated with Limb Ischemia;protein:increased expression:foot muscle, plantar RGD PMID:18691814 RGD:9068903 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP
IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:27474498 PMID:24077211 PMID:30142543 RGD:7364865, RGD:13838658 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hoxd1 homeo box D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IDA
ISO
associated with Diabetic neuropathies;
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17888573 PMID:18930597 PMID:20531396 RGD:7257680 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP
IDA
RGD PMID:21693130 PMID:21843960 RGD:6480665, RGD:6482179 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 treatment IEP
ISO
IDA
associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
RGD
PMID:7582491 PMID:17174526 PMID:23957449 PMID:24077211 PMID:22820166 RGD:7364792, RGD:7364865, RGD:7364827 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:11399514 RGD:8549555 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A treatment IDA
IMP
RGD PMID:23192794 PMID:23246025 RGD:9068942, RGD:9222699 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:19036970 RGD:8655929 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12727271 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta IDA
ISO
CTD Direct Evidence: marker/mechanism
associated with Peripheral Nerve Injuries
CTD
RGD
PMID:7582491 PMID:10401557 PMID:12727271 PMID:17320857 PMID:20937348 More... RGD:1626676, RGD:7401209, RGD:7175548, RGD:6482671 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 IMP
ISO
RGD PMID:19022353 PMID:11585580 RGD:8662898, RGD:8662903 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist severity
treatment
IDA
ISO
IMP
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Arthritis, Experimental; rat model treated with human protein
CTD
RGD
PMID:8864563 PMID:15317861 PMID:17174526 PMID:20937348 PMID:23092240 More... RGD:6909165, RGD:8549800, RGD:7401210, RGD:6909175 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 treatment IMP
IDA
IEP
associated with Sciatic Neuropathy; mRNA,protein:increased expression:spinal cord: RGD PMID:12755376 PMID:18423867 PMID:22189457 RGD:8662973, RGD:8662980, RGD:8662977 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il33 interleukin 33 IMP RGD PMID:29329586 RGD:40400909 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il6 interleukin 6 IEP
ISO
associated with Foot Injuries; protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:dorsal root ganglion
CTD
RGD
PMID:7582491 PMID:10401557 PMID:18652822 PMID:18988309 PMID:23953943 RGD:8662979, RGD:10402830 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor IEP mRNA:increased expression:dorsal root ganglion RGD PMID:23953943 RGD:10402830 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Insr insulin receptor treatment ISO associated with Diabetic Neuropathies
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:18331706 PMID:23511693 RGD:10403050 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Itga1 integrin subunit alpha 1 IMP knock-down using a specific monoclonal antibody or RNAi
PGE2-induced
RGD PMID:15836982 PMID:14984413 RGD:2302139, RGD:2302389 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itga2 integrin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga3 integrin subunit alpha 3 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
JBrowse link
G Itga5 integrin subunit alpha 5 IMP epinephrine-induced
knock-down using a specific monoclonal antibody or RNAi
RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itgb1 integrin subunit beta 1 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEP RGD PMID:25972297 RGD:13793383 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jak2 Janus kinase 2 treatment IMP
ISO
associated with Diabetic Neuropathies RGD PMID:18636982 PMID:23511693 RGD:6483031, RGD:10403050 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jak3 Janus kinase 3 treatment IEP RGD PMID:21434883 RGD:11533942 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IMP RGD PMID:17855600 RGD:10411908 NCBI chr 2:195,063,967...195,099,233
Ensembl chr 2:195,071,769...195,099,233
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:16675954 RGD:9831112 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 IEP associated with Bone Neoplasms;protein:decreased expression:dorsal root ganglia (rat) RGD PMID:23352759 RGD:9686417 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653
JBrowse link
G Kmo kynurenine 3-monooxygenase treatment IMP RGD PMID:26524415 RGD:13703043 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Kng2 kininogen 2 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:2010815 PMID:2128375 PMID:3061568 PMID:7493622 PMID:7582491 More... RGD:11059894 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29143802 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:23665054 RGD:11560531 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 onset ISO RGD PMID:19427893 RGD:7495807 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17237256 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mc1r melanocortin 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19996949 NCBI chr19:51,452,448...51,455,375 JBrowse link
G Mc4r melanocortin 4 receptor IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:20081244 RGD:6484233 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Men1 menin 1 IEP associated with Sciatic Neuropathy;protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20369282 RGD:9589142 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Mfn2 mitofusin 2 IEP
ISO
mRNA:decreased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:28587902 PMID:28587902 RGD:12910704 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir15b microRNA 15b IDA RGD PMID:28012171 RGD:13782150 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir381 microRNA 381 treatment IDA RGD PMID:30142543 RGD:13838658 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mir96 microRNA 96 treatment IDA associated with Sciatic Neuropathy RGD PMID:24234845 RGD:11553932 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
JBrowse link
G Mmp3 matrix metallopeptidase 3 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18754875 PMID:22056600 RGD:8693664 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24382350 RGD:10040983 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nefh neurofilament heavy chain treatment IEP RGD PMID:21071147 RGD:27226885 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Ngf nerve growth factor treatment ISO
IMP
IDA
associated with Cystitis
CTD Direct Evidence: marker/mechanism
associated with Peripheral Nerve Injuries;
CTD
RGD
PMID:20457222 PMID:16203088 PMID:18448607 PMID:22839415 PMID:11425916 RGD:7242799, RGD:7242803, RGD:7242849, RGD:8657088 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor treatment IMP associated with Brachial Plexus Neuropathies RGD PMID:23324933 RGD:10413898 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:23891900 RGD:9831150 NCBI chr10:54,544,588...54,557,854
Ensembl chr10:54,544,588...54,558,434
JBrowse link
G Nos1 nitric oxide synthase 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19300402 PMID:23909597 RGD:7257597 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989504 PMID:19300402 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y treatment IEP associated with Sciatic Neuropathy RGD PMID:19556004 RGD:10448929 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nrg1 neuregulin 1 IEP associated with Sciatic Neuropathy RGD PMID:22212401 RGD:10449019 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15659614 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IMP RGD PMID:17667845 PMID:20351485 RGD:5144120, RGD:5684352 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEP
associated with inflammation;protein:increased expression:dorsal root ganglion: RGD PMID:12470870 PMID:21958434 RGD:8657091, RGD:8657122 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntsr1 neurotensin receptor 1 IDA RGD PMID:22396077 RGD:9743902 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP associated with Diabetes Mellitus, Experimental; RGD PMID:16924480 RGD:9834947 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IEP associated with Sciatic Neuropathy;mRNA:increased expression:spinal cord lumbar segment,dorsal root ganglion: RGD PMID:12106803 RGD:9835017 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17996026 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G P2rx2 purinergic receptor P2X 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
JBrowse link
G P2rx4 purinergic receptor P2X 4 treatment IMP associated with Peripheral Nerve Injuries; RGD PMID:29927790 RGD:40924654 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO
IMP
RGD PMID:20398327 PMID:20136836 RGD:6480525, RGD:6480526 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment IDA RGD PMID:17179954 RGD:9835416 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:23235561 RGD:10003116 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pla2g4a phospholipase A2 group IVA IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12665541 PMID:19231294 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:26732138 RGD:11572421 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Prkcb protein kinase C, beta IDA associated with inflammation;protein:increased activity:spinal cord RGD PMID:16360284 RGD:1625519 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:11738263 PMID:12582831 PMID:20457222 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcg protein kinase C, gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19955894 PMID:27093858 PMID:12560106 RGD:28867224 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkcz protein kinase C, zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27899695 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 treatment ISO RGD PMID:14973199 RGD:7775058 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Prok2 prokineticin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385
JBrowse link
G Prokr1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:120,022,301...120,033,379
Ensembl chr 4:120,021,747...120,033,379
JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:16925995 RGD:10041052 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11375261 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP protein:increased expression:lumbar spinal cord dorsal horn (rat) RGD PMID:17413918 RGD:5688169 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment IMP RGD PMID:20423341 RGD:10003041 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptges3 prostaglandin E synthase 3 IMP RGD PMID:16192391 RGD:5688057 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17989504 PMID:17413918 RGD:5688169 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:17112505 PMID:17989504 PMID:15464832 RGD:5688224 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18976650 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment IMP associated with lesion of sciatic nerve RGD PMID:27641322 RGD:13524513 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16545521 PMID:19070548 RGD:6484253 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23264124 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Sin3a SIN3 transcription regulator family member A IEP associated with Arthritis, Experimental;mRNA:decreased expression:spinal cord, neuron RGD PMID:17553988 RGD:9495916 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192
JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20086212 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:increased expression:dorsal horn of spinal cord, neuron RGD PMID:22160634 RGD:9999169 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079
JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IMP RGD PMID:24098399 RGD:8694290 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syn2 synapsin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:18701217 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8864563 PMID:9714424 PMID:10499367 PMID:12351280 PMID:12787826 More... NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15964684 PMID:17123731 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP associated with Experimental Pancreatitis, Chronic RGD PMID:26645248 RGD:14995470 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Thbd thrombomodulin treatment ISO associated with Inflammation
CTD Direct Evidence: therapeutic
CTD
RGD
PMID:27474498 PMID:24004409 RGD:11038687 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tlr2 toll-like receptor 2 ISO
IDA
RGD PMID:17355971 PMID:24204973 RGD:8553059, RGD:8553185 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 IMP
ISO
RGD PMID:20714435 PMID:24204973 PMID:15809417 RGD:4144070, RGD:8553185, RGD:7815040 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor IMP
ISO
IDA
IEP
CTD Direct Evidence: marker/mechanism
associated with Diabetic Neuropathies;
mRNA,protein:increased expression:spinal cord:
protein:increased expression:lumbar vertebra:
CTD
RGD
PMID:7582491 PMID:7881729 PMID:10401557 PMID:12727271 PMID:16472913 More... RGD:7387300, RGD:7401179, RGD:7394757, RGD:7394741, RGD:7394737, RGD:7387302, RGD:7387300 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO CTD Direct Evidence: therapeutic CTD PMID:16769263 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IMP
IEP
ISO
associated with Sciatic Neuropathy RGD PMID:12752784 PMID:22652595 PMID:21712071 PMID:24257399 PMID:20417692 More... RGD:5130913, RGD:8661750, RGD:8548873, RGD:8661737, RGD:8661726, RGD:5130939 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO
IMP
associated with Sciatic Neuropathy RGD PMID:18463260 PMID:22652595 RGD:5130960, RGD:8661750 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP
ISO
associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:18234885 PMID:21481532 PMID:23523557 PMID:18954467 RGD:10043618 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IMP associated with Inflammation RGD PMID:19439599 RGD:7247605 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IMP RGD PMID:19439599 RGD:7247605 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IEP
ISO
associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:12151517 PMID:18234885 PMID:18774343 PMID:23006841 PMID:21958434 RGD:8657122 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17251
    disease of anatomical entity 16595
      nervous system disease 12130
        Neurologic Manifestations 5466
          Pain 307
            Hyperalgesia 197
Path 2
Term Annotations click to browse term
  disease 17251
    disease of anatomical entity 16595
      nervous system disease 12130
        Neurologic Manifestations 5466
          Sensation Disorders 1110
            Somatosensory Disorders 312
              Hyperalgesia 197
paths to the root