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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:bipolar disorder
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Accession:DOID:3312 term browser browse the term
Definition:A mood disorder that involves alternating periods of mania and depression. (DO)
Synonyms:exact_synonym: BPAD;   Bipolar and Related Disorders;   Mania;   Manic Depressive Psychosis;   bipolar affective disorder;   bipolar affective psychoses;   bipolar affective psychosis;   bipolar depression;   bipolar disorder manic phase;   bipolar disorders;   depressive-manic psych.;   manias;   manic bipolar I disorder;   manic bipolar affective disorder;   manic depression;   manic depressive disorder;   manic disorder;   manic disorders;   manic state;   manic states;   manic-depressive psychoses;   mixed bipolar disorder
 related_synonym: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
 primary_id: MESH:D000068105;   MESH:D001714
 xref: GARD:10249;   ICD10CM:F31;   ICD9CM:296.40;   ICD9CM:296.60;   ICD9CM:296.80;   NCI:C34423;   NCI:C34424;   NCI:C34805
For additional species annotation, visit the Alliance of Genome Resources.


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bipolar disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEA GAD PMID:15118671 RGD:1331525 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adcy2 adenylate cyclase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Add3 adducin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma RGD PMID:22137759 RGD:5686381 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agt angiotensinogen ISO GAD PMID:15118671 RGD:1331525 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21570127 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO DNA:SNP, haplotype: :multiple (human) RGD PMID:20214684 RGD:5509071 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ank3 ankyrin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18711365 PMID:21926974 PMID:31043756 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO
ISS
MouseDO PMID:9646882 RGD:1358437 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO DNA:SNP: :rs28536160 (human) RGD PMID:24012103 RGD:14700651 NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 PMID:19018715 PMID:15118671 RGD:1331525 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25395965 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Brd1 bromodomain containing 1 susceptibility ISO DNA,SNP,haplotype:3'UTR: RGD PMID:16924267 RGD:9586096 NCBI chr 7:119,774,187...119,822,031
Ensembl chr 7:119,774,188...119,822,031
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18711365 PMID:21926972 PMID:21926974 PMID:31043756 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO CTD Direct Evidence: marker/mechanism CTD PMID:28194001 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISS MouseDO NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO RGD PMID:15034225 RGD:1358456 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd47 Cd47 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:18391128 RGD:5688274 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO DNA:SNP: :rs324650 (human)
protein:decreased expression:cerebral cortex
RGD PMID:20351719 PMID:19103464 RGD:5509579, RGD:5509584 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Clock clock circadian regulator ISS MouseDO NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11772685 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cplx1 complexin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr14:1,184,638...1,216,392 JBrowse link
G Cplx2 complexin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
JBrowse link
G Ddc dopa decarboxylase ISO DNA:deletions:5' utr, intron:g.-601delG, g.722_725delGAGA (human) RGD PMID:12555230 RGD:1358586 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Disc1 DISC1 scaffold protein susceptibility ISO DNA;SNPs: :rs2738864,rs16841582 (human)
DNA:SNPs: :rs1538979, rs821577, rs821633 (human)
DNA:SNPs: :multiple
RGD PMID:21222298 PMID:18317464 PMID:15386212 RGD:5509829, RGD:5509836, RGD:5509833 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
JBrowse link
G Dixdc1 DIX domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19153942 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd5 dopamine receptor D5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
JBrowse link
G Fads2 fatty acid desaturase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fstl5 follistatin-like 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:160,857,989...161,526,589
Ensembl chr 2:160,856,291...161,526,589
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 ISO DNA:repeat:intron:IVS8CA (human) RGD PMID:11840313 RGD:1358391 NCBI chr  X:150,244,745...150,501,566
Ensembl chr  X:150,261,607...150,501,559
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 ISO RGD PMID:9514592 RGD:1358630 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO protein:decreased expression:prefrontal cortex layers 2-5 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:15560956 PMID:18534564 RGD:6480428 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15560956 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO DNA:polymorphism RGD PMID:15909293 RGD:1601281 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18332879 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO DNA:repeat:promoter:(GT)18-33 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:31043756 PMID:12809987 RGD:1358644 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:16549338 RGD:1642201 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO mRNA, protein:decreased expression:frontal cortex (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:12808434 PMID:19400979 RGD:5685029 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grn granulin precursor ISO protein:decreased expression:plasma RGD PMID:24581833 RGD:10401641 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20357757 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20357757 PMID:17357145 PMID:16397405 RGD:1641929, RGD:1641931 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IEA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:14708030 PMID:15118671 RGD:1331525 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO DNA:missense mutation:cds:p.C23S (human) RGD PMID:8823764 RGD:1358737 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Impa2 inositol monophosphatase 2 susceptibility ISO DNA:SNPs:promoter:-461C>T, -207T>C(human) RGD PMID:9322233 PMID:11673796 PMID:14699425 RGD:6480265, RGD:6480269, RGD:6480267 NCBI chr18:60,834,206...60,867,575
Ensembl chr18:60,834,246...60,865,641
JBrowse link
G Ins2 insulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:5506046 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
JBrowse link
G Kat6b lysine acetyltransferase 6B ISO DNA:mutations:multiple (human) RGD PMID:24444492 RGD:9588521 NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
JBrowse link
G L1cam L1 cell adhesion molecule ISO associated with Depressive Disorder; mRNA:increased expression:blood (human) RGD PMID:18430502 RGD:6483084 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Lman2l lectin, mannose-binding 2-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 9:38,683,174...38,685,249
Ensembl chr 9:38,661,712...38,685,337
JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:haplotype: : RGD PMID:24856568 RGD:12910826 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO DNA:missense mutation:cds:m.3644T>C (human) RGD PMID:15533721 RGD:5490261 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17074966 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO DNA:snps:introns:IVS6+32T>C, IVS7+11G>C, IVS12+21C>A (human) RGD PMID:15050861 RGD:1358750 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncan neurocan ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:20368511 RGD:6484696 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19135101 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrg1 neuregulin 1 ISO DNA:SNP:enhancer: (rs35753505) RGD PMID:18585932 RGD:39131291 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Ntng1 netrin G1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17507910 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Ntng2 netrin G2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17507910 NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO protein:decreased expression:cerebellum
CTD Direct Evidence: marker/mechanism
CTD PMID:19018715 PMID:21612826 RGD:5684549 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Pacs1 phosphofurin acidic cluster sorting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:202,437,503...202,569,473
Ensembl chr 1:202,437,505...202,569,473
JBrowse link
G Pc pyruvate carboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pde4b phosphodiesterase 4B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18394866 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit ISS MouseDO NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2843795 PMID:9664777 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pou3f2 POU class 3 homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 5:36,077,930...36,083,838
Ensembl chr 5:36,077,930...36,083,838
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B ISO DNA, mRNA:SNPs, haplotype, splice variant:multiple RGD PMID:23295814 RGD:13515076 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO mRNA, protein:decreased expression:prefrontal cortex RGD PMID:20038946 RGD:5688160 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA, protein:increased expression:prefrontal cortex RGD PMID:20038946 RGD:5688160 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pvalb parvalbumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Rap1gap Rap1 GTPase-activating protein ISO mRNA, protein:increased expression:dorsolateral prefrontal cortex (human) RGD PMID:16687443 RGD:5490162 NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253
JBrowse link
G Reln reelin ISO protein:decreased expression:hippocampus (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:11126396 PMID:14708030 PMID:15560956 PMID:11126396 RGD:2324681 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G RT1-Da RT1 class II, locus Da ISO RGD PMID:16687443 RGD:5490162 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G S100b S100 calcium binding protein B IEP
ISO
protein:increased expression:cerebrospinal fluid
CTD Direct Evidence: marker/mechanism
CTD PMID:15581912 PMID:16476148 PMID:15581912 RGD:5508853 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
JBrowse link
G Serpina1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Slc18a1 solute carrier family 18 member A1 ISO DNA:SNPs:5' utr, cds:g.-584A>G (rs988713), p.T136I (rs1390938) (human) RGD PMID:16936705 RGD:5131197 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
JBrowse link
G Slc5a3 solute carrier family 5 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16420717 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism
DNA:repeats:promoter:
CTD PMID:11772685 PMID:16395126 PMID:10484962 RGD:36947381 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Snap25 synaptosome associated protein 25 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14708030 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Snca synuclein alpha ISO RGD PMID:19198857 RGD:6478716 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sp4 Sp4 transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19401786 NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
JBrowse link
G Srpk2 SRSF protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:18281098 RGD:11039413 NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
JBrowse link
G Ssbp2 single-stranded DNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 2:22,650,488...22,933,696
Ensembl chr 2:22,651,258...22,933,696
JBrowse link
G Sstr5 somatostatin receptor 5 ISO DNA:SNP, missense mutations, haplotype: :573G>A, p.L48M, p.P335L (human) RGD PMID:12192619 RGD:1358589 NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
JBrowse link
G Stard9 StAR-related lipid transfer domain containing 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 3:107,581,097...107,672,746
Ensembl chr 3:107,581,164...107,673,898
JBrowse link
G Stk4 serine/threonine kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 susceptibility ISO DNA:SNPs:promoter,intron: RGD PMID:28178086 RGD:13209005 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15845098 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tenm4 teneurin transmembrane protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21926972 NCBI chr 1:149,895,097...151,263,315
Ensembl chr 1:150,780,381...151,259,144
JBrowse link
G Thsd7a thrombospondin type 1 domain containing 7A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO protein:increased expression:plasma RGD PMID:20861651 RGD:7205488 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tph2 tryptophan hydroxylase 2 ISO mRNA:increased expression:frontal association cortex
ClinVar Annotator: match by term: Bipolar affective disorder, susceptibility to
ClinVar PMID:17905754 PMID:19319927 PMID:16240163 RGD:5686358 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 8:111,275,973...111,355,491
Ensembl chr 8:111,276,354...111,355,092
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23602965 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23602965 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Tshb thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:6455462 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:plasma RGD PMID:19839997 RGD:7207027 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Zcchc2 zinc finger CCHC-type containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373
JBrowse link
G Zfp592 zinc finger protein 592 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31043756 NCBI chr 1:134,951,286...135,002,443
Ensembl chr 1:134,967,783...135,002,443
JBrowse link
Major Affective Disorder 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xbp1 X-box binding protein 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Major affective disorder 7
OMIM
CTD
ClinVar
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17205
    disease of anatomical entity 16551
      nervous system disease 12097
        central nervous system disease 10373
          brain disease 9736
            disease of mental health 7038
              cognitive disorder 1948
                mood disorder 265
                  bipolar disorder 113
                    Major Affective Disorder 3 0
                    Major Affective Disorder 4 0
                    Major Affective Disorder 5 0
                    Major Affective Disorder 6 0
                    Major Affective Disorder 7 1
                    Major Affective Disorder 8 0
                    Major Affective Disorder 9 0
                    Mental Health Wellness 1 0
                    Mental Health Wellness 2 0
                    bipolar I disorder 0
                    bipolar ll disorder 0
                    cyclothymic disorder 0
paths to the root