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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Spinal Cord Injuries
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Accession:DOID:9000039 term browser browse the term
Definition:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Synonyms:exact_synonym: Post Traumatic Myelopathy;   Post-Traumatic Myelopathies;   Spinal Cord Contusion;   Spinal Cord Contusions;   Spinal Cord Injury;   Spinal Cord Laceration;   Spinal Cord Lacerations;   Spinal Cord Transection;   Spinal Cord Transections;   Spinal Cord Trauma;   Spinal Cord Traumas;   Traumatic Myelopathies;   Traumatic Myelopathy
 narrow_synonym: acute spinal cord injury
 primary_id: MESH:D013119;   RDO:0006597
For additional species annotation, visit the Alliance of Genome Resources.


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Spinal Cord Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment ISO
IEP
IMP
mRNA:increased expression:spinal cord RGD PMID:20410530, PMID:25763638, PMID:20410530, PMID:20410530 RGD:12790978, RGD:12791993, RGD:12790978, RGD:12790978 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Acan aggrecan IEP protein:altered expression:spinal cord (rat) RGD PMID:14769391 RGD:2315837 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 IDA RGD PMID:20456005 RGD:10755338 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 IEP
IDA
protein:altered expression:spinal cord,dorsal root ganglion, urinary bladder RGD PMID:15698618, PMID:15913892 RGD:2325309, RGD:2325306 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum RGD PMID:16213239 RGD:5686719 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adora1 adenosine A1 receptor IMP
IDA
IEP
protein:decreased expression:spinal cord RGD PMID:18289533, PMID:20065990, PMID:17853654 RGD:5129096, RGD:5129094, RGD:4890369 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor IEP RGD PMID:17559837 RGD:4890378 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra1a adrenoceptor alpha 1A IEP mRNA:increased expression:aorta RGD PMID:16524515 RGD:5688371 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP protein:increased expression:spinal cord (rat) RGD PMID:20195207 RGD:2325645 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP protein:altered expression:spinal cord dorsal horn (rat) RGD PMID:17158026 RGD:2313037 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:20678995 RGD:10040962 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17457363 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 3:80,634,470...80,830,068
Ensembl chr 3:80,634,470...80,830,068
JBrowse link
G Ankrd1 ankyrin repeat domain 1 IEP mRNA:increased expression:spinal cord, dorsal root ganglion, neuron RGD PMID:17610582 RGD:5133279 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B IEP RGD PMID:25034417 RGD:10401137 NCBI chr 5:62,070,709...62,094,633
Ensembl chr 5:62,071,346...62,094,633
JBrowse link
G Anxa1 annexin A1 treatment ISO
IEP
mRNA,protein:increased expression:neuron,glial cell RGD PMID:17917587, PMID:15248295 RGD:2306891, RGD:10053688 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 IEP mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa5 annexin A5 IEP mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEP RGD PMID:21748659 RGD:10053608 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 IEP mRNA:increased expression:spinal cord RGD PMID:18637713 RGD:2315670 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoe apolipoprotein E ISO
IEP
DNA:polymorphism:exon: RGD PMID:18581664, PMID:30036659 RGD:7771551, RGD:13703128 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Aqp1 aquaporin 1 IEP
ISO
protein:increased expression:spinal cord, neuron, astrocyte
CTD Direct Evidence: marker/mechanism
CTD PMID:21092735, PMID:18248364, PMID:21092735 RGD:2307072, RGD:5148013 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp4 aquaporin 4 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:21092735, PMID:21092735, PMID:21280976, PMID:20517941 RGD:5148013, RGD:5148035, RGD:5148027 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Atf4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 IEP
ISO
protein:increased expression:axon
CTD Direct Evidence: marker/mechanism
CTD PMID:29793971, PMID:25040536 RGD:11553820 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 IEP protein:increased expression:axon RGD PMID:25040536 RGD:11553820 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase IEP protein:increased expression:spinal cord RGD PMID:21748659 RGD:10053608 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEP protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor IEP mRNA,protein:decreased expression:spinal cord: RGD PMID:28035406 RGD:14390163 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:27256506 RGD:13792677 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcan brevican treatment IEP RGD PMID:15016081 RGD:9589823 NCBI chr 2:187,359,674...187,373,133
Ensembl chr 2:187,359,677...187,372,657
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:27256506 RGD:13792677 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IDA
IEP
RGD PMID:16022868, PMID:24551172, PMID:19203225 RGD:4891112, RGD:10059354, RGD:4891066 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 treatment ISO
IEP
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD PMID:29793971, PMID:21806471, PMID:23852559, PMID:24559459 RGD:6483100, RGD:11561922, RGD:11561918 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmp2 bone morphogenetic protein 2 IDA RGD PMID:23770801 RGD:9068404 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 treatment IDA
ISO
RGD PMID:23770801, PMID:18803859 RGD:9068404, RGD:9068437 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like IEP protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Brca2 BRCA2, DNA repair associated IEP mRNA,protein:increased expression:spinal cord: RGD PMID:21748659 RGD:10053608 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G C1qb complement C1q B chain IEP mRNA:increased expression RGD PMID:16345062 RGD:1599510 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G Capn1 calpain 1 treatment IMP RGD PMID:23102374 RGD:13792496 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta IEP protein:decreased expression:spinal cord RGD PMID:20141154 RGD:9685028 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Casp1 caspase 1 IDA protein:increased expression, increased activation:spinal cord RGD PMID:18367607 RGD:2315889 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 treatment IEP
IDA
associated with Diabetes Mellitus, Experimental RGD PMID:19215662, PMID:26884858 RGD:2311450, RGD:11560925 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 treatment IMP
IEP
IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:14588118, PMID:18378144, PMID:27256506, PMID:27339639, PMID:21748659 RGD:2293322, RGD:13792677, RGD:13782345, RGD:10053608 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 treatment IEP
IDA
RGD PMID:21748659, PMID:27339639 RGD:10053608, RGD:13782345 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 IEP protein:increased phosphorylation:spinal cord RGD PMID:17275798 RGD:2289124 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 IEP mRNA:increased expression:spinal cord RGD PMID:9698165 RGD:5135274 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:spinal cord segment (mouse) RGD PMID:20478301 RGD:4889905 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd3 cyclin D3 IEP protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 IEP protein:increased expression:spinal cord RGD PMID:16759516 RGD:2289281 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccnh cyclin H IEP mRNA, protein:increased expression:spinal cord RGD PMID:21710280 RGD:9590263 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 IEP RGD PMID:21332278 RGD:5688138 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IEP protein:increased expression:spinal cord RGD PMID:18338959 RGD:4144888
G Cd274 CD274 molecule IEP mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cdc42 cell division cycle 42 IEP mRNA:increased expression:spinal cord RGD PMID:15736231 RGD:5688276 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEP protein:increased expression:spinal cord dura mater (rat) RGD PMID:19672039 RGD:2316488 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk19 cyclin-dependent kinase 19 IEP mRNA, protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IDA protein:decreased expression, altered localization:spinal cord, neuron, microglial cell RGD PMID:18319192 RGD:2293615 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chl1 cell adhesion molecule L1-like IEP protein:increased expression:spinal cord (rat) RGD PMID:21337374 RGD:6483045 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Cnr1 cannabinoid receptor 1 IEP RGD PMID:18930143 RGD:2316199 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 IEP RGD PMID:18930143 RGD:2316199 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Crh corticotropin releasing hormone IEP protein:altered expression:spinal cord (rat) RGD PMID:20458328 RGD:5490964 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crp C-reactive protein IDA RGD PMID:22404382 RGD:6903321 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO RGD PMID:15658127 RGD:10449531 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:21953623 RGD:10450511 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 ISO
IDA
RGD PMID:22243800, PMID:19604403, PMID:22042562 RGD:5686844, RGD:5686859, RGD:5686848 NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
JBrowse link
G Ctss cathepsin S IEP RGD PMID:16344894 RGD:2303423 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP RGD PMID:9698165 RGD:5135274 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP RGD PMID:19170890 RGD:2311365 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyba cytochrome b-245 alpha chain IEP mRNA:increased expression:spinal cord RGD PMID:16345062 RGD:1599510 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain ISO mRNA,protein:increased expression:microglia: RGD PMID:20679217 RGD:11040629 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Dab2 DAB adaptor protein 2 IEP protein:increased expression:spinal cord RGD PMID:17317100 RGD:7243246 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dcc DCC netrin 1 receptor IEP RGD PMID:16998900 RGD:2314373 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP protein:decreased expression:spinal cord RGD PMID:18630599, PMID:19383246 RGD:7771572, RGD:7771580 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egfr epidermal growth factor receptor IMP
IEP
protein:increased phosphorylation:spinal cord, astrocyte (rat) RGD PMID:20869112, PMID:21402118 RGD:5131525, RGD:5131454 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A IEP mRNA, protein:increased expression:gastrocnemius RGD PMID:23238062 RGD:10395360 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Endog endonuclease G IEP RGD PMID:16689664 RGD:8655990 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Eno2 enolase 2 IEP protein:increased expression:serum, cerebrospinal fluid RGD PMID:18343116 RGD:2293743 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Ensa endosulfine alpha IEP mRNA:decreased expression:spinal cord RGD PMID:16344894 RGD:2303423 NCBI chr 2:197,752,544...197,759,882
Ensembl chr 2:197,752,544...197,759,882
JBrowse link
G Epha3 Eph receptor A3 IEP RGD PMID:16083359 RGD:2301766 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Epha4 Eph receptor A4 IMP
IEP
ISO
RGD PMID:17970742, PMID:17418490, PMID:21931787 RGD:5688750, RGD:5688782, RGD:5688764 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Epha7 Eph receptor A7 IMP mRNA:increased expression:spinal cord RGD PMID:16983667 RGD:2301957 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22196867 RGD:10401074 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP mRNA, protein:increased expression:spinal cord RGD PMID:11797086 RGD:2289967 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Esr1 estrogen receptor 1 IEP RGD PMID:25105782 RGD:10045844 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 IEP RGD PMID:25105782 RGD:10045844 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F2 coagulation factor II IEP RGD PMID:16344894 RGD:2303423 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:23574812 RGD:11344882 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor IEP
IDA
protein:increased expression:cervical spinal cord RGD PMID:17518537, PMID:29738767, PMID:17703359 RGD:2290177, RGD:13792580, RGD:2290176 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO
IDA
Human FGF1 used in rat model of spinal cord injury RGD PMID:21663406, PMID:18482974, PMID:20488178, PMID:8662542 RGD:5509875, RGD:2317692, RGD:5509877, RGD:5509876 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:26079325 RGD:12437066 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IEP mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:20347014 RGD:7205459 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Foxo3 forkhead box O3 IEP protein:decreased expression:spinal cord,neuron, astrocyte: RGD PMID:22930444 RGD:10402202 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxp3 forkhead box P3 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gap43 growth associated protein 43 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase treatment IDA RGD PMID:27256506 RGD:13792677 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO RGD PMID:22342994 RGD:5688774 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gfap glial fibrillary acidic protein treatment ISO
IEP
protein:increased expression:spinal cord RGD PMID:10225952, PMID:24968269, PMID:21250919 RGD:6480471, RGD:40924652, RGD:6480511 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:25261791 RGD:12907564 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IMP
IEP
RGD PMID:23403365, PMID:24183749 RGD:8662431, RGD:8662460 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjc2 gap junction protein, gamma 2 treatment IEP RGD PMID:26415641 RGD:13208513 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP protein:increased expression:spinal cord (rat) RGD PMID:27150525 RGD:13506243 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:22975889 RGD:8552988 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IEP protein:increased expression:spinal cord, neuron, microglial cell (rat) RGD PMID:23359120 RGD:13792782 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Grn granulin precursor ISO mRNA, protein:increased expression:spinal cord: RGD PMID:19946692 RGD:5509603 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 IEP mRNA:increased expression:lumbar segment of spinal cord (rat) RGD PMID:22160604 RGD:5687769 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Hgf hepatocyte growth factor treatment ISO
IEP
IDA
mRNA,protein:increased expression:spinal cord: RGD PMID:22140459, PMID:17549731, PMID:17549731 RGD:8548666, RGD:2317487, RGD:2317487 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD PMID:21092735, PMID:21092735 RGD:5148013 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 IEP mRNA:increased expression:spinal cord RGD PMID:20195207 RGD:2325645 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:23943397 RGD:10766443 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:16671478 RGD:1626425 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IEP protein:decreased expression:spinal cord (rat) RGD PMID:24499940 RGD:10445836 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO mRNA: increased expression RGD PMID:21933012 RGD:5685666 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 treatment IEP mRNA,protein:increased expression:spinal cord: RGD PMID:12098653, PMID:30287503 RGD:10402749, RGD:38549580 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:8627308 RGD:11522712 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10 interleukin 10 treatment IEP RGD PMID:29691718 RGD:14975124 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 treatment IDA
IEP
RGD PMID:18367607, PMID:23140983 RGD:2315889, RGD:8655974 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta treatment IEP
IDA
mRNA, protein:increased expression:spinal cord RGD PMID:16038625, PMID:29691718, PMID:23209732 RGD:1626673, RGD:14975124, RGD:7175523 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 IEP mRNA,protein:increased expression:spinal cord RGD PMID:16456668 RGD:7207035 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist IDA
ISO
protein:increased expression:serum (human) RGD PMID:16038625, PMID:17964877 RGD:1626673, RGD:6907102 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il4 interleukin 4 IMP RGD PMID:20623539 RGD:5128562 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor IEP mRNA:increased expression:spinal cord RGD PMID:20623539 RGD:5128562 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 treatment IDA
IEP
RGD PMID:27085942, PMID:29691718 RGD:11062150, RGD:14975124 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf1 interferon regulatory factor 1 IEP RGD PMID:11723173 RGD:2298928 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irf5 interferon regulatory factor 5 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 severity IEP protein:decreased expression:cerebrospinal fluid RGD PMID:21559420 RGD:40907059 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Jak2 Janus kinase 2 treatment IMP RGD PMID:23274522 RGD:10411896 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IDA protein:increased phosphorylation:neuron RGD PMID:21132399 RGD:4889994 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP protein:decreased expression:spinal cord RGD PMID:20375134 RGD:8662905 NCBI chr13:90,722,945...90,753,338
Ensembl chr13:90,723,092...90,752,581
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 treatment IDA RGD PMID:22425721 RGD:9831183 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Kdm6b lysine demethylase 6B IEP mRNA:increased expression:spinal cord (rat) RGD PMID:22578249 RGD:9587821 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
JBrowse link
G Kdr kinase insert domain receptor IEP mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kif3b kinesin family member 3B IEP protein:increased expression:spinal cord RGD PMID:23093447 RGD:11049594 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
JBrowse link
G Klk6 kallikrein related-peptidase 6 IEP protein:increased expression:spinal cord RGD PMID:16987227 RGD:2314866 NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488
JBrowse link
G Kmo kynurenine 3-monooxygenase IEP mRNA,protein:increased expression:spinal cord: RGD PMID:26524415 RGD:13703043 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Lep leptin IEP RGD PMID:19777863 RGD:5128780 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lrp1 LDL receptor related protein 1 treatment IDA RGD PMID:23867460 RGD:13800520 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrp5 LDL receptor related protein 5 treatment IEP RGD PMID:24090150 RGD:12798566 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Lum lumican IEP protein:increased expression:spinal cord RGD PMID:18482974 RGD:2317692 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
JBrowse link
G Map1b microtubule-associated protein 1B IEP protein:increased phosphorylation:spinal cord, neuron RGD PMID:17880387 RGD:2304007 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment IEP protein:increased expression:spinal cord RGD PMID:24559459, PMID:23637053, PMID:23852559 RGD:11561918, RGD:11564330, RGD:11561922 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:21704982 RGD:6483323 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP protein:increased expression:white matter and grey matter: RGD PMID:10331432 RGD:10412645 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapt microtubule-associated protein tau treatment IEP RGD PMID:22052241 RGD:8158113 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdm2 MDM2 proto-oncogene IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase IEP mRNA, protein:increased expression:spinal cord (rat) RGD PMID:17549731 RGD:2317487 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mfn1 mitofusin 1 treatment IEP protein:altered expression:spinal cord, mitochondrion (rat) RGD PMID:26981103, PMID:26079325 RGD:12910837, RGD:12437066 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mfn2 mitofusin 2 treatment IEP protein:increased expression:spinal cord (rat) RGD PMID:28404953, PMID:26079325 RGD:12910735, RGD:12437066 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA:increased expression:spinal cord, microglial cell RGD PMID:15067555 RGD:1641997 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir21 microRNA 21 exacerbates IMP RGD PMID:31102912 RGD:41410823 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir214 microRNA 214 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr13:80,130,905...80,131,014 JBrowse link
G Mir411 microRNA 411 IEP RGD PMID:29738767 RGD:13792580 NCBI chr 6:133,858,849...133,858,924
Ensembl chr 6:133,858,844...133,858,939
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP RGD PMID:24436993 RGD:8657106 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:25763638 RGD:12791993 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:spinal cord RGD PMID:22986158 RGD:6909148 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrc1 mannose receptor, C type 1 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 IMP RGD PMID:20438613 RGD:5687694 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IMP RGD PMID:20678995 RGD:10040962 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D IEP mRNA:increased expression:spinal cord RGD PMID:18930143 RGD:2316199 NCBI chr 4:9,965,323...10,004,650
Ensembl chr 4:9,966,891...10,002,247
JBrowse link
G Ncam1 neural cell adhesion molecule 1 treatment ISO RGD PMID:28529158 RGD:40924632 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP protein:increased expression:spinal cord RGD PMID:14644473 RGD:2314450 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nefh neurofilament heavy treatment IDA
IEP
RGD PMID:18772508, PMID:32168135 RGD:9698443, RGD:27226888 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefl neurofilament light treatment IDA RGD PMID:18772508 RGD:9698443 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium treatment IDA RGD PMID:18772508 RGD:9698443 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 treatment IDA RGD PMID:24747453 RGD:10412730 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:21134362 RGD:10413867 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor IEP
IMP
RGD PMID:16915089, PMID:12499054 RGD:5144069, RGD:5144073 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor treatment IEP
IMP
mRNA:increased expression:spinal cord RGD PMID:11223160, PMID:23748892 RGD:5144100, RGD:10414079 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nkx6-1 NK6 homeobox 1 IMP RGD PMID:18687784 RGD:2311166 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Nlk nemo like kinase IEP protein:increased expression:grey matter: RGD PMID:24395089 RGD:12791278 NCBI chr10:65,840,052...65,963,932
Ensembl chr10:65,840,052...65,963,932
JBrowse link
G Nog noggin treatment ISO RGD PMID:18221366 RGD:10429192 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Nos1 nitric oxide synthase 1 IEP
IMP
protein:increased expression:spinal cord RGD PMID:19291395, PMID:20633123 RGD:5132595, RGD:5131936 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 IEP mRNA:altered expression:thoracic aorta RGD PMID:17287083 RGD:4891407 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 IEP RGD PMID:17287083 RGD:4891407 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP protein:increased expression:spinal cord (rat) RGD PMID:24747453, PMID:28881715 RGD:10412730, RGD:13434916 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ntf3 neurotrophin 3 ISO RGD PMID:16022868 RGD:4891112 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IDA
IMP
RGD PMID:22027236, PMID:20597685 RGD:5684547, RGD:5684898 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IEP mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 treatment ISO
IMP
RGD PMID:28452182, PMID:22173726 RGD:40902836, RGD:40902844 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO CTD Direct Evidence: therapeutic CTD PMID:15258577 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:15696051, PMID:21748659 RGD:10053608 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd1 programmed cell death 1 treatment IEP RGD PMID:29665726 RGD:40886268 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
Ensembl chr 9:101,307,764...101,319,845
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 IEP mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:21568693 RGD:6482306 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO
IEP
protein:increased expression:spinal cord RGD PMID:21868473, PMID:19306380 RGD:6482718, RGD:6482721 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g6 phospholipase A2 group VI ISO protein:increased expression:spinal cord RGD PMID:21868473 RGD:6482718 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:21573723 RGD:6483797 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:21573723 RGD:6483797 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pon1 paraoxonase 1 treatment IDA RGD PMID:12897486 RGD:8547682 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IEP RGD PMID:20058304 RGD:2324875 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IDA RGD PMID:22208735 RGD:6484263 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma IEP protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:29033188 RGD:13514047 NCBI chr12:39,864,302...39,882,030
Ensembl chr12:39,864,295...39,882,030
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A IEP
ISO
mRNA:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:29793971, PMID:17578450 RGD:9999410 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prkcg protein kinase C, gamma ISO protein:decreased expression:spinal cord (mouse) RGD PMID:10501452 RGD:28867228 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP
IEP
protein:increased expression:microglia, macrophage RGD PMID:17184185, PMID:11063829 RGD:5688221, RGD:5688246 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:18606213 RGD:5135219 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 treatment IDA
IEP
RGD PMID:15016081, PMID:18065151, PMID:12895450 RGD:9589823, RGD:9590124, RGD:9590113 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Rara retinoic acid receptor, alpha IEP RGD PMID:16420438 RGD:2314291 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rbmx RNA binding motif protein, X-linked IEP RGD PMID:23180094 RGD:10053723 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:17918744 RGD:2298849 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a treatment IMP RGD PMID:16585268 RGD:9850138 NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514
JBrowse link
G Rpsa ribosomal protein SA IEP RGD PMID:19196078 RGD:11041651 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 IDA RGD PMID:16109750, PMID:16718433 RGD:2317321, RGD:2317320 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:15792522 RGD:1599333 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Shh sonic hedgehog signaling molecule treatment IMP RGD PMID:24837681 RGD:12879409 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 treatment IDA RGD PMID:27256506 RGD:13792677 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link
G Slc25a27 solute carrier family 25, member 27 ISO protein:increased expression:spinal cord RGD PMID:18534681 RGD:6482843 NCBI chr 9:19,880,468...19,907,506
Ensembl chr 9:19,880,473...19,907,458
JBrowse link
G Slit1 slit guidance ligand 1 ISO RGD PMID:16262652 RGD:2316136 NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
JBrowse link
G Slit2 slit guidance ligand 2 IEP mRNA, protein:increased expression:spinal cord RGD PMID:19783284 RGD:2316127 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Slit3 slit guidance ligand 3 ISO RGD PMID:16262652 RGD:2316136 NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEP RGD PMID:11723173 RGD:2298928 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO human protein in a rat model
CTD Direct Evidence: therapeutic
human gene in a rat model
CTD PMID:17457363, PMID:18722523, PMID:16689664 RGD:8655939, RGD:8655990 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sox2 SRY-box transcription factor 2 IEP RGD PMID:23169458 RGD:8661675 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO RGD PMID:17611274 RGD:2300052 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15592854 RGD:6483848 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqstm1 sequestosome 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18945947 RGD:2304258 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tbp TATA box binding protein IEP protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:24710803 RGD:9681729 NCBI chr 1:57,491,381...57,509,335
Ensembl chr 1:57,491,643...57,508,449
JBrowse link
G Tert telomerase reverse transcriptase ISO
IEP
mRNA, protein:increased expression:spinal cord RGD PMID:15798365, PMID:23793903 RGD:2291993, RGD:11038671 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IMP RGD PMID:15145083 RGD:2302103 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IMP RGD PMID:15145083 RGD:2302103 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15307903 RGD:1580060 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Thbs1 thrombospondin 1 IEP protein:increased expression:spinal cord RGD PMID:19719963 RGD:2317939 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tlr1 toll-like receptor 1 treatment ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:21970496, PMID:21970496 RGD:7246886, RGD:7246886 NCBI chr14:45,062,662...45,065,014
Ensembl chr14:45,062,662...45,081,991
JBrowse link
G Tlr4 toll-like receptor 4 severity ISO RGD PMID:25990044 RGD:14700556 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnc tenascin C IEP mRNA:increased expression:spinal cord RGD PMID:11085900 RGD:4889619 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:20633123 RGD:5131936 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:cerebrospinal fluid RGD PMID:16083358 RGD:1624185 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP mRNA,protein:increased expression:urinary bladder, dorsal root ganglion: RGD PMID:21367919 RGD:10043365 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 treatment IEP RGD PMID:19169264, PMID:25763638 RGD:10003030, RGD:12791993 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
G Tug1 taurine up-regulated 1 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr14:83,878,757...83,885,791
Ensembl chr14:83,878,295...83,887,584
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 IEP protein:increased expression:neuron, axon RGD PMID:25040536 RGD:11553820 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Vegfa vascular endothelial growth factor A IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD PMID:21092735, PMID:21092735 RGD:5148013 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor IDA RGD PMID:20125055 RGD:2325181 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
G Vim vimentin ISO
IEP
protein:increased expression:spinal cord RGD PMID:10225952, PMID:21250919 RGD:6480471, RGD:6480511 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vwf von Willebrand factor IEP RGD PMID:25771801 RGD:13673888 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xdh xanthine dehydrogenase IEP protein:increased expression:spinal cord RGD PMID:1649310 RGD:13209021 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xylt1 xylosyltransferase 1 IMP RGD PMID:18765417 RGD:2313145 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
JBrowse link
Spinal Cord Compression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 IEP mRNA, protein:increased expression, increased activity:spinal cord (rat) RGD PMID:22425718 RGD:10449098 NCBI chr 3:5,519,921...5,558,390
Ensembl chr 3:5,519,990...5,558,166
JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP mRNA, protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:116,830,773...116,832,299 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO
mRNA, protein:increased expression:liver, serum (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:15135227, PMID:15855648 RGD:11526154 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Egr1 early growth response 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20675054 RGD:5131876 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:9675307 RGD:10450552 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Epo erythropoietin IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Fas Fas cell surface death receptor treatment ISO human protein in a rat model
protein:increased expression:spinal cord:
RGD PMID:16689665, PMID:21490053, PMID:16202410 RGD:1582444, RGD:12904017, RGD:8663485 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand treatment ISO protein:increased expression:spinal cord: RGD PMID:21490053, PMID:21490053 RGD:12904017, RGD:12904017 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP protein:increased expression:spinal cord RGD PMID:17244329 RGD:8655633 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:25595990 RGD:12437079 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 IEP protein:decreased expression:spinal cord, thoracic vertebrae (rat) RGD PMID:20399821 RGD:2326108 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:spinal cord (mouse) RGD PMID:21787762 RGD:6218959 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:cerebrospinal fluid, serum RGD PMID:30327453 RGD:14975119 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:21671795 RGD:6483029 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Mt2A metallothionein 2A ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:15592854 RGD:6483848 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29323048 RGD:13504709 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135227 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:spinal cord (rat) RGD PMID:21224756 RGD:5130917 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP
ISO
protein:increased expression:spinal cord (rat)
human protein in rat model
RGD PMID:21224756, PMID:21224756 RGD:5130917, RGD:5130917 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    Wounds and Injuries 860
      Spinal Cord Injuries 264
        Autonomic Dysreflexia 0
        Central Cord Syndrome 0
        Spinal Cord Compression 21
Path 2
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      nervous system disease 11853
        central nervous system disease 10192
          spinal cord disease 1471
            Spinal Cord Injuries 264
              Autonomic Dysreflexia 0
              Central Cord Syndrome 0
              Spinal Cord Compression 21
paths to the root