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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Spinal Cord Injuries
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Accession:DOID:9000039 term browser browse the term
Definition:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Synonyms:exact_synonym: Post Traumatic Myelopathy;   Post-Traumatic Myelopathies;   Spinal Cord Contusion;   Spinal Cord Contusions;   Spinal Cord Injury;   Spinal Cord Laceration;   Spinal Cord Lacerations;   Spinal Cord Transection;   Spinal Cord Transections;   Spinal Cord Trauma;   Spinal Cord Traumas;   Traumatic Myelopathies;   Traumatic Myelopathy
 narrow_synonym: acute spinal cord injury
 primary_id: MESH:D013119;   RDO:0006597
For additional species annotation, visit the Alliance of Genome Resources.



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Spinal Cord Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment ISO
IEP
IMP
mRNA:increased expression:spinal cord RGD PMID:20410530 PMID:25763638 PMID:20410530 PMID:20410530 RGD:12790978, RGD:12791993, RGD:12790978, RGD:12790978 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Acan aggrecan IEP protein:altered expression:spinal cord (rat) RGD PMID:14769391 RGD:2315837 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 IDA RGD PMID:20456005 RGD:10755338 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 IEP
IDA
protein:altered expression:spinal cord,dorsal root ganglion, urinary bladder RGD PMID:15698618 PMID:15913892 RGD:2325309, RGD:2325306 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum RGD PMID:16213239 RGD:5686719 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora1 adenosine A1 receptor IMP
IEP
IDA
protein:decreased expression:spinal cord RGD PMID:18289533 PMID:17853654 PMID:20065990 RGD:5129096, RGD:4890369, RGD:5129094 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor IEP RGD PMID:17559837 RGD:4890378 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra1a adrenoceptor alpha 1A IEP mRNA:increased expression:aorta RGD PMID:16524515 RGD:5688371 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP protein:increased expression:spinal cord (rat) RGD PMID:20195207 RGD:2325645 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP protein:altered expression:spinal cord dorsal horn (rat) RGD PMID:17158026 RGD:2313037 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEP RGD PMID:20678995 RGD:10040962 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17457363 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Ankrd1 ankyrin repeat domain 1 IEP mRNA:increased expression:spinal cord, dorsal root ganglion, neuron RGD PMID:17610582 RGD:5133279 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B IEP RGD PMID:25034417 RGD:10401137 NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717
JBrowse link
G Anxa1 annexin A1 treatment ISO
IEP
mRNA,protein:increased expression:neuron,glial cell RGD PMID:17917587 PMID:15248295 RGD:2306891, RGD:10053688 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 IEP mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa5 annexin A5 IEP mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEP RGD PMID:21748659 RGD:10053608 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 IEP mRNA:increased expression:spinal cord RGD PMID:18637713 RGD:2315670 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoe apolipoprotein E ISO
IEP
DNA:polymorphism:exon: RGD PMID:18581664 PMID:30036659 RGD:7771551, RGD:13703128 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Aqp1 aquaporin 1 IEP
ISO
protein:increased expression:spinal cord, neuron, astrocyte
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:21092735 PMID:18248364 PMID:21092735 RGD:2307072, RGD:5148013 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp4 aquaporin 4 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21092735 PMID:21092735 PMID:20517941 PMID:21280976 RGD:5148013, RGD:5148027, RGD:5148035 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Atf4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atg5 autophagy related 5 IEP
ISO
protein:increased expression:axon
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:29793971 PMID:25040536 RGD:11553820 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 IEP protein:increased expression:axon RGD PMID:25040536 RGD:11553820 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atm ATM serine/threonine kinase IEP protein:increased expression:spinal cord RGD PMID:21748659 RGD:10053608 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEP protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEP protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor IEP mRNA,protein:decreased expression:spinal cord: RGD PMID:28035406 RGD:14390163 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:27256506 RGD:13792677 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcan brevican treatment IEP RGD PMID:15016081 RGD:9589823 NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:27256506 RGD:13792677 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IEP
IDA
RGD PMID:16022868 PMID:19203225 PMID:24551172 RGD:4891112, RGD:4891066, RGD:10059354 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 treatment ISO
IEP
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:29793971 PMID:21806471 PMID:23852559 PMID:24559459 RGD:6483100, RGD:11561922, RGD:11561918 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bmp2 bone morphogenetic protein 2 IDA RGD PMID:23770801 RGD:9068404 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 treatment IDA
ISO
RGD PMID:23770801 PMID:18803859 RGD:9068404, RGD:9068437 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like IEP protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Brca2 BRCA2, DNA repair associated IEP mRNA,protein:increased expression:spinal cord: RGD PMID:21748659 RGD:10053608 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G C1qb complement C1q B chain IEP mRNA:increased expression RGD PMID:16345062 RGD:1599510 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G Capn1 calpain 1 treatment IMP RGD PMID:23102374 RGD:13792496 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta IEP protein:decreased expression:spinal cord RGD PMID:20141154 RGD:9685028 NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
JBrowse link
G Casp1 caspase 1 IDA protein:increased expression, increased activation:spinal cord RGD PMID:18367607 RGD:2315889 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 treatment IEP
IDA
associated with Diabetes Mellitus, Experimental RGD PMID:19215662 PMID:26884858 RGD:2311450, RGD:11560925 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 treatment IMP
ISO
IEP
IDA
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:14588118 PMID:18378144 PMID:21748659 PMID:27339639 PMID:27256506 RGD:2293322, RGD:10053608, RGD:13782345, RGD:13792677 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 treatment IEP
IDA
RGD PMID:21748659 PMID:27339639 RGD:10053608, RGD:13782345 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 IEP protein:increased phosphorylation:spinal cord RGD PMID:17275798 RGD:2289124 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 IEP mRNA:increased expression:spinal cord RGD PMID:9698165 RGD:5135274 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:spinal cord segment (mouse) RGD PMID:20478301 RGD:4889905 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnd3 cyclin D3 IEP protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 IEP protein:increased expression:spinal cord RGD PMID:16759516 RGD:2289281 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnh cyclin H IEP mRNA, protein:increased expression:spinal cord RGD PMID:21710280 RGD:9590263 NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 IEP RGD PMID:21332278 RGD:5688138 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IEP protein:increased expression:spinal cord RGD PMID:18338959 RGD:4144888 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd274 CD274 molecule IEP mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cdc42 cell division cycle 42 IEP mRNA:increased expression:spinal cord RGD PMID:15736231 RGD:5688276 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEP protein:increased expression:spinal cord dura mater (rat) RGD PMID:19672039 RGD:2316488 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk19 cyclin-dependent kinase 19 IEP mRNA, protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IDA protein:decreased expression, altered localization:spinal cord, neuron, microglial cell RGD PMID:18319192 RGD:2293615 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chl1 cell adhesion molecule L1-like IEP protein:increased expression:spinal cord (rat) RGD PMID:21337374 RGD:6483045 NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
JBrowse link
G Cnr1 cannabinoid receptor 1 IEP RGD PMID:18930143 RGD:2316199 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 IEP RGD PMID:18930143 RGD:2316199 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Cr2 complement C3d receptor 2 IEP protein:increased expression:cerebrospinal fluid RGD PMID:26502875 RGD:11343913 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
G Crh corticotropin releasing hormone IEP protein:altered expression:spinal cord (rat) RGD PMID:20458328 RGD:5490964 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crp C-reactive protein IDA RGD PMID:22404382 RGD:6903321 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO RGD PMID:15658127 RGD:10449531 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:21953623 RGD:10450511 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 ISO
IDA
RGD PMID:22243800 PMID:19604403 PMID:22042562 RGD:5686844, RGD:5686859, RGD:5686848 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
JBrowse link
G Ctss cathepsin S IEP RGD PMID:16344894 RGD:2303423 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP RGD PMID:9698165 RGD:5135274 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP RGD PMID:19170890 RGD:2311365 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyba cytochrome b-245 alpha chain IEP mRNA:increased expression:spinal cord RGD PMID:16345062 RGD:1599510 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain ISO mRNA,protein:increased expression:microglia: RGD PMID:20679217 RGD:11040629 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Dab2 DAB adaptor protein 2 IEP protein:increased expression:spinal cord RGD PMID:17317100 RGD:7243246 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Dcc DCC netrin 1 receptor IEP RGD PMID:16998900 RGD:2314373 NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP protein:decreased expression:spinal cord RGD PMID:18630599 PMID:19383246 RGD:7771572, RGD:7771580 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Efnb2 ephrin B2 IEP mRNA,protein:increased expression:fibroblast, astrocyte
protein:increased phosporylation:spinal cord
RGD PMID:33794069 PMID:12944508 RGD:127285659, RGD:127285804 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
JBrowse link
G Egfr epidermal growth factor receptor IMP
IEP
protein:increased phosphorylation:spinal cord, astrocyte (rat) RGD PMID:20869112 PMID:21402118 RGD:5131525, RGD:5131454 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A IEP mRNA, protein:increased expression:gastrocnemius RGD PMID:23238062 RGD:10395360 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Endog endonuclease G IEP RGD PMID:16689664 RGD:8655990 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Eno2 enolase 2 IEP protein:increased expression:serum, cerebrospinal fluid RGD PMID:18343116 RGD:2293743 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ensa endosulfine alpha IEP mRNA:decreased expression:spinal cord RGD PMID:16344894 RGD:2303423 NCBI chr 2:183,185,552...183,192,888
Ensembl chr 2:183,185,552...183,194,847
JBrowse link
G Epha3 Eph receptor A3 IEP RGD PMID:16083359 RGD:2301766 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Epha4 Eph receptor A4 IMP
IEP
ISO
RGD PMID:17970742 PMID:17418490 PMID:21931787 RGD:5688750, RGD:5688782, RGD:5688764 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Epha7 Eph receptor A7 IMP mRNA:increased expression:spinal cord RGD PMID:16983667 RGD:2301957 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
JBrowse link
G Ephb2 Eph receptor B2 ameliorates IMP
IEP
RGD PMID:33794069 PMID:12944508 RGD:127285659, RGD:127285804 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22196867 RGD:10401074 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP mRNA, protein:increased expression:spinal cord RGD PMID:11797086 RGD:2289967 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Esr1 estrogen receptor 1 IEP RGD PMID:25105782 RGD:10045844 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 IEP RGD PMID:25105782 RGD:10045844 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F2 coagulation factor II IEP RGD PMID:16344894 RGD:2303423 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:23574812 RGD:11344882 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor IEP
IDA
protein:increased expression:cervical spinal cord RGD PMID:17518537 PMID:29738767 PMID:17703359 RGD:2290177, RGD:13792580, RGD:2290176 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO
IDA
Human FGF1 used in rat model of spinal cord injury RGD PMID:21663406 PMID:18482974 PMID:20488178 PMID:8662542 RGD:5509875, RGD:2317692, RGD:5509877, RGD:5509876 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:26079325 RGD:12437066 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IEP mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:20347014 RGD:7205459 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo3 forkhead box O3 IEP protein:decreased expression:spinal cord,neuron, astrocyte: RGD PMID:22930444 RGD:10402202 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gap43 growth associated protein 43 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase treatment IDA RGD PMID:27256506 RGD:13792677 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO RGD PMID:22342994 RGD:5688774 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein treatment ISO
IEP
protein:increased expression:spinal cord RGD PMID:10225952 PMID:24968269 PMID:21250919 RGD:6480471, RGD:40924652, RGD:6480511 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:25261791 RGD:12907564 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IMP
IEP
RGD PMID:23403365 PMID:24183749 RGD:8662431, RGD:8662460 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gjc2 gap junction protein, gamma 2 treatment IEP RGD PMID:26415641 RGD:13208513 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP protein:increased expression:spinal cord (rat) RGD PMID:27150525 RGD:13506243 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:22975889 RGD:8552988 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IEP protein:increased expression:spinal cord, neuron, microglial cell (rat) RGD PMID:23359120 RGD:13792782 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Grn granulin precursor ISO mRNA, protein:increased expression:spinal cord: RGD PMID:19946692 RGD:5509603 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 IEP mRNA:increased expression:lumbar segment of spinal cord (rat) RGD PMID:22160604 RGD:5687769 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Hgf hepatocyte growth factor treatment ISO
IEP
IDA
mRNA,protein:increased expression:spinal cord: RGD PMID:22140459 PMID:17549731 PMID:17549731 RGD:8548666, RGD:2317487, RGD:2317487 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:21092735 PMID:21092735 RGD:5148013 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 IEP mRNA:increased expression:spinal cord RGD PMID:20195207 RGD:2325645 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:23943397 RGD:10766443 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:16671478 RGD:1626425 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IEP protein:decreased expression:spinal cord (rat) RGD PMID:24499940 RGD:10445836 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO mRNA: increased expression RGD PMID:21933012 RGD:5685666 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 treatment IEP mRNA,protein:increased expression:spinal cord: RGD PMID:12098653 PMID:30287503 RGD:10402749, RGD:38549580 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:8627308 RGD:11522712 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein IEP mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Il10 interleukin 10 treatment IEP RGD PMID:29691718 RGD:14975124 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 treatment IDA
IEP
RGD PMID:18367607 PMID:23140983 RGD:2315889, RGD:8655974 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta treatment IEP
IDA
mRNA, protein:increased expression:spinal cord RGD PMID:16038625 PMID:29691718 PMID:23209732 RGD:1626673, RGD:14975124, RGD:7175523 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 IEP mRNA,protein:increased expression:spinal cord RGD PMID:16456668 RGD:7207035 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist IDA
ISO
protein:increased expression:serum (human) RGD PMID:16038625 PMID:17964877 RGD:1626673, RGD:6907102 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il4 interleukin 4 IMP RGD PMID:20623539 RGD:5128562 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor IEP mRNA:increased expression:spinal cord RGD PMID:20623539 RGD:5128562 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 treatment IDA
IEP
RGD PMID:27085942 PMID:29691718 RGD:11062150, RGD:14975124 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf1 interferon regulatory factor 1 IEP RGD PMID:11723173 RGD:2298928 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irf5 interferon regulatory factor 5 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 severity IEP protein:decreased expression:cerebrospinal fluid RGD PMID:21559420 RGD:40907059 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Jak2 Janus kinase 2 treatment IMP RGD PMID:23274522 RGD:10411896 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IDA protein:increased phosphorylation:neuron RGD PMID:21132399 RGD:4889994 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP protein:decreased expression:spinal cord RGD PMID:20375134 RGD:8662905 NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 treatment IDA RGD PMID:22425721 RGD:9831183 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kdm6b lysine demethylase 6B IEP mRNA:increased expression:spinal cord (rat) RGD PMID:22578249 RGD:9587821 NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kdr kinase insert domain receptor IEP mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif3b kinesin family member 3B IEP protein:increased expression:spinal cord RGD PMID:23093447 RGD:11049594 NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963
JBrowse link
G Klk6 kallikrein related-peptidase 6 IEP protein:increased expression:spinal cord RGD PMID:16987227 RGD:2314866 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
JBrowse link
G Kmo kynurenine 3-monooxygenase IEP mRNA,protein:increased expression:spinal cord: RGD PMID:26524415 RGD:13703043 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Lep leptin IEP RGD PMID:19777863 RGD:5128780 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lrp1 LDL receptor related protein 1 treatment IDA RGD PMID:23867460 RGD:13800520 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrp5 LDL receptor related protein 5 treatment IEP RGD PMID:24090150 RGD:12798566 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Lum lumican IEP protein:increased expression:spinal cord RGD PMID:18482974 RGD:2317692 NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
JBrowse link
G Map1b microtubule-associated protein 1B IEP protein:increased phosphorylation:spinal cord, neuron RGD PMID:17880387 RGD:2304007 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment IEP protein:increased expression:spinal cord RGD PMID:24559459 PMID:23637053 PMID:23852559 RGD:11561918, RGD:11564330, RGD:11561922 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:21704982 RGD:6483323 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP protein:increased expression:white matter and grey matter: RGD PMID:10331432 RGD:10412645 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapt microtubule-associated protein tau treatment IEP RGD PMID:22052241 RGD:8158113 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mdm2 MDM2 proto-oncogene IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase IEP mRNA, protein:increased expression:spinal cord (rat) RGD PMID:17549731 RGD:2317487 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfn1 mitofusin 1 treatment IEP protein:altered expression:spinal cord, mitochondrion (rat) RGD PMID:26981103 PMID:26079325 RGD:12910837, RGD:12437066 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 treatment IEP protein:increased expression:spinal cord (rat) RGD PMID:28404953 PMID:26079325 RGD:12910735, RGD:12437066 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA:increased expression:spinal cord, microglial cell RGD PMID:15067555 RGD:1641997 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mir21 microRNA 21 exacerbates IMP RGD PMID:31102912 RGD:41410823 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir214 microRNA 214 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G Mir411 microRNA 411 IEP RGD PMID:29738767 RGD:13792580 NCBI chr 6:128,723,189...128,723,264
Ensembl chr 6:128,723,184...128,723,279
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP RGD PMID:24436993 RGD:8657106 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:25763638 RGD:12791993 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:spinal cord RGD PMID:22986158 RGD:6909148 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrc1 mannose receptor, C type 1 treatment IEP RGD PMID:24968269 RGD:40924652 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 IMP RGD PMID:20438613 RGD:5687694 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IMP RGD PMID:20678995 RGD:10040962 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D IEP mRNA:increased expression:spinal cord RGD PMID:18930143 RGD:2316199 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Ncam1 neural cell adhesion molecule 1 treatment ISO RGD PMID:28529158 RGD:40924632 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP protein:increased expression:spinal cord RGD PMID:14644473 RGD:2314450 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nefh neurofilament heavy chain treatment IDA
IEP
RGD PMID:18772508 PMID:32168135 RGD:9698443, RGD:27226888 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefl neurofilament light chain treatment IDA RGD PMID:18772508 RGD:9698443 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain treatment IDA RGD PMID:18772508 RGD:9698443 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IDA RGD PMID:24747453 RGD:10412730 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:21134362 RGD:10413867 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor IEP
IMP
RGD PMID:16915089 PMID:12499054 RGD:5144069, RGD:5144073 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor treatment IEP
IMP
mRNA:increased expression:spinal cord RGD PMID:11223160 PMID:23748892 RGD:5144100, RGD:10414079 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nkx6-1 NK6 homeobox 1 IMP RGD PMID:18687784 RGD:2311166 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
JBrowse link
G Nlk nemo like kinase IEP protein:increased expression:grey matter: RGD PMID:24395089 RGD:12791278 NCBI chr10:63,467,163...63,590,960
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Nog noggin treatment ISO RGD PMID:18221366 RGD:10429192 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Nos1 nitric oxide synthase 1 IEP
IMP
protein:increased expression:spinal cord RGD PMID:19291395 PMID:20633123 RGD:5132595, RGD:5131936 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 IEP mRNA:altered expression:thoracic aorta RGD PMID:17287083 RGD:4891407 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 IEP RGD PMID:17287083 RGD:4891407 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP protein:increased expression:spinal cord (rat) RGD PMID:24747453 PMID:28881715 RGD:10412730, RGD:13434916 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ntf3 neurotrophin 3 ISO RGD PMID:16022868 RGD:4891112 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IDA
IMP
RGD PMID:22027236 PMID:20597685 RGD:5684547, RGD:5684898 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IEP mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 treatment ISO
IMP
RGD PMID:28452182 PMID:22173726 RGD:40902836, RGD:40902844 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO CTD Direct Evidence: therapeutic CTD PMID:15258577 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:15696051 PMID:21748659 RGD:10053608 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd1 programmed cell death 1 treatment IEP RGD PMID:29665726 RGD:40886268 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 IEP mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:21568693 RGD:6482306 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO
IEP
protein:increased expression:spinal cord RGD PMID:21868473 PMID:19306380 RGD:6482718, RGD:6482721 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g6 phospholipase A2 group VI ISO protein:increased expression:spinal cord RGD PMID:21868473 RGD:6482718 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:21573723 RGD:6483797 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:21573723 RGD:6483797 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pon1 paraoxonase 1 treatment IDA RGD PMID:12897486 RGD:8547682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IEP RGD PMID:20058304 RGD:2324875 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IDA RGD PMID:22208735 RGD:6484263 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma IEP protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:29033188 RGD:13514047 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A IEP
ISO
mRNA:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:29793971 PMID:17578450 RGD:9999410 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prkcg protein kinase C, gamma ISO protein:decreased expression:spinal cord (mouse) RGD PMID:10501452 RGD:28867228 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP
IEP
protein:increased expression:microglia, macrophage RGD PMID:17184185 PMID:11063829 RGD:5688221, RGD:5688246 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP RGD PMID:18606213 RGD:5135219 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 treatment IDA
IEP
RGD PMID:15016081 PMID:18065151 PMID:12895450 RGD:9589823, RGD:9590124, RGD:9590113 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
JBrowse link
G Rara retinoic acid receptor, alpha IEP RGD PMID:16420438 RGD:2314291 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rbmx RNA binding motif protein, X-linked IEP RGD PMID:23180094 RGD:10053723 NCBI chr  X:135,305,237...135,314,806
Ensembl chr  X:135,305,325...135,314,743
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:17918744 RGD:2298849 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a treatment IMP RGD PMID:16585268 RGD:9850138 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
JBrowse link
G Rpsa ribosomal protein SA IEP RGD PMID:19196078 RGD:11041651 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 IDA RGD PMID:16109750 PMID:16718433 RGD:2317321, RGD:2317320 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:15792522 RGD:1599333 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Shh sonic hedgehog signaling molecule treatment IMP RGD PMID:24837681 RGD:12879409 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 treatment IDA RGD PMID:27256506 RGD:13792677 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
JBrowse link
G Slc25a27 solute carrier family 25, member 27 ISO protein:increased expression:spinal cord RGD PMID:18534681 RGD:6482843 NCBI chr 9:17,306,898...17,333,942
Ensembl chr 9:17,307,023...17,332,731
JBrowse link
G Slc7a5 solute carrier family 7 member 5 IEP protein:increased expression:spinal cord RGD PMID:19388351 RGD:151361131 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slit1 slit guidance ligand 1 ISO RGD PMID:16262652 RGD:2316136 NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127
JBrowse link
G Slit2 slit guidance ligand 2 IEP mRNA, protein:increased expression:spinal cord RGD PMID:19783284 RGD:2316127 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Slit3 slit guidance ligand 3 ISO RGD PMID:16262652 RGD:2316136 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519
JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEP RGD PMID:11723173 RGD:2298928 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO human protein in a rat model
CTD Direct Evidence: therapeutic
human gene in a rat model
CTD
RGD
PMID:17457363 PMID:18722523 PMID:16689664 RGD:8655939, RGD:8655990 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sox2 SRY-box transcription factor 2 IEP RGD PMID:23169458 RGD:8661675 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO RGD PMID:17611274 RGD:2300052 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15592854 RGD:6483848 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18945947 RGD:2304258 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tbp TATA box binding protein IEP protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:24710803 RGD:9681729 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
JBrowse link
G Tert telomerase reverse transcriptase ISO
IEP
mRNA, protein:increased expression:spinal cord RGD PMID:15798365 PMID:23793903 RGD:2291993, RGD:11038671 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IMP RGD PMID:15145083 RGD:2302103 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IMP RGD PMID:15145083 RGD:2302103 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15307903 RGD:1580060 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Thbs1 thrombospondin 1 IEP protein:increased expression:spinal cord RGD PMID:19719963 RGD:2317939 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tlr1 toll-like receptor 1 treatment ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:21970496 PMID:21970496 RGD:7246886, RGD:7246886 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr4 toll-like receptor 4 severity ISO RGD PMID:25990044 RGD:14700556 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnc tenascin C IEP mRNA:increased expression:spinal cord RGD PMID:11085900 RGD:4889619 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:20633123 RGD:5131936 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:cerebrospinal fluid RGD PMID:16083358 RGD:1624185 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 IEP protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf7 TNF receptor associated factor 7 IEP mRNA, protein:increased expression:spinal cord RGD PMID:30100091 RGD:151356968 NCBI chr10:13,533,570...13,552,290
Ensembl chr10:13,533,570...13,552,203
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP mRNA,protein:increased expression:urinary bladder, dorsal root ganglion: RGD PMID:21367919 RGD:10043365 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 treatment IEP RGD PMID:19169264 PMID:25763638 RGD:10003030, RGD:12791993 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
G Tug1 taurine up-regulated 1 treatment IEP RGD PMID:30287503 RGD:38549580 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 IEP protein:increased expression:neuron, axon RGD PMID:25040536 RGD:11553820 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Vegfa vascular endothelial growth factor A IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:21092735 PMID:21092735 RGD:5148013 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor IDA RGD PMID:20125055 RGD:2325181 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vim vimentin ISO
IEP
protein:increased expression:spinal cord RGD PMID:10225952 PMID:21250919 RGD:6480471, RGD:6480511 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vwf von Willebrand factor IEP RGD PMID:25771801 RGD:13673888 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase IEP protein:increased expression:spinal cord RGD PMID:1649310 RGD:13209021 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xylt1 xylosyltransferase 1 IMP RGD PMID:18765417 RGD:2313145 NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783
JBrowse link
Spinal Cord Compression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 IEP mRNA, protein:increased expression, increased activity:spinal cord (rat) RGD PMID:22425718 RGD:10449098 NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687
JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP mRNA, protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO
mRNA, protein:increased expression:liver, serum (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:15135227 PMID:15855648 RGD:11526154 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd163 CD163 molecule disease_progression IEP protein:increased expression:gray matter of spinal cord, white matter of spinal cord (rat) RGD PMID:23775900 RGD:149735576 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Egr1 early growth response 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20675054 RGD:5131876 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:9675307 RGD:10450552 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Epo erythropoietin IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Fas Fas cell surface death receptor treatment ISO human protein in a rat model
protein:increased expression:spinal cord:
RGD PMID:16689665 PMID:16202410 PMID:21490053 RGD:1582444, RGD:8663485, RGD:12904017 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand treatment ISO protein:increased expression:spinal cord: RGD PMID:21490053 PMID:21490053 RGD:12904017, RGD:12904017 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP protein:increased expression:spinal cord RGD PMID:17244329 RGD:8655633 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:25595990 RGD:12437079 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 IEP protein:decreased expression:spinal cord, thoracic vertebrae (rat) RGD PMID:20399821 RGD:2326108 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:spinal cord (mouse) RGD PMID:21787762 RGD:6218959 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:cerebrospinal fluid, serum RGD PMID:30327453 RGD:14975119 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:21671795 RGD:6483029 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Mt2A metallothionein 2A ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:15592854 RGD:6483848 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29323048 RGD:13504709 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135227 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:spinal cord (rat) RGD PMID:21224756 RGD:5130917 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP
ISO
protein:increased expression:spinal cord (rat)
human protein in rat model
RGD PMID:21224756 PMID:21224756 RGD:5130917, RGD:5130917 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18133
    Wounds and Injuries 900
      Spinal Cord Injuries 270
        Autonomic Dysreflexia 0
        Central Cord Syndrome 0
        Spinal Cord Compression 22
Path 2
Term Annotations click to browse term
  disease 18133
    disease of anatomical entity 17503
      nervous system disease 13174
        central nervous system disease 11297
          spinal cord disease 1669
            Spinal Cord Injuries 270
              Autonomic Dysreflexia 0
              Central Cord Syndrome 0
              Spinal Cord Compression 22
paths to the root