RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Spinal Cord Injuries
Accession: DOID:9000039
browse the term
Definition: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Synonyms: exact_synonym: Post Traumatic Myelopathy; Post-Traumatic Myelopathies; Spinal Cord Contusion; Spinal Cord Contusions; Spinal Cord Injury; Spinal Cord Laceration; Spinal Cord Lacerations; Spinal Cord Transection; Spinal Cord Transections; Spinal Cord Trauma; Spinal Cord Traumas; Traumatic Myelopathies; Traumatic Myelopathy
narrow_synonym: acute spinal cord injury
primary_id: MESH:D013119 ; RDO:0006597
For additional species annotation, visit the
Alliance of Genome Resources .
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Abcc8
ATP binding cassette subfamily C member 8
treatment
ISO IEP IMP
mRNA:increased expression:spinal cord
RGD
PMID:20410530 , PMID:25763638 , PMID:20410530 , PMID:20410530
RGD:12790978 , RGD:12791993 , RGD:12790978 , RGD:12790978
NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
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Acan
aggrecan
IEP
protein:altered expression:spinal cord (rat)
RGD
PMID:14769391
RGD:2315837
NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
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Adarb1
adenosine deaminase, RNA-specific, B1
IDA
RGD
PMID:20456005
RGD:10755338
NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
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Adcyap1
adenylate cyclase activating polypeptide 1
IEP IDA
protein:altered expression:spinal cord,dorsal root ganglion, urinary bladder
RGD
PMID:15698618 , PMID:15913892
RGD:2325309 , RGD:2325306
NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:serum
RGD
PMID:16213239
RGD:5686719
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adora1
adenosine A1 receptor
IMP IDA IEP
protein:decreased expression:spinal cord
RGD
PMID:18289533 , PMID:20065990 , PMID:17853654
RGD:5129096 , RGD:5129094 , RGD:4890369
NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
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Adora2a
adenosine A2a receptor
IEP
RGD
PMID:17559837
RGD:4890378
NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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Adra1a
adrenoceptor alpha 1A
IEP
mRNA:increased expression:aorta
RGD
PMID:16524515
RGD:5688371
NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
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Ager
advanced glycosylation end product-specific receptor
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:20195207
RGD:2325645
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Aif1
allograft inflammatory factor 1
IEP
protein:altered expression:spinal cord dorsal horn (rat)
RGD
PMID:17158026
RGD:2313037
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
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Akt1
AKT serine/threonine kinase 1
IEP
RGD
PMID:20678995
RGD:10040962
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Akt1s1
AKT1 substrate 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17457363
NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
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Ambra1
autophagy and beclin 1 regulator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 3:80,634,470...80,830,068
Ensembl chr 3:80,634,470...80,830,068
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Ankrd1
ankyrin repeat domain 1
IEP
mRNA:increased expression:spinal cord, dorsal root ganglion, neuron
RGD
PMID:17610582
RGD:5133279
NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
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Anp32b
acidic nuclear phosphoprotein 32 family member B
IEP
RGD
PMID:25034417
RGD:10401137
NCBI chr 5:62,070,709...62,094,633
Ensembl chr 5:62,071,346...62,094,633
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Anxa1
annexin A1
treatment
ISO IEP
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:17917587 , PMID:15248295
RGD:2306891 , RGD:10053688
NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
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Anxa2
annexin A2
IEP
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:15248295
RGD:10053688
NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
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Anxa5
annexin A5
IEP
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:15248295
RGD:10053688
NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
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Apaf1
apoptotic peptidase activating factor 1
IEP
RGD
PMID:21748659
RGD:10053608
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
IEP
mRNA:increased expression:spinal cord
RGD
PMID:18637713
RGD:2315670
NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
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Apoe
apolipoprotein E
ISO IEP
DNA:polymorphism:exon:
RGD
PMID:18581664 , PMID:30036659
RGD:7771551 , RGD:13703128
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
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Aqp1
aquaporin 1
IEP ISO
protein:increased expression:spinal cord, neuron, astrocyte CTD Direct Evidence: marker/mechanism
CTD
PMID:21092735 , PMID:18248364 , PMID:21092735
RGD:2307072 , RGD:5148013
NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
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Aqp4
aquaporin 4
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21092735 , PMID:21092735 , PMID:21280976 , PMID:20517941
RGD:5148013 , RGD:5148035 , RGD:5148027
NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
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Atf4
activating transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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Atg5
autophagy related 5
IEP ISO
protein:increased expression:axon CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971 , PMID:25040536
RGD:11553820
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
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Atg7
autophagy related 7
IEP
protein:increased expression:axon
RGD
PMID:25040536
RGD:11553820
NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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Atm
ATM serine/threonine kinase
IEP
protein:increased expression:spinal cord
RGD
PMID:21748659
RGD:10053608
NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
IEP
protein:decreased expression:tail, skeletal muscle
RGD
PMID:21930674
RGD:13782071
NCBI chr 1:197,855,912...197,875,038
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
IEP
protein:decreased expression:tail, skeletal muscle
RGD
PMID:21930674
RGD:13782071
NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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Bambi
BMP and activin membrane-bound inhibitor
IEP
mRNA,protein:decreased expression:spinal cord:
RGD
PMID:28035406
RGD:14390163
NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:27256506
RGD:13792677
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcan
brevican
treatment
IEP
RGD
PMID:15016081
RGD:9589823
NCBI chr 2:187,359,674...187,373,133
Ensembl chr 2:187,359,677...187,372,657
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Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:27256506
RGD:13792677
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bdnf
brain-derived neurotrophic factor
treatment
ISO IDA IEP
RGD
PMID:16022868 , PMID:24551172 , PMID:19203225
RGD:4891112 , RGD:10059354 , RGD:4891066
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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Becn1
beclin 1
treatment
ISO IEP
protein:increased expression:spinal cord CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971 , PMID:21806471 , PMID:23852559 , PMID:24559459
RGD:6483100 , RGD:11561922 , RGD:11561918
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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Bmp2
bone morphogenetic protein 2
IDA
RGD
PMID:23770801
RGD:9068404
NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
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Bmp4
bone morphogenetic protein 4
treatment
IDA ISO
RGD
PMID:23770801 , PMID:18803859
RGD:9068404 , RGD:9068437
NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
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Bnip3
BCL2 interacting protein 3
IEP
protein:increased expression:spinal cord
RGD
PMID:23637053
RGD:11564330
NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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Bnip3l
BCL2 interacting protein 3 like
IEP
protein:increased expression:spinal cord
RGD
PMID:23637053
RGD:11564330
NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
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Brca2
BRCA2, DNA repair associated
IEP
mRNA,protein:increased expression:spinal cord:
RGD
PMID:21748659
RGD:10053608
NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
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C1qb
complement C1q B chain
IEP
mRNA:increased expression
RGD
PMID:16345062
RGD:1599510
NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
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Capn1
calpain 1
treatment
IMP
RGD
PMID:23102374
RGD:13792496
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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Capzb
capping actin protein of muscle Z-line subunit beta
IEP
protein:decreased expression:spinal cord
RGD
PMID:20141154
RGD:9685028
NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
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Casp1
caspase 1
IDA
protein:increased expression, increased activation:spinal cord
RGD
PMID:18367607
RGD:2315889
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
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Casp12
caspase 12
treatment
IEP IDA
associated with Diabetes Mellitus, Experimental
RGD
PMID:19215662 , PMID:26884858
RGD:2311450 , RGD:11560925
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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Casp3
caspase 3
treatment
IMP IEP IDA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14588118 , PMID:18378144 , PMID:27256506 , PMID:27339639 , PMID:21748659
RGD:2293322 , RGD:13792677 , RGD:13782345 , RGD:10053608
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp9
caspase 9
treatment
IEP IDA
RGD
PMID:21748659 , PMID:27339639
RGD:10053608 , RGD:13782345
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cav1
caveolin 1
IEP
protein:increased phosphorylation:spinal cord
RGD
PMID:17275798
RGD:2289124
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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Ccl12
chemokine (C-C motif) ligand 12
IEP
mRNA:increased expression:spinal cord
RGD
PMID:9698165
RGD:5135274
NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
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Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:spinal cord segment (mouse)
RGD
PMID:20478301
RGD:4889905
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccnd3
cyclin D3
IEP
protein:increased expression:spinal cord
RGD
PMID:18008145
RGD:2316019
NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
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Ccne1
cyclin E1
IEP
protein:increased expression:spinal cord
RGD
PMID:16759516
RGD:2289281
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Ccnh
cyclin H
IEP
mRNA, protein:increased expression:spinal cord
RGD
PMID:21710280
RGD:9590263
NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
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Ccr1
C-C motif chemokine receptor 1
IEP
RGD
PMID:21332278
RGD:5688138
NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
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Ccr2
C-C motif chemokine receptor 2
IEP
protein:increased expression:spinal cord
RGD
PMID:18338959
RGD:4144888
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Cd274
CD274 molecule
IEP
mRNA:increased expression:microglial cell
RGD
PMID:29665726
RGD:40886268
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
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Cdc42
cell division cycle 42
IEP
mRNA:increased expression:spinal cord
RGD
PMID:15736231
RGD:5688276
NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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Cdk1
cyclin-dependent kinase 1
IEP
protein:increased expression:spinal cord dura mater (rat)
RGD
PMID:19672039
RGD:2316488
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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Cdk19
cyclin-dependent kinase 19
IEP
mRNA, protein:increased expression:spinal cord
RGD
PMID:18008145
RGD:2316019
NCBI chr20:45,458,499...45,598,799
Ensembl chr20:45,458,558...45,598,798
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
IDA
protein:decreased expression, altered localization:spinal cord, neuron, microglial cell
RGD
PMID:18319192
RGD:2293615
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Chl1
cell adhesion molecule L1-like
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:21337374
RGD:6483045
NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
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Cnr1
cannabinoid receptor 1
IEP
RGD
PMID:18930143
RGD:2316199
NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
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Cnr2
cannabinoid receptor 2
IEP
RGD
PMID:18930143
RGD:2316199
NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
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Crh
corticotropin releasing hormone
IEP
protein:altered expression:spinal cord (rat)
RGD
PMID:20458328
RGD:5490964
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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Crp
C-reactive protein
IDA
RGD
PMID:22404382
RGD:6903321
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Csf2
colony stimulating factor 2
treatment
ISO
RGD
PMID:15658127
RGD:10449531
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:21953623
RGD:10450511
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Cspg4
chondroitin sulfate proteoglycan 4
ISO IDA
RGD
PMID:22243800 , PMID:19604403 , PMID:22042562
RGD:5686844 , RGD:5686859 , RGD:5686848
NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
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Ctss
cathepsin S
IEP
RGD
PMID:16344894
RGD:2303423
NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
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Cxcl1
C-X-C motif chemokine ligand 1
IEP
RGD
PMID:9698165
RGD:5135274
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl10
C-X-C motif chemokine ligand 10
IEP
RGD
PMID:19170890
RGD:2311365
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cyba
cytochrome b-245 alpha chain
IEP
mRNA:increased expression:spinal cord
RGD
PMID:16345062
RGD:1599510
NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
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Cybb
cytochrome b-245 beta chain
ISO
mRNA,protein:increased expression:microglia:
RGD
PMID:20679217
RGD:11040629
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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Dab2
DAB adaptor protein 2
IEP
protein:increased expression:spinal cord
RGD
PMID:17317100
RGD:7243246
NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
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Dcc
DCC netrin 1 receptor
IEP
RGD
PMID:16998900
RGD:2314373
NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
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Ddit3
DNA-damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Dusp1
dual specificity phosphatase 1
treatment
IEP
protein:decreased expression:spinal cord
RGD
PMID:18630599 , PMID:19383246
RGD:7771572 , RGD:7771580
NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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Egfr
epidermal growth factor receptor
IMP IEP
protein:increased phosphorylation:spinal cord, astrocyte (rat)
RGD
PMID:20869112 , PMID:21402118
RGD:5131525 , RGD:5131454
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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Eif5a
eukaryotic translation initiation factor 5A
IEP
mRNA, protein:increased expression:gastrocnemius
RGD
PMID:23238062
RGD:10395360
NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
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Endog
endonuclease G
IEP
RGD
PMID:16689664
RGD:8655990
NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
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Eno2
enolase 2
IEP
protein:increased expression:serum, cerebrospinal fluid
RGD
PMID:18343116
RGD:2293743
NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047 Ensembl chr 9:157,285,179...157,294,047
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Ensa
endosulfine alpha
IEP
mRNA:decreased expression:spinal cord
RGD
PMID:16344894
RGD:2303423
NCBI chr 2:197,752,544...197,759,882
Ensembl chr 2:197,752,544...197,759,882
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Epha3
Eph receptor A3
IEP
RGD
PMID:16083359
RGD:2301766
NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
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Epha4
Eph receptor A4
IMP IEP ISO
RGD
PMID:17970742 , PMID:17418490 , PMID:21931787
RGD:5688750 , RGD:5688782 , RGD:5688764
NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
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Epha7
Eph receptor A7
IMP
mRNA:increased expression:spinal cord
RGD
PMID:16983667
RGD:2301957
NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
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Epo
erythropoietin
treatment
ISO
RGD
PMID:22196867
RGD:10401074
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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Erbb3
erb-b2 receptor tyrosine kinase 3
IEP
mRNA, protein:increased expression:spinal cord
RGD
PMID:11797086
RGD:2289967
NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
G
Esr1
estrogen receptor 1
IEP
RGD
PMID:25105782
RGD:10045844
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Esr2
estrogen receptor 2
IEP
RGD
PMID:25105782
RGD:10045844
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
G
F2
coagulation factor II
IEP
RGD
PMID:16344894
RGD:2303423
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
G
Fadd
Fas associated via death domain
treatment
IEP
RGD
PMID:23574812
RGD:11344882
NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
G
Fas
Fas cell surface death receptor
IEP IDA
protein:increased expression:cervical spinal cord
RGD
PMID:17518537 , PMID:29738767 , PMID:17703359
RGD:2290177 , RGD:13792580 , RGD:2290176
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
G
Fgf1
fibroblast growth factor 1
ISO IDA
Human FGF1 used in rat model of spinal cord injury
RGD
PMID:21663406 , PMID:18482974 , PMID:20488178 , PMID:8662542
RGD:5509875 , RGD:2317692 , RGD:5509877 , RGD:5509876
NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
G
Fgf2
fibroblast growth factor 2
treatment
IEP
RGD
PMID:24968269
RGD:40924652
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Fis1
fission, mitochondrial 1
treatment
IEP
RGD
PMID:26079325
RGD:12437066
NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
G
Flt1
Fms related receptor tyrosine kinase 1
IEP
mRNA:increased expression:spinal cord, astrocyte, macrophage
RGD
PMID:17409380
RGD:5684414
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
G
Fn1
fibronectin 1
ISO
RGD
PMID:20347014
RGD:7205459
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
G
Foxo3
forkhead box O3
IEP
protein:decreased expression:spinal cord,neuron, astrocyte:
RGD
PMID:22930444
RGD:10402202
NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
G
Foxp3
forkhead box P3
treatment
IEP
RGD
PMID:30287503
RGD:38549580
NCBI chr X:15,753,175...15,768,648
Ensembl chr X:15,753,175...15,768,522
G
Gap43
growth associated protein 43
treatment
IEP
RGD
PMID:24968269
RGD:40924652
NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
treatment
IDA
RGD
PMID:27256506
RGD:13792677
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
G
Gdnf
glial cell derived neurotrophic factor
ISO
RGD
PMID:22342994
RGD:5688774
NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
G
Gfap
glial fibrillary acidic protein
treatment
ISO IEP
protein:increased expression:spinal cord
RGD
PMID:10225952 , PMID:24968269 , PMID:21250919
RGD:6480471 , RGD:40924652 , RGD:6480511
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
G
Ghsr
growth hormone secretagogue receptor
IMP
RGD
PMID:25261791
RGD:12907564
NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
G
Gja1
gap junction protein, alpha 1
treatment
IMP IEP
RGD
PMID:23403365 , PMID:24183749
RGD:8662431 , RGD:8662460
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Gjc2
gap junction protein, gamma 2
treatment
IEP
RGD
PMID:26415641
RGD:13208513
NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
G
Got2
glutamic-oxaloacetic transaminase 2
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:27150525
RGD:13506243
NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
G
Gper1
G protein-coupled estrogen receptor 1
IMP
RGD
PMID:22975889
RGD:8552988
NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
G
Grk6
G protein-coupled receptor kinase 6
IEP
protein:increased expression:spinal cord, neuron, microglial cell (rat)
RGD
PMID:23359120
RGD:13792782
NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
G
Grn
granulin precursor
ISO
mRNA, protein:increased expression:spinal cord:
RGD
PMID:19946692
RGD:5509603
NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
G
Gsta4
glutathione S-transferase alpha 4
IEP
mRNA:increased expression:lumbar segment of spinal cord (rat)
RGD
PMID:22160604
RGD:5687769
NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
G
Hgf
hepatocyte growth factor
treatment
ISO IEP IDA
mRNA,protein:increased expression:spinal cord:
RGD
PMID:22140459 , PMID:17549731 , PMID:17549731
RGD:8548666 , RGD:2317487 , RGD:2317487
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
G
Hif1a
hypoxia inducible factor 1 subunit alpha
IEP ISO
protein:increased expression:spinal cord CTD Direct Evidence: marker/mechanism
CTD
PMID:21092735 , PMID:21092735
RGD:5148013
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
G
Hmgb1
high mobility group box 1
IEP
mRNA:increased expression:spinal cord
RGD
PMID:20195207
RGD:2325645
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
G
Hmox1
heme oxygenase 1
treatment
IEP
RGD
PMID:23943397
RGD:10766443
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hrh3
histamine receptor H3
IDA
RGD
PMID:16671478
RGD:1626425
NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
IEP
protein:decreased expression:spinal cord (rat)
RGD
PMID:24499940
RGD:10445836
NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
G
Hspa5
heat shock protein family A (Hsp70) member 5
ISO
mRNA: increased expression
RGD
PMID:21933012
RGD:5685666
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Hspb1
heat shock protein family B (small) member 1
treatment
IEP
mRNA,protein:increased expression:spinal cord:
RGD
PMID:12098653 , PMID:30287503
RGD:10402749 , RGD:38549580
NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
G
Icam1
intercellular adhesion molecule 1
treatment
IMP
RGD
PMID:8627308
RGD:11522712
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Id1
inhibitor of DNA binding 1, HLH protein
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
G
Id2
inhibitor of DNA binding 2
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
G
Id3
inhibitor of DNA binding 3, HLH protein
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
G
Il10
interleukin 10
treatment
IEP
RGD
PMID:29691718
RGD:14975124
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il18
interleukin 18
treatment
IDA IEP
RGD
PMID:18367607 , PMID:23140983
RGD:2315889 , RGD:8655974
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il1b
interleukin 1 beta
treatment
IEP IDA
mRNA, protein:increased expression:spinal cord
RGD
PMID:16038625 , PMID:29691718 , PMID:23209732
RGD:1626673 , RGD:14975124 , RGD:7175523
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1r1
interleukin 1 receptor type 1
IEP
mRNA,protein:increased expression:spinal cord
RGD
PMID:16456668
RGD:7207035
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
G
Il1rn
interleukin 1 receptor antagonist
IDA ISO
protein:increased expression:serum (human)
RGD
PMID:16038625 , PMID:17964877
RGD:1626673 , RGD:6907102
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il4
interleukin 4
IMP
RGD
PMID:20623539
RGD:5128562
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Il4r
interleukin 4 receptor
IEP
mRNA:increased expression:spinal cord
RGD
PMID:20623539
RGD:5128562
NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
G
Il6
interleukin 6
treatment
IDA IEP
RGD
PMID:27085942 , PMID:29691718
RGD:11062150 , RGD:14975124
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Irf1
interferon regulatory factor 1
IEP
RGD
PMID:11723173
RGD:2298928
NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
G
Irf5
interferon regulatory factor 5
treatment
IEP
RGD
PMID:24968269
RGD:40924652
NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
G
Itih4
inter-alpha-trypsin inhibitor heavy chain 4
severity
IEP
protein:decreased expression:cerebrospinal fluid
RGD
PMID:21559420
RGD:40907059
NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
G
Jak2
Janus kinase 2
treatment
IMP
RGD
PMID:23274522
RGD:10411896
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IDA
protein:increased phosphorylation:neuron
RGD
PMID:21132399
RGD:4889994
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
IEP
protein:decreased expression:spinal cord
RGD
PMID:20375134
RGD:8662905
NCBI chr13:90,722,945...90,753,338
Ensembl chr13:90,723,092...90,752,581
G
Kcnk2
potassium two pore domain channel subfamily K member 2
treatment
IDA
RGD
PMID:22425721
RGD:9831183
NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
G
Kdm6b
lysine demethylase 6B
IEP
mRNA:increased expression:spinal cord (rat)
RGD
PMID:22578249
RGD:9587821
NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
G
Kdr
kinase insert domain receptor
IEP
mRNA:increased expression:spinal cord, astrocyte, macrophage
RGD
PMID:17409380
RGD:5684414
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
G
Kif3b
kinesin family member 3B
IEP
protein:increased expression:spinal cord
RGD
PMID:23093447
RGD:11049594
NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
G
Klk6
kallikrein related-peptidase 6
IEP
protein:increased expression:spinal cord
RGD
PMID:16987227
RGD:2314866
NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488
G
Kmo
kynurenine 3-monooxygenase
IEP
mRNA,protein:increased expression:spinal cord:
RGD
PMID:26524415
RGD:13703043
NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
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Lep
leptin
IEP
RGD
PMID:19777863
RGD:5128780
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lrp1
LDL receptor related protein 1
treatment
IDA
RGD
PMID:23867460
RGD:13800520
NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
G
Lrp5
LDL receptor related protein 5
treatment
IEP
RGD
PMID:24090150
RGD:12798566
NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
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Lum
lumican
IEP
protein:increased expression:spinal cord
RGD
PMID:18482974
RGD:2317692
NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
G
Map1b
microtubule-associated protein 1B
IEP
protein:increased phosphorylation:spinal cord, neuron
RGD
PMID:17880387
RGD:2304007
NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
G
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
treatment
IEP
protein:increased expression:spinal cord
RGD
PMID:24559459 , PMID:23637053 , PMID:23852559
RGD:11561918 , RGD:11564330 , RGD:11561922
NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
G
Map2
microtubule-associated protein 2
IDA
RGD
PMID:21704982
RGD:6483323
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
IEP
protein:increased expression:white matter and grey matter:
RGD
PMID:10331432
RGD:10412645
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
G
Mapt
microtubule-associated protein tau
treatment
IEP
RGD
PMID:22052241
RGD:8158113
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
G
Mdm2
MDM2 proto-oncogene
IEP
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
G
Met
MET proto-oncogene, receptor tyrosine kinase
IEP
mRNA, protein:increased expression:spinal cord (rat)
RGD
PMID:17549731
RGD:2317487
NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
G
Mfn1
mitofusin 1
treatment
IEP
protein:altered expression:spinal cord, mitochondrion (rat)
RGD
PMID:26981103 , PMID:26079325
RGD:12910837 , RGD:12437066
NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
G
Mfn2
mitofusin 2
treatment
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:28404953 , PMID:26079325
RGD:12910735 , RGD:12437066
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
G
Mif
macrophage migration inhibitory factor
IEP
mRNA:increased expression:spinal cord, microglial cell
RGD
PMID:15067555
RGD:1641997
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
G
Mir21
microRNA 21
exacerbates
IMP
RGD
PMID:31102912
RGD:41410823
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
G
Mir214
microRNA 214
treatment
IEP
RGD
PMID:30287503
RGD:38549580
NCBI chr13:80,130,905...80,131,014
G
Mir411
microRNA 411
IEP
RGD
PMID:29738767
RGD:13792580
NCBI chr 6:133,858,849...133,858,924
Ensembl chr 6:133,858,844...133,858,939
G
Mmp2
matrix metallopeptidase 2
treatment
IEP
RGD
PMID:24436993
RGD:8657106
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
G
Mmp9
matrix metallopeptidase 9
treatment
IEP
RGD
PMID:25763638
RGD:12791993
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Mpo
myeloperoxidase
IEP
protein:increased activity:spinal cord
RGD
PMID:22986158
RGD:6909148
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
G
Mrc1
mannose receptor, C type 1
treatment
IEP
RGD
PMID:24968269
RGD:40924652
NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
G
Mt-nd3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
IMP
RGD
PMID:20438613
RGD:5687694
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
G
Mtor
mechanistic target of rapamycin kinase
treatment
IMP
RGD
PMID:20678995
RGD:10040962
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
G
Napepld
N-acyl phosphatidylethanolamine phospholipase D
IEP
mRNA:increased expression:spinal cord
RGD
PMID:18930143
RGD:2316199
NCBI chr 4:9,965,323...10,004,650
Ensembl chr 4:9,966,891...10,002,247
G
Ncam1
neural cell adhesion molecule 1
treatment
ISO
RGD
PMID:28529158
RGD:40924632
NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
G
Ncf2
neutrophil cytosolic factor 2
IEP
protein:increased expression:spinal cord
RGD
PMID:14644473
RGD:2314450
NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
G
Nefh
neurofilament heavy
treatment
IDA IEP
RGD
PMID:18772508 , PMID:32168135
RGD:9698443 , RGD:27226888
NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
G
Nefl
neurofilament light
treatment
IDA
RGD
PMID:18772508
RGD:9698443
NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
G
Nefm
neurofilament medium
treatment
IDA
RGD
PMID:18772508
RGD:9698443
NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
G
Nfe2l2
nuclear factor, erythroid 2-like 2
treatment
IDA
RGD
PMID:24747453
RGD:10412730
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nfkbia
NFKB inhibitor alpha
treatment
IEP
RGD
PMID:21134362
RGD:10413867
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
G
Ngf
nerve growth factor
IEP IMP
RGD
PMID:16915089 , PMID:12499054
RGD:5144069 , RGD:5144073
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
G
Ngfr
nerve growth factor receptor
treatment
IEP IMP
mRNA:increased expression:spinal cord
RGD
PMID:11223160 , PMID:23748892
RGD:5144100 , RGD:10414079
NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
G
Nkx6-1
NK6 homeobox 1
IMP
RGD
PMID:18687784
RGD:2311166
NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
G
Nlk
nemo like kinase
IEP
protein:increased expression:grey matter:
RGD
PMID:24395089
RGD:12791278
NCBI chr10:65,840,052...65,963,932
Ensembl chr10:65,840,052...65,963,932
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Nog
noggin
treatment
ISO
RGD
PMID:18221366
RGD:10429192
NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
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Nos1
nitric oxide synthase 1
IEP IMP
protein:increased expression:spinal cord
RGD
PMID:19291395 , PMID:20633123
RGD:5132595 , RGD:5131936
NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
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Nos2
nitric oxide synthase 2
IEP
mRNA:altered expression:thoracic aorta
RGD
PMID:17287083
RGD:4891407
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nos3
nitric oxide synthase 3
IEP
RGD
PMID:17287083
RGD:4891407
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:24747453 , PMID:28881715
RGD:10412730 , RGD:13434916
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Ntf3
neurotrophin 3
ISO
RGD
PMID:16022868
RGD:4891112
NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
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Ntrk1
neurotrophic receptor tyrosine kinase 1
IEP
mRNA:decreased expression:spinal cord
RGD
PMID:18585435
RGD:2308892
NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
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Ntrk2
neurotrophic receptor tyrosine kinase 2
IDA IMP
RGD
PMID:22027236 , PMID:20597685
RGD:5684547 , RGD:5684898
NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
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Ntrk3
neurotrophic receptor tyrosine kinase 3
IEP
mRNA:decreased expression:spinal cord
RGD
PMID:18585435
RGD:2308892
NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
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Olig2
oligodendrocyte transcription factor 2
treatment
ISO IMP
RGD
PMID:28452182 , PMID:22173726
RGD:40902836 , RGD:40902844
NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
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P2rx7
purinergic receptor P2X 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15258577
NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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Parp1
poly (ADP-ribose) polymerase 1
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15696051 , PMID:21748659
RGD:10053608
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pdcd1
programmed cell death 1
treatment
IEP
RGD
PMID:29665726
RGD:40886268
NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845 Ensembl chr 9:101,307,764...101,319,845
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Pdcd1lg2
programmed cell death 1 ligand 2
IEP
mRNA:increased expression:microglial cell
RGD
PMID:29665726
RGD:40886268
NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193
G
Pdgfb
platelet derived growth factor subunit B
ISO
RGD
PMID:21568693
RGD:6482306
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
G
Pla2g2a
phospholipase A2 group IIA
ISO IEP
protein:increased expression:spinal cord
RGD
PMID:21868473 , PMID:19306380
RGD:6482718 , RGD:6482721
NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
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Pla2g6
phospholipase A2 group VI
ISO
protein:increased expression:spinal cord
RGD
PMID:21868473
RGD:6482718
NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
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Plau
plasminogen activator, urokinase
ISO
RGD
PMID:21573723
RGD:6483797
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Plaur
plasminogen activator, urokinase receptor
ISO
RGD
PMID:21573723
RGD:6483797
NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
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Pon1
paraoxonase 1
treatment
IDA
RGD
PMID:12897486
RGD:8547682
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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Ppard
peroxisome proliferator-activated receptor delta
IEP
RGD
PMID:20058304
RGD:2324875
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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Ppargc1a
PPARG coactivator 1 alpha
IDA
RGD
PMID:22208735
RGD:6484263
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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Ppp1cc
protein phosphatase 1 catalytic subunit gamma
IEP
protein:increased expression:spinal cord, astrocyte, microglial cell
RGD
PMID:29033188
RGD:13514047
NCBI chr12:39,864,302...39,882,030
Ensembl chr12:39,864,295...39,882,030
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
IEP ISO
mRNA:increased expression:spinal cord (rat) CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971 , PMID:17578450
RGD:9999410
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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Prkcg
protein kinase C, gamma
ISO
protein:decreased expression:spinal cord (mouse)
RGD
PMID:10501452
RGD:28867228
NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
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Ptgs1
prostaglandin-endoperoxide synthase 1
IMP IEP
protein:increased expression:microglia, macrophage
RGD
PMID:17184185 , PMID:11063829
RGD:5688221 , RGD:5688246
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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Ptgs2
prostaglandin-endoperoxide synthase 2
IEP
RGD
PMID:18606213
RGD:5135219
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
treatment
IDA IEP
RGD
PMID:15016081 , PMID:18065151 , PMID:12895450
RGD:9589823 , RGD:9590124 , RGD:9590113
NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
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Rara
retinoic acid receptor, alpha
IEP
RGD
PMID:16420438
RGD:2314291
NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
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Rbmx
RNA binding motif protein, X-linked
IEP
RGD
PMID:23180094
RGD:10053723
NCBI chr X:159,881,835...159,891,405
Ensembl chr X:159,884,885...159,891,326
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Rela
RELA proto-oncogene, NF-kB subunit
IMP
RGD
PMID:17918744
RGD:2298849
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Rgma
repulsive guidance molecule BMP co-receptor a
treatment
IMP
RGD
PMID:16585268
RGD:9850138
NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514
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Rpsa
ribosomal protein SA
IEP
RGD
PMID:19196078
RGD:11041651
NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
G
Scn3a
sodium voltage-gated channel alpha subunit 3
IDA
RGD
PMID:16109750 , PMID:16718433
RGD:2317321 , RGD:2317320
NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
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Serpinc1
serpin family C member 1
treatment
ISO
RGD
PMID:15792522
RGD:1599333
NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
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Shh
sonic hedgehog signaling molecule
treatment
IMP
RGD
PMID:24837681
RGD:12879409
NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
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Siah1
siah E3 ubiquitin protein ligase 1
treatment
IDA
RGD
PMID:27256506
RGD:13792677
NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
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Slc25a27
solute carrier family 25, member 27
ISO
protein:increased expression:spinal cord
RGD
PMID:18534681
RGD:6482843
NCBI chr 9:19,880,468...19,907,506
Ensembl chr 9:19,880,473...19,907,458
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Slit1
slit guidance ligand 1
ISO
RGD
PMID:16262652
RGD:2316136
NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
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Slit2
slit guidance ligand 2
IEP
mRNA, protein:increased expression:spinal cord
RGD
PMID:19783284
RGD:2316127
NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
G
Slit3
slit guidance ligand 3
ISO
RGD
PMID:16262652
RGD:2316136
NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
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Smurf1
SMAD specific E3 ubiquitin protein ligase 1
IEP
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
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Socs2
suppressor of cytokine signaling 2
IEP
RGD
PMID:11723173
RGD:2298928
NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
G
Sod1
superoxide dismutase 1
treatment
ISO
human protein in a rat model CTD Direct Evidence: therapeutic human gene in a rat model
CTD
PMID:17457363 , PMID:18722523 , PMID:16689664
RGD:8655939 , RGD:8655990
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
G
Sox2
SRY-box transcription factor 2
IEP
RGD
PMID:23169458
RGD:8661675
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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Sparc
secreted protein acidic and cysteine rich
ISO
RGD
PMID:17611274
RGD:2300052
NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
G
Spp1
secreted phosphoprotein 1
ISO
RGD
PMID:15592854
RGD:6483848
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
G
Sqstm1
sequestosome 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Tacr1
tachykinin receptor 1
IMP
RGD
PMID:18945947
RGD:2304258
NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
G
Tbp
TATA box binding protein
IEP
protein:increased expression:spinal cord, astrocyte, microglial cell
RGD
PMID:24710803
RGD:9681729
NCBI chr 1:57,491,381...57,509,335
Ensembl chr 1:57,491,643...57,508,449
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Tert
telomerase reverse transcriptase
ISO IEP
mRNA, protein:increased expression:spinal cord
RGD
PMID:15798365 , PMID:23793903
RGD:2291993 , RGD:11038671
NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
G
Tgfb1
transforming growth factor, beta 1
IMP
RGD
PMID:15145083
RGD:2302103
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tgfb2
transforming growth factor, beta 2
IMP
RGD
PMID:15145083
RGD:2302103
NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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Thbd
thrombomodulin
ISO
RGD
PMID:15307903
RGD:1580060
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
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Thbs1
thrombospondin 1
IEP
protein:increased expression:spinal cord
RGD
PMID:19719963
RGD:2317939
NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
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Tlr1
toll-like receptor 1
treatment
ISO
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:21970496 , PMID:21970496
RGD:7246886 , RGD:7246886
NCBI chr14:45,062,662...45,065,014
Ensembl chr14:45,062,662...45,081,991
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Tlr4
toll-like receptor 4
severity
ISO
RGD
PMID:25990044
RGD:14700556
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnc
tenascin C
IEP
mRNA:increased expression:spinal cord
RGD
PMID:11085900
RGD:4889619
NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
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Tnf
tumor necrosis factor
IMP
RGD
PMID:20633123
RGD:5131936
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
IEP
protein:increased expression:cerebrospinal fluid
RGD
PMID:16083358
RGD:1624185
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Tp53
tumor protein p53
IEP
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
IEP
mRNA,protein:increased expression:urinary bladder, dorsal root ganglion:
RGD
PMID:21367919
RGD:10043365
NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
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Trpm4
transient receptor potential cation channel, subfamily M, member 4
treatment
IEP
RGD
PMID:19169264 , PMID:25763638
RGD:10003030 , RGD:12791993
NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
G
Tug1
taurine up-regulated 1
treatment
IEP
RGD
PMID:30287503
RGD:38549580
NCBI chr14:83,878,757...83,885,791
Ensembl chr14:83,878,295...83,887,584
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Ulk1
unc-51 like autophagy activating kinase 1
IEP
protein:increased expression:neuron, axon
RGD
PMID:25040536
RGD:11553820
NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
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Vegfa
vascular endothelial growth factor A
IEP ISO
protein:increased expression:spinal cord CTD Direct Evidence: marker/mechanism
CTD
PMID:21092735 , PMID:21092735
RGD:5148013
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Vhl
von Hippel-Lindau tumor suppressor
IDA
RGD
PMID:20125055
RGD:2325181
NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
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Vim
vimentin
ISO IEP
protein:increased expression:spinal cord
RGD
PMID:10225952 , PMID:21250919
RGD:6480471 , RGD:6480511
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Vwf
von Willebrand factor
IEP
RGD
PMID:25771801
RGD:13673888
NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
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Xbp1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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Xdh
xanthine dehydrogenase
IEP
protein:increased expression:spinal cord
RGD
PMID:1649310
RGD:13209021
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Xylt1
xylosyltransferase 1
IMP
RGD
PMID:18765417
RGD:2313145
NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
IEP
mRNA, protein:increased expression, increased activity:spinal cord (rat)
RGD
PMID:22425718
RGD:10449098
NCBI chr 3:5,519,921...5,558,390
Ensembl chr 3:5,519,990...5,558,166
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Amigo3
adhesion molecule with Ig like domain 3
IEP
mRNA, protein:increased expression:dorsal root ganglion (rat)
RGD
PMID:23613963
RGD:14390159
NCBI chr 8:116,830,773...116,832,299
G
Ccl2
C-C motif chemokine ligand 2
IEP ISO
mRNA, protein:increased expression:liver, serum (rat) CTD Direct Evidence: marker/mechanism
CTD
PMID:15135227 , PMID:15855648
RGD:11526154
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Egr1
early growth response 1
IEP
protein:increased expression:spinal cord dorsal horn (rat)
RGD
PMID:20675054
RGD:5131876
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:9675307
RGD:10450552
NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
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Epo
erythropoietin
IEP
protein:increased expression:neuron, endothelium, glia:
RGD
PMID:15792521
RGD:11041719
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
G
Epor
erythropoietin receptor
IEP
protein:increased expression:neuron, endothelium, glia:
RGD
PMID:15792521
RGD:11041719
NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
G
Fas
Fas cell surface death receptor
treatment
ISO
human protein in a rat model protein:increased expression:spinal cord:
RGD
PMID:16689665 , PMID:21490053 , PMID:16202410
RGD:1582444 , RGD:12904017 , RGD:8663485
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Faslg
Fas ligand
treatment
ISO
protein:increased expression:spinal cord:
RGD
PMID:21490053 , PMID:21490053
RGD:12904017 , RGD:12904017
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Fgf2
fibroblast growth factor 2
IEP
protein:increased expression:spinal cord
RGD
PMID:17244329
RGD:8655633
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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Fis1
fission, mitochondrial 1
treatment
IEP
RGD
PMID:25595990
RGD:12437079
NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
IEP
protein:decreased expression:spinal cord, thoracic vertebrae (rat)
RGD
PMID:20399821
RGD:2326108
NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
G
Hspa4
heat shock protein family A (Hsp70) member 4
ISO
protein:increased expression:spinal cord (mouse)
RGD
PMID:21787762
RGD:6218959
NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
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Il6
interleukin 6
IEP
protein:increased expression:cerebrospinal fluid, serum
RGD
PMID:30327453
RGD:14975119
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
L1cam
L1 cell adhesion molecule
ISO
RGD
PMID:21671795
RGD:6483029
NCBI chr X:156,901,244...156,928,064
Ensembl chr X:156,909,913...156,928,057
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Mt2A
metallothionein 2A
ISO
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:15592854
RGD:6483848
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
G
Nos3
nitric oxide synthase 3
treatment
IEP
RGD
PMID:29323048
RGD:13504709
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
G
Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12227717
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15135227
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
G
Tnfrsf1a
TNF receptor superfamily member 1A
IEP
protein:increased expression:spinal cord (rat)
RGD
PMID:21224756
RGD:5130917
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
G
Tnfrsf1b
TNF receptor superfamily member 1B
IEP ISO
protein:increased expression:spinal cord (rat) human protein in rat model
RGD
PMID:21224756 , PMID:21224756
RGD:5130917 , RGD:5130917
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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