RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Experimental Arthritis
Accession: DOID:9002457
browse the term
Definition: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
Synonyms: exact_synonym: Adjuvant Arthritis; Arthritis, Adjuvant-Induced; Collagen Arthritides; Collagen Arthritis; Collagen-Induced Arthritides; Collagen-Induced Arthritis
primary_id: MESH:D001169
alt_id: RDO:0004914
For additional species annotation, visit the
Alliance of Genome Resources .
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A2m
alpha-2-macroglobulin
IEP
protein:increased expression:serum
RGD
PMID:6163339
RGD:10046032
NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
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Abcb1a
ATP binding cassette subfamily B member 1A
IEP ISO
mRNA:altered expression:liver CTD Direct Evidence: marker/mechanism mRNA:decreased expression:intestinal mucosa (rat)
CTD
PMID:17827786 , PMID:19152228 , PMID:17827786
RGD:2315573 , RGD:11040994
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcc6
ATP binding cassette subfamily C member 6
IEP
mRNA:decreased expression:kidney
RGD
PMID:22974786
RGD:11038789
NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
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Abcg2
ATP binding cassette subfamily G member 2
IEP
mRNA:decreased expression:small intestine
RGD
PMID:19152228
RGD:2315573
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Acan
aggrecan
treatment
IEP
RGD
PMID:25821409
RGD:12879456
NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
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Ace
angiotensin I converting enzyme
IEP
RGD
PMID:20213806
RGD:2325221
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Acsl1
acyl-CoA synthetase long-chain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18988084
NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
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Acsl4
acyl-CoA synthetase long-chain family member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18988084
NCBI chr X:113,596,247...113,660,024
Ensembl chr X:113,596,239...113,659,944
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Acsl5
acyl-CoA synthetase long-chain family member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18988084
NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
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Adam10
ADAM metallopeptidase domain 10
IEP
RGD
PMID:23897050
RGD:13703039
NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
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Adam17
ADAM metallopeptidase domain 17
IEP
RGD
PMID:23897050
RGD:13703039
NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
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Adipoq
adiponectin, C1Q and collagen domain containing
IEP ISO
protein:increased expression:serum CTD Direct Evidence: marker/mechanism
CTD
PMID:23326410 , PMID:21681567 , PMID:19026984
RGD:5685385 , RGD:5686814
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Adk
adenosine kinase
IMP
RGD
PMID:11160636
RGD:6482663
NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
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Ahcy
adenosylhomocysteinase
IDA
RGD
PMID:11123369
RGD:1598898
NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25194622
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Akt1
AKT serine/threonine kinase 1
treatment
IDA
RGD
PMID:22391142
RGD:10041007
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20472598
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Alox15
arachidonate 15-lipoxygenase
ISO
RGD
PMID:19675173
RGD:5509599
NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
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Anxa1
annexin A1
IMP ISO
RGD
PMID:10403283 , PMID:23267026
RGD:2306928 , RGD:7421573
NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
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Aoc3
amine oxidase, copper containing 3
IMP
RGD
PMID:16947396
RGD:2313925
NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313
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Apoa4
apolipoprotein A4
IEP
protein:decreased expression:blood serum (rat)
RGD
PMID:10892728
RGD:5685694
NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
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Arrb1
arrestin, beta 1
IEP
protein:increased expression:knee, synoviocyte (rat)
RGD
PMID:20965243
RGD:5509895
NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
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Arrb2
arrestin, beta 2
IEP
protein:increased expression:knee, synoviocyte (rat)
RGD
PMID:20965243
RGD:5509895
NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
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Atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
IMP
RGD
PMID:17408934
RGD:5144054
NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:21199477 , PMID:22978269
RGD:10054249 , RGD:10054498
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:21199477 , PMID:22978269
RGD:10054249 , RGD:10054498
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bdkrb1
bradykinin receptor B1
IMP
RGD
PMID:15001555
RGD:1625760
NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
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Bglap
bone gamma-carboxyglutamate protein
ISO
protein:decreased expression:serum
RGD
PMID:21406003
RGD:6483549
NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
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Btk
Bruton tyrosine kinase
treatment
IMP
RGD
PMID:22228807
RGD:11040701
NCBI chr X:105,360,922...105,390,580
Ensembl chr X:105,360,922...105,390,580
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C3
complement C3
treatment
ISO IDA
RGD
PMID:20051658 , PMID:7347767
RGD:7411688 , RGD:11041098
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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C5
complement C5
ISO IMP
RGD
PMID:20975959 , PMID:12355496
RGD:5130175 , RGD:1600637
NCBI chr 3:14,049,993...14,113,931 NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
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Cabin1
calcineurin binding protein 1
ISO
RGD
PMID:22275266
RGD:10054391
NCBI chr20:13,836,032...13,963,003
Ensembl chr20:13,836,030...13,963,003
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Calca
calcitonin-related polypeptide alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16690336
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22450443
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cbl
Cbl proto-oncogene
treatment
IDA
RGD
PMID:16984225
RGD:2306289
NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
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Cblb
Cbl proto-oncogene B
IMP
RGD
PMID:16984225
RGD:2306289
NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
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Ccl2
C-C motif chemokine ligand 2
treatment
IMP IDA IEP
mRNA, protein:increased expression:synovium
RGD
PMID:18292571 , PMID:24583103 , PMID:18726678 , PMID:17052673
RGD:2307052 , RGD:11526142 , RGD:2307008 , RGD:2307143
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl3
C-C motif chemokine ligand 3
IEP
mRNA, protein:increased expression:synovium, monocytes
RGD
PMID:17052673
RGD:2307143
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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Ccl5
C-C motif chemokine ligand 5
IMP IEP
mRNA, protein:increased expression:synovium, monocytes
RGD
PMID:9637726 , PMID:17052673
RGD:4889940 , RGD:2307143
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccl7
C-C motif chemokine ligand 7
onset
ISO
RGD
PMID:17178563
RGD:6483780
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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Ccr1
C-C motif chemokine receptor 1
ISO IEP
RGD
PMID:18608173 , PMID:14674010
RGD:5688144 , RGD:1582346
NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
G
Ccr2
C-C motif chemokine receptor 2
IEP
RGD
PMID:16320322
RGD:4144893
G
Ccr5
C-C motif chemokine receptor 5
treatment
IEP
mRNA:increased expression:ankle (rat)
RGD
PMID:14674010 , PMID:22289897
RGD:1582346 , RGD:5687744
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
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Cd28
Cd28 molecule
IEP
RGD
PMID:18601859
RGD:2307202
NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
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Cd4
Cd4 molecule
treatment
ISO IMP
RGD
PMID:15479897 , PMID:12010568
RGD:10058957 , RGD:10058960
NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
G
Cd40
CD40 molecule
ISO
RGD
PMID:20435931
RGD:5490544
NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
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Cd40lg
CD40 ligand
treatment
IDA ISO IEP
protein:increased expression:plasma (rat)
RGD
PMID:27218142 , PMID:7689748 , PMID:22611405
RGD:11344958 , RGD:11352696 , RGD:11352298
NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562
G
Cd44
CD44 molecule (Indian blood group)
IEP
protein:increased expression:joint, macrophage, lymphocyte
RGD
PMID:8639178
RGD:2289388
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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Cd46
CD46 molecule
ISO
RGD
PMID:21852528
RGD:6483461
NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
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Cd59
CD59 molecule
IDA
RGD
PMID:14519760
RGD:1600483
NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
G
Cd69
Cd69 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12882836
NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
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Cd80
Cd80 molecule
ISO
RGD
PMID:22004797
RGD:6902903
NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
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Cdc42
cell division cycle 42
ISO
protein:increased activation:bone marrow, macrophage
RGD
PMID:21266780
RGD:5688271
NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
treatment
ISO
RGD
PMID:10395320
RGD:8552686
NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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Cfh
complement factor H
ISO
RGD
PMID:19828624
RGD:5684557
NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
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Col2a1
collagen type II alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16200597 PMID:21188452 PMID:23326410 PMID:24709313 PMID:25194622 PMID:25481498 PMID:26070417 PMID:29908986 PMID:29935983
NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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Cp
ceruloplasmin
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19330884 , PMID:19205849
RGD:2314686
NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
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Cpox
coproporphyrinogen oxidase
IEP
protein:decreased activity:liver (rat)
RGD
PMID:9173682
RGD:1600958
NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
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Crhr1
corticotropin releasing hormone receptor 1
IMP
RGD
PMID:17550594
RGD:1626231
NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19330884
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:12742377
RGD:11039465
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Csk
C-terminal Src kinase
IMP
RGD
PMID:10411542
RGD:5134371
NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
treatment
IMP ISO
RGD
PMID:22354915 , PMID:7543497
RGD:7204500 , RGD:7204519
NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
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Ctsb
cathepsin B
IEP
mRNA:increased expression:knee joint, synovium (rat)
RGD
PMID:17195213
RGD:2315521
NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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Ctsk
cathepsin K
IEP
mRNA:increased expression:synovium, bone marrow
RGD
PMID:15353610
RGD:1601025
NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
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Ctss
cathepsin S
ISO
RGD
PMID:21439785
RGD:5686915
NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
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Cx3cl1
C-X3-C motif chemokine ligand 1
IEP
RGD
PMID:11465708
RGD:4892002
NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
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Cx3cr1
C-X3-C motif chemokine receptor 1
IEP
protein:increased expression:spinal cord
RGD
PMID:17123734 , PMID:11465708
RGD:4891969 , RGD:4892002
NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
G
Cxcl1
C-X-C motif chemokine ligand 1
IEP
RGD
PMID:19096963
RGD:4889415
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl6
C-X-C motif chemokine ligand 6
severity
IMP
RGD
PMID:10358204
RGD:5135272
NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
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Dhodh
dihydroorotate dehydrogenase (quinone)
IMP
RGD
PMID:15182735
RGD:2316231
NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
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Dnmt1
DNA methyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25194984
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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Drd1
dopamine receptor D1
treatment
IEP IDA
mRNA:increased expression:corpus striatum (rat)
RGD
PMID:23762129 , PMID:23762129
RGD:7248592 , RGD:7248592
NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
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Drd2
dopamine receptor D2
treatment
IEP IDA
mRNA:increased expression:corpus striatum (rat)
RGD
PMID:23762129 , PMID:23762129
RGD:7248592 , RGD:7248592
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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Edn1
endothelin 1
ISO
mRNA:increased expression:inguinal lymph node (mouse)
RGD
PMID:22249931
RGD:8661695
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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Egfr
epidermal growth factor receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:7589090
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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Esr1
estrogen receptor 1
treatment
ISO
associated with Osteoporosis
RGD
PMID:20112355
RGD:10045851
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Esr2
estrogen receptor 2
IDA
RGD
PMID:16269464
RGD:5508854
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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F2
coagulation factor II
ISO
RGD
PMID:21436072
RGD:5147764
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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F2r
coagulation factor II (thrombin) receptor
severity
ISO
RGD
PMID:19674841
RGD:7387269
NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
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F2rl1
F2R like trypsin receptor 1
ISO
RGD
PMID:12511586
RGD:735010
NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
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Faslg
Fas ligand
treatment
IMP
RGD
PMID:22354915
RGD:7204500
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Fcgr1a
Fc fragment of IgG receptor Ia
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12875993 , PMID:16670289
RGD:9685708
NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
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Fcgr2a
Fc fragment of IgG receptor IIa
onset
ISO
RGD
PMID:18354234 , PMID:16623928
RGD:5508446 , RGD:5508457
NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036 Ensembl chr13:91,168,973...91,198,036
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Fcgr2b
Fc fragment of IgG receptor IIb
ISO
RGD
PMID:23341540
RGD:11344930
NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
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Fgf8
fibroblast growth factor 8
IMP
RGD
PMID:18699993
RGD:2314157
NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
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Fgfr1
Fibroblast growth factor receptor 1
ISO
RGD
PMID:22833219
RGD:10402072
NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
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Flt1
Fms related receptor tyrosine kinase 1
ISO
RGD
PMID:19180491
RGD:6483591
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
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Flt3
Fms related receptor tyrosine kinase 3
IAGP
RGD
PMID:10857786
RGD:61066
NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
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Foxp3
forkhead box P3
treatment
IEP
mRNA,protein:decreased expression:lung
RGD
PMID:29264841 , PMID:23643080
RGD:38549364 , RGD:38599003
NCBI chr X:15,753,175...15,768,648
Ensembl chr X:15,753,175...15,768,522
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Gja1
gap junction protein, alpha 1
IMP
RGD
PMID:23165424
RGD:7207259
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Gli1
GLI family zinc finger 1
treatment
IEP
RGD
PMID:25821409
RGD:12879456
NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
G
Gpi
glucose-6-phosphate isomerase
ISO
RGD
PMID:23911657
RGD:11051957
NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
G
Grk2
G protein-coupled receptor kinase 2
disease_progression treatment
IEP
protein:increased expression:aorta (rat) protein:altered expression:T cell (rat)
RGD
PMID:28653218 , PMID:28349925 , PMID:28631356
RGD:13513975 , RGD:13513979 , RGD:13513976
NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
G
Grn
granulin precursor
ISO
RGD
PMID:21393509
RGD:5509782
NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
G
Gsk3b
glycogen synthase kinase 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16713974
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
G
Havcr2
hepatitis A virus cellular receptor 2
IEP
mRNA,protein:altered expression:bone:
RGD
PMID:25264706
RGD:9686117
NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
G
Hdac6
histone deacetylase 6
treatment
ISO
RGD
PMID:23541634
RGD:9681550
NCBI chr X:15,295,372...15,316,673
Ensembl chr X:15,295,473...15,316,671
G
Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
IDA
RGD
PMID:21679445
RGD:8693318
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
G
Hmgb1
high mobility group box 1
IEP
protein:altered localization:cytoplasm, extracellular matrix
RGD
PMID:12384917
RGD:728698
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:17119970
RGD:5508468
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Hp
haptoglobin
IEP
mRNA, protein:increased expression:tendon, ankle protein:increased expression:serum
RGD
PMID:12801280 , PMID:15899029
RGD:1626375 , RGD:1626370
NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
G
Hspd1
heat shock protein family D (Hsp60) member 1
IDA
RGD
PMID:15529360 , PMID:10882416
RGD:1624244 , RGD:12910542
NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
G
Ifng
interferon gamma
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19203382 PMID:22450443 , PMID:12412757 , PMID:7774621
RGD:2311498 , RGD:10755750
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
G
Igf1
insulin-like growth factor 1
IEP
protein:decreased expression:plasma
RGD
PMID:19246225
RGD:2306697
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Igfbp3
insulin-like growth factor binding protein 3
IEP
mRNA, protein:increased expression:kidney, serum
RGD
PMID:14642797
RGD:10402760
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
treatment
ISO IMP
RGD
PMID:21087862 , PMID:19652024
RGD:7495772 , RGD:7495778
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
treatment
IDA
RGD
PMID:16684367
RGD:12791276
NCBI chr X:156,254,187...156,280,046
Ensembl chr X:156,257,173...156,270,748
G
Il10
interleukin 10
treatment
IEP ISO IDA
CTD Direct Evidence: marker/mechanism|therapeutic protein:decreased expression:serum:
CTD
PMID:20974942 PMID:22450443 , PMID:19193354 , PMID:19169271 , PMID:23140046 , PMID:22052031 , PMID:15270736
RGD:2311059 , RGD:8662976 , RGD:7193038 , RGD:7364838 , RGD:1626677
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il13
interleukin 13
treatment
ISO IMP
CTD Direct Evidence: therapeutic
CTD
PMID:10444273 , PMID:17665443 , PMID:11860705
RGD:4889497 , RGD:8549606
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
G
Il15
interleukin 15
ISO
RGD
PMID:20188418
RGD:5000761
NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
G
Il17a
interleukin 17A
treatment
IMP ISO IEP IDA
CTD Direct Evidence: marker/mechanism protein:increased expression:serum (rat)
CTD
PMID:20974942 , PMID:20925596 , PMID:23377547 , PMID:21194185 , PMID:20925596
RGD:4781444 , RGD:9130803 , RGD:9068936 , RGD:4781444
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
G
Il18
interleukin 18
disease_progression
IEP IMP
RGD
PMID:19096963 , PMID:15147345
RGD:4889415 , RGD:4889503
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il1a
interleukin 1 alpha
IDA IEP
protein:increased expression:serum:
RGD
PMID:20379758 , PMID:19169271
RGD:6907373 , RGD:8662976
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il1b
interleukin 1 beta
treatment
IDA IEP ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum (rat)
CTD
PMID:19330884 PMID:20131233 PMID:20974942 PMID:22450443 , PMID:21557995 , PMID:29408684 , PMID:24028507 , PMID:23140046
RGD:7175317 , RGD:13792834 , RGD:10755447 , RGD:7193038
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1rl1
interleukin 1 receptor-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20472598
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
G
Il1rn
interleukin 1 receptor antagonist
treatment
ISO IEP
rat model treated with human protein human gene in a rat model mRNA:increased expression:popliteal lymph node (rat) mouse model treated with human protein
RGD
PMID:15270736 , PMID:12727108 , PMID:10921508 , PMID:22267332 , PMID:23006786
RGD:1626677 , RGD:8551745 , RGD:8551741 , RGD:8549801 , RGD:6907376
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il2
interleukin 2
treatment
IEP IDA
protein:increased expression:serum:
RGD
PMID:19169271 , PMID:2492102
RGD:8662976 , RGD:10047055
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
G
Il20
interleukin 20
IMP
RGD
PMID:20722035
RGD:5147393
NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715
G
Il2ra
interleukin 2 receptor subunit alpha
IDA
RGD
PMID:17928458
RGD:2325988
NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
G
Il33
interleukin 33
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20472598
NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
G
Il4
interleukin 4
treatment
IMP ISO IEP
CTD Direct Evidence: therapeutic
CTD
PMID:10444273 , PMID:16869003 , PMID:23972727 , PMID:23140046
RGD:2317300 , RGD:10402790 , RGD:7193038
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Il6
interleukin 6
treatment
IEP ISO IDA IMP
CTD Direct Evidence: marker/mechanism
CTD
PMID:20131233 PMID:20974942 PMID:22450443 , PMID:24028507 , PMID:8607900 , PMID:10381487 , PMID:23503893
RGD:10755447 , RGD:11060267 , RGD:11049553 , RGD:11049551
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Il6st
interleukin 6 cytokine family signal transducer
ISO
RGD
PMID:20626857
RGD:5509945
NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
G
Itga4
integrin subunit alpha 4
treatment
IMP
RGD
PMID:12969328
RGD:9698440
NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
G
Itgb2
integrin subunit beta 2
IMP
RGD
PMID:8881759
RGD:6482229
NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
G
Itgb3
integrin subunit beta 3
IMP
protein:increased expression:endothelial cell
RGD
PMID:16869003
RGD:2317300
NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
G
Jag1
jagged canonical Notch ligand 1
ISO
RGD
PMID:19265135
RGD:6482234
NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
G
Jak1
Janus kinase 1
treatment
IMP
RGD
PMID:29452839
RGD:19165139
NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
G
Jak2
Janus kinase 2
treatment
ISO IDA
RGD
PMID:22339472 , PMID:23711144 , PMID:22800927
RGD:10403066 , RGD:10403081 , RGD:10403074
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
G
Jak3
Janus kinase 3
treatment
IMP IEP
RGD
PMID:25762693 , PMID:18234077 , PMID:21434883
RGD:11533938 , RGD:11533944 , RGD:11533942
NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
G
Klkb1
kallikrein B1
IMP IEP
RGD
PMID:22739815 , PMID:9783057
RGD:7297047 , RGD:7327138
NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
G
Kng2
kininogen 2
IEP
peptidoglycan-polysaccharide-induced arthritis in Lewis rats
RGD
PMID:9214434 , PMID:1996642
RGD:1600547 , RGD:11059895
NCBI chr11:81,509,185...81,516,759
G
Kyat1
kynurenine aminotransferase 1
IMP
RGD
PMID:16984225
RGD:2306289
NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
G
Lep
leptin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15142272
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lgals3
galectin 3
IEP
RGD
PMID:16507131
RGD:1625684
NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
RGD
PMID:16331767
RGD:10412332
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
G
Mif
macrophage migration inhibitory factor
IDA
RGD
PMID:10765927
RGD:1642012
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
G
Mir152
microRNA 152
ISO IEP
CTD Direct Evidence: marker/mechanism miRNA:decreased exression:synovial membrane of synovial joint
CTD
PMID:25194984 , PMID:25194984
RGD:21066343
NCBI chr10:84,719,319...84,719,403
Ensembl chr10:84,719,319...84,719,403
G
Mir26a
microRNA 26a
EXP
CTD Direct Evidence: therapeutic
CTD
PMID:24423102
NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
G
Mmp1
matrix metallopeptidase 1
IDA IEP
RGD
PMID:21288455 , PMID:24011916 , PMID:21108488
RGD:7207362 , RGD:8549748 , RGD:7207365
NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
G
Mmp13
matrix metallopeptidase 13
treatment
IEP IDA
RGD
PMID:24244039 , PMID:11435459
RGD:8694124 , RGD:1582329
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
G
Mmp3
matrix metallopeptidase 3
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism mRNA:increased expression:ankle joint
CTD
PMID:20974942 , PMID:20703013 , PMID:24244039 , PMID:24244039 , PMID:24011916 , PMID:21679445
RGD:7241231 , RGD:8694124 , RGD:8694124 , RGD:8549748 , RGD:8693318
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
G
Mmp9
matrix metallopeptidase 9
IEP
protein:increased expression:cartilage, serum, synovial fluid
RGD
PMID:17463159
RGD:1642035
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22450443
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
G
Mt-atp8
mitochondrially encoded ATP synthase membrane subunit 8
susceptibility
ISO
DNA:transversion: :m.7778G>T (mouse)
RGD
PMID:19759059
RGD:5490297
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
G
Mtor
mechanistic target of rapamycin kinase
treatment
IEP
RGD
PMID:22391142
RGD:10041007
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
G
Myd88
MYD88, innate immune signal transduction adaptor
ISO
RGD
PMID:20131263
RGD:8552884
NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
G
Myod1
myogenic differentiation 1
treatment
IEP
RGD
PMID:23781298
RGD:9686078
NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
G
Myog
myogenin
treatment
IDA
RGD
PMID:23781298
RGD:9686078
NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
G
Ncf1
neutrophil cytosolic factor 1
severity
IAGP
DNA:missense mutations:cds:p.M106V, p.M153T (rat)
RGD
PMID:12461526
RGD:628543
NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
G
Nod2
nucleotide-binding oligomerization domain containing 2
ISO
RGD
PMID:21424514 , PMID:20131263
RGD:5508728 , RGD:8552884
NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
G
Nos2
nitric oxide synthase 2
IMP ISO
protein:increased expression:ankle joint (mouse)
RGD
PMID:12826065 , PMID:21880869
RGD:1358527 , RGD:5509060
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nos3
nitric oxide synthase 3
treatment
IEP
RGD
PMID:29337196
RGD:13504725
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
G
Npsr1
neuropeptide S receptor 1
treatment
IMP
RGD
PMID:24884567
RGD:9831205
NCBI chr 8:25,246,174...25,483,582
Ensembl chr 8:25,246,292...25,482,647
G
Nqo1
NAD(P)H quinone dehydrogenase 1
severity
ISO
RGD
PMID:16905546
RGD:11073695
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nr1h2
nuclear receptor subfamily 1, group H, member 2
ISO
RGD
PMID:21859686
RGD:6480864
NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
G
Nr1h3
nuclear receptor subfamily 1, group H, member 3
ISO
RGD
PMID:21859686
RGD:6480864
NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
G
Nras
NRAS proto-oncogene, GTPase
IEP
RGD
PMID:18706093
RGD:2300006
NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
G
Nts
neurotensin
IEP
RGD
PMID:8518953
RGD:9743903
NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
G
Orm1
orosomucoid 1
IEP
protein:increased expression:liver
RGD
PMID:16166348
RGD:2316639
NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
G
P2ry12
purinergic receptor P2Y12
IMP
RGD
PMID:22028806
RGD:6480518
NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
G
Pam
peptidylglycine alpha-amidating monooxygenase
IDA
RGD
PMID:17138865
RGD:6483527
NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
G
Parp1
poly (ADP-ribose) polymerase 1
severity
ISO
RGD
PMID:16356201
RGD:5684009
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pecam1
platelet and endothelial cell adhesion molecule 1
severity
ISO
protein:increased expression:knee joint, blood vessels (mouse)
RGD
PMID:22548760 , PMID:14613294 , PMID:21982514
RGD:6484738 , RGD:6771222 , RGD:6771177
NCBI chr10:94,850,971...94,913,202
G
Pgf
placental growth factor
ISO
RGD
PMID:19180491
RGD:6483591
NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
ISO
RGD
PMID:18412166
RGD:6482696
NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
G
Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:20374644 , PMID:18412166
RGD:6482684 , RGD:6482696
NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
G
Plau
plasminogen activator, urokinase
ISO
RGD
PMID:20973954
RGD:6483801
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
G
Ptch1
patched 1
treatment
IEP
RGD
PMID:25821409
RGD:12879456
NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
G
Ptger4
prostaglandin E receptor 4
treatment disease_progression
ISO IEP IMP
CTD Direct Evidence: marker/mechanism mRNA:increased expression:tarsal joint, synovium (rat)
CTD
PMID:18287210 , PMID:20423341 , PMID:11207665 , PMID:18287210
RGD:10003041 , RGD:10043377 , RGD:10003052
NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
G
Ptges
prostaglandin E synthase
IEP
mRNA, protein:increased expression:paw
RGD
PMID:12707354
RGD:2300108
NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
G
Ptges3
prostaglandin E synthase 3
IEP
mRNA:increased expression:paw (rat)
RGD
PMID:12707354
RGD:2300108
NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
G
Ptgs1
prostaglandin-endoperoxide synthase 1
IEP
mRNA, protein:increased expression:synovium
RGD
PMID:22289897
RGD:5687744
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IMP IEP ISO
mRNA, protein:increased expression:synovium protein:increased expression:autopod joint
RGD
PMID:18758904 , PMID:22289897 , PMID:21765105
RGD:2300221 , RGD:5687744 , RGD:5508310
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Ptpn22
protein tyrosine phosphatase, non-receptor type 22
IEP
protein:increased expression:metatarsophalangeal joint, mononuclear cell (rat)
RGD
PMID:24998229
RGD:11532752
NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
G
Rag2
recombination activating 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20974942
NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
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RT1-Db1
RT1 class II, locus Db1
ISO
RGD
PMID:21665435 , PMID:19950279
RGD:5147558 , RGD:5147586
NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
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S100a8
S100 calcium binding protein A8
IEP
RGD
PMID:8343166
RGD:633930
NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
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S100a9
S100 calcium binding protein A9
IEP
RGD
PMID:8343166
RGD:633930
NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
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Serpinc1
serpin family C member 1
IEP
protein:decreased expression:plasma
RGD
PMID:22781611
RGD:11035273
NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
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Sfrp4
secreted frizzled-related protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25194984
NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
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Shh
sonic hedgehog signaling molecule
treatment
IEP
RGD
PMID:25821409
RGD:12879456
NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
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Slc11a1
solute carrier family 11 member 1
severity
ISO
RGD
PMID:17122779
RGD:5684943
NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
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Slpi
secretory leukocyte peptidase inhibitor
treatment
IEP
protein:decreased expression:articular cartilage of joint
RGD
PMID:10449524 , PMID:9744360
RGD:634208 , RGD:9999431
NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
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Smo
smoothened, frizzled class receptor
treatment
IEP
RGD
PMID:25821409
RGD:12879456
NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
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Socs3
suppressor of cytokine signaling 3
IEP
mRNA:increased expression:mononuclear cell
RGD
PMID:16507131
RGD:1625684
NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
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Spn
sialophorin
IMP
associated with Staphylococcal Infections
RGD
PMID:7927732
RGD:2303983
NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
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Stat1
signal transducer and activator of transcription 1
IDA ISO
protein:increased tyrosine phosphorylation:macrophage, synovial cell CTD Direct Evidence: marker/mechanism
CTD
PMID:15188379 , PMID:14674010
RGD:1582346
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Stat3
signal transducer and activator of transcription 3
treatment
IDA ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15188379 PMID:21937456 , PMID:23711144
RGD:10403081
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tac1
tachykinin, precursor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9259450
NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
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Tgfb1
transforming growth factor, beta 1
IEP
RGD
PMID:29763498
RGD:15036801
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tgfbr2
transforming growth factor, beta receptor 2
IEP
protein:increased expression:synovium
RGD
PMID:9010265
RGD:1601623
NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
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Thbd
thrombomodulin
ISO
RGD
PMID:16879225
RGD:5685015
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
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Timp4
TIMP metallopeptidase inhibitor 4
IMP
RGD
PMID:12483743
RGD:2290463
NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
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Tjp1
tight junction protein 1
IEP
RGD
PMID:18848892
RGD:2325138
NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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Tlr2
toll-like receptor 2
IEP ISO
RGD
PMID:21725847 , PMID:20131263
RGD:7241099 , RGD:8552884
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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Tlr3
toll-like receptor 3
IEP IMP
mRNA, protein:increased expression:spleen (rat)
RGD
PMID:20500834 , PMID:20500834
RGD:5128706 , RGD:5128706
NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
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Tnf
tumor necrosis factor
treatment
IDA IEP ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum:
CTD
PMID:7589090 PMID:9598899 PMID:19203382 PMID:19330884 PMID:19765281 PMID:20131233 PMID:20974942 PMID:21452922 PMID:22450443 , PMID:23052485 , PMID:29408684 , PMID:24028507 , PMID:24394943 , PMID:19169271 , PMID:21690068 , PMID:23140046
RGD:7245941 , RGD:13792834 , RGD:10755447 , RGD:10450611 , RGD:8662976 , RGD:8661761 , RGD:7193038
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfrsf11b
TNF receptor superfamily member 11B
IEP ISO
mRNA:decreased expression:bone CTD Direct Evidence: therapeutic
CTD
PMID:23333834 , PMID:16696922
RGD:1624171
NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
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Tnfrsf1a
TNF receptor superfamily member 1A
treatment
IDA IEP ISO
RGD
PMID:23052485 , PMID:21690068 , PMID:20370892
RGD:7245941 , RGD:8661761 , RGD:8661729
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Tnfrsf1b
TNF receptor superfamily member 1B
treatment
ISO IEP IDA
human protein in rat model
RGD
PMID:21463515 , PMID:21690068 , PMID:23052485
RGD:5131255 , RGD:8661761 , RGD:7245941
NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
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Trpv2
transient receptor potential cation channel, subfamily V, member 2
treatment
ISO
RGD
PMID:25869297
RGD:9999444
NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
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Txndc5
thioredoxin domain containing 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326410
NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9598899 PMID:26221077
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Vim
vimentin
IDA
RGD
PMID:7516431
RGD:6480480
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Vip
vasoactive intestinal peptide
ISO IDA
RGD
PMID:21998117 , PMID:19055696
RGD:5685376 , RGD:5685612
NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
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Xdh
xanthine dehydrogenase
IEP
protein:increased expression:brain, mitochondrion
RGD
PMID:25870945
RGD:13208957
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Xylt1
xylosyltransferase 1
IEP
mRNA:decreased expression:articular cartilage
RGD
PMID:19001053
RGD:2313142
NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
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