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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Wolff-Parkinson-White syndrome
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Accession:DOID:384 term browser browse the term
Definition:A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Synonyms:exact_synonym: Anomalous A-V excitation;   Anomalous Ventricular Excitation Syndrome;   Auriculoventricular Accessory Pathway Syndrome;   False Bundle-Branch Block Syndrome;   Ventricular Pre-Excitation with Arrhythmia;   WPW syndrome;   anomalous atrioventricular excitation
 narrow_synonym: FAMILIAL HYPERTROPHIC CARDIOMYOPATHY WITH WOLFF-PARKINSON-WHITE SYNDROME;   Wolff-Parkinson-White syndrome, childhood-onset;   accessory atrioventricular pathways
 related_synonym: WOLFF-PARKINSON-WHITE PATTERN;   Wolf Parkinson White syndrome
 primary_id: MESH:D014927
 alt_id: OMIM:194200
 xref: GARD:7897;   ICD9CM:426.7;   NCI:C35132
For additional species annotation, visit the Alliance of Genome Resources.


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Wolff-Parkinson-White syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 3:105,507,403...105,512,939
Ensembl chr 3:105,507,403...105,512,939
JBrowse link
G Actn2 actinin alpha 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:22584458 PMID:28492532 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Ank2 ankyrin 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISS OMIM:194200 MouseDO NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25633834 PMID:25741868 PMID:28492532 PMID:28600387 PMID:28616568 PMID:29071820 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Casq2 calsequestrin 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome ClinVar NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Dnaaf3 dynein, axonemal, assembly factor 3 ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ClinVar PMID:22876777 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:72,874,131...72,882,867
Ensembl chr 1:72,874,404...72,883,002
JBrowse link
G Dpp6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 4:4,021,021...4,943,675
Ensembl chr 4:4,021,008...4,473,307
JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379
JBrowse link
G Flna filamin A ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Flnc filamin C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791
JBrowse link
G Fnip1 folliculin interacting protein 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:39,786,687...39,870,188 JBrowse link
G Gja5 gap junction protein, alpha 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191
JBrowse link
G Jup junction plakoglobin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:27532257 PMID:28492532 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:9799083 PMID:15840476 PMID:17470695 PMID:19716085 PMID:19841300 PMID:21185501 PMID:22199116 PMID:22378279 PMID:22581653 PMID:22949429 PMID:23571586 PMID:24033266 PMID:24190995 PMID:25637381 PMID:25705178 PMID:25741868 PMID:25985138 PMID:26159999 PMID:28492532 PMID:28739325 PMID:28988457 PMID:29167462 PMID:29197658 PMID:30615648 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Lama4 laminin subunit alpha 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:23861362 PMID:28492532 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Lamc1 laminin subunit gamma 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr13:70,656,727...70,783,515
Ensembl chr13:70,658,707...70,783,515
JBrowse link
G Lmna lamin A/C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:10612827 PMID:25741868 PMID:28492532 PMID:28663758 PMID:31383942 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISS OMIM:194200 MouseDO NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mybpc3 myosin binding protein C3 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:18533079 PMID:20414521 PMID:20624503 PMID:21415409 PMID:21835320 PMID:22765922 PMID:23233322 PMID:23299917 PMID:24033266 PMID:24093860 PMID:25524337 PMID:25741868 PMID:25971843 PMID:26090888 PMID:27267291 PMID:28420666 PMID:28492532 PMID:30446606 PMID:30731207 PMID:30871747 PMID:30972196 NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730
JBrowse link
G Myh11 myosin heavy chain 11 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Myh6 myosin heavy chain 6 ISO DNA:missense mutation:exon:p.E1885K (c.5653G>A) (human)
ClinVar Annotator: match by term: Wolff-Parkinson-White pattern
ClinVar PMID:15998695 PMID:20215591 PMID:22194935 PMID:22361390 PMID:23299917 PMID:23861362 PMID:24033266 PMID:24119082 PMID:25741868 PMID:27194543 PMID:28088328 PMID:28492532, PMID:26284702 RGD:12792281 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:7581410 PMID:10521296 PMID:11186938 PMID:11447480 PMID:12749056 PMID:15358028 PMID:15757018 PMID:16267253 PMID:16858239 PMID:17125710 PMID:18029407 PMID:18409188 PMID:18506004 PMID:19150014 PMID:19880069 PMID:20031618 PMID:20624503 PMID:20965760 PMID:21127202 PMID:21551322 PMID:21799269 PMID:22765922 PMID:22857948 PMID:22958901 PMID:23074333 PMID:23233322 PMID:23283745 PMID:23299917 PMID:23794396 PMID:24033266 PMID:24093860 PMID:24111713 PMID:24793961 PMID:25031304 PMID:25342278 PMID:25351510 PMID:25637381 PMID:25741868 PMID:26743238 PMID:26969327 PMID:27066506 PMID:27247418 PMID:27387980 PMID:27532257 PMID:27737317 PMID:27788187 PMID:27831900 PMID:28138913 PMID:28356264 PMID:28420666 PMID:28492532 PMID:28615295 PMID:28790153 PMID:29121657 PMID:29300372 PMID:30871747 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nde1 nudE neurodevelopment protein 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr10:860,513...904,624
Ensembl chr10:860,521...896,938
JBrowse link
G Nebl nebulette ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr17:84,141,014...84,247,038
Ensembl chr17:84,140,489...84,488,601
JBrowse link
G Nodal nodal growth differentiation factor ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:19064609 PMID:25741868 PMID:28492532 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Pitx2 paired-like homeodomain 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
JBrowse link
G Prdm16 PR/SET domain 16 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern
ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome
ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome, childhood-onset
ClinVar
OMIM
PMID:10355918 PMID:10820940 PMID:11407343 PMID:11748095 PMID:11827995 PMID:14519435 PMID:14722619 PMID:15611370 PMID:15673802 PMID:16836667 PMID:17483151 PMID:17711718 PMID:19808419 PMID:20031621 PMID:20381067 PMID:20888928 PMID:21409595 PMID:23778007 PMID:23829931 PMID:23992123 PMID:24033266 PMID:24503780 PMID:25741868 PMID:25997934 PMID:27532257 PMID:28341588 PMID:28431061 PMID:28492532 PMID:28498465 PMID:28917552 PMID:29121657 PMID:29298659, PMID:11748095, PMID:15611370 RGD:1580719, RGD:1580718 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Rbm20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 1:274,391,932...274,589,816
Ensembl chr 1:274,391,932...274,589,816
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:15,672,370...15,685,285
Ensembl chr10:15,672,382...15,685,284
JBrowse link
G Ryr2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern
ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome
ClinVar PMID:24033266 PMID:24558114 PMID:25041964 PMID:25351510 PMID:25467552 PMID:25637381 PMID:25741868 PMID:25925909 PMID:26383259 PMID:28404607 PMID:28492532 PMID:30615648 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:18752142 PMID:18752973 PMID:22581653 PMID:25326637 PMID:25741868 PMID:28492532 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Slc26a4 solute carrier family 26 member 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:11317356 PMID:12642503 PMID:14679580 PMID:15099345 PMID:15355436 PMID:16570074 PMID:16950989 PMID:17503324 PMID:18285825 PMID:19017801 PMID:20597900 PMID:22285650 PMID:23336812 PMID:24033266 PMID:24224479 PMID:25372295 PMID:25394566 PMID:28492532 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Snta1 syntrophin, alpha 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:23631430 PMID:28492532 NCBI chr 3:149,874,023...149,905,980
Ensembl chr 3:149,874,030...149,905,944
JBrowse link
G Tbx20 T-box transcription factor 20 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 8:25,849,394...25,904,570
Ensembl chr 8:25,850,962...25,904,570
JBrowse link
G Tbx5 T-box transcription factor 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr12:42,059,688...42,148,226
Ensembl chr12:42,097,626...42,148,146
JBrowse link
G Tcap titin-cap ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 NCBI chr10:86,337,705...86,338,414
Ensembl chr10:86,337,728...86,338,411
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnni3 troponin I3, cardiac type ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ClinVar PMID:9241277 PMID:11815426 PMID:12860912 PMID:15524171 PMID:15607392 PMID:18175163 PMID:18414213 PMID:20474083 PMID:21310275 PMID:21511876 PMID:22876777 PMID:23967088 PMID:24033266 PMID:24503780 PMID:24510615 PMID:25324519 PMID:25741868 PMID:25940119 PMID:26440512 PMID:28492532 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ClinVar PMID:18414213 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:72,889,270...72,899,629
Ensembl chr 1:72,889,270...72,899,659
JBrowse link
G Tnnt2 troponin T2, cardiac type ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 5:129,024,505...129,083,226
Ensembl chr 5:129,043,675...129,082,442
Ensembl chr 5:129,043,675...129,082,442
JBrowse link
G Ttn titin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25589632 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Vcl vinculin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 5:33,608,489...33,696,487
Ensembl chr 5:33,609,136...33,664,435
JBrowse link

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  disease 16091
    physical disorder 2462
      congenital heart disease 1057
        Wolff-Parkinson-White syndrome 53
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  disease 16091
    Developmental Diseases 9586
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8437
        Congenital Abnormalities 4721
          Cardiovascular Abnormalities 1109
            congenital heart disease 1057
              Wolff-Parkinson-White syndrome 53
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