RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Brain Injuries
Accession: DOID:9000998
browse the term
Definition: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Synonyms: exact_synonym: Acute Brain Injuries; Acute Brain Injury; Brain Injury; Brain Laceration; Brain Lacerations; Focal Brain Injuries; Focal Brain Injury
primary_id: MESH:D001930 ; RDO:0005055
For additional species annotation, visit the
Alliance of Genome Resources .
G
Abcc8
ATP binding cassette subfamily C member 8
treatment
IMP
RGD
PMID:21107131
RGD:12791995
NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
G
Acan
aggrecan
IEP
mRNA:increased expression:fascia dentata (rat)
RGD
PMID:18511192
RGD:2315807
NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
G
Actr2
actin related protein 2
IEP
mRNA, protein:decreased expression:hippocampus (rat)
RGD
PMID:22120305
RGD:11530046
NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
G
Adcyap1
adenylate cyclase activating polypeptide 1
IDA
RGD
PMID:16689670
RGD:2325298
NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
G
Adra1a
adrenoceptor alpha 1A
IEP
mRNA:increased expression:frontal cortex
RGD
PMID:20974230
RGD:5688366
NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
G
Ager
advanced glycosylation end product-specific receptor
ISO IEP
protein:increased expression:brain (rat)
RGD
PMID:22915134 , PMID:24859607 , PMID:22491548
RGD:7245513 , RGD:8696001 , RGD:7245557
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
G
Aif1
allograft inflammatory factor 1
IEP
protein:increased expression:cerebral cortex (rat)
RGD
PMID:19520144
RGD:2313020
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
IEP
protein:increased expression:nucleus:
RGD
PMID:12091479
RGD:10053567
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
G
Akt1
AKT serine/threonine kinase 1
IEP
protein:increased phosphorylation:brain, neuron
RGD
PMID:16234845
RGD:5509090
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
G
Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:7909931 PMID:17188501
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
G
Ambp
alpha-1-microglobulin/bikunin precursor
ISO
protein:increased expression:urine
RGD
PMID:14592616
RGD:6904155
NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
G
Ank3
ankyrin 3
IEP
RGD
PMID:20557305
RGD:6767288
NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
G
Anp32a
acidic nuclear phosphoprotein 32 family member A
IEP
RGD
PMID:24385964
RGD:10401136
NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
G
Apaf1
apoptotic peptidase activating factor 1
IEP
protein:increased expression:cerebral cortex
RGD
PMID:11567033
RGD:2325751
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
G
Apbb1
amyloid beta precursor protein binding family B member 1
IEP
mRNA:increased expression:brain
RGD
PMID:12707777
RGD:2301208
NCBI chr 1:170,387,625...170,411,263
Ensembl chr 1:170,387,609...170,404,056
G
Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11447995
NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
G
Apod
apolipoprotein D
IEP
mRNA, protein:increased expression:cerebral cortex, glia cell, neuron
RGD
PMID:10501208
RGD:2311202
NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
G
Apoe
apolipoprotein E
ISO
GAD
PMID:15118671
RGD:1331525
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
G
App
amyloid beta precursor protein
ISO
protein:increased expression:hippocampus
RGD
PMID:16300758
RGD:10054281
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
G
Aqp4
aquaporin 4
IEP ISO
protein:increased expression:cerebral cortex
RGD
PMID:21083433 , PMID:21488209
RGD:5148014 , RGD:5148034
NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
G
Asic1
acid sensing ion channel subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21307247
NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
G
Astn1
astrotactin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14499481
NCBI chr13:76,054,965...76,370,674
Ensembl chr13:76,055,410...76,370,674
G
Atg12
autophagy related 12
IEP
protein:altered localization:brain
RGD
PMID:18059433
RGD:2301217
NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
G
Atp5pd
ATP synthase peripheral stalk subunit d
treatment
IDA
RGD
PMID:26813465
RGD:13800884
NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
G
Avpr1a
arginine vasopressin receptor 1A
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:17244947
RGD:2300372
NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
G
Bad
BCL2-associated agonist of cell death
IEP
mRNA, protein:increased expression:cerebral cortex
RGD
PMID:15941375
RGD:2292694
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
G
Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:20888848
RGD:10054247
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcat1
branched chain amino acid transaminase 1
IEP
Protein:increased expression:neurons
RGD
PMID:10686349
RGD:631308
NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
G
Bcl2
BCL2, apoptosis regulator
treatment
IMP IEP
RGD
PMID:18093155 , PMID:20888848
RGD:2293059 , RGD:10054247
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Bdnf
brain-derived neurotrophic factor
IEP ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:15500971 PMID:21269288 , PMID:20544832
RGD:4891136
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
G
Becn1
beclin 1
IEP ISO
protein:increased expression:neuron, astrocyte protein:increased expression:hippocampus protein:increased expression:brain
RGD
PMID:18500386 , PMID:24221859 , PMID:16874043
RGD:6483098 , RGD:11558018 , RGD:6483314
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
G
Birc5
baculoviral IAP repeat-containing 5
IEP
mRNA, protein:increased expression:brain, astrocyte, neuron
RGD
PMID:15453988
RGD:2293136
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
G
Bmp6
bone morphogenetic protein 6
IEP
protein:increased expression:brain, astrocyte, neuron
RGD
PMID:16388909
RGD:2289020
NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
G
Bmpr2
bone morphogenetic protein receptor type 2
IEP
mRNA:increased expression:dentate gyrus, neuron
RGD
PMID:9080432
RGD:5129488
NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
G
Bysl
bystin-like
IEP
mRNA, protein:increased expression:substantia nigra, striatum (rat)
RGD
PMID:15305856
RGD:2316201
NCBI chr 9:15,393,461...15,403,212
Ensembl chr 9:15,393,330...15,403,117
G
C1qa
complement C1q A chain
IEP
RGD
PMID:23808389
RGD:10054313
NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
G
C3
complement C3
IEP
RGD
PMID:23808389
RGD:10054313
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
G
Cask
calcium/calmodulin dependent serine protein kinase
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr X:9,815,652...10,156,155
Ensembl chr X:9,815,652...10,156,155
G
Casp1
caspase 1
IEP
mRNA, protein:increased expression:brain
RGD
PMID:17188500
RGD:2315917
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
G
Casp12
caspase 12
severity
IEP
mRNA, protein:increased expression, increased activity:cerebral cortex, hippocampus, neuron, astrocyte
RGD
PMID:14675152
RGD:2311485
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
G
Casp3
caspase 3
treatment
IEP
RGD
PMID:20888848
RGD:10054247
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp8
caspase 8
IEP
protein:altered localization
RGD
PMID:15590916
RGD:1624191
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Cast
calpastatin
severity
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:15307896
RGD:5509821
NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
G
Ccl2
C-C motif chemokine ligand 2
treatment
IEP ISO IMP
protein:increased expression:brain, neuron CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:19210118 , PMID:11113322
RGD:2306999 , RGD:9587789
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
G
Ccl20
C-C motif chemokine ligand 20
treatment
IEP
RGD
PMID:22040257
RGD:7483630
NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
G
Ccr5
C-C motif chemokine receptor 5
IEP
mRNA:increased expression:hippocampus
RGD
PMID:24344922
RGD:8552265
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
G
Cd14
CD14 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
G
Cd40
CD40 molecule
treatment
IDA
RGD
PMID:23924471
RGD:7248749
NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
G
Cd40lg
CD40 ligand
treatment
IEP IDA
RGD
PMID:11755016 , PMID:25972624
RGD:8547803 , RGD:11344972
NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
IEP
protein:increased expression:nucleus:
RGD
PMID:9914434
RGD:8662346
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
IEP
protein:decreased expression:cerebral cortex
RGD
PMID:21728064
RGD:10045359
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
G
Cebpa
CCAAT/enhancer binding protein alpha
ISO
mRNA, protein:increased expression:cerebral cortex (mouse)
RGD
PMID:19833158
RGD:10401206
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
G
Cebpb
CCAAT/enhancer binding protein beta
ISO
mRNA, protein:increased expression:cerebral cortex (mouse) CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:19833158
RGD:10401206
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
G
Ces1d
carboxylesterase 1D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
G
Cfb
complement factor B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17474994
NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066 Ensembl chr20:4,536,203...4,561,066
G
Chrm2
cholinergic receptor, muscarinic 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
G
Ckmt1
creatine kinase, mitochondrial 1
treatment
IEP
RGD
PMID:24252176
RGD:11565089
NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
G
Clec4e
C-type lectin domain family 4, member E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 4:156,271,087...156,276,243
Ensembl chr 4:156,270,920...156,276,304
G
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
IEP
protein:increased expression:hippocampus
RGD
PMID:20215974
RGD:6483336
NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
G
Comt
catechol-O-methyltransferase
IEP
protein:increased expression:hippocampus
RGD
PMID:17240060
RGD:2289740
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
G
Crp
C-reactive protein
disease_progression
ISO
RGD
PMID:24456846
RGD:9585646
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
G
Csf2
colony stimulating factor 2
disease_progression
IDA
RGD
PMID:21515263
RGD:5686795
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
G
Csf3
colony stimulating factor 3
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:24239694
RGD:11039431
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
G
Cspg4
chondroitin sulfate proteoglycan 4
IEP
protein:altered expression:cerebral cortex
RGD
PMID:19473238
RGD:5686860
NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
G
Cul5
cullin 5
IEP
mRNA, protein:decreased expression:cerebral cortex, hippocampus
RGD
PMID:17010517
RGD:2301432
NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
G
Cxcl1
C-X-C motif chemokine ligand 1
IEP
mRNA:increased expression:choroid plexus, cerebral cortex
RGD
PMID:19471279
RGD:5135009
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
G
Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
G
Cxcl2
C-X-C motif chemokine ligand 2
IEP
protein:increased expression:brain, neuron
RGD
PMID:19210118
RGD:2306999
NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
IEP
mRNA:increased expression:hindbrain
RGD
PMID:16329132
RGD:1599699
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
G
Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
IEP
RGD
PMID:18847377
RGD:2301705
NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
G
Dab2
DAB adaptor protein 2
IEP
RGD
PMID:15774263
RGD:7243841
NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
G
Dnmt1
DNA methyltransferase 1
IEP
RGD
PMID:19429151
RGD:9588608
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
G
Dpysl2
dihydropyrimidinase-like 2
IEP
protein:increased degradation:cerebral cortex, hippocampus
RGD
PMID:17402852
RGD:2303056
NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
G
Drd2
dopamine receptor D2
IDA
RGD
PMID:18509630
RGD:2311580
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
G
Dusp5
dual specificity phosphatase 5
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:12503083
RGD:2317873
NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
IDA
RGD
PMID:11526986
RGD:10395358
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
G
Eif3e
eukaryotic translation initiation factor 3 subunit E
treatment
IMP
RGD
PMID:22960363
RGD:10395371
NCBI chr 7:82,997,694...83,037,231
G
Elk1
ETS transcription factor ELK1
IDA
RGD
PMID:15362724
RGD:7488910
NCBI chr X:1,287,875...1,304,822
Ensembl chr X:1,297,099...1,304,822
G
Epas1
endothelial PAS domain protein 1
treatment
IDA
RGD
PMID:22960363
RGD:10395371
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
G
Epha4
Eph receptor A4
ISO
protein:increased expression, increased activity:astrocyte
RGD
PMID:22318127
RGD:5688763
NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
G
Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:21075124
RGD:5688356
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
G
Epo
erythropoietin
treatment
ISO IEP
CTD Direct Evidence: therapeutic mRNA:increased expression:brain:
CTD
PMID:20833152 , PMID:23063952 , PMID:18093155
RGD:10401061 , RGD:2293059
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
G
Epor
erythropoietin receptor
IEP
mRNA:increased expression:brain:
RGD
PMID:18093155
RGD:2293059
NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
G
F2
coagulation factor II
severity
ISO
RGD
PMID:21355766
RGD:5147766
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
G
Fas
Fas cell surface death receptor
IEP ISO
mRNA:increased expression:hippocampus associated with Hyperoxia
RGD
PMID:16078565 , PMID:19107989
RGD:1600354 , RGD:8662854
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
G
Fgf2
fibroblast growth factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21269288
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Fmr1
FMRP translational regulator 1
IEP
protein:altered localization:hippocampus (rat)
RGD
PMID:16510718
RGD:11667962
NCBI chr X:154,684,924...154,722,369
Ensembl chr X:154,684,935...154,722,314
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9630518
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
G
Foxp1
forkhead box P1
treatment
IDA
RGD
PMID:26842647
RGD:11561903
NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
G
G6pd
glucose-6-phosphate dehydrogenase
IEP
protein:decreased expression:hippocampus
RGD
PMID:18501200
RGD:2307353
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
G
Gabrg3
gamma-aminobutyric acid type A receptor subunit gamma 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:112,158,525...112,812,267
Ensembl chr 1:112,158,519...112,811,936
G
Gdnf
glial cell derived neurotrophic factor
IEP
mRNA:increased expression:brain
RGD
PMID:18501516
RGD:2324932
NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
G
Gja1
gap junction protein, alpha 1
treatment
IEP
RGD
PMID:23485053
RGD:8662424
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Gja5
gap junction protein, alpha 5
IEP
protein:increased expression:cerebral artery
RGD
PMID:21895483
RGD:7207391
NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
G
Gpx1
glutathione peroxidase 1
IEP
mRNA:decreased expression:hippocampus, neuron
RGD
PMID:15791111
RGD:2306624
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Grm8
glutamate metabotropic receptor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
G
Gsk3b
glycogen synthase kinase 3 beta
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24675465 , PMID:22643085
RGD:10045646
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
G
Gsn
gelsolin
IEP
RGD
PMID:14588109
RGD:1599864
NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
G
Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
IEP
mRNA,protein:decreased expression:hippocampus:
RGD
PMID:11726545
RGD:9686434
NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
G
Hmgb1
high mobility group box 1
treatment
IMP
RGD
PMID:22915134
RGD:7245513
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
IMP
RGD
PMID:18562561
RGD:5508455
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Hmox1
heme oxygenase 1
IEP
RGD
PMID:23470432
RGD:10755702
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hp
haptoglobin
IEP
mRNA:increased expression:liver
RGD
PMID:23172820
RGD:11041806
NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:21549006
RGD:5147593
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
G
Hspa4
heat shock protein family A (Hsp70) member 4
IEP
protein:increased expression:cerebral white matter (rat)
RGD
PMID:22067617
RGD:5688785
NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
G
Hspb1
heat shock protein family B (small) member 1
IEP
RGD
PMID:11746764
RGD:6480530
NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
G
Htr7
5-hydroxytryptamine receptor 7
IMP
RGD
PMID:22465320
RGD:6482178
NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
G
Icam1
intercellular adhesion molecule 1
IEP
protein:increased expression:brain:
RGD
PMID:16230799
RGD:11522716
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Ifnl3
interferon, lambda 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:85,236,243...85,237,775
Ensembl chr 1:85,236,243...85,237,775
G
Igf1
insulin-like growth factor 1
treatment
ISO
human protein in a rat model
RGD
PMID:9344566
RGD:12904928
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Igf2
insulin-like growth factor 2
IEP
mRNA:decreased expression:brain
RGD
PMID:11123717
RGD:5509972
NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
G
Il10
interleukin 10
severity treatment
ISO IDA
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:23075771 , PMID:23971414
RGD:7364822 , RGD:7364983
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il12rb2
interleukin 12 receptor subunit beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:98,049,195...98,141,562
Ensembl chr 4:98,052,842...98,141,482
G
Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr X:118,443,955...118,514,716
Ensembl chr X:118,443,823...118,513,061
G
Il16
interleukin 16
IEP
RGD
PMID:17983426
RGD:5024939
NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
G
Il17rd
interleukin 17 receptor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr16:2,670,471...2,737,271
Ensembl chr16:2,670,618...2,731,808
G
Il18
interleukin 18
severity
IMP ISO
mRNA, protein:increased expression:brain
RGD
PMID:17188500 , PMID:17188500
RGD:2315917 , RGD:2315917
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il18r1
interleukin 18 receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
G
Il1a
interleukin 1 alpha
IEP ISO
mRNA, protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:16024175
RGD:2311098
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il1b
interleukin 1 beta
IEP ISO
mRNA, protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism protein:increased expression:brain, cerebrospinal fluid mRNA, protein:increased expression:brain
CTD
PMID:19800810 PMID:21549006 , PMID:16024175 , PMID:22503903 , PMID:17612572
RGD:2311098 , RGD:6482651 , RGD:1626652
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1r1
interleukin 1 receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
G
Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25665855
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
G
Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
G
Il3
interleukin 3
disease_progression
IDA ISO
protein: increased expression: brain: microdialysis perfusate
RGD
PMID:21515263 , PMID:20717122
RGD:5686795 , RGD:5686886
NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
G
Il31ra
interleukin 31 receptor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:44,333,347...44,408,005
Ensembl chr 2:44,336,006...44,394,709
G
Il4
interleukin 4
IEP
protein:decreased expression:plasma
RGD
PMID:24519543
RGD:10402802
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Il5
interleukin 5
treatment
IEP
RGD
PMID:24602693 , PMID:24530657
RGD:11522766 , RGD:11522770
NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
G
Il6
interleukin 6
IEP ISO
protein:increased expression:cerebrospinal fluid (rat) CTD Direct Evidence: marker/mechanism
CTD
PMID:19800810 PMID:21549006 PMID:23159883 , PMID:10027774
RGD:11049549
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Il7
interleukin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
G
Il9r
interleukin 9 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:15,697,216...15,708,684
Ensembl chr10:15,696,824...15,710,423
G
Irf1
interferon regulatory factor 1
IEP ISO
mRNA:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:12503083
RGD:2317873
NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
G
Jak2
Janus kinase 2
IMP
RGD
PMID:21596098
RGD:6483023
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
IEP
RGD
PMID:20861444
RGD:8662901
NCBI chr13:90,722,945...90,753,338
Ensembl chr13:90,723,092...90,752,581
G
Kdr
kinase insert domain receptor
IEP IMP
protein:increased expression:cerebral cortex
RGD
PMID:21307798 , PMID:19733172
RGD:5684382 , RGD:5684402
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
G
Lep
leptin
IEP
RGD
PMID:21276361
RGD:5128517
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lsg1
large 60S subunit nuclear export GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14499481
NCBI chr11:73,693,862...73,723,457
Ensembl chr11:73,693,814...73,723,501
G
Ly86
lymphocyte antigen 86
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr17:28,104,535...28,191,447
Ensembl chr17:28,104,589...28,191,436
G
Mag
myelin-associated glycoprotein
susceptibility
IMP
RGD
PMID:17156367
RGD:9685230
NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733
G
Map1b
microtubule-associated protein 1B
IEP
protein:increased expression, increased phosphorylation:brain
RGD
PMID:10906717
RGD:2304029
NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
G
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
IEP
RGD
PMID:24221859
RGD:11558018
NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
G
Map2
microtubule-associated protein 2
IEP IDA
protein:decreased expression:cerebral cortex, neuron
RGD
PMID:21401443 , PMID:20568963
RGD:6483087 , RGD:6483089
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
G
Mbl2
mannose binding lectin 2
disease_progression
ISO
RGD
PMID:18183030
RGD:12910935
NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
G
Mbp
myelin basic protein
IDA
RGD
PMID:18583256
RGD:7349333
NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
G
Mdm2
MDM2 proto-oncogene
IEP
protein:increased expression:brain cortex (rat)
RGD
PMID:15165363
RGD:2317397
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
G
Mif
macrophage migration inhibitory factor
IEP
RGD
PMID:15922484
RGD:1641989
NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
G
Mir132
microRNA 132
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
G
Mir144
microRNA 144
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447
G
Mir153
microRNA 153
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr 6:145,105,064...145,105,150
Ensembl chr 6:145,105,064...145,105,150
G
Mir183
microRNA 183
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
G
Mmp9
matrix metallopeptidase 9
treatment
IDA IMP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19631748 , PMID:16671440 , PMID:24661104
RGD:1582656 , RGD:13207312
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
G
Mt-co2
mitochondrially encoded cytochrome c oxidase II
IEP
mRNA, protein:increased expression:hippocampus
RGD
PMID:11686499
RGD:2302298
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
G
Mt2A
metallothionein 2A
ISO IEP
mRNA:increased expression:liver (mouse) mRNA:increased expression:dentate gyrus (rat)
RGD
PMID:22363575 , PMID:15650329
RGD:6483812 , RGD:6483847
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
G
Mt3
metallothionein 3
treatment
IDA IEP
RGD
PMID:16314047 , PMID:10595827 , PMID:10218634
RGD:6480628 , RGD:9685805 , RGD:9685803
NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
G
Myoc
myocilin
IEP
mRNA:increased expression:cerebral cortex (rat)
RGD
PMID:12799138
RGD:7401267
NCBI chr13:80,517,531...80,527,928
Ensembl chr13:80,517,536...80,527,928
G
Nfe2l2
nuclear factor, erythroid 2-like 2
IEP
protein:increased expression:lung:
RGD
PMID:18787991 , PMID:25089700
RGD:5134971 , RGD:11576302
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Ngb
neuroglobin
severity
IEP
RGD
PMID:21915648
RGD:9743963
NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
G
Ngfr
nerve growth factor receptor
treatment
IDA
RGD
PMID:23940017
RGD:10414074
NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
G
Nos2
nitric oxide synthase 2
IEP
RGD
PMID:11526986
RGD:10395358
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nppb
natriuretic peptide B
ISO
associated with lung diseases;protein:increased expression:serum: CTD Direct Evidence: therapeutic
CTD
PMID:19803787 , PMID:23837838
RGD:7247620
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
G
Npy
neuropeptide Y
IEP
protein:increased expression:adrenal medulla
RGD
PMID:23570732
RGD:10448961
NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
G
Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
mRNA:increased expression:lung associated with Subarachnoid Hemorrhage
RGD
PMID:18787991 , PMID:20864352
RGD:5134971 , RGD:11035222
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Nt5e
5' nucleotidase, ecto
IEP
protein:altered expression:cerebral cortex (rat)
RGD
PMID:21337375
RGD:5134348
NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
G
P2ry1
purinergic receptor P2Y1
IEP
protein:increased expression:brain, astrocyte
RGD
PMID:19115395
RGD:2315811
NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
G
Palld
palladin, cytoskeletal associated protein
IEP
protein:increased expression:brain, astrocyte
RGD
PMID:12932445
RGD:2325786
NCBI chr16:31,865,712...31,948,168
G
Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17640816
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pawr
pro-apoptotic WT1 regulator
IEP
mRNA,protein:increased expression:brain:
RGD
PMID:11421591
RGD:9835358
NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
G
Pde4d
phosphodiesterase 4D
IEP
mRNA, protein:alternative form, decreased phosphorylation:brain
RGD
PMID:23057870
RGD:7327147
NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
G
Pdgfa
platelet derived growth factor subunit A
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
G
Pdgfb
platelet derived growth factor subunit B
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
G
Pdgfra
platelet derived growth factor receptor alpha
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
G
Pdgfrb
platelet derived growth factor receptor beta
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
G
Pecam1
platelet and endothelial cell adhesion molecule 1
IDA
RGD
PMID:22658532
RGD:6484732
NCBI chr10:94,850,971...94,913,202
G
Pglyrp1
peptidoglycan recognition protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111
G
Pgr
progesterone receptor
IEP
RGD
PMID:23211561
RGD:7248711
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
G
Phb
prohibitin
IEP
protein:increased oxidation:cerebral cortex
RGD
PMID:17518533
RGD:2292409
NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
G
Phb2
prohibitin 2
IEP
RGD
PMID:24566151
RGD:12903261
NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367
G
Pias1
protein inhibitor of activated STAT, 1
IEP
protein:decreased expression:brain, nucleus
RGD
PMID:21545521
RGD:8693413
NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
G
Ppara
peroxisome proliferator activated receptor alpha
IDA
agonist more effective in combination with simvastatin
RGD
PMID:18562561
RGD:5508455
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
G
Ppargc1a
PPARG coactivator 1 alpha
treatment
ISO IEP
protein:decreased expression:frontal cortex (rat)
RGD
PMID:22642418 , PMID:24345766
RGD:6484257 , RGD:10059630
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
IEP ISO
protein: :hippocampus CTD Direct Evidence: marker/mechanism
CTD
PMID:14499481 , PMID:19751097
RGD:6483311
NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
G
Prf1
perforin 1
ISO
RGD
PMID:20537642
RGD:6482807
NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
G
Ptger3
prostaglandin E receptor 3
IEP
protein:increased expression:striatum, microglia (rat)
RGD
PMID:15234107
RGD:9850280
NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO IEP
protein:increased expression:microglia, macrophage protein:increased expression:microglial cells, macrophage, endothelial cell
RGD
PMID:19719848 , PMID:11565600 , PMID:12005397
RGD:5688162 , RGD:5688242 , RGD:5688239
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
G
Ptgs2
prostaglandin-endoperoxide synthase 2
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12410334 PMID:20810888 PMID:21549006 , PMID:21866634 , PMID:19719848
RGD:5508191 , RGD:5688162
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Ptprz1
protein tyrosine phosphatase, receptor type Z1
IEP
RGD
PMID:12088737
RGD:727637
NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
G
Rchy1
ring finger and CHY zinc finger domain containing 1
IEP
protein:increased expression:cerebral cortex
RGD
PMID:21728064
RGD:10045359
NCBI chr14:17,615,968...17,631,715
Ensembl chr14:17,615,968...17,631,714
G
Reg3b
regenerating family member 3 beta
IEP
mRNA:increased expression:cerebral cortex (rat)
RGD
PMID:19351265
RGD:9831399
NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
G
Rela
RELA proto-oncogene, NF-kB subunit
IEP
protein:increased expression:ileum
RGD
PMID:18288455
RGD:2298787
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Ret
ret proto-oncogene
IEP
mRNA:increased expression:brain
RGD
PMID:18501516
RGD:2324932
NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
G
Rhoa
ras homolog family member A
IEP
protein:increased expression:microglial cell, brain
RGD
PMID:17929039
RGD:2298888
NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
G
Robo1
roundabout guidance receptor 1
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
G
Robo2
roundabout guidance receptor 2
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr11:11,062,866...12,618,793
Ensembl chr11:11,062,790...11,585,765
G
Robo3
roundabout guidance receptor 3
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr 8:39,892,792...39,923,735
Ensembl chr 8:39,892,792...39,907,478
G
Rps27a
ribosomal protein S27a
IEP
mRNA:decreased expression:cerebral cortex, hippocampus
RGD
PMID:17936732
RGD:11041870
NCBI chr14:113,966,163...113,968,440
Ensembl chr14:113,966,611...113,968,268 Ensembl chr 5:113,966,611...113,968,268
G
S100b
S100 calcium binding protein B
severity
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:11520488 PMID:21783483 , PMID:21976236
RGD:5508761
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
G
Sele
selectin E
IEP
protein:increased expression:brain
RGD
PMID:19107536
RGD:2313599
NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
G
Serpinc1
serpin family C member 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21534203
NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
G
Serpinf1
serpin family F member 1
treatment
ISO IEP
human gene in a rat model protein:altered expression:cerebellum (rat)
RGD
PMID:20142768 , PMID:17709187
RGD:8612994 , RGD:8622925
NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
G
Sirt1
sirtuin 1
treatment
IEP
RGD
PMID:17970622
RGD:9497541
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
G
Skp2
S-phase kinase associated protein 2
IEP
protein:increased expression:brain
RGD
PMID:19852587
RGD:2315049
NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
G
Slc18a3
solute carrier family 18 member A3
IEP
protein:decreased expression:brain
RGD
PMID:18848922
RGD:5686682
NCBI chr16:8,682,668...8,685,529
Ensembl chr16:8,682,669...8,685,529
G
Slit1
slit guidance ligand 1
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
G
Slit3
slit guidance ligand 3
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
G
Snca
synuclein alpha
ISO IEP
RGD
PMID:14637093 , PMID:25089700
RGD:6480195 , RGD:11576302
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
G
Sncb
synuclein, beta
ISO
RGD
PMID:14637093
RGD:6480195
NCBI chr17:10,384,472...10,392,776
Ensembl chr17:10,384,511...10,392,843
G
Sncg
synuclein, gamma
ISO
RGD
PMID:14637093
RGD:6480195
NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
G
Snw1
SNW domain containing 1
IEP
mRNA, protein:increased expression:cerebral cortex (rat)
RGD
PMID:22965216
RGD:11035237
NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
G
Sod1
superoxide dismutase 1
ISO
RGD
PMID:16248885
RGD:1581214
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
G
Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24462953 , PMID:16248885
RGD:1581214
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Sparc
secreted protein acidic and cysteine rich
IEP
mRNA:increased expression:brain, blood vessel
RGD
PMID:9704602
RGD:2300066
NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
G
Sstr2
somatostatin receptor 2
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
G
Sstr3
somatostatin receptor 3
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
G
Sstr4
somatostatin receptor 4
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
G
Stat1
signal transducer and activator of transcription 1
IMP
RGD
PMID:21596098
RGD:6483023
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
G
Stat3
signal transducer and activator of transcription 3
IMP IDA
protein:increased phosphorylation:brain
RGD
PMID:21596098 , PMID:22145815 , PMID:22827467
RGD:6483023 , RGD:8694312 , RGD:6892706
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
G
Strn
striatin
IEP
RGD
PMID:16351572
RGD:2311293
NCBI chr 6:1,232,729...1,319,603
Ensembl chr 6:1,237,758...1,319,541
G
Tardbp
TAR DNA binding protein
ISO
RGD
PMID:22101322
RGD:5687195
NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
G
Tf
transferrin
IEP
RGD
PMID:22538758
RGD:7244386
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
G
Th
tyrosine hydroxylase
IEP
protein:decreased activity:striatum (rat)
RGD
PMID:21047500
RGD:5128822
NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
G
Thbd
thrombomodulin
onset
ISO
RGD
PMID:17895610
RGD:5685007
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
G
Ticam2
toll-like receptor adaptor molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
G
Timp1
TIMP metallopeptidase inhibitor 1
IEP
mRNA:increased expression:brain, astrocytes
RGD
PMID:10719361
RGD:2290468
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
G
Timp2
TIMP metallopeptidase inhibitor 2
IEP
mRNA:increased expression:brain, neuron, microglial cell
RGD
PMID:10719361
RGD:2290468
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
G
Tjp1
tight junction protein 1
IEP
RGD
PMID:19889224
RGD:2325128
NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
G
Tlr1
toll-like receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr14:45,062,662...45,065,014
Ensembl chr14:45,062,662...45,081,991
G
Tlr2
toll-like receptor 2
IEP ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:18316784
RGD:2312713
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
G
Tlr4
toll-like receptor 4
IEP ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:18316784
RGD:2312713
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tlr9
toll-like receptor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
G
Tnf
tumor necrosis factor
ISO IMP
CTD Direct Evidence: marker/mechanism
CTD
PMID:19800810 PMID:21549006 , PMID:10674461
RGD:13825262
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Tnfrsf13b
TNF receptor superfamily member 13B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:47,399,834...47,422,907
Ensembl chr10:47,412,582...47,420,951
G
Tnfrsf13c
TNF receptor superfamily member 13C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 7:123,453,799...123,456,289
Ensembl chr 7:123,453,788...123,456,268
G
Tnfrsf14
TNF receptor superfamily member 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
G
Tnfrsf1a
TNF receptor superfamily member 1A
IEP ISO
protein:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006 , PMID:17074049
RGD:1624183
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
G
Tnfsf10
TNF superfamily member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
G
Tnfsf12
TNF superfamily member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077
G
Traf4
Tnf receptor associated factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:65,418,688...65,424,802
Ensembl chr10:65,418,700...65,424,802
G
Trpm2
transient receptor potential cation channel, subfamily M, member 2
IEP
mRNA, protein:increased expression:cerebral cortex, hippocampus
RGD
PMID:20309649
RGD:9999437
NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
G
Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
IEP
mRNA:decreased expression:cerebral cortex, hippocampus (rat)
RGD
PMID:17936732
RGD:11041870
NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
G
Ucp2
uncoupling protein 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12858170 , PMID:12858170
RGD:7204436
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
G
Vegfa
vascular endothelial growth factor A
IEP ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18065154 , PMID:12230324
RGD:1580574
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
G
Vegfb
vascular endothelial growth factor B
IEP
mRNA, protein:increased expression:brain
RGD
PMID:12230324
RGD:1580574
NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
G
Vim
vimentin
ISO IEP
protein:increased expression:brain
RGD
PMID:19728994 , PMID:15527750
RGD:6480519 , RGD:6480527
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
G
Xdh
xanthine dehydrogenase
treatment
IEP
RGD
PMID:26528358
RGD:13208950
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
G
Cfl1
cofilin 1
treatment
ISO
RGD
PMID:25708984
RGD:12738361
NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
G
Drd2
dopamine receptor D2
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
G
Drd3
dopamine receptor D3
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
G
Drd4
dopamine receptor D4
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
G
Il6
interleukin 6
treatment
IDA
RGD
PMID:27113205
RGD:11062140
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Casp3
caspase 3
treatment
IEP
RGD
PMID:28140659
RGD:13782305
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp8
caspase 8
treatment
IEP
RGD
PMID:28140659
RGD:13782305
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
S100b
S100 calcium binding protein B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30076900
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
G
Adam10
ADAM metallopeptidase domain 10
IEP
RGD
PMID:22489706
RGD:13703033
NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
G
App
amyloid beta precursor protein
treatment
ISO
RGD
PMID:29320530
RGD:13782048
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
G
Bad
BCL2-associated agonist of cell death
treatment
IEP
RGD
PMID:24582457
RGD:13782254
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
G
Capn1
calpain 1
IEP
protein:increased expression:cytosol, plasma membrane
RGD
PMID:9469158
RGD:13792664
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
G
Capn2
calpain 2
IEP
RGD
PMID:9469158
RGD:13792664
NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
G
Cxcl10
C-X-C motif chemokine ligand 10
treatment
ISO
RGD
PMID:26435412
RGD:27095897
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
G
Drd1
dopamine receptor D1
treatment
IEP
RGD
PMID:24047867
RGD:13506948
NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
G
Drd2
dopamine receptor D2
treatment
IEP
RGD
PMID:24047867
RGD:13506948
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
G
Fubp1
far upstream element binding protein 1
IEP
RGD
PMID:23797733
RGD:13673879
NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
G
Gnal
G protein subunit alpha L
IEP
RGD
PMID:29215295
RGD:13513923
NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
G
Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Itgb1
integrin subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
G
Lama1
laminin subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
G
Lamp2
lysosomal-associated membrane protein 2
IEP
protein:increased expression:hippocampus:
RGD
PMID:28365875
RGD:13703062
NCBI chr X:124,722,628...124,766,079
Ensembl chr X:124,722,628...124,766,044
G
Mapt
microtubule-associated protein tau
treatment
IDA IEP
RGD
PMID:28412141 , PMID:25771151 , PMID:26484783 , PMID:26729399
RGD:13800902 , RGD:13800917 , RGD:13800912 , RGD:13800909
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
G
Mir155
microRNA 155
ISO
RGD
PMID:28804446
RGD:25314324
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
G
Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
G
Ncstn
nicastrin
ISO
RGD
PMID:18240300
RGD:13801189
NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
G
Nfe2l2
nuclear factor, erythroid 2-like 2
IEP
protein:increased expression:brain:
RGD
PMID:30855558
RGD:26884463
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nmnat1
nicotinamide nucleotide adenylyltransferase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27822499
NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254
G
Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Ocln
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
G
Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15829224 PMID:28642177
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pde10a
phosphodiesterase 10A
IEP
RGD
PMID:29215295
RGD:13513923
NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
G
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
IEP
RGD
PMID:20713027
RGD:13830881
NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
G
Ppp3r2
protein phosphatase 3, regulatory subunit B, beta
IEP
RGD
PMID:20713027
RGD:13830881
NCBI chr 5:64,945,583...64,946,578
Ensembl chr 5:64,945,583...64,946,580
G
Psen1
presenilin 1
ISO
RGD
PMID:18240300
RGD:13801189
NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
G
Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593 PMID:28642177
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:28433746
RGD:14995478
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Tp53
tumor protein p53
treatment
IMP
RGD
PMID:27553877
RGD:14995939
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Ube4b
ubiquitination factor E4B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27822499
NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069
G
Apoe
apolipoprotein E
susceptibility
ISO
DNA:polymorphism:exon:
RGD
PMID:9214529
RGD:7495763
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
G
Tardbp
TAR DNA binding protein
ISO
protein:increased expression:brain
RGD
PMID:20720505
RGD:5687179
NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all