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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:ovarian carcinoma
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Accession:DOID:4001 term browser browse the term
Definition:An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. (DO)
Synonyms:primary_id: RDO:9002506
 xref: NCI:C4908
For additional species annotation, visit the Alliance of Genome Resources.


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ovarian carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 ISO DNA:amplification (human) RGD PMID:16721043 RGD:2315603 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Amh anti-Mullerian hormone treatment ISO RGD PMID:16533786 RGD:2315652 NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO protein:increased expression:ovary RGD PMID:15277215 RGD:2289032 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO ClinVar Annotator: match by term: Ovarian carcinoma ClinVar PMID:8808710 PMID:20373018 PMID:21614564 PMID:23175448 PMID:25452441 More... NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Cabin1 calcineurin binding protein 1 ISO DNA:hypermethylation: : RGD PMID:18757082 RGD:10054392 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 treatment ISO RGD PMID:26910918 RGD:18337281 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600
JBrowse link
G Casp6 caspase 6 ISO RGD PMID:17283169 RGD:2301336 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Cav1 caveolin 1 ISO RGD PMID:11032026 RGD:2289113 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnd1 cyclin D1 treatment ISO RGD PMID:18025280 RGD:2296036 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 IEP protein:increased expression:ovary RGD PMID:12713563 RGD:2289335 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO protein:increased expression:peritoneal fluid, leukocyte (human) RGD PMID:11948121 RGD:4892092 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Dusp1 dual specificity phosphatase 1 disease_progression ISO RGD PMID:12432554 RGD:2298695 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Edn1 endothelin 1 ISO mRNA, protein:increased expression:ovarian tumor (human) RGD PMID:9973223 RGD:4144954 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Hdac3 histone deacetylase 3 disease_progression ISO RGD PMID:18714364 RGD:2306205 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Il13 interleukin 13 ISO RGD PMID:14984938 RGD:2290344 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor disease_progression ISO RGD PMID:18005407 RGD:2302169 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
JBrowse link
G Klk13 kallikrein related-peptidase 13 ISO mRNA:increased expression:ovary RGD PMID:19707197 RGD:2314862 NCBI chr 1:94,165,381...94,177,002
Ensembl chr 1:94,165,381...94,177,002
JBrowse link
G L1cam L1 cell adhesion molecule severity ISO protein:increased expression:ovary, serum (human)
human cells, mouse model
RGD PMID:13678974 PMID:16424028 RGD:6483445, RGD:6483449 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Letmd1 LETM1 domain containing 1 ISO mRNA, protein:increased expression:ovary RGD PMID:12879013 RGD:2314918 NCBI chr 7:131,584,241...131,597,797
Ensembl chr 7:131,584,259...131,597,796
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:12644821 RGD:2306053 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 disease_progression ISO expression of the human gene inhibits metastatic colonization of secondary sites by cancer cells in the SKOV3ip.1 cell line model system RGD PMID:16489030 RGD:2293338 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mmp13 matrix metallopeptidase 13 disease_progression ISO DNA:polymorphism:promoter RGD PMID:12974393 PMID:19258954 RGD:2306083, RGD:2306074 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b ISO DNA:polymorphisms, nonsense mutation RGD PMID:11507041 RGD:2298954 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO mRNA:decreased expression:ovarian carcinoma (human) RGD PMID:16270321 RGD:2317019 NCBI chr16:51,202,497...51,347,791
Ensembl chr16:51,253,562...51,347,793
JBrowse link
G Muc16 mucin 16, cell surface associated IEP RGD PMID:20356397 RGD:2325203 NCBI chr 8:16,164,531...16,323,126 JBrowse link
G Mutyh mutY DNA glycosylase ISO ClinVar Annotator: match by term: Ovarian carcinoma ClinVar PMID:11818965 PMID:12606733 PMID:15931596 PMID:15987719 PMID:16492921 More... NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 ISO mRNA:increased expression:ovary RGD PMID:11161850 RGD:2293537 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO RGD PMID:7907945 RGD:2299073 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 severity ISO protein:increased expression:ovary RGD PMID:17533742 RGD:2299164 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Prkca protein kinase C, alpha severity ISO RGD PMID:12888898 RGD:2292460 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkci protein kinase C, iota disease_progression ISO RGD PMID:12888898 RGD:2292460 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO protein:increased expression:ovary
protein:increased tyrosine phosphorylation:ovary
RGD PMID:10526262 PMID:15455382 RGD:2292572, RGD:2292563 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Rhoa ras homolog family member A disease_progression ISO mRNA, protein:increased expression:ovary RGD PMID:12808121 RGD:2298873 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhoc ras homolog family member C ISO mRNA:increased expression:ovary RGD PMID:12808121 RGD:2298873 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
JBrowse link
G Six1 SIX homeobox 1 severity ISO mRNA:increased expression:female gonad (human) RGD PMID:17409410 RGD:11561962 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975
JBrowse link
G Smad2 SMAD family member 2 ISO RGD PMID:14985451 RGD:2299967 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO DNA:hypermethylation RGD PMID:15361843 RGD:2298907 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO DNA:hypermethylation RGD PMID:15361843 RGD:2298907 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Stk11 serine/threonine kinase 11 susceptibility ISO DNA:loss of heterozygosity, missense mutation:p.P281L RGD PMID:10429654 RGD:2298556 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tff1 trefoil factor 1 ISO RGD PMID:9066601 RGD:2292004 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 disease_progression ISO protein:increased expression:ovary RGD PMID:17009974 RGD:2290414 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
G Vegfd vascular endothelial growth factor D disease_progression ISO RGD PMID:18343598 RGD:2315478 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
familiar ovarian carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad51c RAD51 paralog C ISO ClinVar Annotator: match by term: Familial ovarian carcinoma ClinVar PMID:33832919 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
ovarian clear cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid1a AT-rich interaction domain 1A treatment ISO human cell in mouse model RGD PMID:21900401 RGD:126725086 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
ovarian serous carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef10l Rho guanine nucleotide exchange factor 10 like susceptibility ISO DNA:SNP:intron:rs10788679(human) RGD PMID:29979793 RGD:14348955 NCBI chr 5:152,792,247...152,935,255
Ensembl chr 5:152,792,252...152,919,538
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO ovarian serous carcinoma RGD PMID:16627982 RGD:2293332 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Ncam1 neural cell adhesion molecule 1 disease_progression ISO RGD PMID:25455994 RGD:40907066 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Pten phosphatase and tensin homolog exacerbates ISO protein:increased expression:ovary, peritoneum (human) RGD PMID:26166715 RGD:11532228 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Wt1 WT1 transcription factor ISO RGD PMID:19856421 RGD:2315539 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
ovarian serous cystadenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:26619011 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:16439621 PMID:19376813 PMID:22876591 PMID:24033266 PMID:24446311 More... NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:22908275 PMID:26619011 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:25741868 PMID:26619011 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More... NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:25741868 PMID:26168268 PMID:26619011 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Ovarian Serous Cystadenocarcinoma ClinVar PMID:1349175 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1569604 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
ovarian small cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Small cell carcinoma of the ovary, hypercalcemic type ClinVar NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
ovary adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 disease_progression ISO RGD PMID:17885491 RGD:2316011 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Ovarian Adenocarcinoma ClinVar PMID:15457249 PMID:18339846 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator severity ISO mRNA, protein:increased expression:female gonad (human) RGD PMID:18709641 RGD:11535054 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096
JBrowse link
ovary serous adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid1a AT-rich interaction domain 1A ISO ClinVar Annotator: match by term: Primary low grade serous adenocarcinoma of ovary ClinVar NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO ClinVar Annotator: match by term: Ovarian Serous Surface Papillary Adenocarcinoma ClinVar PMID:16084575 PMID:16455195 PMID:16949048 PMID:17100994 PMID:19656164 More... NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated ISO ClinVar Annotator: match by term: Ovarian Serous Surface Papillary Adenocarcinoma ClinVar PMID:16793542 PMID:18704680 PMID:25741868 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Bsg basigin (Ok blood group) ISO protein:increased expression:ovary RGD PMID:16633062 RGD:2289053 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Primary low grade serous adenocarcinoma of ovary ClinVar PMID:2278970 PMID:3122217 PMID:7773929 PMID:8439212 PMID:12460918 More... NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Tp53 tumor protein p53 ISO DNA, protein:loss of heterozygosity, increased expression:ovary RGD PMID:1310251 RGD:2290540 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17205
    disease of cellular proliferation 7034
      cancer 4989
        cell type cancer 3396
          carcinoma 2915
            ovarian carcinoma 64
              familiar ovarian carcinoma 1
              ovarian clear cell carcinoma 1
              ovarian large-cell neuroendocrine carcinoma 0
              ovarian seromucinous carcinoma 0
              ovarian serous carcinoma 5
              ovarian small cell carcinoma + 1
              ovarian squamous cell carcinoma 0
              ovary adenocarcinoma + 17
              ovary papillary carcinoma 0
Path 2
Term Annotations click to browse term
  disease 17205
    disease of anatomical entity 16551
      Urogenital Diseases 4356
        Female Urogenital Diseases and Pregnancy Complications 2044
          Female Urogenital Diseases 1739
            female reproductive system disease 1735
              Adnexal Diseases 795
                ovarian disease 786
                  Ovarian Neoplasms 479
                    ovarian cancer 334
                      ovary epithelial cancer 86
                        malignant ovarian surface epithelial-stromal neoplasm 64
                          ovarian carcinoma 64
                            familiar ovarian carcinoma 1
                            ovarian clear cell carcinoma 1
                            ovarian large-cell neuroendocrine carcinoma 0
                            ovarian seromucinous carcinoma 0
                            ovarian serous carcinoma 5
                            ovarian small cell carcinoma + 1
                            ovarian squamous cell carcinoma 0
                            ovary adenocarcinoma + 17
                            ovary papillary carcinoma 0
paths to the root