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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:withdrawal disorder
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Accession:DOID:0060001 term browser browse the term
Definition:A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol. (DO)
Synonyms:exact_synonym: Drug Withdrawal Symptom;   Substance Withdrawal Syndrome;   Substance Withdrawal Syndromes;   Withdrawal Symptom;   drug withdrawal symptoms;   withdrawal symptoms
 narrow_synonym: alcohol withdrawal
 primary_id: MESH:D013375
 xref: EFO:0004777;   EFO:0005800


show annotations for term's descendants           Sort by:
withdrawal disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16914643 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16914643 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16226742 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:14756803 PMID:16226742 PMID:16470403 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 IEP protein:increased expression:ventral tegmental area RGD PMID:23927484 RGD:401900655 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein IEP
ISO		 associated with morphine dependence;protein:increased expression:brain (rat)
associated with morphine dependence; mRNA,protein:increased expression:brain (mouse)		 RGD PMID:19262551 PMID:27730515 RGD:401938601, RGD:401959609 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 ISO CTD Direct Evidence: therapeutic CTD PMID:21600884 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4040330 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with nicotine dependence
associated with morphine dependence;mRNA:alternative form:frontal cortex, midbrain		 CTD
RGD		 PMID:12574402 PMID:24682499 PMID:25392083 RGD:401940143, RGD:401950484 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I treatment ISO RGD PMID:25871318 RGD:14995950 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV IEP associated with alcohol use disorder;protein:decreased expression:brain RGD PMID:11181917 RGD:401959326 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9496717 PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12154229 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18184829 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19644040 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18184829 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:18184829 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:15537871 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18705688 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO associated with alcohol dependence; DNA:SNP:cd: c.158G>A (human) RGD PMID:11900601 RGD:401940190 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment
sexual_dimorphism 		ISO
IDA
IEP
IMP		 CTD Direct Evidence: marker/mechanism
associated with heroin dependence;protein:decreased phosphorylation:nucleus accumbens
associated with morphine dependence
associated with alcohol use disorder;protein:altered phosphorylation:brain, nucleus
associated with nicotine dependence;protein:decreased expression, decreased phosphorylation:brain, multiple
associated with alcohol dependence
associated with morphine dependence;protein:increased promoter binding:frontal cortex, midbrain
associated with morphine dependence;protein:altered phosphorylation:ventral tegmental area
associated with morphine dependence;protein:increased phosphorylation:prefrontal cortex
associated with alcohol use disorder;mRNA:increased expression:cerebellum		 CTD
RGD		 PMID:18596687 PMID:25711798 PMID:19108758 PMID:11181917 PMID:16641242 More... RGD:401959753, RGD:401959375, RGD:401959326, RGD:401959318, RGD:401959212, RGD:401950487, RGD:401950486, RGD:401950484, RGD:401940143, RGD:401938641, RGD:401938640, RGD:401938639 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone IEP
ISO		 mRNA:increased expression:amygdala (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12968131 PMID:18596687 PMID:12782395 RGD:5508177 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:12858318 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Drd1 dopamine receptor D1 IEP protein:increased expression:nucleus accumbens (rat) RGD PMID:20435100 RGD:7248622 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17189962 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Faah fatty acid amide hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18705688 PMID:19002671 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IEP mRNA:decreased expression:prefrontal cortex (rat) RGD PMID:24810662 RGD:11667955 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:15196791 PMID:15196794 PMID:18485423 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP associated with morphine dependence;protein:increased expression:Brainstem (rat) RGD PMID:20438612 RGD:401900159 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 severity
sexual_dimorphism 		ISO
IEP		 associated with alcohol dependence;DNA:haplotype: :
in female only, associated with alcohol dependence:protein:increased expression:cerebral cortex,hippocampus		 RGD PMID:19111404 PMID:15976529 RGD:401900129, RGD:1643202 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 IEP associated with alcohol dependence:protein:increased expression:cerebral cortex RGD PMID:15976529 RGD:1643202 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12199159 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnao1 G protein subunit alpha o1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12199159 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:12199159 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ameliorates ISO
IEP
IMP		 CTD Direct Evidence: marker/mechanism
benzodiazepine withdrawal;protein:increased expression:hippocampal formation, synapse (rat)
cocaine withdrawal
heroin withdrawal disorder;protein:increased phosphorylation:multiple (rat)		 CTD
RGD		 PMID:11404432 PMID:12511956 PMID:18924138 PMID:12511956 PMID:19084907 RGD:405100713, RGD:728494, RGD:401976470 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12511956 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A severity ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12878694 PMID:23113297 RGD:401938657 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B severity IEP RGD PMID:23113297 RGD:401938657 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 severity IEP RGD PMID:23113297 RGD:401938657 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 severity IEP RGD PMID:23113297 RGD:401938657 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Hcrt hypocretin neuropeptide precursor severity ISO CTD Direct Evidence: marker/mechanism
associated with alcohol dependence;mRNA:decreased expression:blood plasma (human)		 CTD
RGD		 PMID:20738730 PMID:21621370 RGD:401960070 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hcrtr1 hypocretin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20667500 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8870037 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8870037 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO associated with alcohol dependence;DNA:SNP: :140G>C RGD PMID:19060480 RGD:401900293 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO
IEP
IMP		 associated with alcohol dependence
mRNA:decreased expression:hippocampus, ventral tegmental area
associated with Cocaine-Related Disorders
associated with morphine dependence;mRNA:decreased expression:peripheral blood mononuclear cell		 RGD PMID:19060480 PMID:26031442 PMID:12398913 PMID:28082900 PMID:18801381 RGD:401900293, RGD:401901090, RGD:401900759, RGD:401900741, RGD:13464135 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA:decreased editing:hippocampus		 CTD
RGD		 PMID:17105947 PMID:26031442 RGD:401901090 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Kdm4c lysine demethylase 4C susceptibility ISO DNA:snps:multiple (human) RGD PMID:22072270 RGD:9587485 NCBI chr 5:88,100,710...88,306,821
Ensembl chr 5:88,100,733...88,306,818 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism
associated with heroin dependence;protein:decreased phosphorylation:nucleus accumbens
associated with morphine dependence
associated with morphine dependence;protein:increased phosphorylation:prefrontal cortex		 CTD
RGD		 PMID:17549049 PMID:25711798 PMID:18772347 PMID:23035088 RGD:401959753, RGD:401950487, RGD:401938640 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism
associated with heroin dependence;protein:decreased phosphorylation:nucleus accumbens
associated with morphine dependence
associated with morphine dependence;protein:increased phosphorylation:prefrontal cortex		 CTD
RGD		 PMID:17549049 PMID:25711798 PMID:18772347 PMID:23035088 RGD:401959753, RGD:401950487, RGD:401938640 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 associated with alcohol dependence;DNA,protein:hypermethylation,decreased expression:promoter,serum
associated with alcohol dependence;protein:altered expression:brain
associated with alcohol dependence;protein:decreased expression:plasma		 RGD PMID:21392176 PMID:16252071 PMID:18639986 RGD:401965410, RGD:401976435, RGD:401965411 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19751225 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nptx2 neuronal pentraxin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19084905 NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345 		JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:16952158 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2415332 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP
IEP
ISO		 mRNA:increased expression:bed nucleus of stria terminalis
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:9463367 PMID:20232057 PMID:22515275 PMID:30075159 RGD:9834942, RGD:401850573 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 severity ISO associated with heroin dependence; DNA:SNP:CDS (rs6848893) (human) RGD PMID:26692286 RGD:11532896 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin IEP associated with cocaine abuse;mRNA:altered expression:hippocampal formation, nucleus accumbens
associated with opioid abuse		 RGD PMID:30818133 PMID:9045086 RGD:401851051, RGD:401851908 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Per1 period circadian regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20738730 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20434889 PMID:20738730 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Per3 period circadian regulator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20738730 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: therapeutic CTD PMID:10680585 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:225122 PMID:15689546 PMID:15714323 PMID:20738730 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B treatment IDA associated with Morphine Dependence RGD PMID:25604667 RGD:13514096 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 severity IEP RGD PMID:23113297 RGD:401938657 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888 		JBrowse link
G Prl prolactin treatment ISO CTD Direct Evidence: marker/mechanism
associated with opiate dependence		 CTD
RGD		 PMID:9037573 PMID:6932063 RGD:401959329 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptger3 prostaglandin E receptor 3 treatment IMP RGD PMID:10708732 RGD:10043351 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ren renin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28415 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rhoa ras homolog family member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 IEP
ISO		 protein:increased expression:cerebral cortex
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:14598306 PMID:15976529 RGD:1643202 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17000009 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Smad1 SMAD family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad5 SMAD family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7692360 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Th tyrosine hydroxylase IEP protein:increased serine phosphorylation:brainstem (rat) RGD PMID:20973778 RGD:5128830 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Alcohol Withdrawal Delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:11841893 RGD:1626329 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:serum RGD PMID:17434673 RGD:401965399 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:16318954 RGD:5688289 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Alcohol Withdrawal Seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D susceptibility IEP mRNA, protein:increased expression:inferior colliculus (rat) RGD PMID:25556199 RGD:152985539 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility ISO DNA:SNP:exon:A>G(human) RGD PMID:23238469 RGD:401959213 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Pdyn prodynorphin ISO mRNA:increased expression:brain RGD PMID:15869750 RGD:401850576 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21283641 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
alcohol withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Clock clock circadian regulator severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 no_association
treatment		 ISO DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*3 (636G>A, rs4986893),CYP2C19*17 (-806C>T, rs12248560) (human)
DNA:SNP:promoter:CYP2C19*17 (-806C>T,rs12248560)(human)
DNA:SNP:cds:CYP2C19*2 (681G>A,rs4244285)(human)		 RGD PMID:27099220 PMID:30325732 PMID:31957548 RGD:401960863, RGD:401960882, RGD:401960880 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Drd4 dopamine receptor D4 severity ISO DNA:repeats:exon: RGD PMID:20359751 RGD:401959612 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 severity ISO DNA:SNPs,haplotypes:multiple RGD PMID:24603855 RGD:401976481 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP protein:altered expression:brain RGD PMID:26727528 PMID:31778691 RGD:405101372, RGD:405255665 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 IEP mRNA, protein:increased expression:hippocampus (rat) RGD PMID:12488536 RGD:402528882 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:plasma RGD PMID:8727238 RGD:401976550 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP mRNA:decreased expression:hippocampus, cerebral cortex (rat) RGD PMID:20028355 RGD:10448926 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Per1 period circadian regulator 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 severity ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:3816539 RGD:401960110 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
morphine withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein treatment IEP RGD PMID:30550948 RGD:401959617 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP mRNA:increased expression:ventral tegmental area (rat) RGD PMID:30550948 RGD:401959617 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA RGD PMID:21171355 RGD:401959750 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Egr1 early growth response 1 treatment IEP RGD PMID:30550948 RGD:401959617 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP mRNA:increased expression:caudate putamen,nucleus accumbens
protein:increased expression:central nervous system
protein:increased expression:periaqueductal gray,neuron		 RGD PMID:11122358 PMID:12814374 PMID:9460759 RGD:405100959, RGD:405101374, RGD:405100960 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IEP
IMP		 associated with Pain;protein:increased expression:central amygdaloid nucleus (rat)
protein:increased phosphorylation:hippocampal formation, postsynaptic density (rat)
mRNA:altered expression:cerebral cortex, hippocampus (rat)		 RGD PMID:25716866 PMID:19077125 PMID:10822164 PMID:25716866 RGD:401976466, RGD:405101691, RGD:405100240, RGD:401976466 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment IMP RGD PMID:25308750 RGD:401965469 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Oprd1 opioid receptor, delta 1 IMP RGD PMID:12814374 RGD:405101374 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 IMP RGD PMID:12814374 RGD:405101374 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 IMP RGD PMID:12814374 RGD:405101374 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Per2 period circadian regulator 2 ameliorates ISO RGD PMID:20434889 RGD:401976532 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
neonatal abstinence syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase treatment
ameliorates		 ISO DNA:SNPs:cds: (rs4680,rs750603) c.158A>G (human)
DNA:SNP: 158A>G (rs4680) (human)
associated with maternal opioid abuse;DNA:SNP:intron (rs740603) (human)		 RGD PMID:27983768 PMID:23632726 PMID:26233486 RGD:401950496, RGD:11097592, RGD:11079504 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 treatment ISO DNA:SNP: :CYP2B6*6 (516G>T,785A>G) ((human) RGD PMID:28320034 RGD:401901176 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO mRNA:decreased expression:placenta RGD PMID:34352367 RGD:401938659 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity ISO associated with maternal opioid abuse;DNA:SNP:intron (rs702764) (human) RGD PMID:26233486 RGD:11079504 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
ameliorates		 ISO DNA:SNP: 118A>G (rs1799971) (human)
associated with maternal opioid abuse;DNA:SNP:intron (rs1799971) (human)		 RGD PMID:23632726 PMID:26233486 RGD:11097592, RGD:11079504 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pnoc prepronociceptin severity ISO associated with maternal opioid abuse;DNA:SNP:intron (rs732636|rs351776|rs2614095 ) (human) RGD PMID:26233486 RGD:11079504 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
opiate withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngf nerve growth factor ISO protein:increased expression:plasma RGD PMID:8727238 RGD:401976550 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Chemically-Induced Disorders 1385
      substance-related disorder 702
        withdrawal disorder 96
          alcohol withdrawal syndrome + 21
          neonatal abstinence syndrome 6
          opiate withdrawal syndrome + 12
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          brain disease 11633
            disease of mental health 8300
              substance-related disorder 702
                withdrawal disorder 96
                  alcohol withdrawal syndrome + 21
                  neonatal abstinence syndrome 6
                  opiate withdrawal syndrome + 12
paths to the root