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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3567
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rgs4
Name: regulator of G-protein signaling 4
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rgs4decreases expressionISORGS4 (Homo sapiens)6480464CTDPiroxicam results in decreased expression of RGS4 mRNAPMID:19192274 PMID:21858171
Rgs4multiple interactionsISORGS4 (Homo sapiens)6480464CTDCisplatin promotes the reaction [Piroxicam results in decreased expression of RGS4 mRNA]PMID:21858171
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