RGS4 (regulator of G protein signaling 4) - Rat Genome Database

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Gene: RGS4 (regulator of G protein signaling 4) Homo sapiens
Analyze
Symbol: RGS4
Name: regulator of G protein signaling 4
RGD ID: 70082
HGNC Page HGNC:10000
Description: Predicted to enable GTPase activator activity; GTPase activity; and calmodulin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Part of cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp761F1924; MGC2124; MGC60244; regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; schizophrenia disorder 9; SCZD9
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,068,871 - 163,076,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,068,775 - 163,076,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,038,661 - 163,046,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,305,285 - 161,313,216 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,770,808 - 159,778,036NCBI
Celera1136,142,715 - 136,150,908 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,283,724 - 134,291,924 (+)NCBIHuRef
CHM1_11164,461,279 - 164,469,481 (+)NCBICHM1_1
T2T-CHM13v2.01162,413,422 - 162,421,357 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-amphetamine  (ISO)
(S)-timolol (anhydrous)  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-methylcholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
Ampullosporin  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (ISO)
azathioprine  (EXP)
benzo[a]pyrene  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP)
cadmium atom  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cytarabine  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
doramapimod  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
eticlopride(1+)  (ISO)
flavonoids  (ISO)
formaldehyde  (EXP)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
irinotecan  (ISO)
kenpaullone  (ISO)
ketamine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
maneb  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nitrofen  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(I:C)  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
prednisolone  (EXP,ISO)
progesterone  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sarin  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
Soman  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
temozolomide  (EXP)
Tesaglitazar  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. Blazer LL, etal., ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.
3. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
4. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Druey KM, etal., Nature 1996 Feb 22;379(6567):742-6.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
7. RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. Ko WK, etal., Neurobiol Dis. 2014 Oct;70:138-48. doi: 10.1016/j.nbd.2014.06.013. Epub 2014 Jun 24.
8. Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. Lin TC, etal., Epilepsy Behav. 2009 Feb;14(2):316-23. doi: 10.1016/j.yebeh.2008.12.005. Epub 2009 Jan 4.
9. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. Namvar S, etal., J Neurol Sci. 2017 Apr 15;375:450-459. doi: 10.1016/j.jns.2017.02.047. Epub 2017 Feb 22.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. Rivero G, etal., Neuropharmacology. 2012 Feb;62(2):1044-51. doi: 10.1016/j.neuropharm.2011.10.015. Epub 2011 Oct 31.
14. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
15. A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Taccola G, etal., Exp Neurol. 2016 Dec;286:1-11. doi: 10.1016/j.expneurol.2016.09.008. Epub 2016 Sep 15.
16. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
17. Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats. Zarzuelo MJ, etal., Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.
Additional References at PubMed
PMID:8756726   PMID:9405622   PMID:9576926   PMID:9660808   PMID:9674973   PMID:9748280   PMID:9754621   PMID:10387017   PMID:10608901   PMID:10685342   PMID:10727532   PMID:10747990  
PMID:10767329   PMID:10784452   PMID:10791963   PMID:10869340   PMID:10982407   PMID:11148035   PMID:11297424   PMID:11428836   PMID:11507164   PMID:11602604   PMID:11904384   PMID:12023979  
PMID:12422374   PMID:12436019   PMID:12477932   PMID:12564955   PMID:12642592   PMID:12840049   PMID:12920194   PMID:14634662   PMID:14702039   PMID:14732600   PMID:14755443   PMID:15182322  
PMID:15274033   PMID:15369705   PMID:15381923   PMID:15383626   PMID:15489334   PMID:15660667   PMID:16082709   PMID:16176390   PMID:16246308   PMID:16344560   PMID:16380905   PMID:16508931  
PMID:16526029   PMID:16604300   PMID:16631129   PMID:16710414   PMID:16791139   PMID:16860780   PMID:16904822   PMID:16905560   PMID:17006672   PMID:17055463   PMID:17092693   PMID:17106420  
PMID:17185339   PMID:17220356   PMID:17301167   PMID:17408693   PMID:17410640   PMID:17515439   PMID:17588543   PMID:17707117   PMID:17722013   PMID:18031991   PMID:18198266   PMID:18204343  
PMID:18262772   PMID:18434012   PMID:18443239   PMID:18470533   PMID:18583979   PMID:18584117   PMID:18622782   PMID:18804346   PMID:18834502   PMID:19041089   PMID:19059885   PMID:19201815  
PMID:19282471   PMID:19324084   PMID:19367581   PMID:19416973   PMID:19460752   PMID:19536175   PMID:19549919   PMID:19913121   PMID:19937977   PMID:20414142   PMID:20430014   PMID:20627871  
PMID:20628086   PMID:20630860   PMID:20712983   PMID:20816714   PMID:21041608   PMID:21209077   PMID:21674833   PMID:21910931   PMID:22157635   PMID:22253691   PMID:22310500   PMID:22753418  
PMID:23093381   PMID:23332465   PMID:23630294   PMID:23733193   PMID:23911251   PMID:24009623   PMID:24297163   PMID:24658140   PMID:25289860   PMID:25402006   PMID:26088132   PMID:26119705  
PMID:26640232   PMID:26910404   PMID:26987813   PMID:28219718   PMID:28514442   PMID:30214040   PMID:31330059   PMID:31386272   PMID:31587286   PMID:32199913   PMID:32386256   PMID:32392739  
PMID:32501280   PMID:32517689   PMID:33961781   PMID:34767639   PMID:34893540   PMID:35628613   PMID:37047106   PMID:38432633  


Genomics

Comparative Map Data
RGS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,068,871 - 163,076,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,068,775 - 163,076,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,038,661 - 163,046,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,305,285 - 161,313,216 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,770,808 - 159,778,036NCBI
Celera1136,142,715 - 136,150,908 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,283,724 - 134,291,924 (+)NCBIHuRef
CHM1_11164,461,279 - 164,469,481 (+)NCBICHM1_1
T2T-CHM13v2.01162,413,422 - 162,421,357 (+)NCBIT2T-CHM13v2.0
Rgs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,569,046 - 169,575,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,569,046 - 169,575,211 (-)EnsemblGRCm39 Ensembl
GRCm381169,741,477 - 169,747,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,741,477 - 169,747,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv371171,671,608 - 171,677,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361171,578,350 - 171,584,295 (-)NCBIMGSCv36mm8
Celera1172,167,498 - 172,173,650 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
Rgs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,469,593 - 84,475,884 (-)NCBIGRCr8
mRatBN7.21381,936,775 - 81,943,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,564,610 - 84,570,879 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,857,386 - 85,863,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,089,853 - 83,096,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
Rgs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,338,960 - 13,347,610 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,340,812 - 13,347,598 (-)NCBIChiLan1.0ChiLan1.0
RGS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2186,701,675 - 86,709,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,370,272 - 86,378,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,488,317 - 138,496,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,284,040 - 142,292,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,284,040 - 142,292,225 (+)Ensemblpanpan1.1panPan2
RGS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,771,454 - 19,778,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,771,441 - 19,779,190 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3819,826,659 - 19,834,129 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03819,854,868 - 19,862,329 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3819,824,617 - 19,862,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13819,830,174 - 19,837,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,181,940 - 20,189,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,473,021 - 20,480,491 (-)NCBIUU_Cfam_GSD_1.0
Rgs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,671,010 - 103,678,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937238102,061 - 109,474 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937238101,948 - 109,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,383,345 - 87,390,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,383,336 - 87,390,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,096,206 - 95,103,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12565,729,344 - 65,735,278 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2565,726,394 - 65,735,381 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605567,526,009 - 67,532,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,569,854 - 1,579,627 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248261,570,143 - 1,577,300 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGS4
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1
pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1
pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2
pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1
pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:162040050-167480663)x1 copy number loss See cases [RCV000053915] Chr1:162040050..167480663 [GRCh38]
Chr1:162009840..167449900 [GRCh37]
Chr1:160276464..165716524 [NCBI36]
Chr1:1q23.3-24.2
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1
pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2
pathogenic
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2
pathogenic
NM_001102445.3(RGS4):c.127C>A (p.Arg43Ser) single nucleotide variant not specified [RCV004662973] Chr1:163069320 [GRCh38]
Chr1:163039110 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_001102445.3(RGS4):c.128G>T (p.Arg43Leu) single nucleotide variant not specified [RCV004662971] Chr1:163069321 [GRCh38]
Chr1:163039111 [GRCh37]
Chr1:1q23.3
uncertain significance
GRCh37/hg19 1q23.3(chr1:162536242-163169281)x3 copy number gain not provided [RCV001258477] Chr1:162536242..163169281 [GRCh37]
Chr1:1q23.3
uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
GRCh37/hg19 1q23.3-24.3(chr1:162330810-171532331) copy number loss not specified [RCV002053680] Chr1:162330810..171532331 [GRCh37]
Chr1:1q23.3-24.3
pathogenic
GRCh37/hg19 1q23.2-24.1(chr1:160417296-166197042) copy number loss not specified [RCV002053658] Chr1:160417296..166197042 [GRCh37]
Chr1:1q23.2-24.1
pathogenic
NM_005613.6(RGS4):c.338A>G (p.Lys113Arg) single nucleotide variant not specified [RCV004327570] Chr1:163073582 [GRCh38]
Chr1:163043372 [GRCh37]
Chr1:1q23.3
uncertain significance
GRCh37/hg19 1q23.3(chr1:161924068-164761399)x1 copy number loss not provided [RCV002474557] Chr1:161924068..164761399 [GRCh37]
Chr1:1q23.3
likely pathogenic
NM_001102445.3(RGS4):c.124G>T (p.Gly42Cys) single nucleotide variant not specified [RCV004189727] Chr1:163069317 [GRCh38]
Chr1:163039107 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.400A>T (p.Arg134Trp) single nucleotide variant not specified [RCV004102362] Chr1:163074342 [GRCh38]
Chr1:163044132 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.523C>A (p.Leu175Ile) single nucleotide variant not specified [RCV004158116] Chr1:163074465 [GRCh38]
Chr1:163044255 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_001102445.3(RGS4):c.44G>A (p.Gly15Glu) single nucleotide variant not specified [RCV004237857] Chr1:163068978 [GRCh38]
Chr1:163038768 [GRCh37]
Chr1:1q23.3
likely benign
NM_005613.6(RGS4):c.232G>A (p.Ala78Thr) single nucleotide variant not specified [RCV004194937] Chr1:163073476 [GRCh38]
Chr1:163043266 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_001102445.3(RGS4):c.89C>T (p.Ala30Val) single nucleotide variant not specified [RCV004233004] Chr1:163069282 [GRCh38]
Chr1:163039072 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.89C>T (p.Ser30Phe) single nucleotide variant not specified [RCV004154712] Chr1:163072439 [GRCh38]
Chr1:163042229 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_001102445.3(RGS4):c.155C>A (p.Thr52Lys) single nucleotide variant not specified [RCV004089818] Chr1:163069348 [GRCh38]
Chr1:163039138 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_001102445.3(RGS4):c.61G>T (p.Ala21Ser) single nucleotide variant not specified [RCV004173901] Chr1:163069254 [GRCh38]
Chr1:163039044 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.-62G>T single nucleotide variant not specified [RCV004254844] Chr1:163069423 [GRCh38]
Chr1:163039213 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.539C>T (p.Pro180Leu) single nucleotide variant not specified [RCV004336673] Chr1:163074481 [GRCh38]
Chr1:163044271 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.539C>G (p.Pro180Arg) single nucleotide variant not specified [RCV004449211] Chr1:163074481 [GRCh38]
Chr1:163044271 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.395G>A (p.Cys132Tyr) single nucleotide variant not specified [RCV004449208] Chr1:163074337 [GRCh38]
Chr1:163044127 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.-47C>T single nucleotide variant not specified [RCV004449207] Chr1:163069438 [GRCh38]
Chr1:163039228 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.451G>A (p.Glu151Lys) single nucleotide variant not specified [RCV004449210] Chr1:163074393 [GRCh38]
Chr1:163044183 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.220G>A (p.Ala74Thr) single nucleotide variant not specified [RCV004662972] Chr1:163073464 [GRCh38]
Chr1:163043254 [GRCh37]
Chr1:1q23.3
uncertain significance
NM_005613.6(RGS4):c.497G>A (p.Arg166His) single nucleotide variant not specified [RCV004671944] Chr1:163074439 [GRCh38]
Chr1:163044229 [GRCh37]
Chr1:1q23.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4375
Count of miRNA genes:979
Interacting mature miRNAs:1166
Transcripts:ENST00000367906, ENST00000367908, ENST00000367909, ENST00000421743, ENST00000491263, ENST00000527393, ENST00000527809, ENST00000528938, ENST00000531057, ENST00000533019
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
407203847GWAS852823_Hmonocyte count QTL GWAS852823 (human)5e-09monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)1163075958163075959Human
407164686GWAS813662_Hcardiac troponin I measurement QTL GWAS813662 (human)0.000009cardiac troponin I measurementblood troponin level (CMO:0001283)1163069063163069064Human
407202095GWAS851071_Hleukocyte count QTL GWAS851071 (human)2e-49leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)1163075958163075959Human
407203688GWAS852664_Hleukocyte count QTL GWAS852664 (human)8e-09leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)1163075958163075959Human

Markers in Region
D1S1679  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371162,361,915 - 162,362,069UniSTSGRCh37
Build 361160,628,539 - 160,628,693RGDNCBI36
Celera1135,464,981 - 135,465,139RGD
Cytogenetic Map1q23.3UniSTS
HuRef1133,606,635 - 133,606,781UniSTS
Marshfield Genetic Map1170.84RGD
Marshfield Genetic Map1170.84UniSTS
Whitehead-RH Map1721.1UniSTS
Whitehead-YAC Contig Map1 UniSTS
D1S1631  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371105,660,652 - 105,660,779UniSTSGRCh37
Build 361105,462,175 - 105,462,302RGDNCBI36
Celera1103,839,382 - 103,839,509RGD
Cytogenetic Map1q23.3UniSTS
HuRef1103,611,364 - 103,611,497UniSTS
Marshfield Genetic Map1136.88UniSTS
Marshfield Genetic Map1136.88RGD
deCODE Assembly Map1125.75UniSTS
D1S1653  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,932,774 - 157,932,881UniSTSGRCh37
Build 361156,199,398 - 156,199,505RGDNCBI36
Celera1131,004,178 - 131,004,281RGD
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1p13UniSTS
Cytogenetic Map1q21.3UniSTS
HuRef1129,290,751 - 129,290,854UniSTS
Marshfield Genetic Map1164.09RGD
Marshfield Genetic Map1164.09UniSTS
deCODE Assembly Map1151.68UniSTS
Whitehead-RH Map1697.6UniSTS
Whitehead-YAC Contig Map1 UniSTS
D1S551  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37182,895,296 - 82,895,464UniSTSGRCh37
Build 36182,667,884 - 82,668,052RGDNCBI36
Celera181,131,624 - 81,131,796RGD
Cytogenetic Map1q23.3UniSTS
HuRef181,028,870 - 81,029,050UniSTS
Marshfield Genetic Map1113.69UniSTS
Marshfield Genetic Map1113.69RGD
TNG Radiation Hybrid Map147350.0UniSTS
deCODE Assembly Map1107.4UniSTS
Stanford-G3 RH Map14085.0UniSTS
Stanford-G3 RH Map14079.0UniSTS
Whitehead-RH Map1230.3UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map1544.9UniSTS
D1S1656  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371230,905,305 - 230,905,457UniSTSGRCh37
Build 361228,971,928 - 228,972,080RGDNCBI36
Celera1204,171,298 - 204,171,446RGD
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1q42.11-q42.3UniSTS
HuRef1201,390,019 - 201,390,167UniSTS
Marshfield Genetic Map1245.05UniSTS
Marshfield Genetic Map1245.05RGD
TNG Radiation Hybrid Map1116299.0UniSTS
deCODE Assembly Map1234.69UniSTS
Stanford-G3 RH Map19172.0UniSTS
Whitehead-RH Map1908.3UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map12036.9UniSTS
D1S534  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371119,678,264 - 119,678,466UniSTSGRCh37
Build 361119,479,787 - 119,479,989RGDNCBI36
Celera1117,909,107 - 117,909,310RGD
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1p21-q21UniSTS
Cytogenetic Map1p12UniSTS
HuRef1117,537,320 - 117,537,526UniSTS
Marshfield Genetic Map1151.88UniSTS
Marshfield Genetic Map1151.88RGD
deCODE Assembly Map1140.68UniSTS
Stanford-G3 RH Map15594.0UniSTS
Whitehead-RH Map1482.5UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map1873.0UniSTS
D1S196  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371167,604,128 - 167,604,404UniSTSGRCh37
GRCh371167,604,300 - 167,604,432UniSTSGRCh37
Build 361165,870,924 - 165,871,056RGDNCBI36
Celera1140,713,389 - 140,713,655UniSTS
Celera1140,713,551 - 140,713,683RGD
Cytogenetic Map1q24.2UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map1q21-q23UniSTS
HuRef1138,850,205 - 138,850,471UniSTS
HuRef1138,850,367 - 138,850,499UniSTS
Marshfield Genetic Map1181.49UniSTS
Marshfield Genetic Map1181.49RGD
Genethon Genetic Map1186.4UniSTS
TNG Radiation Hybrid Map175834.0UniSTS
deCODE Assembly Map1169.4UniSTS
Stanford-G3 RH Map16393.0UniSTS
GeneMap99-GB4 RH Map1605.8UniSTS
Whitehead-RH Map1750.1UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map11463.1UniSTS
GeneMap99-G3 RH Map16349.0UniSTS
D1S3723  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q23.3UniSTS
Marshfield Genetic Map1140.39UniSTS
Marshfield Genetic Map1140.39RGD
D1S1677  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,559,701 - 163,559,903UniSTSGRCh37
Build 361161,826,325 - 161,826,527RGDNCBI36
Celera1136,663,745 - 136,663,947RGD
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map1q23UniSTS
HuRef1134,804,939 - 134,805,141UniSTS
Marshfield Genetic Map1175.62RGD
Marshfield Genetic Map1175.62UniSTS
deCODE Assembly Map1161.5UniSTS
Whitehead-YAC Contig Map1 UniSTS
D1S1622  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37130,310,954 - 30,311,213UniSTSGRCh37
Build 36130,083,541 - 30,083,800RGDNCBI36
Celera128,558,502 - 28,558,757RGD
Cytogenetic Map1q23.3UniSTS
HuRef128,413,499 - 28,413,755UniSTS
Marshfield Genetic Map156.74UniSTS
Marshfield Genetic Map156.74RGD
deCODE Assembly Map148.69UniSTS
IB1262  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,045,474 - 163,045,715UniSTSGRCh37
Build 361161,312,098 - 161,312,339RGDNCBI36
Celera1136,149,791 - 136,150,032RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,290,807 - 134,291,048UniSTS
GeneMap99-GB4 RH Map1596.44UniSTS
GeneMap99-GB4 RH Map1592.58UniSTS
Whitehead-RH Map1735.4UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH12512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,045,562 - 163,045,708UniSTSGRCh37
Build 361161,312,186 - 161,312,332RGDNCBI36
Celera1136,149,879 - 136,150,025RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,290,895 - 134,291,041UniSTS
GeneMap99-GB4 RH Map1592.58UniSTS
NCBI RH Map11446.5UniSTS
G29255  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,046,391 - 163,046,530UniSTSGRCh37
Build 361161,313,015 - 161,313,154RGDNCBI36
Celera1136,150,707 - 136,150,846RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,291,723 - 134,291,862UniSTS
SHGC-32116  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,046,439 - 163,046,588UniSTSGRCh37
Build 361161,313,063 - 161,313,212RGDNCBI36
Celera1136,150,755 - 136,150,904RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,291,771 - 134,291,920UniSTS
GeneMap99-GB4 RH Map1593.1UniSTS
Whitehead-RH Map1722.2UniSTS
GeneMap99-G3 RH Map16207.0UniSTS
RGS4_784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,045,557 - 163,046,427UniSTSGRCh37
Build 361161,312,181 - 161,313,051RGDNCBI36
Celera1136,149,874 - 136,150,743RGD
HuRef1134,290,890 - 134,291,759UniSTS
A003B46  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,045,548 - 163,045,660UniSTSGRCh37
Build 361161,312,172 - 161,312,284RGDNCBI36
Celera1136,149,865 - 136,149,977RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,290,881 - 134,290,993UniSTS
GeneMap99-GB4 RH Map1594.21UniSTS
HSC1YC112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371163,045,522 - 163,045,727UniSTSGRCh37
Build 361161,312,146 - 161,312,351RGDNCBI36
Celera1136,149,839 - 136,150,044RGD
Cytogenetic Map1q23.3UniSTS
HuRef1134,290,855 - 134,291,060UniSTS
GeneMap99-GB4 RH Map1594.31UniSTS
Whitehead-RH Map1733.0UniSTS
D1S1599  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q23.3UniSTS
Whitehead-YAC Contig Map1 UniSTS
AA004315  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef1134,289,538 - 134,289,637UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2371 2745 2235 4892 1714 2286 4 615 1163 455 2190 6452 5697 45 3729 1 848 1706 1560 173 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001102445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF493928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL583850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI547160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA253378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA660018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA660695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC318279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC334933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ346662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ346663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ346664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF054877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U27768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000367906   ⟹   ENSP00000356882
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,072,044 - 163,074,816 (+)Ensembl
Ensembl Acc Id: ENST00000367908   ⟹   ENSP00000356884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,069,361 - 163,076,591 (+)Ensembl
Ensembl Acc Id: ENST00000367909   ⟹   ENSP00000356885
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,069,361 - 163,076,802 (+)Ensembl
Ensembl Acc Id: ENST00000421743   ⟹   ENSP00000397181
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,068,775 - 163,076,802 (+)Ensembl
Ensembl Acc Id: ENST00000491263
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,069,363 - 163,076,591 (+)Ensembl
Ensembl Acc Id: ENST00000527393
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,068,935 - 163,073,494 (+)Ensembl
Ensembl Acc Id: ENST00000527809   ⟹   ENSP00000433261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,069,361 - 163,074,755 (+)Ensembl
Ensembl Acc Id: ENST00000528938   ⟹   ENSP00000432194
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,072,146 - 163,074,427 (+)Ensembl
Ensembl Acc Id: ENST00000531057   ⟹   ENSP00000436106
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,069,361 - 163,074,708 (+)Ensembl
Ensembl Acc Id: ENST00000533019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,070,537 - 163,074,343 (+)Ensembl
RefSeq Acc Id: NM_001102445   ⟹   NP_001095915
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,068,871 - 163,076,802 (+)NCBI
GRCh371163,038,396 - 163,046,592 (+)ENTREZGENE
Build 361161,305,285 - 161,313,216 (+)NCBI Archive
HuRef1134,283,724 - 134,291,924 (+)ENTREZGENE
CHM1_11164,461,279 - 164,469,481 (+)NCBI
T2T-CHM13v2.01162,413,422 - 162,421,357 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001113380   ⟹   NP_001106851
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,071,905 - 163,076,802 (+)NCBI
GRCh371163,038,396 - 163,046,592 (+)ENTREZGENE
HuRef1134,283,724 - 134,291,924 (+)ENTREZGENE
CHM1_11164,464,587 - 164,469,481 (+)NCBI
T2T-CHM13v2.01162,416,463 - 162,421,357 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001113381   ⟹   NP_001106852
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,069,254 - 163,076,802 (+)NCBI
GRCh371163,038,396 - 163,046,592 (+)ENTREZGENE
HuRef1134,283,724 - 134,291,924 (+)ENTREZGENE
CHM1_11164,461,927 - 164,469,481 (+)NCBI
T2T-CHM13v2.01162,413,805 - 162,421,357 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005613   ⟹   NP_005604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,069,361 - 163,076,802 (+)NCBI
GRCh371163,038,396 - 163,046,592 (+)ENTREZGENE
Build 361161,305,619 - 161,313,216 (+)NCBI Archive
HuRef1134,283,724 - 134,291,924 (+)ENTREZGENE
CHM1_11164,461,647 - 164,469,481 (+)NCBI
T2T-CHM13v2.01162,413,912 - 162,421,357 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001095915   ⟸   NM_001102445
- Peptide Label: isoform 1
- UniProtKB: P49798 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005604   ⟸   NM_005613
- Peptide Label: isoform 2
- UniProtKB: A7YVV7 (UniProtKB/Swiss-Prot),   A7XA59 (UniProtKB/Swiss-Prot),   A7XA58 (UniProtKB/Swiss-Prot),   A7XA56 (UniProtKB/Swiss-Prot),   B1APZ3 (UniProtKB/Swiss-Prot),   P49798 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106852   ⟸   NM_001113381
- Peptide Label: isoform 4
- UniProtKB: P49798 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106851   ⟸   NM_001113380
- Peptide Label: isoform 3
- UniProtKB: P49798 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000436106   ⟸   ENST00000531057
Ensembl Acc Id: ENSP00000356885   ⟸   ENST00000367909
Ensembl Acc Id: ENSP00000356882   ⟸   ENST00000367906
Ensembl Acc Id: ENSP00000356884   ⟸   ENST00000367908
Ensembl Acc Id: ENSP00000433261   ⟸   ENST00000527809
Ensembl Acc Id: ENSP00000397181   ⟸   ENST00000421743
Ensembl Acc Id: ENSP00000432194   ⟸   ENST00000528938
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49798-F1-model_v2 AlphaFold P49798 1-205 view protein structure

Promoters
RGD ID:6850798
Promoter ID:EP73193
Type:multiple initiation site
Name:HS_RGS4
Description:Regulator of G-protein signalling 4.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361161,305,775 - 161,305,835EPD
RGD ID:6857950
Promoter ID:EPDNEW_H2140
Type:initiation region
Name:RGS4_1
Description:regulator of G protein signaling 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,069,362 - 163,069,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10000 AgrOrtholog
COSMIC RGS4 COSMIC
Ensembl Genes ENSG00000117152 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367906 ENTREZGENE
  ENST00000367906.7 UniProtKB/Swiss-Prot
  ENST00000367908 ENTREZGENE
  ENST00000367908.8 UniProtKB/Swiss-Prot
  ENST00000367909 ENTREZGENE
  ENST00000367909.11 UniProtKB/Swiss-Prot
  ENST00000421743 ENTREZGENE
  ENST00000421743.6 UniProtKB/Swiss-Prot
  ENST00000527809.5 UniProtKB/Swiss-Prot
  ENST00000528938.1 UniProtKB/TrEMBL
  ENST00000531057.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000117152 GTEx
HGNC ID HGNC:10000 ENTREZGENE
Human Proteome Map RGS4 Human Proteome Map
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_RGS4 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5999 UniProtKB/Swiss-Prot
NCBI Gene 5999 ENTREZGENE
OMIM 602516 OMIM
PANTHER PTHR10845:SF184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34375 PharmGKB
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A7XA56 ENTREZGENE
  A7XA58 ENTREZGENE
  A7XA59 ENTREZGENE
  A7YVV7 ENTREZGENE
  B1APZ3 ENTREZGENE
  E9PR32_HUMAN UniProtKB/TrEMBL
  E9PS05_HUMAN UniProtKB/TrEMBL
  P49798 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A7XA56 UniProtKB/Swiss-Prot
  A7XA58 UniProtKB/Swiss-Prot
  A7XA59 UniProtKB/Swiss-Prot
  A7YVV7 UniProtKB/Swiss-Prot
  B1APZ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 RGS4  regulator of G protein signaling 4    regulator of G-protein signaling 4  Symbol and/or name change 5135510 APPROVED
2016-04-05 RGS4  regulator of G-protein signaling 4  SCZD9  schizophrenia disorder 9  Data merged from RGD:1343330 737654 PROVISIONAL