RGD Reference Report - CASK associates with glutamate receptor interacting protein and signaling molecules. - Rat Genome Database

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CASK associates with glutamate receptor interacting protein and signaling molecules.

Authors: Hong, CJ  Hsueh, YP 
Citation: Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
RGD ID: 2326120
Pubmed: PMID:17084383   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.10.113   (Journal Full-text)

CASK has been implicated in synaptic protein targeting, synaptic organization, and transcriptional regulation. Here, three more CASK associated proteins, GRIP1, PKCepsilon, and RGS4, were initially identified by immunoprecipitation and mass analysis, and confirmed by immunoprecipitation-immunoblotting assay using rat brain extract. Via the interaction with GRIP1, GluR2/3 was also co-immunoprecipitated by CASK antibody from rat brain. The PDZ and SH3-GK domains of CASK were demonstrated as the associated domains for GRIP1 and PKCepsilon, respectively. The associations between CASK, PKCepsilon, and RGS4 were up-regulated in the adult brain compared with postnatal day 11 rat brain. In contrast, the associations of CASK with Mint1, GRIP1, and GluR2/3 were down-regulated in the adult brain. These results suggest that CASK protein complex is developmentally regulated by unknown signals. In conclusion, our study suggests that the CASK protein complex not only functions as a scaffold but also recruits signaling molecules and may contribute to signal transduction.

Gene Ontology Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Apba1  (amyloid beta precursor protein binding family A member 1)
Cask  (calcium/calmodulin dependent serine protein kinase)
Grip1  (glutamate receptor interacting protein 1)
Lin7b  (lin-7 homolog B, crumbs cell polarity complex component)
Prkce  (protein kinase C, epsilon)
Rgs4  (regulator of G-protein signaling 4)

Objects referenced in this article
Gene Lin7c lin-7 homolog C, crumbs cell polarity complex component Rattus norvegicus
Gene Ncoa2 nuclear receptor coactivator 2 Rattus norvegicus

Additional Information