Gnai1 (G protein subunit alpha i1) - Rat Genome Database
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Gene: Gnai1 (G protein subunit alpha i1) Rattus norvegicus
Analyze
Symbol: Gnai1
Name: G protein subunit alpha i1
RGD ID: 2713
Description: Exhibits several functions, including GTPase activating protein binding activity; magnesium ion binding activity; and purine ribonucleoside binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and regulation of cAMP-mediated signaling. Localizes to several cellular components, including centrosome; membrane raft; and plasma membrane. Orthologous to human GNAI1 (G protein subunit alpha i1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenylate cyclase-inhibiting G alpha protein; BPGTPB; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit
Orthologs:
Homo sapiens (human) : GNAI1 (G protein subunit alpha i1)  HGNC  Alliance
Mus musculus (house mouse) : Gnai1 (guanine nucleotide binding protein (G protein), alpha inhibiting 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gnai1 (G protein subunit alpha i1)
Pan paniscus (bonobo/pygmy chimpanzee) : GNAI1 (G protein subunit alpha i1)
Canis lupus familiaris (dog) : GNAI1 (G protein subunit alpha i1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gnai1 (G protein subunit alpha i1)
Sus scrofa (pig) : GNAI1 (G protein subunit alpha i1)
Chlorocebus sabaeus (African green monkey) : GNAI1 (G protein subunit alpha i1)
Heterocephalus glaber (naked mole-rat) : Gnai1 (G protein subunit alpha i1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0413,405,136 - 13,486,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0413,388,073 - 13,470,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4412,465,089 - 12,495,028 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1412,465,088 - 12,495,028 (+)NCBI
Celera412,346,868 - 12,428,695 (+)NCBICelera
Cytogenetic Map4q11NCBI
RH 3.4 Map449.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcidiol  (EXP)
carbon nanotube  (ISO)
chrysene  (ISO)
clofibric acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diphenhydramine  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
glucose  (ISO)
Guanabenz  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorooctanoic acid  (EXP)
phenol red  (ISO)
picrotoxin  (EXP)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
quercetin  (ISO)
reserpine  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

References

References - curated
1. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
2. Berghuis AM, etal., Structure. 1996 Nov 15;4(11):1277-90.
3. Cho H and Kehrl JH, J Cell Biol. 2007 Jul 16;178(2):245-55.
4. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
5. Coleman DE, etal., Science. 1994 Sep 2;265(5177):1405-12.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
8. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
9. Kapoor N, etal., J Mol Biol. 2009 Nov 6;393(4):882-97. doi: 10.1016/j.jmb.2009.08.043. Epub 2009 Aug 22.
10. Kaya AI, etal., J Biol Chem. 2014 Aug 29;289(35):24475-87. doi: 10.1074/jbc.M114.572875. Epub 2014 Jul 18.
11. Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
12. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Mannoury la Cour C, etal., Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. RGD automated data pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Shu FJ, etal., Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.
22. Straiker AJ, etal., J Neurosci 2002 Apr 1;22(7):2460-8.
23. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
24. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Tesmer JJ, etal., Cell. 1997 Apr 18;89(2):251-61.
26. Vellano CP, etal., Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.
27. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:7937899   PMID:8521505   PMID:9705312   PMID:9772163   PMID:11121039   PMID:15381255   PMID:15866880   PMID:16805845   PMID:17406063   PMID:17897319   PMID:18162186   PMID:18356833  
PMID:18541531   PMID:19056867   PMID:19151257   PMID:19252090   PMID:20679342   PMID:21853086   PMID:22230296   PMID:22327364   PMID:22871113   PMID:23027904   PMID:23250758   PMID:23870127  
PMID:24596087   PMID:26253820   PMID:26620557   PMID:26766442   PMID:27558716   PMID:27936598   PMID:28627018   PMID:29476059  


Genomics

Comparative Map Data
Gnai1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0413,405,136 - 13,486,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0413,388,073 - 13,470,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4412,465,089 - 12,495,028 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1412,465,088 - 12,495,028 (+)NCBI
Celera412,346,868 - 12,428,695 (+)NCBICelera
Cytogenetic Map4q11NCBI
RH 3.4 Map449.5RGD
GNAI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl779,768,028 - 80,226,181 (+)EnsemblGRCh38hg38GRCh38
GRCh38780,134,831 - 80,226,181 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37779,764,140 - 79,848,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36779,602,076 - 79,686,661 (+)NCBINCBI36hg18NCBI36
Build 34779,408,790 - 79,493,376NCBI
Celera774,464,804 - 74,549,389 (+)NCBI
Cytogenetic Map7q21.11NCBI
HuRef774,366,659 - 74,451,137 (+)NCBIHuRef
CHM1_1779,694,209 - 79,778,804 (+)NCBICHM1_1
CRA_TCAGchr7v2779,095,649 - 79,180,223 (+)NCBI
Gnai1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39518,470,133 - 18,565,411 (-)NCBI
GRCm38518,265,135 - 18,360,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl518,265,135 - 18,360,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv37517,770,953 - 17,866,231 (-)NCBIGRCm37mm9NCBIm37
MGSCv36517,776,959 - 17,872,237 (-)NCBImm8
Celera515,230,415 - 15,321,001 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.16NCBI
Gnai1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554105,388,184 - 5,467,022 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554105,388,184 - 5,467,022 (-)NCBIChiLan1.0ChiLan1.0
GNAI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1785,766,875 - 85,851,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl785,812,249 - 85,851,283 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0772,102,937 - 72,188,124 (+)NCBIMhudiblu_PPA_v0panPan3
GNAI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1819,924,235 - 19,951,244 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11819,924,381 - 19,952,956 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gnai1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936810353,405 - 435,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9100,182,757 - 100,272,625 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19100,187,878 - 100,272,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29110,559,455 - 110,592,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAI1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2168,687,307 - 68,770,360 (-)Ensembl
ChlSab1.12168,687,809 - 68,770,415 (-)NCBI
Gnai1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473928,995,173 - 29,074,354 (+)NCBI

Position Markers
RH94471  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0413,485,947 - 13,486,138NCBIRnor6.0
Rnor_5.0413,469,360 - 13,469,551UniSTSRnor5.0
RGSC_v3.4412,494,109 - 12,494,300UniSTSRGSC3.4
Celera412,427,776 - 12,427,967UniSTS
Cytogenetic Map4q11UniSTS
RH 3.4 Map449.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4125545519Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4125545519Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4125545519Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4126654881Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4126803291Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4128352196Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4128352196Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4128352196Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4128352196Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4129778604Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4129778604Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4131554484Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)4142118977Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4304411426753655Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4646769343414792Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4657293937703537Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4805218953052189Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)4805218953052189Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)4805218953052189Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4805218953052189Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4805218953052189Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)4805218953052189Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41263897457638974Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:250
Interacting mature miRNAs:294
Transcripts:ENSRNOT00000006978
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 8 6 5 6 74 35 40 11
Low 1 23 49 35 14 35 8 11 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091004   ⟹   ENSRNOP00000074036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)Ensembl
RefSeq Acc Id: NM_013145   ⟹   NP_037277
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0413,405,136 - 13,486,866 (+)NCBI
Rnor_5.0413,388,073 - 13,470,279 (+)NCBI
RGSC_v3.4412,465,089 - 12,495,028 (+)RGD
Celera412,346,868 - 12,428,695 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037277 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40825 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23808 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23809 (Get FASTA)   NCBI Sequence Viewer  
  EDL99446 (Get FASTA)   NCBI Sequence Viewer  
  P10824 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037277   ⟸   NM_013145
- UniProtKB: P10824 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074036   ⟸   ENSRNOT00000091004
Protein Domains
G-alpha

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692817
Promoter ID:EPDNEW_R3341
Type:initiation region
Name:Gnai1_1
Description:G protein subunit alpha i1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0413,405,098 - 13,405,158EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2713 AgrOrtholog
Ensembl Genes ENSRNOG00000057096 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000074036 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091004 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:25686 UniProtKB/Swiss-Prot
NCBI Gene 25686 ENTREZGENE
PANTHER PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gnai1 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAI UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC234720
UniGene Rn.11391 ENTREZGENE
UniProt GNAI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q45QN2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnai1  G protein subunit alpha i1  Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1  Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting 1  Gnai1  guanine nucleotide binding protein, alpha inhibiting 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gnai1  Guanine nucleotide binding protein, alpha inhibiting 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in olfactory, brain, kidney, lung, and intestine 632848
gene_expression mRNA-abundant in hippocampus 625670
gene_process selectively interacts with different G-protein coupled receptors 625670
gene_process involved in presynaptic inhibition 625670