Gnai1 (G protein subunit alpha i1) - Rat Genome Database

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Gene: Gnai1 (G protein subunit alpha i1) Rattus norvegicus
Symbol: Gnai1
Name: G protein subunit alpha i1
RGD ID: 2713
Description: Enables several functions, including GTPase activating protein binding activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including cellular response to forskolin; negative regulation of synaptic transmission; and regulation of cAMP-mediated signaling. Located in centrosome; cytoplasm; and plasma membrane. Part of protein-containing complex. Orthologous to human GNAI1 (G protein subunit alpha i1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase-inhibiting G alpha protein; BPGTPB; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2416,814,000 - 16,898,119 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl416,814,001 - 16,896,417 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx421,928,981 - 22,013,064 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0417,743,905 - 17,829,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,126,937 - 16,211,023 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0413,405,136 - 13,486,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0413,388,073 - 13,470,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4412,465,089 - 12,495,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1412,465,088 - 12,495,028 (+)NCBI
Celera412,346,868 - 12,428,695 (+)NCBICelera
RH 3.4 Map449.5RGD
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (EXP)
carbon nanotube  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
chrysene  (ISO)
clofibric acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diphenhydramine  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
glucose  (ISO)
Guanabenz  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
malathion  (ISO)
maneb  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenol red  (ISO)
picrotoxin  (EXP)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
quercetin  (ISO)
reserpine  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA,ISO,ISS)
centrosome  (IDA,IEA,ISO)
cytoplasm  (IBA,IDA,ISO)
heterotrimeric G-protein complex  (IBA,IEA,TAS)
midbody  (IEA,ISO,ISS)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IDA,ISO,TAS)
protein-containing complex  (IDA)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
2. Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Berghuis AM, etal., Structure. 1996 Nov 15;4(11):1277-90.
3. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. Cho H and Kehrl JH, J Cell Biol. 2007 Jul 16;178(2):245-55.
4. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. Clement N, etal., J Cell Physiol. 2006 Sep;208(3):495-505.
5. Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Coleman DE, etal., Science. 1994 Sep 2;265(5177):1405-12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
8. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Jones DT and Reed RR, J Biol Chem 1987 Oct 15;262(29):14241-9.
9. Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins. Kapoor N, etal., J Mol Biol. 2009 Nov 6;393(4):882-97. doi: 10.1016/j.jmb.2009.08.043. Epub 2009 Aug 22.
10. A conserved phenylalanine as a relay between the alpha5 helix and the GDP binding region of heterotrimeric Gi protein alpha subunit. Kaya AI, etal., J Biol Chem. 2014 Aug 29;289(35):24475-87. doi: 10.1074/jbc.M114.572875. Epub 2014 Jul 18.
11. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mannoury la Cour C, etal., Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Shu FJ, etal., Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.
22. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. Straiker AJ, etal., J Neurosci 2002 Apr 1;22(7):2460-8.
23. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, etal., J Biol Chem 2003 Mar 7;278(10):8356-62.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Tesmer JJ, etal., Cell. 1997 Apr 18;89(2):251-61.
26. Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Vellano CP, etal., Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.
27. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:7937899   PMID:8521505   PMID:9705312   PMID:9772163   PMID:11121039   PMID:15381255   PMID:15866880   PMID:16805845   PMID:17406063   PMID:17897319   PMID:18162186   PMID:18356833  
PMID:18541531   PMID:19056867   PMID:19151257   PMID:19252090   PMID:20679342   PMID:21853086   PMID:22230296   PMID:22327364   PMID:22871113   PMID:23027904   PMID:23250758   PMID:23870127  
PMID:24596087   PMID:26253820   PMID:26620557   PMID:26766442   PMID:27558716   PMID:27936598   PMID:28627018   PMID:29476059  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2416,814,000 - 16,898,119 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl416,814,001 - 16,896,417 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx421,928,981 - 22,013,064 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0417,743,905 - 17,829,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,126,937 - 16,211,023 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0413,405,136 - 13,486,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0413,388,073 - 13,470,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4412,465,089 - 12,495,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1412,465,088 - 12,495,028 (+)NCBI
Celera412,346,868 - 12,428,695 (+)NCBICelera
RH 3.4 Map449.5RGD
Cytogenetic Map4q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38780,134,831 - 80,226,181 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl779,768,028 - 80,226,181 (+)EnsemblGRCh38hg38GRCh38
GRCh37779,764,147 - 79,855,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36779,602,076 - 79,686,661 (+)NCBINCBI36Build 36hg18NCBI36
Build 34779,408,790 - 79,493,376NCBI
Celera774,464,804 - 74,549,389 (+)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef774,366,659 - 74,451,137 (+)NCBIHuRef
CHM1_1779,694,209 - 79,778,804 (+)NCBICHM1_1
T2T-CHM13v2.0781,386,157 - 81,477,526 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2779,095,649 - 79,180,223 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39518,470,133 - 18,565,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl518,470,133 - 18,565,353 (-)EnsemblGRCm39 Ensembl
GRCm38518,265,135 - 18,360,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl518,265,135 - 18,360,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv37517,770,953 - 17,866,231 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36517,776,959 - 17,872,237 (-)NCBIMGSCv36mm8
Celera515,230,415 - 15,321,001 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.16NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554105,388,184 - 5,467,022 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554105,388,184 - 5,467,022 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan17146,254,502 - 146,339,684 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0772,102,937 - 72,188,124 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1785,766,875 - 85,851,283 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl785,812,249 - 85,851,283 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11819,924,381 - 19,952,956 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1819,924,235 - 19,951,244 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1819,541,512 - 19,621,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01820,317,597 - 20,397,882 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1820,317,438 - 20,397,882 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11819,944,408 - 20,024,681 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01819,496,206 - 19,576,670 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01820,152,237 - 20,232,734 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511861,784,125 - 61,867,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936810353,067 - 438,337 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936810353,405 - 435,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9100,187,843 - 100,272,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19100,187,878 - 100,272,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29110,559,455 - 110,592,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12168,687,809 - 68,770,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2168,687,307 - 68,770,360 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604235,173,786 - 35,256,485 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473928,995,179 - 29,073,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473928,995,173 - 29,074,354 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gnai1
493 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:250
Interacting mature miRNAs:294
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2416,895,497 - 16,895,689 (+)MAPPERmRatBN7.2
Rnor_6.0413,485,947 - 13,486,138NCBIRnor6.0
Rnor_5.0413,469,360 - 13,469,551UniSTSRnor5.0
RGSC_v3.4412,494,109 - 12,494,300UniSTSRGSC3.4
Celera412,427,776 - 12,427,967UniSTS
RH 3.4 Map449.5UniSTS
Cytogenetic Map4q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 20 8 6 5 6 74 35 40 11
Low 1 23 49 35 14 35 8 11 1 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000091004   ⟹   ENSRNOP00000074036
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl416,814,001 - 16,896,417 (+)Ensembl
Rnor_6.0 Ensembl413,405,136 - 13,485,883 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111453   ⟹   ENSRNOP00000077802
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl416,866,173 - 16,896,417 (+)Ensembl
RefSeq Acc Id: NM_013145   ⟹   NP_037277
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2416,814,000 - 16,898,119 (+)NCBI
Rnor_6.0413,405,136 - 13,486,866 (+)NCBI
Rnor_5.0413,388,073 - 13,470,279 (+)NCBI
RGSC_v3.4412,465,089 - 12,495,028 (+)RGD
Celera412,346,868 - 12,428,695 (+)RGD
RefSeq Acc Id: NP_037277   ⟸   NM_013145
- UniProtKB: Q45QN2 (UniProtKB/Swiss-Prot),   P10824 (UniProtKB/Swiss-Prot),   Q45QM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074036   ⟸   ENSRNOT00000091004
RefSeq Acc Id: ENSRNOP00000077802   ⟸   ENSRNOT00000111453
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10824-F1-model_v2 AlphaFold P10824 1-354 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692817
Promoter ID:EPDNEW_R3341
Type:initiation region
Description:G protein subunit alpha i1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0413,405,098 - 13,405,158EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2713 AgrOrtholog
BioCyc Gene G2FUF-45919 BioCyc
Ensembl Genes ENSRNOG00000057096 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021986 UniProtKB/Swiss-Prot
  ENSRNOG00060012765 UniProtKB/Swiss-Prot
  ENSRNOG00065016882 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091004 ENTREZGENE
  ENSRNOT00000091004.2 UniProtKB/Swiss-Prot
  ENSRNOT00000111453.1 UniProtKB/TrEMBL
  ENSRNOT00055037843 UniProtKB/Swiss-Prot
  ENSRNOT00060021730 UniProtKB/Swiss-Prot
  ENSRNOT00065028267 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25686 UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnai1 PhenoGen
  GPROTEINAI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057096 RatGTEx
  ENSRNOG00055021986 RatGTEx
  ENSRNOG00060012765 RatGTEx
  ENSRNOG00065016882 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234720
UniProt A0A8I5Y7W9_RAT UniProtKB/TrEMBL
UniProt Secondary Q45QN2 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnai1  G protein subunit alpha i1  Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1  Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Gnai1  guanine nucleotide binding protein (G protein), alpha inhibiting 1  Gnai1  guanine nucleotide binding protein, alpha inhibiting 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gnai1  Guanine nucleotide binding protein, alpha inhibiting 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in olfactory, brain, kidney, lung, and intestine 632848
gene_expression mRNA-abundant in hippocampus 625670
gene_process selectively interacts with different G-protein coupled receptors 625670
gene_process involved in presynaptic inhibition 625670