RGD Reference Report - mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. - Rat Genome Database

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mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.

Authors: Sans, Nathalie  Wang, Philip Y  Du, Quansheng  Petralia, Ronald S  Wang, Ya-Xian  Nakka, Sajan  Blumer, Joe B  Macara, Ian G  Wenthold, Robert J 
Citation: Sans N, etal., Nat Cell Biol. 2005 Dec;7(12):1179-90. doi: 10.1038/ncb1325. Epub 2005 Nov 20.
RGD ID: 405650352
Pubmed: PMID:16299499   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb1325   (Journal Full-text)

Appropriate trafficking and targeting of glutamate receptors (GluRs) to the postsynaptic density is crucial for synaptic function. We show that mPins (mammalian homologue of Drosophila melanogaster partner of inscuteable) interacts with SAP102 and PSD-95 (two PDZ proteins present in neurons), and functions in the formation of the NMDAR-MAGUK (N-methyl-D-aspartate receptor-membrane-associated guanylate kinase) complex. mPins enhances trafficking of SAP102 and NMDARs to the plasma membrane in neurons. Expression of dominant-negative constructs and short-interfering RNA (siRNA)-mediated knockdown of mPins decreases SAP102 in dendrites and modifies surface expression of NMDARs. mPins changes the number and morphology of dendritic spines and these effects depend on its Galphai interaction domain, thus implicating G-protein signalling in the regulation of postsynaptic structure and trafficking of GluRs.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gnai1Ratglutamatergic synapse is_active_inIDA PMID:16299499SynGO 
Gnai1Ratglutamatergic synapse is_active_inIEP PMID:16299499SynGO 
Gnai1Ratglutamatergic synapse is_active_inNAS PMID:16299499SynGO 
Gnai1Ratpostsynapse is_active_inIDA PMID:16299499SynGO 
Gnai1Ratpostsynapse is_active_inIEP PMID:16299499SynGO 
Gnai1Ratpostsynapse is_active_inNAS PMID:16299499SynGO 
Gpsm2Ratpostsynaptic density is_active_inIDA PMID:16299499SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Gnai1  (G protein subunit alpha i1)
Gpsm2  (G-protein signaling modulator 2)


Additional Information