Gna11 (G protein subunit alpha 11) - Rat Genome Database

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Gene: Gna11 (G protein subunit alpha 11) Rattus norvegicus
Symbol: Gna11
Name: G protein subunit alpha 11
RGD ID: 619749
Description: Enables alkylglycerophosphoethanolamine phosphodiesterase activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; multicellular organism aging; and positive regulation of insulin secretion. Predicted to act upstream of or within several processes, including cellular response to pH; regulation of melanocyte differentiation; and skeletal system development. Located in cytosol and plasma membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; angiotensin II signaling pathway via AT1 receptor; eicosanoid signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: g alpha-11; G-protein subunit alpha-11; guanine nucleotide binding protein, alpha 11; guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1k; Hg1k
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.278,163,752 - 8,177,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,162,750 - 8,179,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,049,827 - 11,063,675 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,925,490 - 12,939,339 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,792,631 - 10,806,445 (+)NCBIRnor_WKY
Rnor_6.0711,033,400 - 11,047,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,033,317 - 11,047,437 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,200,712 - 11,214,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,636,748 - 9,662,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,636,747 - 9,662,492 (+)NCBI
Celera76,354,654 - 6,368,340 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity. Aoyama C, etal., Biochem J. 2011 Dec 1;440(2):241-50. doi: 10.1042/BJ20110545.
2. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. Bangasser DA, etal., Mol Psychiatry. 2010 Sep;15(9):877, 896-904. Epub 2010 Jun 15.
3. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
4. Short-term cocaine treatment causes neuroadaptive changes in Galphaq and Galpha11 proteins in rats undergoing withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):349-55. Epub 2004 Jun 2.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
8. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
9. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
10. An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine. Mannoury La Cour C, etal., Synapse. 2009 Feb;63(2):95-105.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Chronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytes. Rachdaoui N, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E303-10.
18. Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Rahman MA, etal., Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):379-86.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
Additional References at PubMed
PMID:10818132   PMID:11438569   PMID:15322542   PMID:15574748   PMID:15716410   PMID:16365309   PMID:17110338   PMID:17194762   PMID:17897319   PMID:18703424   PMID:18820027   PMID:19056867  
PMID:19199708   PMID:20036247   PMID:20393598   PMID:21464134   PMID:21649864   PMID:22733973   PMID:23376485   PMID:23533145   PMID:23696743  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.278,163,752 - 8,177,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,162,750 - 8,179,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,049,827 - 11,063,675 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,925,490 - 12,939,339 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,792,631 - 10,806,445 (+)NCBIRnor_WKY
Rnor_6.0711,033,400 - 11,047,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,033,317 - 11,047,437 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,200,712 - 11,214,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,636,748 - 9,662,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,636,747 - 9,662,492 (+)NCBI
Celera76,354,654 - 6,368,340 (+)NCBICelera
Cytogenetic Map7q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38193,094,362 - 3,123,999 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,094,362 - 3,123,999 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,094,360 - 3,123,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,045,408 - 3,072,468 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,045,529 - 3,072,452NCBI
Celera193,028,658 - 3,055,719 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,861,199 - 2,888,094 (+)NCBIHuRef
CHM1_1193,110,108 - 3,121,429 (+)NCBICHM1_1
T2T-CHM13v2.0193,068,114 - 3,097,735 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391081,364,558 - 81,380,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,364,558 - 81,381,024 (-)EnsemblGRCm39 Ensembl
GRCm381081,528,724 - 81,545,162 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,528,724 - 81,545,190 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,991,477 - 81,007,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,931,861 - 80,948,175 (-)NCBIMGSCv36mm8
Celera1082,551,913 - 82,568,227 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554955,285,380 - 5,302,631 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,286,891 - 5,302,631 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1193,074,484 - 3,102,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,074,483 - 3,102,124 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,120,398 - 2,149,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
Dog10K_Boxer_Tasha2055,871,216 - 55,890,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,806,259 - 56,825,830 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,806,259 - 56,825,830 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,861,412 - 55,880,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,345,542 - 56,365,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,544,290 - 56,563,840 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118216,045,637 - 216,064,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,770,771 - 1,789,170 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365881,770,777 - 1,789,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl275,437,201 - 75,457,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,439,405 - 75,456,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,071,093 - 76,088,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21-q24NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.162,858,880 - 2,887,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,858,937 - 2,887,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,694,672 - 5,723,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248286,077,851 - 6,093,750 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,078,485 - 6,093,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gna11
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:96
Interacting mature miRNAs:102
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 36 45 34 11 34 1 4 74 35 37 11 1
Low 7 12 7 8 7 7 7 4 7
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007498   ⟹   ENSRNOP00000007498
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,163,406 - 8,179,812 (+)Ensembl
Rnor_6.0 Ensembl711,033,317 - 11,047,437 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111043   ⟹   ENSRNOP00000081654
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,162,750 - 8,179,812 (+)Ensembl
RefSeq Acc Id: NM_031033   ⟹   NP_112295
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,163,752 - 8,177,636 (+)NCBI
Rnor_6.0711,033,400 - 11,047,284 (+)NCBI
Rnor_5.0711,200,712 - 11,214,475 (+)NCBI
RGSC_v3.479,636,748 - 9,662,492 (+)RGD
Celera76,354,654 - 6,368,340 (+)RGD
Protein Sequences
Protein RefSeqs NP_112295 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53112 (Get FASTA)   NCBI Sequence Viewer  
  AAF81690 (Get FASTA)   NCBI Sequence Viewer  
  CAG9553616 (Get FASTA)   NCBI Sequence Viewer  
  EDL89141 (Get FASTA)   NCBI Sequence Viewer  
  Q9JID2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112295   ⟸   NM_031033
- UniProtKB: G3V6Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007498   ⟸   ENSRNOT00000007498
RefSeq Acc Id: ENSRNOP00000081654   ⟸   ENSRNOT00000111043
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JID2-F1-model_v2 AlphaFold Q9JID2 1-359 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694968
Promoter ID:EPDNEW_R5493
Type:initiation region
Description:G protein subunit alpha 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,033,230 - 11,033,290EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619749 AgrOrtholog
BioCyc Gene G2FUF-35039 BioCyc
Ensembl Genes ENSRNOG00000005446 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007498 ENTREZGENE
  ENSRNOP00000007498.3 UniProtKB/TrEMBL
  ENSRNOP00000081654.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007498 ENTREZGENE
  ENSRNOT00000007498.5 UniProtKB/TrEMBL
  ENSRNOT00000111043.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81662 UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gna11 PhenoGen
  GPROTEINAQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6A0_RAT UniProtKB/TrEMBL
  GNA11_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Gna11  G protein subunit alpha 11  Gna11  guanine nucleotide binding protein, alpha 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gna11  guanine nucleotide binding protein, alpha 11    guanine nucleotide-binding protein alpha 11 subunit  Name updated 1299863 APPROVED
2002-08-07 Gna11  guanine nucleotide-binding protein alpha 11 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein expression decreased by chronic ethanol feeding 708317