Gene: GNA11 (G protein subunit alpha 11) Pan paniscus

Analyze

Symbol:

GNA11

Name:

G protein subunit alpha 11

RGD ID:

11781456

Description:

ENCODES a protein that exhibits alkylglycerophosphoethanolamine phosphodiesterase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN action potential (ortholog); cellular response to pH (ortholog); cranial skeletal system development (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; angiotensin II signaling pathway via AT1 receptor; eicosanoid signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant hypocalcemia 2 (ortholog); CLOVES syndrome (ortholog); FOUND IN presynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

guanine nucleotide-binding protein subunit alpha-11

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	7,490,517 - 7,520,487 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	6,723,350 - 6,753,319 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	2,120,398 - 2,149,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,074,484 - 3,102,124 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	3,074,483 - 3,102,124 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal dominant hypocalcemia 2 (ISO)

CLOVES syndrome (ISO)

congenital heart disease (ISO)

Craniofacial Abnormalities (ISO)

disease of cellular proliferation (ISO)

familial hypocalciuric hypercalcemia 2 (ISO)

familial multiple nevi flammei (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

melanoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uveal melanoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (ISO)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IEA)

cellular response to pH (ISO)

cranial skeletal system development (ISO)

developmental pigmentation (ISO)

endothelin receptor signaling pathway (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

glutamate receptor signaling pathway (ISO)

heart development (ISO)

phospholipase C-activating dopamine receptor signaling pathway (IEA,ISO)

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

regulation of blood pressure (ISO)

regulation of melanocyte differentiation (ISO)

signal transduction (IEA)

skeletal system development (ISO)

Cellular Component

cytoplasm (IEA)

cytoplasmic side of plasma membrane (IEA)

heterotrimeric G-protein complex (IEA)

plasma membrane (IEA)

presynapse (ISO)

Molecular Function

alkylglycerophosphoethanolamine phosphodiesterase activity (ISO)

G protein activity (IEA)

G protein-coupled receptor binding (IEA)

G-protein beta/gamma-subunit complex binding (IEA)

GTP binding (IEA)

GTPase activity (IEA)

guanyl nucleotide binding (IEA)

metal ion binding (IEA)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family (ISO)

angiotensin II signaling pathway via AT1 receptor (ISO)

eicosanoid signaling pathway (ISO)

endothelin signaling pathway (ISO)

G protein mediated signaling pathway via Galphaq family (ISO)

oxytocin signaling pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

vasopressin signaling pathway (ISO)

vasopressin signaling pathway via receptor type 1 (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GNA11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	7,490,517 - 7,520,487 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	6,723,350 - 6,753,319 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	2,120,398 - 2,149,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	3,074,484 - 3,102,124 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	3,074,483 - 3,102,124 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

GNA11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	3,094,362 - 3,123,999 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	3,094,320 - 3,124,001 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	19	3,094,360 - 3,123,997 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	3,045,408 - 3,072,468 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	3,045,529 - 3,072,452	NCBI
Celera	19	3,028,658 - 3,055,719 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,861,199 - 2,888,094 (+)	NCBI		HuRef
CHM1_1	19	3,110,108 - 3,121,429 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	3,068,114 - 3,097,735 (+)	NCBI		T2T-CHM13v2.0

Gna11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	81,364,558 - 81,380,996 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	81,364,558 - 81,381,060 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	81,528,724 - 81,545,162 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	81,528,724 - 81,545,190 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	10	80,991,477 - 81,007,791 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,931,861 - 80,948,175 (-)	NCBI		MGSCv36	mm8
Celera	10	82,551,913 - 82,568,227 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Gna11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	8,814,285 - 8,828,628 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	8,814,327 - 8,830,558 (+)	Ensembl				GRCr8
mRatBN7.2	7	8,163,520 - 8,177,863 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,162,750 - 8,179,812 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	11,049,827 - 11,063,675 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	12,925,490 - 12,939,339 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	10,792,631 - 10,806,445 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	7	11,572,554 - 11,586,830 (+)	NCBI
Lyon_Normotensive	7	11,735,866 - 11,750,142 (+)	NCBI
Lyon_Hypertensive	7	11,810,884 - 11,825,160 (+)	NCBI
F344_StmMcwi	7	10,176,879 - 10,191,155 (+)	NCBI
Rnor_6.0	7	11,033,400 - 11,047,284 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,033,317 - 11,047,437 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	7	11,200,712 - 11,214,475 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	9,636,748 - 9,662,492 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	6,354,654 - 6,368,340 (+)	NCBI		Celera
RGSC_v3.1	7	9,636,747 - 9,662,492 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

Gna11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,285,380 - 5,302,631 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955495	5,286,891 - 5,302,631 (-)	NCBI	ChiLan1.0	ChiLan1.0

GNA11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	20	55,871,216 - 55,890,787 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,806,259 - 56,825,830 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,806,259 - 56,825,830 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,861,412 - 55,880,956 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	56,345,542 - 56,365,145 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	56,544,290 - 56,563,840 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gna11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	2	1,911,561 - 1,929,971 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405118	216,045,637 - 216,064,006 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,770,771 - 1,789,170 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,770,777 - 1,789,143 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNA11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	75,437,201 - 75,457,092 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	2	75,439,405 - 75,456,855 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	76,071,093 - 76,088,406 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	2	q21-q24	NCBI

GNA11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	6	59,469,652 - 59,498,779 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666081	5,694,672 - 5,723,312 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	6	2,858,880 - 2,887,694 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	2,858,937 - 2,887,704 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Gna11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	6,078,485 - 6,093,744 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624828	6,077,851 - 6,093,750 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Gna11
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	153,345,555 - 153,361,830 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008972605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054532 ⟹ ENSPPAP00000031667

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	3,074,483 - 3,102,124 (+)	Ensembl

RefSeq Acc Id:

XM_008972605 ⟹ XP_008970853

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	7,490,517 - 7,520,487 (+)	NCBI
NHGRI_mPanPan1	19	6,723,350 - 6,753,319 (+)	NCBI
Mhudiblu_PPA_v0	19	2,120,398 - 2,149,161 (+)	NCBI
PanPan1.1	19	3,074,484 - 3,102,124 (+)	NCBI

Sequence:

show sequence

AGCTGCTGCTGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGCATCAT
CCACGGTGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTACCAGAACATC
TTCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTCTACAAGTACGAGC
AGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAGGTGACCACCTTCGAGCA
TCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGCATCCAGGAATGCTACGACCGC
AGGCGCGAGTACCAGCTCTCCGACTCCGCCAAGTACTACCTGACCGACGTTGACCGCATCGCCA
CCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTGCGGGTCCGCGTGCCCACCACCGGCATCAT
CGAGTACCCTTTCGACCTGGAGAACATCATCTTCCGGATGGTGGATGTGGGGGGCCAGCGGTCG
GAGCGGAGGAAGTGGATCCACTGCTTTGAGAACGTGACATCCATCATGTTTCTCGTCGCCCTCA
GCGAATACGACCAAGTCCTGGTGGAGTCGGACAACGAGAACCGGATGGAGGAGAGCAAAGCCCT
GTTCCGGACCATCATCACCTACCCCTGGTTCCAGAACTCCTCCGTCATCCTCTTCCTCAACAAG
AAGGACCTGCTGGAGGACAAGATCCTGTACTCGCACCTGGTGGACTACTTCCCCGAGTTCGACG
GTCCCCAGCGGGACGCCCAGGCGGCGCGGGAGTTCATCCTGAAGATGTTCGTGGACCTGAACCC
CGACAGCGACAAGATCATCTACTCACACTTCACGTGTGCCACCGACACGGAGAACATCCGCTTC
GTGTTCGCGGCCGTGAAGGACACCATCCTGCAGCTCAACCTCAAGGAGTACAACCTGGTCTGAG
CGCCCAGGCCCAGGGAGACGGGACGGAGACACGGGGCAGGACCTTCCTTCCACGGAGCCTGCGG
CTGCCGGGCGGGTGGCGCTGCCGAGTCCGGGCCGGGGCCTCTGCCCGCGGGAGGAGATTTTTTT
TTTTCATATTTTTAACAAATGGTTTTTATTTCACAGTTATCAGGGGATGTACATCTCTCCCTCC
GTACACTTCGCGCACCTTCTCACCTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008970853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000031667.1
	ENSPPAP00050014585

RefSeq Acc Id:

XP_008970853 ⟸ XM_008972605

- UniProtKB:

A0A2R9BYS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVT
TFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPT
TGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEE
SKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFV
DLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

hide sequence

Ensembl Acc Id:

ENSPPAP00000031667 ⟸ ENSPPAT00000054532

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038754	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050011179	ENTREZGENE
Ensembl Transcript	ENSPPAT00000054532.1	UniProtKB/TrEMBL
	ENSPPAT00050023422	ENTREZGENE
Gene3D-CATH	1.10.400.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	Gprotein_alpha_Q	UniProtKB/TrEMBL
	Gprotein_alpha_su	UniProtKB/TrEMBL
	GproteinA_insert	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	GNA11	ENTREZGENE
PANTHER	GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11	UniProtKB/TrEMBL
	PTHR10218	UniProtKB/TrEMBL
Pfam	G-alpha	UniProtKB/TrEMBL
PRINTS	GPROTEINA	UniProtKB/TrEMBL
	GPROTEINAQ	UniProtKB/TrEMBL
PROSITE	G_ALPHA	UniProtKB/TrEMBL
SMART	G_alpha	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47895	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A2R9BYS3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)