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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620243
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gnai2
Name: G protein subunit alpha i2
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnai2decreases expressionEXP 6480464CTDGlucose results in decreased expression of GNAI2 proteinPMID:18441196
Gnai2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]PMID:18441196
Gnai2multiple interactionsISOGnai2 (Mus musculus)6480464CTDGNAI2 gene mutant form inhibits the reaction [[Glucose co-treated with Amino Acids] results in increased secretion of INS1 protein]; GNAI2 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]PMID:25205820
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