Hyal1 (hyaluronidase 1) - Rat Genome Database

Name: Hyal1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Hyal1 (hyaluronidase 1) Rattus norvegicus

Analyze

Symbol:

Hyal1

Name:

hyaluronidase 1

RGD ID:

1303060

Description:

Predicted to have hyaluronan synthase activity; hyalurononglucosaminidase activity; and transcription factor binding activity. Predicted to be involved in several processes, including hyaluronan metabolic process; regulation of cell growth; and skeletal system development. Predicted to localize to several cellular components, including extracellular space; hyaluranon cable; and lysosome. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in mucopolysaccharidosis and mucopolysaccharidosis IX. Orthologous to human HYAL1 (hyaluronidase 1); PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

hyal-1; hyaluronidase-1; hyaluronoglucosaminidase 1; hyaluronoglucosaminidase-1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HYAL1 (hyaluronidase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hyal1 (hyaluronoglucosaminidase 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Hyal1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HYAL1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HYAL1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hyal1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HYAL1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	HYAL1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hyal1 (hyaluronidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HYAL1 (hyaluronidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Hyal1 (hyaluronoglucosaminidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	chhy-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	108,250,654 - 108,254,526 (+)	NCBI
Rnor_6.0 Ensembl	8	116,332,796 - 116,335,435 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	116,332,834 - 116,337,522 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	115,689,184 - 115,691,497 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,824,562 - 112,826,875 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	112,844,016 - 112,846,330 (+)	NCBI
Celera	8	107,557,375 - 107,559,688 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Kidney Reperfusion Injury (IEP)

mucopolysaccharidosis (ISO)

mucopolysaccharidosis IX (ISO)

pulmonary hypertension (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-hexachlorocyclohexane (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (EXP)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

enalapril (EXP)

endosulfan (EXP)

entinostat (ISO)

fenamidone (ISO)

ferric oxide (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

glyphosate (EXP)

Heptachlor epoxide (ISO)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propanal (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

cartilage development (IEA,ISO,ISS)

cellular response to fibroblast growth factor stimulus (IEA,ISO)

cellular response to interleukin-1 (IEA,ISO,ISS)

cellular response to pH (IEA,ISO,ISS)

cellular response to platelet-derived growth factor stimulus (IEA,ISO,ISS)

cellular response to tumor necrosis factor (IEA,ISO)

cellular response to UV-B (IEA,ISO,ISS)

embryonic skeletal joint morphogenesis (IEA,ISO)

hyaluronan biosynthetic process (IEA,ISO,ISS)

hyaluronan catabolic process (IBA,IEA,ISO)

hyaluronan metabolic process (ISO,ISS)

inflammatory response (IEA,ISO,ISS)

negative regulation of cell growth (IEA,ISO,ISS)

positive regulation of angiogenesis (IEA,ISO,ISS)

positive regulation of cell adhesion (IEA,ISO,ISS)

positive regulation of cell growth (IEA,ISO,ISS)

positive regulation of epithelial cell migration (IEA,ISO,ISS)

positive regulation of epithelial cell proliferation (IEA,ISO,ISS)

positive regulation of G1/S transition of mitotic cell cycle (IEA,ISO,ISS)

positive regulation of growth (ISO,ISS)

positive regulation of hyaluranon cable assembly (IEA,ISO,ISS)

response to antibiotic (IEA,ISO,ISS)

response to reactive oxygen species (IEA,ISO,ISS)

response to virus (IEA,ISO,ISS)

viral entry into host cell (IEA)

Cellular Component

cytoplasm (ISO,ISS)

cytoplasmic vesicle (IBA,IEA,ISO,ISS)

extracellular space (IEA,ISO,ISS)

hyaluranon cable (IEA,ISO,ISS)

lysosome (IEA,ISO,ISS)

Molecular Function

hyaluronan synthase activity (IEA,ISO,ISS)

hyalurononglucosaminidase activity (IEA,ISO)

virus receptor activity (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

glycosaminoglycan degradation pathway (IEA)

References

References - curated


1.	Decleves AE, etal., Nephrol Dial Transplant. 2012 Oct;27(10):3771-81. doi: 10.1093/ndt/gfs098. Epub 2012 Apr 23.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Jacobson A, etal., Int J Cancer 2002 Nov 20;102(3):212-9.
4.	OMIM Disease Annotation Pipeline
5.	Ormiston ML, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L148-57. doi: 10.1152/ajplung.00097.2009. Epub 2009 Nov 13.
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	RGD automated data pipeline
8.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	RGD automated import pipeline for gene-chemical interactions
10.	Triggs-Raine B, etal., Proc Natl Acad Sci U S A. 1999 May 25;96(11):6296-300.

Additional References at PubMed

PMID:9223416	PMID:11296287	PMID:11944887	PMID:12084718	PMID:16600643	PMID:16837837	PMID:16900089	PMID:17170110	PMID:17324121	PMID:18390475	PMID:18718911	PMID:18725949
PMID:18772348	PMID:19478093	PMID:19577615	PMID:20473947	PMID:20554532	PMID:20572808	PMID:21695196	PMID:21699545	PMID:21829529	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Hyal1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	108,250,654 - 108,254,526 (+)	NCBI
Rnor_6.0 Ensembl	8	116,332,796 - 116,335,435 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	116,332,834 - 116,337,522 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	115,689,184 - 115,691,497 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,824,562 - 112,826,875 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	112,844,016 - 112,846,330 (+)	NCBI
Celera	8	107,557,375 - 107,559,688 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

HYAL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	50,299,890 - 50,312,381 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	50,299,889 - 50,312,951 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	50,337,324 - 50,349,812 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,312,324 - 50,324,816 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	50,312,324 - 50,316,008	NCBI
Celera	3	50,310,151 - 50,322,647 (-)	NCBI
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,393,063 - 50,405,514 (-)	NCBI		HuRef
CHM1_1	3	50,289,626 - 50,302,099 (-)	NCBI		CHM1_1

Hyal1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,454,149 - 107,458,898 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	107,454,126 - 107,458,909 (+)	Ensembl
GRCm38	9	107,576,950 - 107,581,699 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,576,927 - 107,581,710 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,479,283 - 107,482,468 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	107,435,053 - 107,438,238 (+)	NCBI			mm8
Celera	9	107,185,725 - 107,188,909 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	58.17	NCBI

Hyal1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,112,771 - 2,115,952 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,113,016 - 2,116,093 (-)	NCBI	ChiLan1.0	ChiLan1.0

HYAL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	51,463,239 - 51,473,030 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,463,239 - 51,467,286 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	50,228,491 - 50,238,798 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

HYAL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,035,924 - 39,040,443 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,038,514 - 39,040,368 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	38,955,644 - 38,961,480 (+)	NCBI
ROS_Cfam_1.0	20	39,390,640 - 39,396,476 (+)	NCBI
UMICH_Zoey_3.1	20	38,758,465 - 38,764,301 (+)	NCBI
UNSW_CanFamBas_1.0	20	39,162,014 - 39,167,822 (+)	NCBI
UU_Cfam_GSD_1.0	20	39,442,045 - 39,447,881 (+)	NCBI

Hyal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	65,077,652 - 65,080,619 (-)	NCBI
SpeTri2.0	NW_004936529	1,838,212 - 1,842,399 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HYAL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,793,569 - 32,800,796 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	32,798,135 - 32,800,705 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,976,670 - 35,979,238 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	13	q21	NCBI

HYAL1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,689,123 - 11,693,144 (-)	NCBI
ChlSab1.1 Ensembl	22	11,688,970 - 11,693,183 (-)	Ensembl

Hyal1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	4,161,204 - 4,165,554 (-)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	9531047	119211942	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10938911	120496129	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	44458129	118087517	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	50529480	128036471	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	65717449	128033050	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	72849686	117849686	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight as a percentage of body weight (CMO:0000654)	8	74917593	121080545	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	76103982	127182642	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	78805083	123805083	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	78805083	123805083	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	78805083	123805083	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	78805083	123805083	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	80697934	125697934	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	83894304	128894304	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	89058229	132243842	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	95963141	122354314	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	100873811	133307652	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102051964	133307652	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	104682575	133307652	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	104682575	133307652	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	107769005	129956433	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	110212979	116947981	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	40
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000021408
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2	24	14	13	14	2	4	3	17	13	11	2
Low	3	41	33	27	6	27	6	7	71	18	28		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_207616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB100600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC139927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000021408 ⟹ ENSRNOP00000021408

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	116,332,796 - 116,335,435 (+)	Ensembl

RefSeq Acc Id:

NM_207616 ⟹ NP_997499

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	108,250,797 - 108,253,110 (+)	NCBI
Rnor_6.0	8	116,332,924 - 116,335,237 (+)	NCBI
Rnor_5.0	8	115,689,184 - 115,691,497 (+)	NCBI
RGSC_v3.4	8	112,824,562 - 112,826,875 (+)	RGD
Celera	8	107,557,375 - 107,559,688 (+)	RGD

Sequence:

show sequence

ATGAAGCCCTTCAGTCCTGAGGTTTCCCCAGACCCATGCCCTGCCACTGCAGCCCACCTGCTTC
GCACCTACACGCTCTTCCTGACCTTGCTGGAGTTGGCCCAAGGTTGCAGAGGTTCCATGGTATC
CAACCGGCCGTTCATCACTGTTTGGAATGCAGACACTCACTGGTGCCTGAAGGACCACGGAGTG
GATGTGGATGTCAGTGTCTTCGACGTGGTTGCCAACAAGGAGCAGAATTTCCAAGGCCCCAACA
TGACTATTTTCTACCGAGAGGAGTTGGGCACCTACCCCTACTATACACCCACCGGGGAACCCGT
ATTTGGTGGTCTGCCCCAGAATGCCAGCCTGGTTACCCACCTTGCTCACGCATTCCAGGACATC
AAGGCTGCCATGCCTGAACCTGACTTCTCGGGACTGGCGGTCATTGATTGGGAGGCTTGGCGCC
CACGATGGGCCTTCAACTGGGACAGCAAGGACATTTATCAGCAGCGCTCAATGGAACTGGTCCG
GGCAGAGCACCCTGATTGGCCAGAAACTTTAGTGGAAGCAGAAGCCCAAGGCCAGTTCCAGGAA
GCTGCAGAGGCCTGGATGGCAGGGACCCTCCAACTGGGGCAGGTACTGCGTCCCCGTGGCCTCT
GGGGCTACTATGGCTTCCCTGACTGCTACAACTACGACTTTCTAAGTCCCAACTACACAGGCCA
GTGCTCACTGAGCATCCATGATCAGAATGACCAGCTAGGGTGGTTGTGGAACCAGAGCTATGCC
CTTTACCCCAGTATTTACTTGCCTGCAGCACTGATGGGCACAGGGAAGTCACAGATGTATGTTC
GATACCGTGTGCAAGAGGCGTTCCGTTTGGCTTTAGTTTCCAGAGACCCTCATGTGCCCATAAT
GCCCTACGTCCAAATCTTCTATGAAAAGACAGATTATCTTCTACCCCTGGAGGAGCTGGAGCAC
AGCCTGGGAGAGAGTGCAGCCCAGGGAGCGGCAGGAGCAGTGCTCTGGATAAGCTCAGAAAAAA
CAAGTACCAAGGAGTCATGCCAAGCCATTAAAGCATACATGGATTCCACACTCGGACCCTTTAT
CCTGAACGTAACCAGTGCAGCTCTTTTGTGCAGCGAAGCTCTGTGTTCTGGCCGTGGTCGTTGT
GTCCGCCATCCCAGTTACCCTGAGGCTCTCCTCACCCTCAGCCCTGCCAGCTTCTCCATTGAGC
CAACACATGATGGCAGACCCCTGAGCCTCAAGGGTACCCTCTCGCTTAAGGATCGGGCACAGAT
GGCTATGAAATTCAAGTGTCGATGCTACCGTGGATGGAGTGGAGAGTGGTGTAAGAAGCAGGAT
ATGTAG

hide sequence

RefSeq Acc Id:

XM_017595794 ⟹ XP_017451283

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	108,250,654 - 108,254,526 (+)	NCBI
Rnor_6.0	8	116,332,834 - 116,337,522 (+)	NCBI

Sequence:

show sequence

TCTAAGCTGGTGCAACTAGGACCAACTTGTGGGACAGAATCCAGCCAAGCCATATTCCGGCTTA
CACAGTGTGCTCAGAAAGTTTGGAGAATGAAGCCCTTCAGTCCTGAGGTTTCCCCAGACCCATG
CCCTGCTACTGCAGCCCACCTGCTTCGCACCTACACGCTCTTCCTGACCTTGCTGGAGTTGGCC
CAAGGTTGCAGAGGTTCCATGGTATCCAACCGGCCGTTCATCACTGTTTGGAATGCAGACACTC
ACTGGTGCCTGAAGGACCACGGAGTGGATGTGGATGTCAGTGTCTTCGACGTGGTTGCCAACAA
GGAGCAGAATTTCCAAGGCCCCAACATGACTATTTTCTACCGAGAGGAGTTGGGCACCTACCCC
TACTATACACCCACCGGGGAACCCGTATTTGGTGGTCTGCCCCAGAATGCCAGCCTGGTTACCC
ACCTTGCTCACGCATTCCAGGACATCAAGGCTGCCATGCCTGAACCTGACTTCTCGGGACTGGC
GGTCATTGATTGGGAGGCTTGGCGCCCACGATGGGCCTTCAACTGGGACAGCAAGGACATTTAT
CAGCAGCGCTCAATGGAACTGGTCCGGGCAGAACACCCTGACTGGCCAGAAACTTTAGTGGAAG
CAGAAGCCCAAGACCAGTTCCAGGAAGCTGCACAGGCCTGGATGGCAGGCACCCTCCAACTGGG
GCAGGAGGAGCTGGAGCACAGCCTGGGAGAGAGTGCAGCCCAGGGAGCGGCAGGAGCAGTGCTC
TGGATAAGCTCAGAAAAAACAAGTACCAAGGAGTCATGCCAAGCCATTAAAGCATACATGGATT
CCACACTCGGACCCTTTATCCTGAACGTAACCAGTGCAGCTCTTTTGTGCAGCGAAGCTCTGTG
TTCTGGCCGTGGTCGTTGTGTCCGCCATCCCAGTTACCCTGAGGCTCTCCTCACCCTCAGCCCT
GCCAGCTTCTCCATTGAGCCAACACATGATGGCAGACCCCTGAGCCTCAAGGGTACCCTCTCGC
TTAAGGATCGGGCACAGATGGCTATGAAATTCAAGTGTCGATGCTACCGTGGATGGAGTGGAGA
GTGGTGTAAGAAGCAGGATATGTAGTGATTTGCTGCACCAGGCTGCATATACTGAACACGGGAC
ATACCCAGGGCCTACCTATGACTTCCTTACATACAGTCACACGCGCACAAATCACAGTCAGGAG
TACACTCAAGCGCTGTCATGGCCGCAATCACACGGGCACATTCACGGGGATAGTCACATAGTGA
ATCAGAATTTAGGCTAGGTACTATCAACTCTGTATCTATAAGGACCTACTCATAGGCAGTTCCT
CCAGAACCTATGAGTCAGCAGTCACAAAAGCTGACATTTGCTCTGTGCCAAGCCCTGTGCTAAG
CAAACACTAGAAGTGGGCCAACTCATTCAGTCTTTACAATCGACATGCTGGGAAGATGAGTACT
TTTTTATTTACTTACTCTGGGAGATAAACTTAGGACCTCACACACACTAGGCAAGTGCTCCAAC
ACTAAGCTATATTCCCAGCCACTGTCCAATGTTGCCCAGCAAGAATAGACAAGCAAGGCCAGGC
ATTGATGATGCTCACCCTTGATCCCAGTACTCAGGAGGCAAGGCCAGCCTGGTCTACATATTGA
GCTCCAGGACAGCCAGGACTACACAGAGCAAATTTCAGCTGTCTCAAAACAAAATGACACTGTC
TCAAAACAAAACAGCCAGGAGAGATGCATATTGAAATCTAGGCTATCTAGCTCTAAAGATAGAA
CATTGCACACCTACTGTGTGTTGATGGTGCCCTAAAAGGATTAGGGAACACAACAACATCACTG
TAAGGGTCCCTGAATCTGCTCAGAGTACTAGCATTCCCCAATCCAGCAAACGAAGCTGTCCTAT
AGTACTTAGCTGTTTAATTAGCTCCTAAAATAGGCAGGCCCCAGAACACAGAAGGTACTGGAGC
TCTACACTTTCATCCAATTGTGTTGTCTGAAGACGACTGCTTCTCATGATCAGGAGGAAGTCCC
GCCTGATCGGACCATTTCCACCGACCCACTAGGATTGGAGACGCTACTAGAGCAGAAACAAAAC
GAAACTCCCATTTCTTTGAGGCTGGAGTTGGGAGAGCTGCAGGCGGAGCTGAACACAGGAAAGC
CGCTAGAAGCCAGAGGCTGAGCGGAGAGGAGGCGGAGCCAACGAGAGGAAACTACGGGCCTAGT
CGCCACCGGAAGGGAAGAAGTCAGGGACAGAATGGGCCTACACTAGTTCTGTTGTGACGCTCAG
AACCAGGGGCGGGTGTCTAGGTGGTGACATTCCGGGCACTGAGAACATAGGAGGAGGTGCGCTG
TCTCCTGCAAAGACTGCAACGAGTCCTCCGTACTGCTGGGACCAGCGTAGGCAGACCGAAGAGT
TGGAGCCAGAGACAGCGAGTTAACCAACCGTGCGCAGGCAGGACGCGGAGCATCTTGGAACTCG
ACTTGAACATGTCAGTATCACCCTCACCTCTCACATGCTGCCCGTTTATCCTCCCTGCGCCTGT
GGTCCCTAAGTTACTGTGTTGCTCCTCAAGTCTTCCCAATGTCGGCCTTTCCCGCTTAGAACTT
GCCGAGCCACACCCACCCATAATCTCGCTTTCAAACCTCCCACTCCCAAAAGATCCGTGGCCTG
TGTCCCGCAAGGGGCAGGTGCACACCCTCCCTGAAGACCCGGAGCTTCGCTCCACCTACAGTGG
TGGGGTCCGAACTGAAGGGGTTAAATCTGTCTGGGGGTGGGGGAGGAACTCTGGCGCTCTGAGC
TAGGGGCGGACCCTTGAGGTTCCTCCTTTCTGACCTTACTTAGAAGGTGTGGAAGCTGGGGAGG
GGGTGCTGCGTCTGCTAAGTCAACTGAGGCAGGTAAGAGGCTTAAAGCCTGGTGTGTGGGATTT
GTGTGAGGAGAGAGGGCTGTCCTCAGGCTCAGGGAAAATTGGGAAAGGGGGTCTGGAGGCACGT
TCTAGAGTGAGTAAGTAAAGGAATGGAACCTGCTGCAAGAAATCCCCCAACATAGACCCTCCTG
GCAGCAGATCCTAGAATACGGTAGGTAAGCAATGGGGTTAACAGCTGGAGCGTTGTGGCCCATG
CCTTTAATCCCAGCACCAGAGGCAGAGGCAGGCAGATCTCTGTGAGTTTTTGGCCAGAGTGACA
CCTCCAAGTGAGTTCGAGGACAGCCAGGACGTTACACATAGAAACCCCCGTCTCAAAAACCAAA
AACAAAACAAAAAATCCAAAAACAGTGGAGTTTCAGCATGGAGGCCCAGGTCCCCACCCTAGTG
GCCGTTGGACACCTGTAAATTTAGGAAGGAAGCTATGGTCCTTATCAGGGTGACTATGAAACTC
AGACCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_997499	(Get FASTA)	NCBI Sequence Viewer
	XP_017451283	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD14368	(Get FASTA)	NCBI Sequence Viewer
	EDL77243	(Get FASTA)	NCBI Sequence Viewer
	Q76HN1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_997499 ⟸ NM_207616
- Peptide Label:	precursor
- UniProtKB:	Q76HN1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKPFSPEVSPDPCPATAAHLLRTYTLFLTLLELAQGCRGSMVSNRPFITVWNADTHWCLKDHGV DVDVSVFDVVANKEQNFQGPNMTIFYREELGTYPYYTPTGEPVFGGLPQNASLVTHLAHAFQDI KAAMPEPDFSGLAVIDWEAWRPRWAFNWDSKDIYQQRSMELVRAEHPDWPETLVEAEAQGQFQE AAEAWMAGTLQLGQVLRPRGLWGYYGFPDCYNYDFLSPNYTGQCSLSIHDQNDQLGWLWNQSYA LYPSIYLPAALMGTGKSQMYVRYRVQEAFRLALVSRDPHVPIMPYVQIFYEKTDYLLPLEELEH SLGESAAQGAAGAVLWISSEKTSTKESCQAIKAYMDSTLGPFILNVTSAALLCSEALCSGRGRC VRHPSYPEALLTLSPASFSIEPTHDGRPLSLKGTLSLKDRAQMAMKFKCRCYRGWSGEWCKKQD M hide sequence

RefSeq Acc Id:

XP_017451283 ⟸ XM_017595794

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKPFSPEVSPDPCPATAAHLLRTYTLFLTLLELAQGCRGSMVSNRPFITVWNADTHWCLKDHGV
DVDVSVFDVVANKEQNFQGPNMTIFYREELGTYPYYTPTGEPVFGGLPQNASLVTHLAHAFQDI
KAAMPEPDFSGLAVIDWEAWRPRWAFNWDSKDIYQQRSMELVRAEHPDWPETLVEAEAQDQFQE
AAQAWMAGTLQLGQEELEHSLGESAAQGAAGAVLWISSEKTSTKESCQAIKAYMDSTLGPFILN
VTSAALLCSEALCSGRGRCVRHPSYPEALLTLSPASFSIEPTHDGRPLSLKGTLSLKDRAQMAM
KFKCRCYRGWSGEWCKKQDM

hide sequence

RefSeq Acc Id:

ENSRNOP00000021408 ⟸ ENSRNOT00000021408

Protein Domains

EGF-like

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696274

Promoter ID:

EPDNEW_R6799

Type:

multiple initiation site

Name:

Hyal1_1

Description:

hyaluronoglucosaminidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,332,795 - 116,332,855	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303060	AgrOrtholog
Ensembl Genes	ENSRNOG00000015858	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000021408	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021408	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hyaluronidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:367166	UniProtKB/Swiss-Prot
NCBI Gene	367166	ENTREZGENE
PANTHER	PTHR11769	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Glyco_hydro_56	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hyal1	PhenoGen
PIRSF	Hyaluronidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	GLHYDRLASE56	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51445	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F1M963_RAT	UniProtKB/TrEMBL
	HYAL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-15	Hyal1	hyaluronidase 1	Hyal1	hyaluronoglucosaminidase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Hyal1	hyaluronoglucosaminidase 1		hyaluronidase 1	Name updated	1299863	APPROVED
2005-02-14	Hyal1	hyaluronidase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)