Inka1 (inka box actin regulator 1) - Rat Genome Database

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Gene: Inka1 (inka box actin regulator 1) Rattus norvegicus
Analyze
Symbol: Inka1
Name: inka box actin regulator 1
RGD ID: 1560778
Description: Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to act upstream of or within neural tube development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human INKA1 (inka box actin regulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam212a; family with sequence similarity 212, member A; hypothetical protein LOC316001; INKA1 protein; LOC316001; PAK4-inhibitor INKA1; RGD1560778; similar to RIKEN cDNA 6530418L21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,552,875 - 117,554,565 (-)NCBIGRCr8
mRatBN7.28108,674,263 - 108,675,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,674,263 - 108,675,953 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,300,737 - 114,302,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,500,060 - 112,501,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,342,700 - 110,344,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,763,149 - 116,764,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,763,001 - 116,764,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,117,472 - 116,119,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,253,800 - 113,255,490 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8107,978,903 - 107,980,593 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20175189   PMID:23376485   PMID:26607847  


Genomics

Comparative Map Data
Inka1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,552,875 - 117,554,565 (-)NCBIGRCr8
mRatBN7.28108,674,263 - 108,675,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,674,263 - 108,675,953 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,300,737 - 114,302,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,500,060 - 112,501,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,342,700 - 110,344,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,763,149 - 116,764,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,763,001 - 116,764,780 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,117,472 - 116,119,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,253,800 - 113,255,490 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8107,978,903 - 107,980,593 (-)NCBICelera
Cytogenetic Map8q32NCBI
INKA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,803,261 - 49,805,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,803,261 - 49,805,030 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,840,694 - 49,842,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,815,691 - 49,817,467 (+)NCBINCBI36Build 36hg18NCBI36
Celera349,806,165 - 49,807,990 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,899,736 - 49,901,512 (+)NCBIHuRef
CHM1_1349,792,748 - 49,794,524 (+)NCBICHM1_1
T2T-CHM13v2.0349,833,138 - 49,834,907 (+)NCBIT2T-CHM13v2.0
Inka1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,861,422 - 107,863,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,861,422 - 107,863,078 (-)EnsemblGRCm39 Ensembl
GRCm389107,984,223 - 107,985,916 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,984,223 - 107,985,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,886,554 - 107,888,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,842,327 - 107,843,980 (-)NCBIMGSCv36mm8
Celera9107,592,634 - 107,594,327 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Inka1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,695,956 - 1,697,485 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,695,956 - 1,697,521 (+)NCBIChiLan1.0ChiLan1.0
INKA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,789,227 - 49,791,262 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,793,983 - 49,796,037 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,734,616 - 49,736,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,971,208 - 50,973,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,971,394 - 50,972,993 (+)Ensemblpanpan1.1panPan2
INKA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,469,103 - 39,477,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,469,146 - 39,470,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,389,947 - 39,398,662 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,825,978 - 39,834,536 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,826,021 - 39,827,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,193,011 - 39,201,745 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,597,246 - 39,605,713 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,876,813 - 39,885,535 (-)NCBIUU_Cfam_GSD_1.0
Inka1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,649,269 - 64,651,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,410,201 - 1,412,023 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,410,244 - 1,412,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INKA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11332,329,872 - 32,332,167 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,509,658 - 35,511,418 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INKA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,206,066 - 11,208,653 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,206,914 - 11,209,867 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,789,672 - 155,791,446 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inka1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,718,573 - 3,721,001 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,717,980 - 3,720,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inka1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000026216
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 6 6 6 6 20 23
Low 1 18 21 20 7 20 2 3 57 8 12 10 2
Below cutoff 2 7 18 5 10 5 6 8 11 7 5 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026216   ⟹   ENSRNOP00000026216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,674,263 - 108,675,953 (-)Ensembl
Rnor_6.0 Ensembl8116,763,001 - 116,764,780 (-)Ensembl
RefSeq Acc Id: NM_001108187   ⟹   NP_001101657
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,552,875 - 117,554,565 (-)NCBI
mRatBN7.28108,674,263 - 108,675,953 (-)NCBI
Rnor_6.08116,763,149 - 116,764,839 (-)NCBI
Rnor_5.08116,117,472 - 116,119,162 (-)NCBI
RGSC_v3.48113,253,800 - 113,255,490 (-)RGD
Celera8107,978,903 - 107,980,593 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101657 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026216
  ENSRNOP00000026216.4
Reference Protein Sequences
RefSeq Acc Id: NP_001101657   ⟸   NM_001108187
- UniProtKB: D4AA62 (UniProtKB/TrEMBL),   A6I321 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026216   ⟸   ENSRNOT00000026216
Protein Domains
FAM212

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA62-F1-model_v2 AlphaFold D4AA62 1-282 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696286
Promoter ID:EPDNEW_R6811
Type:single initiation site
Name:Fam212a_1
Description:family with sequence similarity 212, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,764,842 - 116,764,902EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560778 AgrOrtholog
BioCyc Gene G2FUF-29164 BioCyc
Ensembl Genes ENSRNOG00000019363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026216 ENTREZGENE
  ENSRNOT00000026216.7 UniProtKB/TrEMBL
InterPro FAM212 UniProtKB/TrEMBL
  Inka UniProtKB/TrEMBL
KEGG Report rno:316001 UniProtKB/TrEMBL
NCBI Gene 316001 ENTREZGENE
PANTHER PAK4-INHIBITOR INKA1 UniProtKB/TrEMBL
  PTHR28615 UniProtKB/TrEMBL
Pfam FAM212 UniProtKB/TrEMBL
PhenoGen Inka1 PhenoGen
RatGTEx ENSRNOG00000019363 RatGTEx
UniProt A6I321 ENTREZGENE, UniProtKB/TrEMBL
  D4AA62 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-30 Inka1  inka box actin regulator 1  Fam212a  family with sequence similarity 212, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Fam212a  family with sequence similarity 212, member A  Fam212a  family with sequence similarity 212, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Fam212a  family with sequence similarity 212, member A  RGD1560778  similar to RIKEN cDNA 6530418L21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560778  similar to RIKEN cDNA 6530418L21   RGD1560778_predicted  similar to RIKEN cDNA 6530418L21 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560778_predicted  similar to RIKEN cDNA 6530418L21 (predicted)  LOC316001  similar to RIKEN cDNA 6530418L21  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC316001  similar to RIKEN cDNA 6530418L21      Symbol and Name status set to provisional 70820 PROVISIONAL