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Gene: Pik3r4 (phosphoinositide-3-kinase, regulatory subunit 4) Rattus norvegicus

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Symbol:

Pik3r4

Name:

phosphoinositide-3-kinase, regulatory subunit 4

RGD ID:

1311809

Description:

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; macroautophagy; and vacuolar transport. Predicted to be located in cytoskeleton; intercellular bridge; and intracellular membrane-bounded organelle. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; phosphoinositide metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363131; phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase regulatory subunit 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,146,660 - 115,195,326 (+)	NCBI		GRCr8
mRatBN7.2	8	106,267,908 - 106,316,585 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	106,267,954 - 106,316,584 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	111,890,314 - 111,939,993 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,089,590 - 110,139,269 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	107,932,278 - 107,981,958 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	114,300,248 - 114,350,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	114,300,257 - 114,350,681 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	113,675,758 - 113,725,968 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	110,741,833 - 110,790,709 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	110,762,479 - 110,809,819 (+)	NCBI
Celera	8	105,594,747 - 105,643,191 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

immunodeficiency 21 (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

aristolochic acid A (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

chlordecone (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

FR900359 (ISO)

genistein (EXP)

gentamycin (EXP)

herbicide (ISO)

ivermectin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

mesotrione (ISO)

nickel atom (ISO)

piroxicam (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc dichloride (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome maturation (IEA,ISO)

biological_process (ND)

cellular response to glucose starvation (IEA,ISO,ISS)

early endosome to late endosome transport (IEA,ISO)

late endosome to vacuole transport (IBA,IEA)

macroautophagy (IEA)

pexophagy (IBA)

phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

phosphatidylinositol-3-phosphate biosynthetic process (IEA,ISO)

protein targeting to vacuole (IBA)

receptor catabolic process (IEA,ISO)

regulation of autophagy (IEA,ISO)

regulation of cytokinesis (IEA,ISO)

regulation of macroautophagy (IEA,ISO)

Cellular Component

autophagosome (IEA)

axoneme (IEA,ISO,ISS)

ciliary basal body (IEA,ISO)

cilium (IEA,ISO)

cytoplasmic vesicle (IEA)

endosome (IEA)

intercellular bridge (IEA,ISO)

late endosome (IBA,IEA,ISO,ISS)

membrane (IEA)

microtubule cytoskeleton (IEA,ISO)

nucleus-vacuole junction (IBA)

phosphatidylinositol 3-kinase complex, class III (IEA,ISO,ISS)

phosphatidylinositol 3-kinase complex, class III, type I (IBA)

phosphatidylinositol 3-kinase complex, class III, type II (IBA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (IEA,ISO)

inositol metabolic pathway (ISO)

phosphoinositide metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Mammalian autophagy: core molecular machinery and signaling regulation.	Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.

Additional References at PubMed

PMID:12477932	PMID:14617358	PMID:15057822	PMID:19946888	PMID:20643123	PMID:21062745	PMID:23332761	PMID:24089209

Genomics

Comparative Map Data

Pik3r4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	115,146,660 - 115,195,326 (+)	NCBI		GRCr8
mRatBN7.2	8	106,267,908 - 106,316,585 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	106,267,954 - 106,316,584 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	111,890,314 - 111,939,993 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	110,089,590 - 110,139,269 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	107,932,278 - 107,981,958 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	114,300,248 - 114,350,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	114,300,257 - 114,350,681 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	113,675,758 - 113,725,968 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	110,741,833 - 110,790,709 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	110,762,479 - 110,809,819 (+)	NCBI
Celera	8	105,594,747 - 105,643,191 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

PIK3R4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	130,678,934 - 130,746,829 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	130,678,934 - 130,746,829 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	130,397,778 - 130,465,673 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	131,880,468 - 131,948,386 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	131,880,475 - 131,948,348	NCBI
Celera	3	128,823,051 - 128,890,972 (-)	NCBI		Celera
Cytogenetic Map	3	q22.1	NCBI
HuRef	3	127,782,400 - 127,850,320 (-)	NCBI		HuRef
CHM1_1	3	130,360,774 - 130,428,689 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	133,422,776 - 133,490,673 (-)	NCBI		T2T-CHM13v2.0

Pik3r4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	105,520,156 - 105,564,854 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	105,520,177 - 105,564,856 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	105,642,995 - 105,687,655 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	105,642,978 - 105,687,657 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	105,545,325 - 105,589,985 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	105,501,078 - 105,545,755 (+)	NCBI		MGSCv36	mm8
Celera	9	105,236,861 - 105,284,774 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	56.79	NCBI

Pik3r4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955501	7,604,501 - 7,681,947 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955501	7,604,934 - 7,681,947 (+)	NCBI	ChiLan1.0	ChiLan1.0

PIK3R4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	128,607,846 - 128,710,837 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	128,621,885 - 128,714,033 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	127,743,873 - 127,834,512 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	135,089,584 - 135,157,193 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	135,089,584 - 135,157,193 (-)	Ensembl	panpan1.1		panPan2

PIK3R4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	27,902,500 - 27,973,609 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	27,902,840 - 27,971,892 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	27,876,020 - 27,947,053 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	28,409,021 - 28,480,487 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	28,409,029 - 28,480,489 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	28,103,972 - 28,175,361 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	28,158,914 - 28,236,275 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	28,414,452 - 28,485,590 (-)	NCBI		UU_Cfam_GSD_1.0

Pik3r4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	67,401,776 - 67,472,004 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	4,162,112 - 4,232,510 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	4,162,276 - 4,232,471 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PIK3R4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	1,731,023 - 1,815,556 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	1,730,988 - 1,815,555 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	1,388,518 - 1,533,221 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PIK3R4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	59,444,570 - 59,515,619 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	59,444,616 - 59,515,240 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	32,468,967 - 32,542,919 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pik3r4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	6,642,190 - 6,744,470 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	6,642,195 - 6,744,480 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pik3r4
170 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	195
Count of miRNA genes:	145
Interacting mature miRNAs:	162
Transcripts:	ENSRNOT00000018654
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	88612425	107550209	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

RH141195

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	106,316,358 - 106,316,569 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	114,350,460 - 114,350,670	NCBI	Rnor6.0
Rnor_5.0	8	113,725,742 - 113,725,952	UniSTS	Rnor5.0
RGSC_v3.4	8	110,790,484 - 110,790,694	UniSTS	RGSC3.4
Celera	8	105,642,966 - 105,643,176	UniSTS
RH 3.4 Map	8	1151.0	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018654 ⟹ ENSRNOP00000018654

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	106,267,982 - 106,316,584 (+)	Ensembl
Rnor_6.0 Ensembl	8	114,300,312 - 114,350,681 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090707 ⟹ ENSRNOP00000070282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	106,267,982 - 106,316,584 (+)	Ensembl
Rnor_6.0 Ensembl	8	114,300,257 - 114,350,519 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112633 ⟹ ENSRNOP00000083491

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	106,267,954 - 106,273,700 (+)	Ensembl

RefSeq Acc Id:

NM_001401214 ⟹ NP_001388143

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	115,146,687 - 115,195,326 (+)	NCBI
mRatBN7.2	8	106,267,937 - 106,316,585 (+)	NCBI

RefSeq Acc Id:

XM_006243801 ⟹ XP_006243863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	115,146,660 - 115,195,326 (+)	NCBI
mRatBN7.2	8	106,267,908 - 106,316,585 (+)	NCBI
Rnor_6.0	8	114,300,248 - 114,350,686 (+)	NCBI
Rnor_5.0	8	113,675,758 - 113,725,968 (+)	NCBI

Sequence:

show sequence

CAACAGGAAGTGAAGTCAACCCAGCGGCTTTCCCGGGAGTTCAGCGTTCGCCGCAGGTATTGTG
TGTTAACCTGCCAACCCAGGGGTGCCCATCATTATGGGAAACCAACTAGCTGGTATTGCTCCTT
CCCAGATCCTGTCCGTAGAGAGCTACTTCTCAGACATCCATGACTTTGAATATGATAAGAGTCT
GGGAAGTACTCGGTTTTTTAAAGTTGCTCGAGCGAAGCACCGGGAGGGCCTGGTGGTTGTGAAG
GTCTTTGCAATCCAGGATCCCACGTTGCCTTTAACTAGTTATAAACAGGAGCTGGAGGAACTGA
AAATCAGGCTCCATTCGGCCCAGAACTGCTTACCTTTCCAGAAAGCAGCAGAAAAAGCATCGGA
GAAAGCGGCCATGCTGTTCAGGCAGTACGTGAGGGACAACCTCTACGACCGTATCAGTACCCGT
CCCTTCTTAAATAACATCGAGAAGCGCTGGATCGCCTTCCAGATCCTGACAGCTGTGGACCAAG
CACACAAGTCTGGAGTCCGCCACGGTGACATCAAGACAGAGAACGTGATGGTCACCAGTTGGAA
CTGGGTTCTCCTCACTGATTTTGCCAGTTTTAAGCCCACTTATCTTCCAGAGGACAACCCAGCA
GATTTCAACTATTTCTTTGACACCTCGAGGAGGAGGACTTGCTACATCGCCCCTGAGCGTTTCG
TGGATGGCGGTATGTTCGCCACCGAGTTAGAATACATGAGAGATCCCTCAACTCCTCTTGTCGA
CCTAAATAGCAATCAGAGAACACGGGGAGAGTTGAAGAGGGCCATGGACATCTTTTCAGCAGGT
TGCGTGATAGCCGAGCTCTTCACGGAAGGCGTGCCGTTGTTCGATCTCTCACAACTGTTGGCAT
ACAGAAATGGACATTTTTTCCCTGAGCAAGTGCTAAATAAAATCGAAGATCGCAGTATCAGAGA
ATTGGTAACTCAGATGATCCAGCGGGAGCCGGGACAGCGTTTGGAAGCTGACGACTACCTGAAG
CAGCAGCGTGGCAATGCTTTCCCCGAGGTATTCTATACTTTCCTTCAGCCGTACATGGCTCAGT
TCGCCAAGGAGACCTTTCTCTCTGCAGATGAGCGGATTTTGGTTATACGGAAAGACTTGGGCAA
TATCATTCACAACCTCTGTGGACATGACTTGCCAGAGAAAGCAGAAGGGGAGTCCAAGGCTAGC
GGGCTGGTTGTCCTGGTGTCAGTGATAACGTCCTGCCTGCAGACACTGAAGTCCTGCGACTCCA
AACTGGCTGCCTTGGAGCTCATTCTGCATTTGGCCCCGAGGCTGAGCGTAGAGATCCTTCTGGA
TCGCATCACCCCCTACTTGTTGCATTTCAGCAACAACTCTGTTCCTCGAGTGCGGGCTGAAGCC
CTGAGGACACTCACCAAAGTCCTTGCCCTTGTCCAAGAAGTTCCTCGCAATGATGTCAATATCT
ACCCAGAGTACATTCTCCCCGGCATAGCTCACCTGGCCCAGGACGACGCCACCATCGTCAGACT
GGCCTACGCTGAAAACATAGCTCTGTTGGCCGAGACGGCTCTGCGATTCCTGGAACTAGTGCAG
CTAAAAACTCTCAACATGGAGAACGAGCCGGACAGTGAAGAGGTAGATGAAGCCACGCGTCCTA
ACGGAGACTATGACACAGAGCTCCAGGCCCTACACGAAATGGTCCAGCAGAAGGTTGTCACTTT
GTTAAGTGACCCTGAGAATATTGTGAAACAGACATTGATGGAGAATGGGATCACACGCTTGTGC
GTCTTCTTTGGACGGCAGAAAGCCAACGACGTTCTCTTGTCCCACATGATCACGTTCCTGAATG
ATAAGAATGACTGGCACCTGCGTGGAGCTTTCTTCGATAGCATAGTCGGTGTGGCTGCCTATGT
TGGCTGGCAGAGCTCCTCCATCCTCAAGCCCCTGCTCCAGCAAGGCCTCAGCGATGCCGAGGAG
TTCGTCATTGTGAAAGCTCTCAATGCCCTGACCTGTATGTGCCAGTTAGGGCTGCTGCAGAAAC
CTCATGTCTATGAATTCGCCAGTGATATTGCTCCCTTCCTGTGTCACCCTAATCTGTGGATACG
CTATGGTGCCGTGGGATTCATCACCGTGGTAGCTCATCAGATCAGCACTGCTGACGTCTACTGC
AAGCTCATGCCGTATCTTGACCCGTATATTACACAACCAGTAATACAGATTGAAAGGAAGCTTG
TCTTGCTTAGCGTTCTAAAAGAGCCGGTGAGTCGCTCTATATTTGATTATGCTCTGAGGTCCAA
AGACATCGCTAGCTTGTTCAGACATCTTCACATGCGTCAGAAGAAGCGGAATGGCTCTCTTCTT
GACTGCCCTCCGCCCGAGGACCCTGCCATAGCACAGCTTCTGAAGAAACTGCTCTCCCAGGGGA
TGACCGAAGAAGAGGAAGATAAACTTCTGGCTCTGAAGGACTTCATGATGAAATCAAATCGAGC
AAAAGCTAATGCAGTAGACCAGAGCCACCTGCATGACAGCAGCCAGAAAGGTGTAATTGACTTG
GCAGCCTTGGGCATCACTGGGAGACAAGTTGACCTTGTTAAAACCAAGCAAGAGCCCGATGAGA
AACGGGCTAGGAAGCATGTGAAACAAGACTCCAATGTAAATGAAGAATGGAAAAGCATGTTTGG
GTCACTGGAACCACCGAATATCCCACAGGCCCTGCCTAAAACCAGTGACCATGAGGTGGTTCCA
ACGGGGAAGTCACCTCGCTCTGAGTCCTCTGCTGGTGTCTGTGTCCCTTTGTCAACCTCTCCAC
AGGTTTCCGAAGCAGCACACATCCCCAGTAAGAAGCCGGTGATTCCGGTTGTAAGTAGCACGGT
CCTGCCATCCACTTACCAGATCCGGATCACCACTTGCAAGACTGAACTTCAGCAGCTCATACAA
CAGAAGCGTGAGCAGTGTAACGCAGAGCGCATAGCCAAGCAGATGATGGAGAACGCCGAGTGGG
AGAGCAAGCCACCTCCACCTGGGTGGCGTCCTAAAGGGCTCCTAGTTGCACATCTTCATGAGCA
CAAATCTGCTGTAAATCGAATCAGAGTCTCCGATGAACACTTACTCTTTGCAACGTGCTCAAAT
GATGGTACAGTGAAAATCTGGAACAGTCAGAAGATGGAGGGGAAGACCACTACGACGAGGTCTA
TTCTGACATACAGCCGAATTGGAGGGCGAGTCAAGACACTAACATTTTGCCAAGGCTCCCACTA
CTTGGCCATAGCATCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGTTACCC
AAGTCTCCTAAAATCCACCCTCTACAAAGCAGGATTCTGGATCAGAAGGAAGACGGATGTGTGG
TGGACATGCATCACTTCAACTCGGGGGCACAGTCTGTTCTTGCCTATGCCACAGTGAATGGCTC
TCTGGTTGGATGGGATCTCAGGTCATCAAGCAACGCATGGACATTAAAGCATGACCTGAAGTCA
GGCCTCATCACCTCCTTTGCTGTGGACATCCACCAGTGCTGGCTGTGCATAGGCACGAGCAGCG
GGGCCATGGCGTGTTGGGACATGAGGTTCCAGTTGCCAATTTCCAGTCACTGTCATCCCTCCAG
AGCTCGTATCCGGCGCCTCTCCATGCACCCCTTGTACCAGTCCTGGGTAATTGCAGCTGTTCAG
GGCAACAATGAAGTCTCCATGTGGGACATGGAGACCGGAGACAGGAGACTGACTCTCTGGGCTA
GCAGTGCGCCTCCCCTGTCTGAGTTACAGCCCTCACCGCACAGCGTCCATGGCATCTACTGCAG
CCCTGCGGATGGCAACCCTATCCTGCTGACCGCTGGCTCAGACATGAAAATAAGGTTCTGGGAC
TTGGTTTCCCCAGAGAGGTCCTATGTTGTAGCGGGAAGCACGGGTTCCCCGTCTGTATCCTACT
ACAAGAAGATAATAGAAGGCACGGAGGTTGTCCAGGAAATTCAGAATAAGCAGAAGGTTGGACC
AAGTGATGACACCCCTCGAAGGGGCCCGGAGTCTCTGCCTGTGGGACATCATGACATCATCACA
GATATTGCCACCTTCCAGACCACTCAGGGCTTCATTGTGACTGCTTCTAGAGATGGGATTGTGA
AGGTGTGGAAATAAATCCTGCTGACTTGTATAAAATGCTGTAAAATTAGAAATGTACCATAATT
CAAGACAAAAGGATTTCTAGAGAAGAAACGTCATTTTTGAAGTGTCTGTATTACTGTTTCATGG
CTGAACCAGTCCCAGCCACAGTGGGTAAGGATGTGGGCTTGGTGATTTTCTTCATGTACATCTC
TGAAGAGTTGGCCAGATAGCAGAACCTGGGAGTGCCTGCTGTATATGGAACAGAACAGGTGAGA
AGTGTAAAAAGGAAAGAGGATATGATGCCAGCTTATTTTATATGGAAATGATTGTAAGTCACTA
TGTAAACACTTTTGTTGTTATAAATGCTATTCAAACCGCAAGTAAACTCTATTCAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001388143	(Get FASTA)	NCBI Sequence Viewer
	XP_006243863	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68984	(Get FASTA)	NCBI Sequence Viewer
	EDL77342	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018654
	ENSRNOP00000018654.4
GenBank Protein	P0C0R5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_006243863 ⟸ XM_006243801
- Peptide Label:	isoform X1
- UniProtKB:	P0C0R5 (UniProtKB/Swiss-Prot), B5DFA2 (UniProtKB/TrEMBL), A6I2N5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPL TSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWI AFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRR RTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGV PLFDLSQLLAYRNGHFFPEQVLNKIEDRSIRELVTQMIQREPGQRLEADDYLKQQRGNAFPEVF YTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGESKASGLVVLVSVITS CLQTLKSCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNNSVPRVRAEALRTLTKVLALV QEVPRNDVNIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKTLNMENEPD SEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDV LLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALNALT CMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVAHQISTADVYCKLMPYLDPYIT QPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIASLFRHLHMRQKKRNGSLLDCPPPEDPAIA QLLKKLLSQGMTEEEEDKLLALKDFMMKSNRAKANAVDQSHLHDSSQKGVIDLAALGITGRQVD LVKTKQEPDEKRARKHVKQDSNVNEEWKSMFGSLEPPNIPQALPKTSDHEVVPTGKSPRSESSA GVCVPLSTSPQVSEAAHIPSKKPVIPVVSSTVLPSTYQIRITTCKTELQQLIQQKREQCNAERI AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHLLFATCSNDGTVKIWNSQK MEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSR ILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIH QCWLCIGTSSGAMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDME TGDRRLTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLVSPERSYVVA GSTGSPSVSYYKKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDIATFQTTQGF IVTASRDGIVKVWK hide sequence

Ensembl Acc Id:

ENSRNOP00000018654 ⟸ ENSRNOT00000018654

Ensembl Acc Id:

ENSRNOP00000070282 ⟸ ENSRNOT00000090707

Ensembl Acc Id:

ENSRNOP00000083491 ⟸ ENSRNOT00000112633

RefSeq Acc Id:	NP_001388143 ⟸ NM_001401214
- UniProtKB:	P0C0R5 (UniProtKB/Swiss-Prot), A6I2N5 (UniProtKB/TrEMBL), B5DFA2 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P0C0R5-F1-model_v2	AlphaFold	P0C0R5	1-1358	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696244

Promoter ID:

EPDNEW_R6765

Type:

initiation region

Name:

Pik3r4_1

Description:

phosphoinositide-3-kinase, regulatory subunit 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	114,300,265 - 114,300,325	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311809	AgrOrtholog
BioCyc Gene	G2FUF-29268	BioCyc
BioCyc Pathway	PWY-6352 [3-phosphoinositide biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6352	BioCyc
Ensembl Genes	ENSRNOG00000013669	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000018654	ENTREZGENE
	ENSRNOT00000018654.8	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.10.10	UniProtKB/Swiss-Prot
	2.130.10.10	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	ARM-like	UniProtKB/Swiss-Prot
	ARM-type_fold	UniProtKB/Swiss-Prot
	HEAT_type_2	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	Vps15-like	UniProtKB/Swiss-Prot
	VPS15-like_hel	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
NCBI Gene	363131	ENTREZGENE
PANTHER	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4	UniProtKB/Swiss-Prot
	PTHR17583	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
	VPS15-like_hel	UniProtKB/Swiss-Prot
	WD40	UniProtKB/Swiss-Prot
PhenoGen	Pik3r4	PhenoGen
PROSITE	HEAT_REPEAT	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
	WD_REPEATS_1	UniProtKB/Swiss-Prot
	WD_REPEATS_2	UniProtKB/Swiss-Prot
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013669	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48371	UniProtKB/Swiss-Prot
	SSF50978	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I6A033_RAT	UniProtKB/TrEMBL
	A0A8L2R3Q5_RAT	UniProtKB/TrEMBL
	A6I2N5	ENTREZGENE, UniProtKB/TrEMBL
	B5DFA2	ENTREZGENE, UniProtKB/TrEMBL
	P0C0R5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Pik3r4	phosphoinositide-3-kinase, regulatory subunit 4	Pik3r4	phosphoinositide-3-kinase, regulatory subunit 4, p150	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pik3r4	phosphoinositide-3-kinase, regulatory subunit 4, p150	Pik3r4_predicted	phosphoinositide-3-kinase, regulatory subunit 4, p150 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pik3r4_predicted	phosphoinositide-3-kinase, regulatory subunit 4, p150 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways