PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4) - Rat Genome Database

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Gene: PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4) Sus scrofa
Analyze
Symbol: PIK3R4
Name: phosphoinositide-3-kinase regulatory subunit 4
RGD ID: 14260468
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN autophagosome maturation (inferred); cellular response to glucose starvation (inferred); early endosome to late endosome transport (inferred); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH alkaptonuria (ortholog); genetic disease (ortholog); immunodeficiency 21 (ortholog); FOUND IN phosphatidylinositol 3-kinase complex, class III (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphoinositide 3-kinase regulatory subunit 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,731,023 - 1,815,556 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,730,988 - 1,815,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2131,388,518 - 1,533,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PIK3R4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,731,023 - 1,815,556 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,730,988 - 1,815,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2131,388,518 - 1,533,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383130,678,934 - 130,746,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3130,678,934 - 130,746,829 (-)EnsemblGRCh38hg38GRCh38
GRCh373130,397,778 - 130,465,673 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363131,880,468 - 131,948,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 343131,880,475 - 131,948,348NCBI
Celera3128,823,051 - 128,890,972 (-)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3127,782,400 - 127,850,320 (-)NCBIHuRef
CHM1_13130,360,774 - 130,428,689 (-)NCBICHM1_1
T2T-CHM13v2.03133,422,776 - 133,490,673 (-)NCBIT2T-CHM13v2.0
Pik3r4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399105,520,156 - 105,564,854 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9105,520,177 - 105,564,856 (+)EnsemblGRCm39 Ensembl
GRCm389105,642,995 - 105,687,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9105,642,978 - 105,687,657 (+)EnsemblGRCm38mm10GRCm38
MGSCv379105,545,325 - 105,589,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369105,501,078 - 105,545,755 (+)NCBIMGSCv36mm8
Celera9105,236,861 - 105,284,774 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map956.79NCBI
Pik3r4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,146,660 - 115,195,326 (+)NCBIGRCr8
mRatBN7.28106,267,908 - 106,316,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,267,954 - 106,316,584 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8111,890,314 - 111,939,993 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,089,590 - 110,139,269 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08107,932,278 - 107,981,958 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,300,248 - 114,350,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,300,257 - 114,350,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08113,675,758 - 113,725,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48110,741,833 - 110,790,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18110,762,479 - 110,809,819 (+)NCBI
Celera8105,594,747 - 105,643,191 (+)NCBICelera
Cytogenetic Map8q32NCBI
Pik3r4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555017,604,501 - 7,681,947 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555017,604,934 - 7,681,947 (+)NCBIChiLan1.0ChiLan1.0
PIK3R4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22128,607,846 - 128,710,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13128,621,885 - 128,714,033 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03127,743,873 - 127,834,512 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13135,089,584 - 135,157,193 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3135,089,584 - 135,157,193 (-)Ensemblpanpan1.1panPan2
PIK3R4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12327,902,500 - 27,973,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2327,902,840 - 27,971,892 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2327,876,020 - 27,947,053 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02328,409,021 - 28,480,487 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2328,409,029 - 28,480,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12328,103,972 - 28,175,361 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02328,158,914 - 28,236,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02328,414,452 - 28,485,590 (-)NCBIUU_Cfam_GSD_1.0
Pik3r4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560267,401,776 - 67,472,004 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365294,162,112 - 4,232,510 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365294,162,276 - 4,232,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11559,444,570 - 59,515,619 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1559,444,616 - 59,515,240 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604132,468,967 - 32,542,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247306,642,190 - 6,744,470 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247306,642,195 - 6,744,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PIK3R4
3745 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 3
Low 10 4 2 3 2 20 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000051930   ⟹   ENSSSCP00000055014
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl131,731,017 - 1,815,528 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061418   ⟹   ENSSSCP00000056139
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl131,731,023 - 1,815,556 (+)Ensembl
RefSeq Acc Id: XM_021071332   ⟹   XP_020926991
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1131,730,988 - 1,815,555 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071333   ⟹   XP_020926992
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1131,731,002 - 1,815,549 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020926991 (Get FASTA)   NCBI Sequence Viewer  
  XP_020926992 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000056139
  ENSSSCP00000056139.1
GenBank Protein JAA53702 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_020926991   ⟸   XM_021071332
- UniProtKB: K9IWD2 (UniProtKB/TrEMBL),   A0A481B2C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926992   ⟸   XM_021071333
- UniProtKB: K9IWD2 (UniProtKB/TrEMBL),   A0A481B2C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000055014   ⟸   ENSSSCT00000051930
RefSeq Acc Id: ENSSSCP00000056139   ⟸   ENSSSCT00000061418
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029094 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061418 ENTREZGENE
  ENSSSCT00000061418.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Vps15-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene PIK3R4 ENTREZGENE
PANTHER PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 UniProtKB/TrEMBL
  PTHR17583 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PROSITE HEAT_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287BHR8_PIG UniProtKB/TrEMBL
  A0A481B2C1 ENTREZGENE, UniProtKB/TrEMBL
  K9IWD2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91446 ENTREZGENE