Dusp7 (dual specificity phosphatase 7) - Rat Genome Database

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Gene: Dusp7 (dual specificity phosphatase 7) Rattus norvegicus
Analyze
Symbol: Dusp7
Name: dual specificity phosphatase 7
RGD ID: 735026
Description: Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be active in cytosol. Orthologous to human DUSP7 (dual specificity phosphatase 7); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity protein phosphatase 7; dual specificity protein phosphatase MKP-X; MAP kinase phosphatase; mkp-X
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,888,091 - 115,895,126 (+)NCBIGRCr8
mRatBN7.28107,009,369 - 107,016,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,008,528 - 107,016,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,632,332 - 112,639,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,831,503 - 110,838,534 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,674,294 - 108,681,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,069,095 - 115,076,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,069,095 - 115,076,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,436,772 - 114,443,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,510,358 - 111,515,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18111,530,229 - 111,535,444 (+)NCBI
Celera8106,321,745 - 106,328,777 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9788880   PMID:26435497  


Genomics

Comparative Map Data
Dusp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,888,091 - 115,895,126 (+)NCBIGRCr8
mRatBN7.28107,009,369 - 107,016,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,008,528 - 107,016,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,632,332 - 112,639,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,831,503 - 110,838,534 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,674,294 - 108,681,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,069,095 - 115,076,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,069,095 - 115,076,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,436,772 - 114,443,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,510,358 - 111,515,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18111,530,229 - 111,535,444 (+)NCBI
Celera8106,321,745 - 106,328,777 (+)NCBICelera
Cytogenetic Map8q32NCBI
DUSP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,048,919 - 52,056,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,048,919 - 52,056,571 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,082,935 - 52,090,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,059,799 - 52,065,329 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,059,870 - 52,065,269NCBI
Celera352,062,259 - 52,069,785 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,146,055 - 52,153,134 (-)NCBIHuRef
CHM1_1352,035,473 - 52,042,994 (-)NCBICHM1_1
T2T-CHM13v2.0352,081,823 - 52,089,474 (-)NCBIT2T-CHM13v2.0
Dusp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,245,831 - 106,252,923 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,245,831 - 106,252,923 (+)EnsemblGRCm39 Ensembl
GRCm389106,368,560 - 106,375,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,368,632 - 106,375,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,270,963 - 106,278,055 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,226,733 - 106,233,822 (+)NCBIMGSCv36mm8
MGSCv369107,157,107 - 107,167,680 (+)NCBIMGSCv36mm8
Celera9105,996,040 - 106,003,059 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.46NCBI
Dusp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,685,137 - 3,691,933 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555323,685,137 - 3,691,933 (-)NCBIChiLan1.0ChiLan1.0
DUSP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,043,185 - 52,050,712 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,047,955 - 52,055,470 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,990,115 - 51,997,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,219,167 - 53,226,491 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,219,167 - 53,226,491 (-)Ensemblpanpan1.1panPan2
DUSP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,676,077 - 37,682,003 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,657,725 - 37,665,000 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02038,026,800 - 38,034,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,942,727 - 38,034,072 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,390,441 - 37,397,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,798,934 - 37,806,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,084,030 - 38,091,307 (+)NCBIUU_Cfam_GSD_1.0
DUSP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,199,409 - 34,206,649 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,199,404 - 34,210,621 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,396,095 - 37,404,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,416,262 - 13,423,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,416,287 - 13,423,661 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,480,091 - 153,487,666 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247305,858,480 - 5,865,806 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247305,858,838 - 5,865,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp7
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:174
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000014770
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat

Markers in Region
RH133148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,015,044 - 107,016,278 (+)MAPPERmRatBN7.2
Rnor_6.08115,074,771 - 115,076,004NCBIRnor6.0
Rnor_5.08114,442,448 - 114,443,681UniSTSRnor5.0
RGSC_v3.48111,516,034 - 111,517,267UniSTSRGSC3.4
Celera8106,327,412 - 106,328,651UniSTS
RH 3.4 Map81153.5UniSTS
Cytogenetic Map8q32UniSTS
RH143715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,008,675 - 107,008,818 (+)MAPPERmRatBN7.2
Rnor_6.08115,068,402 - 115,068,544NCBIRnor6.0
Rnor_5.08114,436,079 - 114,436,221UniSTSRnor5.0
RGSC_v3.48111,509,748 - 111,509,890UniSTSRGSC3.4
Celera8106,321,086 - 106,321,228UniSTS
RH 3.4 Map81138.69UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 9 8 12 8 3 74 35 33 11
Low 1 2 48 33 7 33 8 8 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014770   ⟹   ENSRNOP00000014770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,008,528 - 107,016,404 (+)Ensembl
Rnor_6.0 Ensembl8115,069,095 - 115,076,130 (+)Ensembl
RefSeq Acc Id: NM_001100547   ⟹   NP_001094017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88115,888,091 - 115,895,126 (+)NCBI
mRatBN7.28107,009,369 - 107,016,404 (+)NCBI
Rnor_6.08115,069,095 - 115,076,130 (+)NCBI
Rnor_5.08114,436,772 - 114,443,807 (+)NCBI
Celera8106,321,745 - 106,328,777 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094017 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA63896 (Get FASTA)   NCBI Sequence Viewer  
  EDL77319 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014770
  ENSRNOP00000014770.5
GenBank Protein Q63340 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094017   ⟸   NM_001100547
- UniProtKB: Q63340 (UniProtKB/Swiss-Prot),   F1M7V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014770   ⟸   ENSRNOT00000014770
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63340-F1-model_v2 AlphaFold Q63340 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696247
Promoter ID:EPDNEW_R6771
Type:single initiation site
Name:Dusp7_1
Description:dual specificity phosphatase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08115,069,182 - 115,069,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735026 AgrOrtholog
BioCyc Gene G2FUF-29241 BioCyc
Ensembl Genes ENSRNOG00000010789 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014770 ENTREZGENE
  ENSRNOT00000014770.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  MKP UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report rno:300980 UniProtKB/Swiss-Prot
NCBI Gene 300980 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Dusp7 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot
PRINTS MAPKPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010789 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
  SSF52821 UniProtKB/Swiss-Prot
UniProt DUS7_RAT UniProtKB/Swiss-Prot
  F1M7V9 ENTREZGENE
  Q63340 ENTREZGENE
UniProt Secondary F1M7V9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dusp7  dual specificity phosphatase 7      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis 728656