Cish (cytokine inducible SH2-containing protein) - Rat Genome Database

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Gene: Cish (cytokine inducible SH2-containing protein) Rattus norvegicus
Analyze
Symbol: Cish
Name: cytokine inducible SH2-containing protein
RGD ID: 69261
Description: Predicted to enable cytokine receptor binding activity. Involved in cytokine-mediated signaling pathway. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-2 signaling pathway; interleukin-3 signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cis; CIS-1; cytokine inducible SH2-containing protein 1; cytokine-inducible SH2-containing protein; SOCS; suppressor of cytokine signaling
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,850,969 - 116,855,917 (+)NCBIGRCr8
mRatBN7.28107,972,306 - 107,977,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,972,306 - 107,977,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,598,881 - 113,603,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,798,056 - 111,803,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,640,844 - 109,645,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,054,547 - 116,059,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,054,465 - 116,060,723 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,411,027 - 115,415,974 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,541,034 - 112,545,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,560,606 - 112,564,500 (+)NCBI
Celera8107,282,095 - 107,287,043 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-nitrotoluene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrotoluene  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury(1+)  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
oxazepam  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
raloxifene  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
stattic  (ISO)
sulpiride  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo. Mao Y, etal., Endocrinology 1999 Dec;140(12):5505-15.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12586763   PMID:12618484   PMID:15118263   PMID:15378659   PMID:16154995   PMID:16357045   PMID:16956890  


Genomics

Comparative Map Data
Cish
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,850,969 - 116,855,917 (+)NCBIGRCr8
mRatBN7.28107,972,306 - 107,977,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,972,306 - 107,977,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,598,881 - 113,603,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,798,056 - 111,803,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,640,844 - 109,645,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,054,547 - 116,059,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,054,465 - 116,060,723 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,411,027 - 115,415,974 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,541,034 - 112,545,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,560,606 - 112,564,500 (+)NCBI
Celera8107,282,095 - 107,287,043 (+)NCBICelera
Cytogenetic Map8q32NCBI
CISH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,606,489 - 50,611,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,606,489 - 50,611,774 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,643,920 - 50,649,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,618,924 - 50,624,207 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,618,929 - 50,624,207NCBI
Celera350,616,686 - 50,622,064 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,699,815 - 50,705,193 (-)NCBIHuRef
CHM1_1350,596,124 - 50,601,502 (-)NCBICHM1_1
T2T-CHM13v2.0350,636,358 - 50,641,643 (-)NCBIT2T-CHM13v2.0
Cish
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,173,858 - 107,179,983 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,173,225 - 107,179,983 (+)EnsemblGRCm39 Ensembl
GRCm389107,296,659 - 107,302,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,296,026 - 107,302,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,199,020 - 107,204,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,154,790 - 107,160,062 (+)NCBIMGSCv36mm8
Celera9106,902,900 - 106,908,144 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.99NCBI
Cish
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,378,088 - 2,386,000 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,380,380 - 2,386,000 (-)NCBIChiLan1.0ChiLan1.0
CISH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,586,428 - 50,591,908 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,591,174 - 50,596,668 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,531,870 - 50,537,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,769,194 - 51,774,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,769,194 - 51,774,548 (-)Ensemblpanpan1.1panPan2
CISH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,762,239 - 38,767,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,762,378 - 38,766,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,681,549 - 38,686,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,116,466 - 39,121,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,116,453 - 39,121,845 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,484,384 - 38,489,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,887,993 - 38,893,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,167,907 - 39,173,288 (+)NCBIUU_Cfam_GSD_1.0
Cish
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,358,104 - 65,364,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,118,325 - 2,124,684 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,116,786 - 2,124,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CISH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,085,286 - 33,090,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,086,280 - 33,090,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,354,834 - 36,358,941 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CISH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,993,212 - 11,998,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,993,242 - 11,995,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041154,987,569 - 154,992,718 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cish
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,435,847 - 4,440,143 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,434,817 - 4,440,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cish
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:103
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000040056
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
BE107841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,971,875 - 107,972,049 (+)MAPPERmRatBN7.2
Rnor_6.08116,054,117 - 116,054,290NCBIRnor6.0
Rnor_5.08115,410,597 - 115,410,770UniSTSRnor5.0
RGSC_v3.48112,540,604 - 112,540,777UniSTSRGSC3.4
Celera8107,281,665 - 107,281,838UniSTS
RH 3.4 Map81124.0UniSTS
Cytogenetic Map8q32UniSTS
PMC156147P14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,971,848 - 107,972,100 (+)MAPPERmRatBN7.2
Rnor_6.08116,054,090 - 116,054,341NCBIRnor6.0
Rnor_5.08115,410,570 - 115,410,821UniSTSRnor5.0
RGSC_v3.48112,540,577 - 112,540,828UniSTSRGSC3.4
Celera8107,281,638 - 107,281,889UniSTS
Cytogenetic Map8q32UniSTS
PMC156147P15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,972,039 - 107,972,198 (+)MAPPERmRatBN7.2
Rnor_6.08116,054,281 - 116,054,439NCBIRnor6.0
Rnor_5.08115,410,761 - 115,410,919UniSTSRnor5.0
RGSC_v3.48112,540,768 - 112,540,926UniSTSRGSC3.4
Celera8107,281,829 - 107,281,987UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000040056   ⟹   ENSRNOP00000041734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,972,306 - 107,977,250 (+)Ensembl
Rnor_6.0 Ensembl8116,054,465 - 116,060,723 (+)Ensembl
RefSeq Acc Id: NM_031804   ⟹   NP_113992
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,850,969 - 116,855,917 (+)NCBI
mRatBN7.28107,972,306 - 107,977,254 (+)NCBI
Rnor_6.08116,054,547 - 116,059,494 (+)NCBI
Rnor_5.08115,411,027 - 115,415,974 (+)NCBI
RGSC_v3.48112,541,034 - 112,545,982 (+)RGD
Celera8107,282,095 - 107,287,043 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC17502 (Get FASTA)   NCBI Sequence Viewer  
  AAG29815 (Get FASTA)   NCBI Sequence Viewer  
  AAI61930 (Get FASTA)   NCBI Sequence Viewer  
  CAB51743 (Get FASTA)   NCBI Sequence Viewer  
  EDL77261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041734.3
GenBank Protein O70512 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113992   ⟸   NM_031804
- UniProtKB: Q9ERQ1 (UniProtKB/Swiss-Prot),   O70512 (UniProtKB/Swiss-Prot),   B1WBX9 (UniProtKB/TrEMBL),   F7F2E8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041734   ⟸   ENSRNOT00000040056
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70512-F1-model_v2 AlphaFold O70512 1-256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696264
Promoter ID:EPDNEW_R6789
Type:multiple initiation site
Name:Cish_1
Description:cytokine inducible SH2-containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,054,541 - 116,054,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69261 AgrOrtholog
BioCyc Gene G2FUF-29210 BioCyc
Ensembl Genes ENSRNOG00000029543 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040056.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8375557 IMAGE-MGC_LOAD
InterPro CIS_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83681 UniProtKB/TrEMBL
MGC_CLONE MGC:187704 IMAGE-MGC_LOAD
NCBI Gene 83681 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10155:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cish PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029543 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1WBX9 ENTREZGENE, UniProtKB/TrEMBL
  CISH_RAT UniProtKB/Swiss-Prot
  F7F2E8 ENTREZGENE, UniProtKB/TrEMBL
  O70512 ENTREZGENE
  Q9ERQ1 ENTREZGENE
UniProt Secondary Q9ERQ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cish  cytokine inducible SH2-containing protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference