Naa80 (N(alpha)-acetyltransferase 80, NatH catalytic subunit) - Rat Genome Database

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Pathways
Gene: Naa80 (N(alpha)-acetyltransferase 80, NatH catalytic subunit) Rattus norvegicus
Analyze
Symbol: Naa80
Name: N(alpha)-acetyltransferase 80, NatH catalytic subunit
RGD ID: 6496422
Description: Predicted to enable acetyl-CoA binding activity and protein-N-terminal amino-acid acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation; actin modification; and regulation of actin polymerization or depolymerization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NAA80 (N-alpha-acetyltransferase 80, NatH catalytic subunit); INTERACTS WITH aflatoxin B1; glyphosate; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910872; N-acetyltransferase 6; N-acetyltransferase 6 (GCN5-related); N-acetyltransferase 6-like; N-alpha-acetyltransferase 80; Nat6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,132,957 - 117,136,207 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,133,494 - 117,136,207 (+)EnsemblGRCr8
mRatBN7.28108,254,314 - 108,257,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,881,134 - 113,884,384 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,080,291 - 112,083,541 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,923,073 - 109,926,323 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,336,441 - 116,339,691 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,692,701 - 115,695,951 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera8107,560,892 - 107,564,142 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10644992   PMID:12477932   PMID:29581253   PMID:29581307   PMID:30028079  


Genomics

Comparative Map Data
Naa80
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,132,957 - 117,136,207 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,133,494 - 117,136,207 (+)EnsemblGRCr8
mRatBN7.28108,254,314 - 108,257,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,881,134 - 113,884,384 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,080,291 - 112,083,541 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,923,073 - 109,926,323 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,336,441 - 116,339,691 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,692,701 - 115,695,951 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera8107,560,892 - 107,564,142 (+)NCBICelera
Cytogenetic Map8q32NCBI
NAA80
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,296,402 - 50,299,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,296,402 - 50,299,416 (-)Ensemblhg38GRCh38
GRCh37350,333,833 - 50,336,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,308,837 - 50,311,716 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34350,308,837 - 50,311,716NCBI
Celera350,306,664 - 50,309,543 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,389,576 - 50,392,595 (-)NCBIHuRef
CHM1_1350,286,139 - 50,289,158 (-)NCBICHM1_1
T2T-CHM13v2.0350,325,758 - 50,328,761 (-)NCBIT2T-CHM13v2.0
Naa80
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,457,868 - 107,461,247 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,456,086 - 107,461,249 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,580,669 - 107,584,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,578,887 - 107,584,050 (+)Ensemblmm10GRCm38
MGSCv379107,482,501 - 107,486,379 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,438,269 - 107,442,149 (+)NCBIMGSCv36mm8
Celera9107,188,942 - 107,192,827 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.18NCBI
Naa80
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,110,133 - 2,110,744 (-)Ensembl
ChiLan1.0NW_0049555322,109,595 - 2,112,013 (-)NCBIChiLan1.0ChiLan1.0
NAA80
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,279,455 - 50,282,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,284,230 - 50,287,180 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,225,000 - 50,228,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,459,748 - 51,462,764 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,459,748 - 51,462,764 (-)EnsemblpanPan2panpan1.1
NAA80
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,042,078 - 39,044,894 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,963,106 - 38,965,918 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,398,104 - 39,400,916 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12038,765,927 - 38,768,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,169,437 - 39,172,249 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,449,507 - 39,452,319 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Naa80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,073,811 - 65,076,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,834,349 - 1,837,182 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,834,308 - 1,837,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAA80
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,793,572 - 32,794,700 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11332,793,784 - 32,794,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,972,319 - 35,973,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
NAA80
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666041155,299,070 - 155,302,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naa80
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,157,714 - 4,159,927 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Naa80
42 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH139126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,254,313 - 108,254,497 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,441 - 116,336,624NCBIRnor6.0
Rnor_5.08115,692,701 - 115,692,884UniSTSRnor5.0
RGSC_v3.48112,828,079 - 112,828,262UniSTSRGSC3.4
Celera8107,560,892 - 107,561,075UniSTS
RH 3.4 Map81116.6UniSTS
Cytogenetic Map8q32UniSTS
BF387601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,253,956 - 108,254,130 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,084 - 116,336,257NCBIRnor6.0
Rnor_5.08115,692,344 - 115,692,517UniSTSRnor5.0
RGSC_v3.48112,827,722 - 112,827,895UniSTSRGSC3.4
Celera8107,560,535 - 107,560,708UniSTS
RH 3.4 Map81120.8UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000090123   ⟹   ENSRNOP00000069333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,133,494 - 117,136,207 (+)Ensembl
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)Ensembl
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)Ensembl
RefSeq Acc Id: NM_001304776   ⟹   NP_001291705
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,132,957 - 117,136,207 (+)NCBI
mRatBN7.28108,254,314 - 108,257,564 (+)NCBI
Rnor_6.08116,336,441 - 116,339,691 (+)NCBI
Celera8107,560,892 - 107,564,142 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001291705 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069333
  ENSRNOP00000069333.1
RefSeq Acc Id: NP_001291705   ⟸   NM_001304776
- UniProtKB: A0A0G2JV35 (UniProtKB/TrEMBL),   A6I2Y5 (UniProtKB/TrEMBL),   Q3KR83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069333   ⟸   ENSRNOT00000090123
Protein Domains
N-acetyltransferase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696275
Promoter ID:EPDNEW_R6800
Type:initiation region
Name:Nat6_1
Description:N-acetyltransferase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,336,380 - 116,336,440EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6496422 AgrOrtholog
BioCyc Gene G2FUF-29189 BioCyc
Ensembl Genes ENSRNOG00000054063 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090123 ENTREZGENE
  ENSRNOT00000090123.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  NAT6 UniProtKB/TrEMBL
KEGG Report rno:100910872 UniProtKB/TrEMBL
NCBI Gene LOC100910872 ENTREZGENE
PANTHER N-ALPHA-ACETYLTRANSFERASE 80 UniProtKB/TrEMBL
  PTHR13538 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Naa80 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054063 RatGTEx
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A0G2JV35 ENTREZGENE, UniProtKB/TrEMBL
  A6I2Y5 ENTREZGENE, UniProtKB/TrEMBL
  Q3KR83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-27 Naa80  N(alpha)-acetyltransferase 80, NatH catalytic subunit  Nat6  N-acetyltransferase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-17 Nat6  N-acetyltransferase 6  Nat6  N-acetyltransferase 6 (GCN5-related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-12 Nat6  N-acetyltransferase 6 (GCN5-related)  LOC100910872  N-acetyltransferase 6-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910872  N-acetyltransferase 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL