Wdr82 (WD repeat domain 82) - Rat Genome Database

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Pathways
Gene: Wdr82 (WD repeat domain 82) Rattus norvegicus
Analyze
Symbol: Wdr82
Name: WD repeat domain 82
RGD ID: 1584269
Description: Predicted to enable chromatin binding activity and lncRNA binding activity. Predicted to be involved in RNA metabolic process and regulation of DNA-templated transcription. Predicted to act upstream of or within gene expression. Predicted to be located in chromatin; chromosome, telomeric region; and nucleolus. Predicted to be part of PTW/PP1 phosphatase complex and Set1C/COMPASS complex. Orthologous to human WDR82 (WD repeat domain 82); PARTICIPATES IN histone modification pathway; INTERACTS WITH bisphenol A; paracetamol; (+)-catechin (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC686295; similar to CG17293-PA; uncharacterized protein LOC686295; WD repeat-containing protein 82
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Wdr82-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,693,297 - 115,713,262 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,693,315 - 115,713,242 (+)EnsemblGRCr8
mRatBN7.28106,814,569 - 106,834,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,814,569 - 106,834,438 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,439,133 - 112,459,117 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,638,294 - 110,658,278 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,481,100 - 108,501,084 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,866,769 - 114,886,208 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,866,768 - 114,884,635 (+)Ensemblrn6Rnor6.0
Rnor_5.08114,230,824 - 114,249,590 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera8106,137,320 - 106,156,763 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
chromatin binding  (IBA,IEA,ISO)
lncRNA binding  (IEA,ISO)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
4. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
Additional References at PubMed
PMID:12477932   PMID:17355966   PMID:17998332   PMID:18838538   PMID:20516061   PMID:21123813   PMID:22252316   PMID:24270157  


Genomics

Comparative Map Data
Wdr82
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,693,297 - 115,713,262 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,693,315 - 115,713,242 (+)EnsemblGRCr8
mRatBN7.28106,814,569 - 106,834,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8106,814,569 - 106,834,438 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,439,133 - 112,459,117 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,638,294 - 110,658,278 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,481,100 - 108,501,084 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08114,866,769 - 114,886,208 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,866,768 - 114,884,635 (+)Ensemblrn6Rnor6.0
Rnor_5.08114,230,824 - 114,249,590 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera8106,137,320 - 106,156,763 (+)NCBICelera
Cytogenetic Map8q32NCBI
WDR82
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,254,434 - 52,278,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,254,434 - 52,288,020 (-)Ensemblhg38GRCh38
GRCh37352,288,450 - 52,312,665 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,263,478 - 52,287,699 (-)NCBIBuild 36Build 36hg18NCBI36
Celera352,267,750 - 52,291,971 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,350,624 - 52,374,836 (-)NCBIHuRef
CHM1_1352,240,980 - 52,265,189 (-)NCBICHM1_1
T2T-CHM13v2.0352,287,321 - 52,311,534 (-)NCBIT2T-CHM13v2.0
Wdr82
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,048,098 - 106,068,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,048,127 - 106,068,338 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389106,170,925 - 106,191,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,170,928 - 106,191,139 (+)Ensemblmm10GRCm38
MGSCv379106,073,260 - 106,094,037 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369106,029,027 - 106,051,091 (+)NCBIMGSCv36mm8
Celera9105,795,931 - 105,817,446 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.46NCBI
Wdr82
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,863,492 - 3,880,713 (-)Ensembl
ChiLan1.0NW_0049555323,860,785 - 3,880,714 (-)NCBIChiLan1.0ChiLan1.0
WDR82
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,249,908 - 52,274,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,255,184 - 52,278,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,196,740 - 52,220,982 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,426,125 - 53,450,170 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,426,112 - 53,450,170 (-)EnsemblpanPan2panpan1.1
WDR82
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,494,633 - 37,513,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,355,494 - 37,511,125 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2037,476,200 - 37,495,302 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02037,845,019 - 37,864,288 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,845,315 - 37,864,286 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,208,709 - 37,227,979 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,617,461 - 37,636,557 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,902,068 - 37,921,338 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wdr82
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,807,437 - 66,831,322 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365293,568,184 - 3,592,084 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365293,569,354 - 3,591,815 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR82
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,387,808 - 34,412,140 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11334,387,799 - 34,412,190 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,593,058 - 37,617,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR82
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,617,169 - 13,638,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041153,263,001 - 153,286,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr82
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247306,032,426 - 6,067,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Wdr82
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:126
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000074771
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)888612425107550209Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074771   ⟹   ENSRNOP00000064523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,693,315 - 115,708,549 (+)Ensembl
mRatBN7.2 Ensembl8106,814,569 - 106,829,822 (+)Ensembl
Rnor_6.0 Ensembl8114,867,062 - 114,884,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075966   ⟹   ENSRNOP00000068063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8106,814,825 - 106,834,423 (+)Ensembl
Rnor_6.0 Ensembl8114,876,146 - 114,884,635 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076731   ⟹   ENSRNOP00000068259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8114,866,768 - 114,867,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096974   ⟹   ENSRNOP00000095017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,693,315 - 115,713,242 (+)Ensembl
mRatBN7.2 Ensembl8106,814,837 - 106,834,438 (+)Ensembl
RefSeq Acc Id: NM_001271306   ⟹   NP_001258235
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88115,693,297 - 115,713,262 (+)NCBI
mRatBN7.28106,814,569 - 106,834,535 (+)NCBI
Rnor_6.08114,866,769 - 114,886,208 (+)NCBI
Rnor_5.08114,230,824 - 114,249,590 (+)NCBI
Celera8106,137,320 - 106,156,763 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258235 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77331 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064523.3
  ENSRNOP00000068063.2
  ENSRNOP00000095017
  ENSRNOP00000095017.1
RefSeq Acc Id: NP_001258235   ⟸   NM_001271306
- UniProtKB: A0A096MJB3 (UniProtKB/TrEMBL),   A6I2P5 (UniProtKB/TrEMBL),   A0A8I6AN51 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068063   ⟸   ENSRNOT00000075966
Ensembl Acc Id: ENSRNOP00000064523   ⟸   ENSRNOT00000074771
Ensembl Acc Id: ENSRNOP00000068259   ⟸   ENSRNOT00000076731
Ensembl Acc Id: ENSRNOP00000095017   ⟸   ENSRNOT00000096974

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R565-F1-model_v2 AlphaFold M0R565 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696243
Promoter ID:EPDNEW_R6767
Type:initiation region
Name:Wdr82_1
Description:WD repeat domain 82
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08114,866,769 - 114,866,829EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584269 AgrOrtholog
BioCyc Gene G2FUF-29255 BioCyc
Ensembl Genes ENSRNOG00000048441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074771.4 UniProtKB/TrEMBL
  ENSRNOT00000075966.2 UniProtKB/TrEMBL
  ENSRNOT00000096974 ENTREZGENE
  ENSRNOT00000096974.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  Swd2/WDR82 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:686295 UniProtKB/TrEMBL
NCBI Gene 686295 ENTREZGENE
PANTHER PTHR19861 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 82 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PhenoGen Wdr82 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048441 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A096MJB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN51 ENTREZGENE, UniProtKB/TrEMBL
  A6I2P5 ENTREZGENE, UniProtKB/TrEMBL
  M0R565_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-16 Wdr82  WD repeat domain 82  LOC686295  similar to CG17293-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC686295  similar to CG17293-PA      Symbol and Name status set to provisional 70820 PROVISIONAL