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Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Rattus norvegicus
Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Localizes to acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; and piebaldism. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 2-acetamidofluorene.
Type: protein-coding
Also known as: c-kit receptor tyrosine kinase; Kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; protein kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Homo sapiens (human) : KIT (KIT proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Kit (KIT proto-oncogene receptor tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
more info ...
Allele / Splice: KitWs  
Genetic Models: BN-KitWs
Is Marker For: Strains:   F344-TyrCKitH/Kyo   F344-AsipATyrCKitH/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01435,072,131 - 35,149,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,072,108 - 35,149,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,901,860 - 34,979,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,906,043 - 34,984,819 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11434,906,042 - 34,984,819 (-)NCBI
Celera1431,837,543 - 31,913,518 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kit
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620568
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.