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Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Mus musculus
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Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Description: Exhibits SH2 domain binding activity; protease binding activity; and stem cell factor receptor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; hemopoiesis; and positive regulation of macromolecule metabolic process. Localizes to the cell-cell junction and external side of plasma membrane. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: belly-spot; Bs; c-KIT; c-kit proto-oncogene protein; CD117; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; SCO1; SCO5; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine-protein kinase Kit; W
Orthologs:
Homo sapiens (human) : KIT (KIT proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kit (KIT proto-oncogene receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl575,574,916 - 75,656,722 (+)Ensembl
GRCm38575,574,987 - 75,656,722 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37575,971,012 - 76,052,747 (+)NCBIGRCm37mm9NCBIm37
MGSCv36575,856,721 - 75,938,419 (+)NCBImm8
Celera572,859,483 - 72,942,690 (+)NCBICelera
Cytogenetic Map5 C3.3NCBI
cM Map539.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Kit
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731383
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.