RGD Reference Report - Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling. - Rat Genome Database

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Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling.

Authors: Das, AV  James, J  Zhao, X  Rahnenfuhrer, J  Ahmad, I 
Citation: Das AV, etal., Dev Biol. 2004 Sep 1;273(1):87-105.
RGD ID: 2292509
Pubmed: PMID:15302600   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ydbio.2004.05.023   (Journal Full-text)

Neural stem cells are present in specific regions of the adult central nervous system (CNS). Recent evidence suggests that the ciliary epithelium (CE), a CNS derivative, in the adult mammalian eye, harbors a quiescent population of neural stem cells. Here, we report the identification of c-Kit signaling as one of the regulators of adult CE neural stem cells in vitro. c-Kit receptors are expressed in proliferating adult CE neural stem cells and colocalized with neural progenitor markers. Perturbation of c-Kit signaling influences the self-renewal and differentiation of CE neural stem cells, thus demonstrating the role of c-Kit signaling in the maintenance of these cells. In addition, we observed an influence of c-Kit-mediated signaling on the expression of Notch1, another critical regulator of neural stem cells. Our observations suggest that, given the importance of preservation of a stem cell pool for generating different cell types at different times, multiple signaling pathways act in concert for the maintenance of neural stem cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KitRatpositive regulation of cell population proliferation  IMP neural stem cells from the ciliary epithelium of the eyeRGD 
KitRatpositive regulation of Notch signaling pathway  IMP  RGD 
KitRatsomatic stem cell population maintenance  IMP neural stem cells from the ciliary epithelium of the eyeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Kit  (KIT proto-oncogene receptor tyrosine kinase)


Additional Information