Kit (KIT proto-oncogene, receptor tyrosine kinase) - Rat Genome Database

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Gene: Kit (KIT proto-oncogene, receptor tyrosine kinase) Chinchilla lanigera
Analyze
Symbol: Kit
Name: KIT proto-oncogene, receptor tyrosine kinase
RGD ID: 9051831
Description: ENCODES a protein that exhibits cytokine binding (ortholog); protease binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); cell chemotaxis (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); acute myeloid leukemia (ortholog); acute pancreatitis (ortholog); FOUND IN acrosomal vesicle (ortholog); cell surface (ortholog); cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: KIT proto-oncogene receptor tyrosine kinase; mast/stem cell growth factor receptor Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544716,148,605 - 16,226,734 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544716,149,014 - 16,226,151 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
aplastic anemia  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
constipation  (ISO)
cutaneous mastocytosis  (ISO)
disease of cellular proliferation  (ISO)
dysgerminoma  (ISO)
endometrial stromal sarcoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
gastric adenocarcinoma  (ISO)
Gastric Reperfusion Injury  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
gastroschisis  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
Hematologic Neoplasms  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
ileus  (ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
Latent Tuberculosis  (ISO)
leiomyosarcoma  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mast-cell leukemia  (ISO)
mastocytosis  (ISO)
melanoma  (ISO)
myeloproliferative neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
neurofibroma  (ISO)
Ovarian Neoplasms  (ISO)
oxyphilic adenoma  (ISO)
Phyllodes Tumor  (ISO)
piebaldism  (ISO)
primary immunodeficiency disease  (ISO)
Primitive Peripheral Neuroectodermal Tumors  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
systemic mastocytosis  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
uterine carcinosarcoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
cell chemotaxis  (ISO)
cell population proliferation  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cytokine-mediated signaling pathway  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
developmental pigmentation  (ISO)
digestive tract development  (ISO)
ectopic germ cell programmed cell death  (ISO)
embryonic hemopoiesis  (ISO)
epithelial cell proliferation  (ISO)
erythrocyte differentiation  (ISO)
erythropoietin-mediated signaling pathway  (ISO)
Fc receptor signaling pathway  (ISO)
germ cell migration  (ISO)
glycosphingolipid metabolic process  (ISO)
hematopoietic stem cell migration  (ISO)
hemopoiesis  (ISO)
immature B cell differentiation  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (ISO)
Kit signaling pathway  (ISO)
lamellipodium assembly  (ISO)
lymphoid progenitor cell differentiation  (ISO)
male gonad development  (ISO)
mast cell chemotaxis  (ISO)
mast cell degranulation  (ISO)
mast cell differentiation  (ISO)
mast cell proliferation  (ISO)
megakaryocyte development  (ISO)
melanocyte adhesion  (ISO)
melanocyte differentiation  (ISO)
melanocyte migration  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of developmental process  (ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of reproductive process  (ISO)
ovarian follicle development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
pigmentation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of colon smooth muscle contraction  (ISO)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell cytokine production  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of pyloric antrum smooth muscle contraction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
programmed cell death  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of bile acid metabolic process  (ISO)
regulation of cell shape  (ISO)
response to cadmium ion  (ISO)
response to radiation  (ISO)
somatic stem cell division  (ISO)
somatic stem cell population maintenance  (ISO)
spermatid development  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (ISO)
T cell differentiation  (ISO)
tongue development  (ISO)
visual learning  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Kit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544716,148,605 - 16,226,734 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544716,149,014 - 16,226,151 (-)NCBIChiLan1.0ChiLan1.0
KIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38454,657,957 - 54,740,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl454,657,267 - 54,740,783 (+)EnsemblGRCh38hg38GRCh38
GRCh37455,524,124 - 55,606,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,218,852 - 55,301,638 (+)NCBINCBI36hg18NCBI36
Build 34455,365,088 - 55,447,783NCBI
Celera453,026,240 - 53,109,027 (+)NCBI
Cytogenetic Map4q12NCBI
HuRef451,471,979 - 51,554,769 (+)NCBIHuRef
CHM1_1455,559,642 - 55,642,426 (+)NCBICHM1_1
T2T-CHM13v2.0458,146,698 - 58,229,411 (+)NCBI
Kit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39575,735,647 - 75,817,382 (+)NCBIGRCm39mm39
GRCm39 Ensembl575,735,576 - 75,817,382 (+)Ensembl
GRCm38575,574,987 - 75,656,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,574,916 - 75,656,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv37575,971,012 - 76,052,747 (+)NCBIGRCm37mm9NCBIm37
MGSCv36575,856,721 - 75,938,419 (+)NCBImm8
Celera572,859,483 - 72,942,690 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
Kit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21432,547,459 - 32,624,694 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1432,548,877 - 32,624,652 (-)Ensembl
Rnor_6.01435,072,131 - 35,149,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,072,108 - 35,149,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,901,860 - 34,979,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,906,043 - 34,984,819 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11434,906,042 - 34,984,819 (-)NCBI
Celera1431,837,543 - 31,913,518 (-)NCBICelera
Cytogenetic Map14p11NCBI
KIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1475,761,946 - 75,844,473 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,761,946 - 75,844,473 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0469,199,543 - 69,282,323 (-)NCBIMhudiblu_PPA_v0panPan3
KIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,108,442 - 47,190,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,108,504 - 47,190,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1347,065,096 - 47,146,648 (+)NCBI
ROS_Cfam_1.01347,717,855 - 47,799,689 (+)NCBI
ROS_Cfam_1.0 Ensembl1347,717,897 - 47,801,313 (+)Ensembl
UMICH_Zoey_3.11347,394,247 - 47,475,763 (+)NCBI
UNSW_CanFamBas_1.01346,922,748 - 47,004,082 (+)NCBI
UU_Cfam_GSD_1.01347,870,472 - 47,952,050 (+)NCBI
Kit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528529,059,916 - 29,135,385 (-)NCBI
SpeTri2.0NW_00493648217,162,854 - 17,238,319 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,402,043 - 41,493,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1841,402,334 - 41,492,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,550,231 - 43,601,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8p12NCBI
KIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,808,104 - 13,891,003 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl713,808,037 - 13,890,976 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606614,587,172 - 14,670,161 (-)NCBIVero_WHO_p1.0
Kit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476114,733,912 - 14,831,428 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009381   ⟹   ENSCLAP00000009252
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544716,148,605 - 16,226,734 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000009382   ⟹   ENSCLAP00000009253
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544716,148,605 - 16,205,582 (-)Ensembl
RefSeq Acc Id: XM_013518572   ⟹   XP_013374026
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544716,149,014 - 16,226,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518573   ⟹   XP_013374027
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544716,149,014 - 16,226,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518575   ⟹   XP_013374029
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544716,149,014 - 16,201,629 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013374026 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374027 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374029 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013374027   ⟸   XM_013518573
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013374026   ⟸   XM_013518572
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013374029   ⟸   XM_013518575
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000009252   ⟸   ENSCLAT00000009381
RefSeq Acc Id: ENSCLAP00000009253   ⟸   ENSCLAT00000009382
Protein Domains
Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000009252 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAP00000009253 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009381 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAT00000009382 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SCGF_receptor UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
NCBI Gene Kit ENTREZGENE
Pfam PF00047 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF SCGF_recepter UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2YMC7_CHILA UniProtKB/TrEMBL
  A0A8C2YMD0_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Kit  KIT proto-oncogene, receptor tyrosine kinase    KIT proto-oncogene receptor tyrosine kinase  Symbol and/or name change 5135510 APPROVED
2016-08-03 Kit  KIT proto-oncogene receptor tyrosine kinase    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED