Strain Report - Rat Genome Database

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Strain: F344-AsipATyrCKitH/Kyo

Symbol: F344-AsipATyrCKitH/Kyo
Strain: F344-AsipATyrCKitH
Substrain: Kyo
RGD ID: 11040974
Citation ID: RRID:RGD_11040974
Ontology ID: RS:0004158
Alleles: Asip;   Tyr;   Kit
Also Known As: Agouti Fischer; NBRP Rat No: 0769; F344-AsipATyrCKitH/Kyo; F344-Asip^[A]Tyr^[C]Kit^[H]/Kyo
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: 1) point mutation in the exon 2 of Tyrosinase (Tyr) gene (albino phenotype), 2) 19-bp deletion in Asip gene (Agouti phenotype), and 3) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) were targeted by CRISPR/Cas9 system using ssODN. The rat coat colour phenotype was changed from white to Agouti. Background strain: F344/Stm
Last Known Status: Live Animals; Cryopreserved Sperm
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,473,584 - 143,561,170RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.21432,547,459 - 32,624,694RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.21141,115,036 - 141,210,207RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03150,492,010 - 150,579,870RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01435,072,131 - 35,149,638RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01151,012,598 - 151,106,802RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01434,901,860 - 34,979,384RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01157,322,968 - 157,416,594RGD_MAPPER_PIPELINERnor5.0
Rnor_5.03156,860,395 - 156,949,277RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43145,445,175 - 145,536,831RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.41434,906,043 - 34,984,819RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.41143,641,257 - 143,746,315RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Yoshimi K, etal., Nat Commun. 2014 Jun 26;5:4240. doi: 10.1038/ncomms5240.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Agouti coat colour (genetic background: F344/Stm) 1302502
strain_reproduction homozygous condition (wild-type color: Agouti) 1302502