Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: KIT (KIT proto-oncogene, receptor tyrosine kinase) Homo sapiens
Analyze
Symbol: KIT
Name: KIT proto-oncogene, receptor tyrosine kinase
Description: Exhibits cytokine binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein phosphorylation; and protein phosphorylation. Localizes to the extracellular space; fibrillar center; and plasma membrane. Implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Biomarker of several diseases, including Hirschsprung's disease; female reproductive organ cancer (multiple); invasive ductal carcinoma; oxyphilic adenoma; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-Kit; c-Kit protooncogene; CD117; KIT proto-oncogene receptor tyrosine kinase; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MASTC; p145 c-kit; PBT; piebald trait; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Orthologs:
Mus musculus (house mouse) : Kit (KIT proto-oncogene receptor tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kit (KIT proto-oncogene receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl454,657,918 - 54,740,715 (+)Ensembl
GRCh38454,657,928 - 54,740,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37455,524,095 - 55,606,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,218,852 - 55,301,638 (+)NCBINCBI36hg18NCBI36
Build 34455,365,088 - 55,447,783NCBI
Celera453,026,240 - 53,109,027 (+)NCBI
Cytogenetic Map4q12NCBI
HuRef451,471,979 - 51,554,769 (+)NCBIHuRef
CHM1_1455,559,642 - 55,642,426 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data