KIT (KIT proto-oncogene, receptor tyrosine kinase) - Rat Genome Database

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Gene: KIT (KIT proto-oncogene, receptor tyrosine kinase) Homo sapiens
Symbol: KIT
Name: KIT proto-oncogene, receptor tyrosine kinase
RGD ID: 731382
HGNC Page HGNC:6342
Description: Enables cytokine binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space; fibrillar center; and plasma membrane. Implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Biomarker of several diseases, including Hirschsprung's disease; invasive ductal carcinoma; oxyphilic adenoma; reproductive organ cancer (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-Kit; c-Kit protooncogene; CD117; KIT proto-oncogene receptor tyrosine kinase; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MASTC; p145 c-kit; PBT; piebald trait; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38454,657,957 - 54,740,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl454,657,267 - 54,740,783 (+)EnsemblGRCh38hg38GRCh38
GRCh37455,524,124 - 55,606,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,218,852 - 55,301,638 (+)NCBINCBI36Build 36hg18NCBI36
Build 34455,365,088 - 55,447,783NCBI
Celera453,026,240 - 53,109,027 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,471,979 - 51,554,769 (+)NCBIHuRef
CHM1_1455,559,642 - 55,642,426 (+)NCBICHM1_1
T2T-CHM13v2.0458,146,698 - 58,229,411 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)