Gene: Bche (butyrylcholinesterase) Rattus norvegicus
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Symbol: Bche
Name: butyrylcholinesterase
Description: Exhibits choline binding activity and cholinesterase activity. Involved in several processes, including choline metabolic process; neuroblast differentiation; and response to folic acid. Localizes to the endoplasmic reticulum lumen; extracellular space; and membrane. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BCHE (butyrylcholinesterase); PARTICIPATES IN heroin pharmacodynamics pathway; heroin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R,R)-tramadol; 1,2,3-Trichloropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cholinesterase
Orthologs:
Homo sapiens (human) : BCHE (butyrylcholinesterase)  HGNC  Alliance
Mus musculus (house mouse) : Bche (butyrylcholinesterase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bche (butyrylcholinesterase)
Pan paniscus (bonobo/pygmy chimpanzee) : BCHE (butyrylcholinesterase)
Canis lupus familiaris (dog) : BCHE (butyrylcholinesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bche (butyrylcholinesterase)
Sus scrofa (pig) : BCHE (butyrylcholinesterase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Celera2152,547,587 - 152,638,478 (-)NCBICelera
Cytogenetic Map2q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Bche
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619996
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.