Rig1 (RNA sensor RIG-1) - Rat Genome Database

Name: Rig1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Rig1 (RNA sensor RIG-1) Rattus norvegicus

Analyze

Symbol:

Rig1

Name:

RNA sensor RIG-1

RGD ID:

1309460

Description:

Predicted to enable several functions, including ATP hydrolysis activity; GTP binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of defense response; and response to virus. Predicted to act upstream of or within response to exogenous dsRNA. Predicted to be located in actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Orthologous to human RIGI (RNA sensor RIG-I); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

antiviral innate immune response receptor RIG-I; Ddx58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEXD/H-box helicase 58; LOC297989; probable ATP-dependent RNA helicase DDX58

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RIGI (RNA sensor RIG-I)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rigi (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rigi (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RIGI (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RIGI (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rigi (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RIGI (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RIGI (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rigi (RNA sensor RIG-I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RIGI (RNA sensor RIG-I)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rigi (RNA sensor RIG-I)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	drh-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	drh-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rigi	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	55,321,351 - 55,369,947 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	55,321,235 - 55,370,819 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	57,286,594 - 57,336,136 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,105,729 - 59,155,277 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,077,158 - 59,126,758 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	56,486,584 - 56,536,898 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	56,500,734 - 56,536,772 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,033,071 - 61,080,788 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	57,597,131 - 57,645,147 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	57,599,100 - 57,645,200 (-)	NCBI
Celera	5	53,939,534 - 53,986,275 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

Disease Progression (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis-6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

hepatitis C (ISO)

Human Influenza (ISO)

influenza A (ISO)

Orthomyxoviridae Infections (ISO)

primary ciliary dyskinesia (ISO)

psoriasis (ISO)

Singleton-Merten Syndrome 2 (ISO)

West Nile encephalitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

15-deoxy-Delta(12,14)-prostaglandin J2 (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6alpha-methylprednisolone (ISO)

acetamide (EXP)

aconitine (EXP)

all-trans-retinoic acid (EXP,ISO)

alpha-phellandrene (ISO)

amphetamine (EXP)

aripiprazole (ISO)

Aroclor 1254 (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diclofenac (ISO)

dicrotophos (ISO)

dieldrin (EXP)

diethyl malate (ISO)

dioxygen (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

gentamycin (EXP)

hydroxychloroquine (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

metam (ISO)

methamphetamine (EXP)

methapyrilene (EXP,ISO)

methotrexate (ISO)

nefazodone (EXP)

nickel atom (ISO)

nicotine (ISO)

nimesulide (EXP)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

poly(I:C) (ISO)

polymyxin B2 (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

prednisolone (ISO)

propiconazole (ISO)

quercetin (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium aurothiomalate (ISO)

Soman (EXP)

succimer (ISO)

sulforaphane (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiophenes (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (ISO)

cellular response to exogenous dsRNA (ISO)

cytosolic pattern recognition receptor signaling pathway (ISO)

detection of virus (ISO)

gene expression (ISO)

innate immune response (ISO)

positive regulation of defense response to virus by host (ISO)

positive regulation of gene expression (ISO)

positive regulation of granulocyte macrophage colony-stimulating factor production (ISO)

positive regulation of interferon-alpha production (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of interleukin-8 production (ISO)

positive regulation of myeloid dendritic cell cytokine production (ISO)

positive regulation of response to cytokine stimulus (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of tumor necrosis factor production (ISO)

regulation of cell migration (ISO)

response to exogenous dsRNA (ISO)

response to virus (ISO)

RIG-I signaling pathway (ISO)

Cellular Component

actin cytoskeleton (ISO)

bicellular tight junction (ISO)

cytoplasm (ISO)

ribonucleoprotein complex (ISO)

ruffle membrane (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (ISO)

double-stranded DNA binding (ISO)

double-stranded RNA binding (ISO)

GTP binding (ISO)

identical protein binding (ISO)

pattern recognition receptor activity (ISO)

protein binding (ISO)

RNA helicase activity (ISO)

single-stranded RNA binding (ISO)

ubiquitin protein ligase binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis.	Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17079289	PMID:17190814	PMID:17942531	PMID:18243112	PMID:19122199	PMID:19158679	PMID:19211564	PMID:19576794	PMID:19609254	PMID:19631370	PMID:20581823	PMID:21076616
PMID:21102435	PMID:21478870	PMID:21703541	PMID:21957149	PMID:22314235	PMID:22745163	PMID:23950712	PMID:24409285	PMID:24590070	PMID:26471729	PMID:28469175	PMID:31006531

Genomics

Comparative Map Data

Rig1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	55,321,351 - 55,369,947 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	55,321,235 - 55,370,819 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	57,286,594 - 57,336,136 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,105,729 - 59,155,277 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,077,158 - 59,126,758 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	56,486,584 - 56,536,898 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	56,500,734 - 56,536,772 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,033,071 - 61,080,788 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	57,597,131 - 57,645,147 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	57,599,100 - 57,645,200 (-)	NCBI
Celera	5	53,939,534 - 53,986,275 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

RIGI
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	32,455,302 - 32,526,196 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	32,455,302 - 32,526,208 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	32,455,300 - 32,526,194 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	32,445,300 - 32,516,322 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	32,445,704 - 32,516,322	NCBI
Celera	9	32,385,259 - 32,456,256 (-)	NCBI		Celera
Cytogenetic Map	9	p21.1	NCBI
HuRef	9	32,411,092 - 32,481,542 (-)	NCBI		HuRef
CHM1_1	9	32,455,159 - 32,526,318 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	32,471,227 - 32,542,369 (-)	NCBI		T2T-CHM13v2.0

Rigi
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	40,203,775 - 40,239,843 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	40,203,773 - 40,239,828 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	40,203,777 - 40,239,825 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	40,203,773 - 40,239,828 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	40,150,810 - 40,186,858 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	40,394,461 - 40,428,372 (-)	NCBI		MGSCv36	mm8
Celera	4	39,866,998 - 39,902,804 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	20.24	NCBI

Rigi
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	3,093,939 - 3,133,987 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	3,093,895 - 3,135,524 (+)	NCBI	ChiLan1.0	ChiLan1.0

RIGI
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	92,091,345 - 92,178,669 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	32,230,012 - 32,302,159 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	33,040,000 - 33,110,557 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	33,040,000 - 33,110,557 (-)	Ensembl	panpan1.1		panPan2

RIGI
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	49,764,252 - 49,799,626 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	49,764,267 - 49,799,527 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	48,386,814 - 48,422,172 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	50,702,778 - 50,718,163 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	11	49,368,434 - 49,403,794 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,234,998 - 49,270,344 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	49,993,647 - 50,029,015 (-)	NCBI		UU_Cfam_GSD_1.0

Rigi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	164,594,226 - 164,653,026 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	1,140,971 - 1,200,638 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936524	1,141,840 - 1,200,638 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RIGI
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	33,891,763 - 33,933,455 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	33,891,720 - 33,976,151 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	38,145,289 - 38,189,016 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RIGI
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	47,729,040 - 47,800,995 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	47,729,076 - 47,799,570 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	44,621,500 - 44,694,693 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rigi
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	37,133,059 - 37,197,218 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	37,134,718 - 37,204,543 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rig1
441 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	159
Count of miRNA genes:	132
Interacting mature miRNAs:	140
Transcripts:	ENSRNOT00000060765
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			31	15	19	15				15	6	11
Low	3	43	26	26		26	8	11	74	20	35		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000060765 ⟹ ENSRNOP00000057492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	55,322,103 - 55,369,947 (-)	Ensembl
Rnor_6.0 Ensembl	5	56,500,734 - 56,536,772 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107881 ⟹ ENSRNOP00000090460

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	55,322,103 - 55,370,819 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107968 ⟹ ENSRNOP00000094775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	55,321,235 - 55,369,942 (-)	Ensembl

RefSeq Acc Id:

NM_001395071 ⟹ NP_001382000

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	55,321,351 - 55,369,947 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001382000	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98628	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000057492 ⟸ ENSRNOT00000060765

RefSeq Acc Id:

ENSRNOP00000090460 ⟸ ENSRNOT00000107881

RefSeq Acc Id:

ENSRNOP00000094775 ⟸ ENSRNOT00000107968

RefSeq Acc Id:	NP_001382000 ⟸ NM_001395071
- UniProtKB:	D4ADT5 (UniProtKB/TrEMBL), A0A8I6AN81 (UniProtKB/TrEMBL)

Protein Domains

Helicase ATP-binding Helicase C-terminal RLR CTR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADT5-F1-model_v2	AlphaFold	D4ADT5	1-598	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309460	AgrOrtholog
BioCyc Gene	G2FUF-41606	BioCyc
Ensembl Genes	ENSRNOG00000006384	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000057492	ENTREZGENE
	ENSRNOP00000057492.5	UniProtKB/TrEMBL
	ENSRNOP00000090460.1	UniProtKB/TrEMBL
	ENSRNOP00000094775.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060765	ENTREZGENE
	ENSRNOT00000060765.5	UniProtKB/TrEMBL
	ENSRNOT00000107881.1	UniProtKB/TrEMBL
	ENSRNOT00000107968.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	1.20.1320.30	UniProtKB/TrEMBL
	2.170.150.30	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	CARD_dom	UniProtKB/TrEMBL
	CARD_RIG-I_r2	UniProtKB/TrEMBL
	DEAD-like_N	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	Helicase/UvrB_N	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RIG-I_C	UniProtKB/TrEMBL
	RLR_C_sf	UniProtKB/TrEMBL
	RLR_CTR	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
KEGG Report	rno:297989	UniProtKB/TrEMBL
NCBI Gene	297989	ENTREZGENE
PANTHER	ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I	UniProtKB/TrEMBL
	HELICASE WITH DEATH DOMAIN-RELATED	UniProtKB/TrEMBL
Pfam	CARD_2	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	ResIII	UniProtKB/TrEMBL
	RIG-I_C	UniProtKB/TrEMBL
	RIG-I_C-RD	UniProtKB/TrEMBL
PhenoGen	Rig1	PhenoGen
PROSITE	HELICASE_ATP_BIND_1	UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/TrEMBL
	RLR_CTR	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
SMART	DEXDc	UniProtKB/TrEMBL
	HELICc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6AN81	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GKW7_RAT	UniProtKB/TrEMBL
	A6IIQ8_RAT	UniProtKB/TrEMBL
	D4ADT5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-15	Rig1	RNA sensor RIG-1	Ddx58	DEXD/H-box helicase 58	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-13	Ddx58	DEXD/H-box helicase 58	Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	Ddx58_predicted	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ddx58_predicted	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)