Tubb4a (tubulin, beta 4A class IVa) - Rat Genome Database

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Gene: Tubb4a (tubulin, beta 4A class IVa) Rattus norvegicus
Analyze
Symbol: Tubb4a
Name: tubulin, beta 4A class IVa
RGD ID: 619730
Description: Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Predicted to be located in several cellular components, including cytoskeleton; intercellular bridge; and internode region of axon. Predicted to be active in cytoplasm and microtubule. Used to study demyelinating disease. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tubb4; tubulin beta-4A chain; tubulin, beta 4; tubulin, beta 4 class IVa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)Ensembl
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methoxy-17beta-estradiol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
demyelination  (IAGP)
tremors  (IAGP)
References

Additional References at PubMed
PMID:10211825   PMID:11724907   PMID:12475942   PMID:12477932   PMID:14625387   PMID:15277470   PMID:16421295   PMID:16574095   PMID:17634366   PMID:21525035   PMID:21630459   PMID:23106098  
PMID:23284756   PMID:23533145   PMID:24625528   PMID:25931508  


Genomics

Comparative Map Data
Tubb4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)Ensembl
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q12NCBI
TUBB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,494,319 - 6,502,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,494,319 - 6,502,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,494,330 - 6,502,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,445,330 - 6,453,330 (-)NCBINCBI36hg18NCBI36
Build 34196,445,329 - 6,453,330NCBI
Celera196,434,150 - 6,442,152 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,257,064 - 6,265,066 (-)NCBIHuRef
CHM1_1196,493,927 - 6,501,914 (-)NCBICHM1_1
T2T-CHM13v2.0196,483,817 - 6,492,345 (-)NCBI
Tubb4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)Ensembl
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBImm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,133,429 - 3,139,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,134,181 - 3,138,725 (+)NCBIChiLan1.0ChiLan1.0
TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,443,913 - 6,451,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,441,323 - 6,451,785 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,521,425 - 5,529,958 (-)NCBIMhudiblu_PPA_v0panPan3
TUBB4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBI
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBI
ROS_Cfam_1.0 Ensembl2054,351,274 - 54,356,867 (+)Ensembl
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBI
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBI
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBI
Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,008,052 - 214,013,612 (+)NCBI
SpeTri2.0NW_0049365883,821,171 - 3,826,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,599,706 - 72,619,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,599,244 - 72,605,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,063,925 - 73,085,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,104,265 - 6,111,966 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl66,094,130 - 6,111,762 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,895,229 - 1,903,320 (+)NCBIVero_WHO_p1.0
Tubb4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
SGC32809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,918,642 - 1,918,775 (-)MAPPERmRatBN7.2
Rnor_6.099,967,486 - 9,967,618NCBIRnor6.0
Rnor_5.098,967,238 - 8,967,370UniSTSRnor5.0
Celera96,598,948 - 6,599,080UniSTS
RH137126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,917,838 - 1,918,041 (-)MAPPERmRatBN7.2
Rnor_6.099,968,220 - 9,968,422NCBIRnor6.0
Rnor_5.098,967,972 - 8,968,174UniSTSRnor5.0
Celera96,599,682 - 6,599,884UniSTS
MARC_24021-24022:1029778648:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,188 - 51,465,794 (+)MAPPERmRatBN7.2
mRatBN7.291,918,543 - 1,919,149 (-)MAPPERmRatBN7.2
Rnor_6.099,967,112 - 9,967,717NCBIRnor6.0
Rnor_6.01956,228,759 - 56,229,364NCBIRnor6.0
Rnor_5.098,966,864 - 8,967,469UniSTSRnor5.0
Rnor_5.01966,939,876 - 66,940,481UniSTSRnor5.0
RGSC_v3.41953,750,652 - 53,751,257UniSTSRGSC3.4
Celera1950,697,659 - 50,698,264UniSTS
Celera96,598,574 - 6,599,179UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:60
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000075767
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 67 12 14
Low 3 26 26 10 19 10 7 8 22 27 11 7
Below cutoff 17 31 31 31 1 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075767   ⟹   ENSRNOP00000065633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)Ensembl
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)Ensembl
RefSeq Acc Id: NM_080882   ⟹   NP_543158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,917,841 - 1,925,286 (-)NCBI
Rnor_6.099,961,020 - 9,968,420 (+)NCBI
Rnor_5.098,960,772 - 8,968,172 (+)NCBI
Celera96,592,438 - 6,599,882 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_543158 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68216 (Get FASTA)   NCBI Sequence Viewer  
  BAB72260 (Get FASTA)   NCBI Sequence Viewer  
  EDL83577 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_543158   ⟸   NM_080882
- UniProtKB: B4F7C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065633   ⟸   ENSRNOT00000075767
Protein Domains
Tubulin   Tubulin_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4F7C2-F1-model_v2 AlphaFold B4F7C2 1-444 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696438
Promoter ID:EPDNEW_R6963
Type:multiple initiation site
Name:Tubb4a_1
Description:tubulin, beta 4A class IVa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.099,961,046 - 9,961,106EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619730 AgrOrtholog
BioCyc Gene G2FUF-28490 BioCyc
Ensembl Genes ENSRNOG00000047505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065633 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075767 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.600 UniProtKB/TrEMBL
  3.30.1330.20 UniProtKB/TrEMBL
  3.40.50.1440 UniProtKB/TrEMBL
InterPro Beta-tubulin_BS UniProtKB/TrEMBL
  Beta_tubulin UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/TrEMBL
  Tubulin UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/TrEMBL
  Tubulin/FtsZ_C_sf UniProtKB/TrEMBL
  Tubulin/FtsZ_GTPase_sf UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/TrEMBL
KEGG Report rno:29213 UniProtKB/TrEMBL
NCBI Gene 29213 ENTREZGENE
PANTHER Tubulin UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
PhenoGen Tubb4a PhenoGen
PRINTS BETATUBULIN UniProtKB/TrEMBL
  TUBULIN UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/TrEMBL
  TUBULIN_B_AUTOREG UniProtKB/TrEMBL
SMART Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
Superfamily-SCOP Tub_FtsZ_C UniProtKB/TrEMBL
  Tubulin_FtsZ UniProtKB/TrEMBL
UniProt B4F7C2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-19 Tubb4a  tubulin, beta 4A class IVa  Tubb4  tubulin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb4  tubulin, beta 4  Tubb4a  tubulin, beta 4A class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-11 Tubb4  tubulin, beta 4A class IVa  Tubb4a  tubulin, beta 4 class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-11 Tubb4a  tubulin, beta 4A class IVa  Tubb4  tubulin, beta 4A class IVa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb4a  tubulin, beta 4 class IVa  Tubb4  tubulin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tubb4  tubulin, beta 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tubb4  tubulin, beta 4      Symbol and Name status set to provisional 70820 PROVISIONAL