Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells.

Authors: Milochau, A  Lagree, V  Benassy, MN  Chaignepain, S  Papin, J  Garcia-Arcos, I  Lajoix, A  Monterrat, C  Coudert, L  Schmitter, JM  Ochoa, B  Lang, J 
Citation: Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
Pubmed: (View Article at PubMed) PMID:24882364
DOI: Full-text: DOI:10.1016/j.febslet.2014.05.031

Synaptotagmins are two C2 domain-containing transmembrane proteins. The function of calcium-sensitive members in the regulation of post-Golgi traffic has been well established whereas little is known about the calcium-insensitive isoforms constituting half of the protein family. Novel binding partners of synaptotagmin 11 were identified in beta-cells. A number of them had been assigned previously to ER/Golgi derived-vesicles or linked to RNA synthesis, translation and processing. Whereas the C2A domain interacted with the Q-SNARE Vti1a, the C2B domain of syt11 interacted with the SND1, Ago2 and FMRP, components of the RNA-induced silencing complex (RISC). Binding to SND was direct via its N-terminal tandem repeats. Our data indicate that syt11 may provide a link between gene regulation by microRNAs and membrane traffic.


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RGD ID: 8693368
Created: 2014-07-11
Species: All species
Last Modified: 2014-07-11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.