Tubb4a (tubulin, beta 4A class IVA) - Rat Genome Database

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Gene: Tubb4a (tubulin, beta 4A class IVA) Mus musculus
Analyze
Symbol: Tubb4a
Name: tubulin, beta 4A class IVA
RGD ID: 735794
MGI Page MGI
Description: Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Located in several cellular components, including internode region of axon; myelin sheath; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hypomyelinating leukodystrophy 6. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI325297; M(beta)4; Tubb; Tubb4; tubulin beta-4 chain; tubulin beta-4A chain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm6173  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)Ensemblmm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBIMGSCv36mm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
carbon nanotube  (EXP)
D-glucose  (EXP)
diallyl disulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
folic acid  (EXP)
FR900359  (ISO)
glucose  (EXP)
glyphosate  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (EXP,ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalene  (EXP)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (EXP)
paracetamol  (EXP)
pirinixic acid  (EXP)
poly(propylene imine) macromolecule  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination. Duncan ID, etal., Ann Neurol. 2017 May;81(5):690-702. doi: 10.1002/ana.24930. Epub 2017 May 9.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1764997   PMID:2404776   PMID:3024334   PMID:3221863   PMID:3443294   PMID:3782288   PMID:3839797   PMID:6893015   PMID:7472403   PMID:7477376   PMID:7477377   PMID:7538067  
PMID:7649395   PMID:7663515   PMID:7869079   PMID:7891186   PMID:7926030   PMID:8083744   PMID:8344468   PMID:8543661   PMID:8575308   PMID:8630490   PMID:8876243   PMID:8889548  
PMID:9115735   PMID:9362459   PMID:9371744   PMID:10217145   PMID:10330459   PMID:10349636   PMID:10423398   PMID:10479457   PMID:10512984   PMID:10588390   PMID:10929204   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11724907   PMID:12466851   PMID:12477932   PMID:14625387   PMID:14681479   PMID:15042703   PMID:15189821   PMID:16141072   PMID:16141073   PMID:16421295  
PMID:16512683   PMID:16574095   PMID:17079460   PMID:17428829   PMID:17634366   PMID:17965413   PMID:18258849   PMID:18374910   PMID:18603407   PMID:18614564   PMID:18973680   PMID:19056362  
PMID:19136429   PMID:19545277   PMID:19574443   PMID:20564261   PMID:20658693   PMID:21267068   PMID:21270055   PMID:21296049   PMID:21438071   PMID:21677750   PMID:21873635   PMID:22675208  
PMID:22794259   PMID:23213461   PMID:23246003   PMID:23284756   PMID:23341776   PMID:23449471   PMID:23451260   PMID:23469020   PMID:23562608   PMID:24194600   PMID:24274029   PMID:24614889  
PMID:25516972   PMID:25564622   PMID:25649943   PMID:25737280   PMID:26370502   PMID:26514267   PMID:27141870   PMID:27150575   PMID:27341756   PMID:27794000   PMID:28378742   PMID:28827394  
PMID:29382714   PMID:29518331   PMID:29676259   PMID:30110642   PMID:30446499   PMID:30457570   PMID:30562941   PMID:30713523   PMID:31631837   PMID:32317081   PMID:32325033   PMID:32463361  
PMID:34321999   PMID:34474245   PMID:34815492   PMID:35171680   PMID:35676931   PMID:35876806   PMID:35942101   PMID:36130202   PMID:36293380   PMID:36808153   PMID:37142655   PMID:38031972  
PMID:38187761   PMID:38226173   PMID:38355793   PMID:39809135  


Genomics

Comparative Map Data
Tubb4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)Ensemblmm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBIMGSCv36mm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
TUBB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,494,319 - 6,502,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,494,319 - 6,502,848 (-)Ensemblhg38GRCh38
GRCh37196,494,330 - 6,502,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,445,330 - 6,453,330 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,445,329 - 6,453,330NCBI
Celera196,434,150 - 6,442,152 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,257,064 - 6,265,066 (-)NCBIHuRef
CHM1_1196,493,927 - 6,501,914 (-)NCBICHM1_1
T2T-CHM13v2.0196,483,817 - 6,492,345 (-)NCBIT2T-CHM13v2.0
Tubb4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,004,836 - 2,012,281 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl92,004,840 - 2,012,286 (-)EnsemblGRCr8
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,351,879 - 2,359,326 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,701,246 - 7,708,694 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,657,095 - 6,664,543 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)Ensemblrn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q11NCBI
Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,133,429 - 3,139,552 (+)Ensembl
ChiLan1.0NW_0049554953,134,181 - 3,138,725 (+)NCBIChiLan1.0ChiLan1.0
TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,901,916 - 10,910,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,127,833 - 10,136,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,521,425 - 5,529,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,443,913 - 6,451,785 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,441,323 - 6,451,785 (-)EnsemblpanPan2panpan1.1
TUBB4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,351,274 - 54,356,867 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,008,052 - 214,013,612 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,821,110 - 3,826,940 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,821,171 - 3,826,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,599,140 - 72,605,361 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,599,244 - 72,605,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,063,925 - 73,085,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,104,265 - 6,111,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,094,130 - 6,111,762 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660811,895,229 - 1,903,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tubb4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tubb4a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1488,458,261 - 88,464,805 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tubb4a
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:249
Interacting mature miRNAs:252
Transcripts:ENSMUST00000071135
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5173897957534623Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
AI325297  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,083 - 57,080,184UniSTSGRCm38
MGSCv371757,219,506 - 57,219,607UniSTSGRCm37
Celera1761,428,003 - 61,428,104UniSTS
Cytogenetic Map17E1.1UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.5UniSTS
Whitehead/MRC_RH17704.99UniSTS
Tubb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371757,219,881 - 57,220,070UniSTSGRCm37
MGSCv371757,219,592 - 57,220,242UniSTSGRCm37
Celera1761,428,378 - 61,428,567UniSTS
Celera1761,428,089 - 61,428,739UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.5UniSTS
cM Map1734.5UniSTS
MARC_24021-24022:1029778648:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,760 - 57,081,365UniSTSGRCm38
MGSCv371757,220,183 - 57,220,788UniSTSGRCm37
Celera1761,428,680 - 61,429,285UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
cM Map1734.5UniSTS
PMC156124P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,081,132 - 57,081,429UniSTSGRCm38
GRCm381867,401,628 - 67,401,925UniSTSGRCm38
MGSCv371757,220,555 - 57,220,852UniSTSGRCm37
MGSCv371867,561,282 - 67,561,579UniSTSGRCm37
Celera1868,678,718 - 68,679,015UniSTS
Celera1761,429,052 - 61,429,349UniSTS
Cytogenetic Map18E1UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.5UniSTS
Tubb-rs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,376 - 57,080,563UniSTSGRCm38
MGSCv371757,219,799 - 57,219,986UniSTSGRCm37
Celera1761,428,296 - 61,428,483UniSTS
Cytogenetic Map17DUniSTS
cM Map1729.66UniSTS
cM Map1856.0UniSTS
cM Map1734.5UniSTS
Tubb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,169 - 57,080,819UniSTSGRCm38
MGSCv371757,219,592 - 57,220,242UniSTSGRCm37
Celera1761,428,089 - 61,428,739UniSTS
Cytogenetic Map17DUniSTS
Tubb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,458 - 57,080,647UniSTSGRCm38
MGSCv371757,219,881 - 57,220,070UniSTSGRCm37
Celera1761,428,378 - 61,428,567UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.5UniSTS
Tubb5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381757,080,698 - 57,080,896UniSTSGRCm38
GRCm381735,834,987 - 35,835,188UniSTSGRCm38
MGSCv371757,220,121 - 57,220,319UniSTSGRCm37
MGSCv371735,971,932 - 35,972,133UniSTSGRCm37
Celera1761,428,618 - 61,428,816UniSTS
Celera1739,345,049 - 39,345,250UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17DUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000071135   ⟹   ENSMUSP00000071135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)Ensembl
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)Ensembl
RefSeq Acc Id: NM_009451   ⟹   NP_033477
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,387,061 - 57,394,600 (-)NCBI
GRCm381757,080,061 - 57,087,600 (-)NCBI
MGSCv371757,219,489 - 57,227,205 (-)RGD
Celera1761,427,986 - 61,435,703 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40509 (Get FASTA)   NCBI Sequence Viewer  
  AAH49112 (Get FASTA)   NCBI Sequence Viewer  
  AAH54831 (Get FASTA)   NCBI Sequence Viewer  
  BAB28967 (Get FASTA)   NCBI Sequence Viewer  
  EDL38236 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071135
  ENSMUSP00000071135.6
GenBank Protein Q9D6F9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033477   ⟸   NM_009451
- UniProtKB: Q9D6F9 (UniProtKB/Swiss-Prot),   Q80Y54 (UniProtKB/Swiss-Prot),   Q62364 (UniProtKB/Swiss-Prot),   Q3U9U3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000071135   ⟸   ENSMUST00000071135

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D6F9-F1-model_v2 AlphaFold Q9D6F9 1-444 view protein structure

Promoters
RGD ID:13676574
Promoter ID:EPDNEW_M22436
Type:initiation region
Name:Tubb4a_1
Description:Mus musculus tubulin, beta 4A class IVA , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381757,087,600 - 57,087,660EPDNEW
RGD ID:6828869
Promoter ID:MM_KWN:23934
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain
Transcripts:NM_009451
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,226,674 - 57,227,174 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107848 AgrOrtholog
Ensembl Genes ENSMUSG00000062591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000071135 ENTREZGENE
  ENSMUST00000071135.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot
  Beta_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
  Tubulin_CS UniProtKB/Swiss-Prot
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot
KEGG Report mmu:22153 UniProtKB/Swiss-Prot
MGD MGI:107848 ENTREZGENE
NCBI Gene Tubb4a ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot
Pfam Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
PhenoGen Tubb4a PhenoGen
PRINTS BETATUBULIN UniProtKB/Swiss-Prot
  TUBULIN UniProtKB/Swiss-Prot
PROSITE TUBULIN UniProtKB/Swiss-Prot
  TUBULIN_B_AUTOREG UniProtKB/Swiss-Prot
SMART Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot
UniProt Q3U9U3 ENTREZGENE
  Q62364 ENTREZGENE
  Q80Y54 ENTREZGENE
  Q9D6F9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q62364 UniProtKB/Swiss-Prot
  Q80Y54 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-07-28 Tubb4a  tubulin, beta 4A class IVA  Tubb  tubulin, beta 4  Symbol and/or name updated 27372883 PROVISIONAL
2025-07-22 Tubb  tubulin, beta 4  Tubb4a  tubulin, beta 4A class IVA  Symbol and/or name change 5135510 APPROVED
2024-08-21 Tubb4a  tubulin, beta 4A class IVA  Tubb  tubulin, beta 4  Symbol and/or name change 5135510 APPROVED
2024-08-21 Tubb  tubulin, beta 4  Tubb4a  tubulin, beta 4A class IVA  Symbol and/or name change 5135510 APPROVED
2011-10-18 Tubb4a  tubulin, beta 4A class IVA  Tubb4  tubulin, beta 4  Symbol and/or name change 5135510 APPROVED