Tubb4a (tubulin beta 4A class IVa) - Rat Genome Database

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Gene: Tubb4a (tubulin beta 4A class IVa) Heterocephalus glaber
Analyze
Symbol: Tubb4a
Name: tubulin beta 4A class IVa
RGD ID: 18932595
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN negative regulation of microtubule polymerization (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 9 (ortholog); BROWN SYNDROME (ortholog); cerebral palsy (ortholog); FOUND IN axoneme (ortholog); cell projection (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin beta-4A chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tubb4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TUBB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,494,319 - 6,502,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,494,319 - 6,502,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,494,330 - 6,502,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,445,330 - 6,453,330 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,445,329 - 6,453,330NCBI
Celera196,434,150 - 6,442,152 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,257,064 - 6,265,066 (-)NCBIHuRef
CHM1_1196,493,927 - 6,501,914 (-)NCBICHM1_1
T2T-CHM13v2.0196,483,817 - 6,492,345 (-)NCBIT2T-CHM13v2.0
Tubb4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)EnsemblGRCm39 Ensembl
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBIMGSCv36mm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
Tubb4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,004,836 - 2,012,281 (-)NCBIGRCr8
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,351,879 - 2,359,326 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,701,246 - 7,708,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,657,095 - 6,664,543 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q11NCBI
Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,133,429 - 3,139,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,134,181 - 3,138,725 (+)NCBIChiLan1.0ChiLan1.0
TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,901,916 - 10,910,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,127,833 - 10,136,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,521,425 - 5,529,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,443,913 - 6,451,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,441,323 - 6,451,785 (-)Ensemblpanpan1.1panPan2
TUBB4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,351,274 - 54,356,867 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBIUU_Cfam_GSD_1.0
Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,008,052 - 214,013,612 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,821,110 - 3,826,940 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,821,171 - 3,826,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,599,140 - 72,605,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,599,244 - 72,605,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,063,925 - 73,085,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,104,265 - 6,111,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,094,130 - 6,111,762 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,895,229 - 1,903,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004865628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01083335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000014687   ⟹   ENSHGLP00000014542
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248283,584,848 - 3,594,294 (-)Ensembl
RefSeq Acc Id: XM_004865628   ⟹   XP_004865685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004865685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014542
RefSeq Acc Id: XP_004865685   ⟸   XM_004865628
- UniProtKB: A0A0P6K1V8 (UniProtKB/TrEMBL),   A0AAX6Q644 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014542   ⟸   ENSHGLT00000014687


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010413 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014687 ENTREZGENE
Gene3D-CATH Helix hairpin bin UniProtKB/TrEMBL
  Tubulin/FtsZ, C-terminal domain UniProtKB/TrEMBL
  Tubulin/FtsZ, GTPase domain UniProtKB/TrEMBL
InterPro Beta-tubulin_BS UniProtKB/TrEMBL
  Beta_tubulin UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/TrEMBL
  Tubulin UniProtKB/TrEMBL
  Tubulin/FtsZ-like_C UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/TrEMBL
  Tubulin/FtsZ_GTPase_sf UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/TrEMBL
NCBI Gene Tubb4a ENTREZGENE
PANTHER TUBULIN UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
PRINTS BETATUBULIN UniProtKB/TrEMBL
  TUBULIN UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/TrEMBL
  TUBULIN_B_AUTOREG UniProtKB/TrEMBL
SMART Tubulin UniProtKB/TrEMBL
  Tubulin_C UniProtKB/TrEMBL
Superfamily-SCOP Tubulin C-terminal domain-like UniProtKB/TrEMBL
  Tubulin nucleotide-binding domain-like UniProtKB/TrEMBL
UniProt A0A0P6K1V8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q644 ENTREZGENE, UniProtKB/TrEMBL