TUBB4A (tubulin beta 4A class IVa)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: TUBB4A (tubulin beta 4A class IVa) Sus scrofa

Analyze

Symbol:

TUBB4A

Name:

tubulin beta 4A class IVa

RGD ID:

14057406

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activity (inferred); INVOLVED IN negative regulation of microtubule polymerization (inferred); ASSOCIATED WITH cerebral palsy (ortholog); Developmental Disabilities (ortholog); dystonia (ortholog); FOUND IN cell projection (ortholog); cilium (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

tubulin beta-4A chain

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,599,706 - 72,619,450 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,599,244 - 72,605,362 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	73,063,925 - 73,085,100 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral palsy (ISO)

Developmental Disabilities (ISO)

dystonia (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 6 (ISO)

torsion dystonia 4 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule cytoskeleton organization (IBA)

mitotic cell cycle (IBA)

negative regulation of microtubule polymerization (IEA)

Cellular Component

axoneme (IEA)

cell projection (ISO)

cilium (ISO)

cytoplasm (IBA,ISO)

internode region of axon (IEA,ISO)

microtubule (IBA,ISO)

myelin sheath (IEA,ISO)

neuronal cell body (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

GTP binding (IBA)

GTPase activity (IEA)

protein binding (ISO)

structural constituent of cytoskeleton (IBA)

References

Genomics

Comparative Map Data

TUBB4A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,599,706 - 72,619,450 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,599,244 - 72,605,362 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	73,063,925 - 73,085,100 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TUBB4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	6,494,319 - 6,502,848 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	6,494,319 - 6,502,848 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	6,494,330 - 6,502,859 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,445,330 - 6,453,330 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	6,445,329 - 6,453,330	NCBI
Celera	19	6,434,150 - 6,442,152 (-)	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,257,064 - 6,265,066 (-)	NCBI		HuRef
CHM1_1	19	6,493,927 - 6,502,443 (-)	NCBI		CHM1_1

Tubb4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,387,061 - 57,394,600 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	17	57,387,066 - 57,394,782 (-)	Ensembl
GRCm38	17	57,080,061 - 57,087,600 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,080,066 - 57,087,782 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	57,219,489 - 57,227,205 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	56,765,319 - 56,772,683 (-)	NCBI			mm8
Celera	17	61,427,986 - 61,435,703 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.66	NCBI

Tubb4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	1,917,841 - 1,925,286 (-)	NCBI
Rnor_6.0 Ensembl	9	9,961,021 - 9,968,486 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	9	9,961,020 - 9,968,420 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	8,960,772 - 8,968,172 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,592,438 - 6,599,882 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	3,133,429 - 3,139,552 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	3,134,181 - 3,138,725 (+)	NCBI	ChiLan1.0	ChiLan1.0

TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	6,443,913 - 6,451,785 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,441,323 - 6,451,785 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	5,521,425 - 5,529,958 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

TUBB4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	53,697,639 - 53,702,349 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	53,697,643 - 53,702,671 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936588	3,821,171 - 3,826,827 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TUBB4A
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,104,265 - 6,111,966 (-)	NCBI
ChlSab1.1 Ensembl	6	6,094,130 - 6,111,762 (-)	Ensembl

Tubb4a
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	3,588,001 - 3,594,294 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	nervous system	renal system	reproductive system	respiratory system
High
Medium					19
Low	9	2	3	5	4	2	3	3
Below cutoff	1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003480812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK347939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK400174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000014793 ⟹ ENSSSCP00000014392

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	72,599,706 - 72,619,450 (+)	Ensembl

RefSeq Acc Id:

XM_003480812 ⟹ XP_003480860

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	72,599,244 - 72,605,362 (+)	NCBI

Sequence:

show sequence

AGGAACTGACCGCCCCCAACCTCCCCAAACAGATGGCTACTCCGGAGCGCCCAGCTCGGCCCGG
CTAGGAGCCCTCCCAGTTAAAGCGAAGGCACTAAATGGAATGGGGAAGGAGGCCTGGGACAGAG
AAACTGAGGCAGGGCCGCTTGGAGGAAGAGGGAGAAGCAGGATCTCCCCGCGGCTTGTTTACTG
GACGCTCGCTCTCCCTCTCCACCCTCGACCCATCCCCGCAAGACCCGGATCGCCAGGCCCGGCT
TGGAGAGGGGTGGGGGAGGCAGATGGTACTGACGGCGTCTGAGGAGCTTCGCCCCCACCGCCCG
GGGTGGGGTCGCACAGGGCCACCTCGCGTCTCAGCCCCGGGCCCGGGAGGTCTCCAGGAGGCAG
GGGAGGGGGATCGAGAAGGATCTCTCCATCCATTCCAGCACCCTCGGTCCCGGGGCGGGACCAG
GGGGCGGAGCGGGCCAGTGACCGGCCGTGACGCGAGCCCCGCCTGCTCATATAGAGGCGCCTGG
GGGGGCGCAGGGACCGAGCTTCGCCGTCGCCACCGCCGCCGCATCCACCTTCAGCCCCGCCACC
GCAGTTACCAGAACCCTCGCCACCACCGCCTCGACCACCGCCAGGGCCACCATCATGCGAGAGA
TCGTGCACCTGCAAGCCGGCCAGTGCGGCAACCAGATCGGAGCCAAGTTTTGGGAGGTGATCAG
TGATGAGCATGGCATTGATCCCACTGGCACATACCACGGGGACAGCGACCTGCAGTTGGAGAGG
ATCAACGTCTACTACAATGAGGCCACAGGAGGAAATTATGTCCCCAGAGCTGTGCTGGTGGACC
TGGAGCCGGGCACCATGGACTCCGTCCGCTCAGGTCCCTTTGGCCAGATCTTTCGACCTGACAA
CTTTGTGTTTGGCCAATCCGGAGCCGGCAACAACTGGGCCAAGGGCCACTACACAGAGGGCGCC
GAGCTGGTGGACGCGGTTCTGGACGTGGTCCGGAAGGAGGCGGAGAGCTGTGACTGCCTGCAGG
GCTTCCAACTGACCCACTCGCTGGGCGGTGGCACGGGGTCCGGCATGGGGACCCTGCTCATCAG
CAAGATCCGCGAGGAGTTCCCGGACCGGATCATGAACACCTTCAGCGTGGTACCCTCCCCCAAG
GTGTCTGACACGGTGGTGGAGCCCTACAACGCCACGCTGTCGGTTCACCAGCTGGTGGAGAACA
CGGATGAGACCTACTGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTGAAGCT
GACCACCCCCACCTACGGCGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACG
TGCCTGCGCTTCCCGGGCCAGCTCAACGCCGACCTGCGCAAGCTGGCCGTGAACATGGTGCCCT
TCCCCCGCCTGCACTTCTTCATGCCGGGCTTTGCGCCGCTGACCAGCCGGGGCAGCCAGCAGTA
CCGGGCACTGACGGTGCCCGAACTCACCCAGCAGATGTTCGACGCCAAGAACATGATGGCCGCC
TGCGACCCCCGCCACGGCCGCTACCTGACCGTGGCCGCTGTGTTCCGGGGCCGCATGTCCATGA
AGGAGGTGGATGAGCAGATGCTGAGCGTCCAGAGCAAGAACAGCAGCTACTTCGTGGAGTGGAT
TCCCAACAACGTCAAGACGGCCGTGTGCGACATCCCGCCCCGTGGCCTGAAGATGGCCGCCACT
TTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAACAGTTCACGGCCA
TGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGATGAGATGGAGTTCAC
TGAGGCAGAGAGCAACATGAACGACCTGGTGTCCGAGTACCAGCAGTACCAGGATGCCACTGCC
GAGGAGGGCGAGTTCGAGGAGGAGGCAGAGGAGGAGGTAGCCTAGGGCACCTCCATGGCTTCAT
GTCTCCCCCCTGCTCGGCTGCTGACCTCTGACCCCAGAGAACCCTGCTTCACCTTCCAGCCTGA
CTCTCCTGGGACTACCACCTTGCATCTCTTCCCCTGGCTAACCTTTAACCCTTGAGCCCCACTT
TATCTCCAACCCCCTTGAACCTTTTCTACTTAGACCCCACGAGCCCTGCTTCACACAAGCCCAC
CTTGAACTCCATGAGCCCTCCTTCACCCCTGACCTCTCCACCTTTGACCTCCCCACGAACCCCA
TTGCACCCCCAGACCTACAAGCCCTAATTTACGTGGATCTCTTCCCCCCTGAGCCTCTCTGAAC
TTGCCTCATCTTTGACCCCACAAGCCCCACCTGCCCTCTGACCCCACCTTCTCTCCAGATCTCC
CAAAAAGCACTCCCTTTCCCTCCCACCAACCTTGGCTTTCCAGGCATGCTGCTGGGGAAGAGAG
AAGCCCTGGAGCATGTGGGCAAGAGAGGCTGCTCCCTCCCCTCCCTTCACCTCCCCTCAATAAA
TAATTGCTGTCCTGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003480860	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003480860 ⟸ XM_003480812

- Sequence:

show sequence

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYVPRAV
LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCD
CLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQL
VENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN
MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGR
MSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQ
FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA

hide sequence

RefSeq Acc Id:

ENSSSCP00000014392 ⟸ ENSSSCT00000014793

Protein Domains

Tubulin Tubulin_C

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000013545	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000014392	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000014793	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.600	UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/TrEMBL
InterPro	Beta-tubulin_BS	UniProtKB/TrEMBL
	Beta_tubulin	UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/TrEMBL
	Tubulin	UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/TrEMBL
	Tubulin/FtsZ_C_sf	UniProtKB/TrEMBL
	Tubulin/FtsZ_GTPase_sf	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/TrEMBL
KEGG Report	ssc:100736584	UniProtKB/TrEMBL
NCBI Gene	TUBB4A	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/TrEMBL
Pfam	Tubulin	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
PRINTS	BETATUBULIN	UniProtKB/TrEMBL
	TUBULIN	UniProtKB/TrEMBL
PROSITE	TUBULIN	UniProtKB/TrEMBL
	TUBULIN_B_AUTOREG	UniProtKB/TrEMBL
SMART	Tubulin	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52490	UniProtKB/TrEMBL
	SSF55307	UniProtKB/TrEMBL
UniProt	A0A480UV25_PIG	UniProtKB/TrEMBL
	F2Z5K5_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:94579	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM