TUBB4A (tubulin beta 4A class IVa) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TUBB4A (tubulin beta 4A class IVa) Canis lupus familiaris
Analyze
Symbol: TUBB4A
Name: tubulin beta 4A class IVa
RGD ID: 12382145
Description: ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activity (inferred); INVOLVED IN negative regulation of microtubule polymerization (inferred); ASSOCIATED WITH cerebral palsy (ortholog); demyelinating disease (ortholog); Developmental Disabilities (ortholog); FOUND IN cell projection (ortholog); cilium (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: class IVa beta-tubulin; LOW QUALITY PROTEIN: tubulin beta-4A chain; TUBB4; tubulin beta-4A chain; tubulin, beta 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBI
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBI
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBI
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBI
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
TUBB4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,697,643 - 53,702,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBI
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBI
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBI
UNSW_CanFamBas_1.02053,866,868 - 53,871,927 (+)NCBI
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBI
TUBB4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl196,494,319 - 6,502,848 (-)EnsemblGRCh38hg38GRCh38
GRCh38196,494,319 - 6,502,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37196,494,330 - 6,502,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,445,330 - 6,453,330 (-)NCBINCBI36hg18NCBI36
Build 34196,445,329 - 6,453,330NCBI
Celera196,434,150 - 6,442,152 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef196,257,064 - 6,265,066 (-)NCBIHuRef
CHM1_1196,493,927 - 6,501,914 (-)NCBICHM1_1
Tubb4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,387,061 - 57,394,600 (-)NCBIGRCm39mm39
GRCm39 Ensembl1757,387,066 - 57,394,782 (-)Ensembl
GRCm381757,080,061 - 57,087,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,080,066 - 57,087,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,219,489 - 57,227,205 (-)NCBIGRCm37mm9NCBIm37
MGSCv361756,765,319 - 56,772,683 (-)NCBImm8
Celera1761,427,986 - 61,435,703 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.66NCBI
Tubb4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,917,841 - 1,925,286 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl91,917,845 - 1,925,291 (-)Ensembl
Rnor_6.099,961,020 - 9,968,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,961,021 - 9,968,486 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,960,772 - 8,968,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,592,438 - 6,599,882 (+)NCBICelera
Cytogenetic Map9q12NCBI
Tubb4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,133,429 - 3,139,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,134,181 - 3,138,725 (+)NCBIChiLan1.0ChiLan1.0
TUBB4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,443,913 - 6,451,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,441,323 - 6,451,785 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,521,425 - 5,529,958 (-)NCBIMhudiblu_PPA_v0panPan3
Tubb4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,008,052 - 214,013,612 (+)NCBI
SpeTri2.0NW_0049365883,821,171 - 3,826,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBB4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,599,706 - 72,619,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,599,244 - 72,605,362 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,063,925 - 73,085,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TUBB4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,104,265 - 6,111,966 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl66,094,130 - 6,111,762 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660811,895,229 - 1,903,320 (+)NCBIVero_WHO_p1.0
Tubb4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,588,001 - 3,594,294 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 8 8 5
Low 5 5 19 5 6 5 6 6 4 5 6
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029576   ⟹   ENSCAFP00000027491
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2053,697,639 - 53,702,349 (+)Ensembl
RefSeq Acc Id: XM_005632973   ⟹   XP_005633030
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12053,697,643 - 53,702,671 (+)NCBI
Dog10K_Boxer_Tasha2053,444,670 - 53,449,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038428863   ⟹   XP_038284791
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02054,351,606 - 54,356,870 (+)NCBI
RefSeq Acc Id: XM_038428864   ⟹   XP_038284792
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02054,353,186 - 54,356,870 (+)NCBI
RefSeq Acc Id: XM_038455355   ⟹   XP_038311283
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2053,446,241 - 53,449,928 (+)NCBI
RefSeq Acc Id: XM_038504492   ⟹   XP_038360420
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12053,418,321 - 53,423,724 (+)NCBI
RefSeq Acc Id: XM_038567541   ⟹   XP_038423469
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02054,095,881 - 54,101,133 (+)NCBI
RefSeq Acc Id: XM_038631691   ⟹   XP_038487619
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02053,866,868 - 53,871,923 (+)NCBI
RefSeq Acc Id: XM_038631692   ⟹   XP_038487620
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02053,868,475 - 53,871,927 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005633030   ⟸   XM_005632973
- Peptide Label: isoform X1
- UniProtKB: E2RFV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027491   ⟸   ENSCAFT00000029576
RefSeq Acc Id: XP_038360420   ⟸   XM_038504492
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038487619   ⟸   XM_038631691
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038487620   ⟸   XM_038631692
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038284791   ⟸   XM_038428863
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038284792   ⟸   XM_038428864
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038311283   ⟸   XM_038455355
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038423469   ⟸   XM_038567541
- Peptide Label: isoform X1

Promoters
RGD ID:13687081
Promoter ID:EPDNEW_C5149
Type:initiation region
Name:TUBB4A_1
Description:tubulin beta 4A class IVa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12053,697,695 - 53,697,755EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 53701354 53701355 A C snv Australian Terrier (AR001)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018634 Ensembl
NCBI Gene TUBB4A ENTREZGENE
UniProt E2RFV2 ENTREZGENE
VGNC ID VGNC:47989 ENTREZGENE