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Gene: Pax8 (paired box 8) Rattus norvegicus

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Symbol:

Pax8

Name:

paired box 8

RGD ID:

620434

Description:

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8); PARTICIPATES IN thyroid cancer pathway; INTERACTS WITH (S)-nicotine; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC93376; paired box gene 8; paired box protein Pax-8; Pax-8 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PAX8 (paired box 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PTCH1 (patched 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PAX8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pax8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pax8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	egl-38	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sv	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pax8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	27,584,000 - 27,641,094 (-)	NCBI		GRCr8
mRatBN7.2	3	7,185,721 - 7,242,363 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	7,185,723 - 7,242,363 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	10,289,591 - 10,345,823 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	18,875,838 - 18,932,068 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,065,649 - 17,121,886 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	1,527,316 - 1,586,019 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	1,527,279 - 1,584,946 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	1,520,144 - 1,576,052 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	2,671,478 - 2,726,801 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	2,672,153 - 2,726,345 (-)	NCBI
Celera	3	2,022,899 - 2,078,650 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

congenital hypothyroidism (ISO,ISS)

congenital nongoitrous hypothyroidism 2 (ISO)

COVID-19 (ISO)

Follicular Thyroid Cancer (ISO)

genetic disease (ISO)

obesity (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (ISO)

(S)-nicotine (EXP,ISO)

1,2-dichloroethane (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

bathocuproine disulfonic acid (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium dichloride (EXP,ISO)

calcium atom (EXP)

calcium(0) (EXP)

cannabidiol (EXP)

carmustine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cocaine (ISO)

colforsin daropate hydrochloride (ISO)

corn oil (EXP)

DDE (ISO)

decabromodiphenyl ether (EXP)

diallyl trisulfide (ISO)

endosulfan (EXP)

ethylparaben (ISO)

flavonoids (EXP)

folic acid (ISO)

furan (EXP)

glyphosate (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

mono(2-ethyl-5-hydroxyhexyl) phthalate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nicotine (EXP,ISO)

paracetamol (EXP,ISO)

perchlorate (EXP)

perfluorobutanesulfonic acid (EXP)

perfluorobutyric acid (EXP)

perfluorododecanoic acid (EXP)

perfluorohexanesulfonic acid (EXP,ISO)

perfluorohexanoic acid (EXP)

perfluorononanoic acid (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

perfluoroundecanoic acid (EXP)

potassium iodide (EXP)

pyrrolidine dithiocarbamate (EXP)

quercetin (ISO)

resveratrol (EXP,ISO)

silicon dioxide (EXP,ISO)

sirolimus (ISO)

sodium dichromate (ISO)

sodium perchlorate (EXP)

streptozocin (ISO)

thioacetamide (EXP)

thiram (ISO)

trichloroethene (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in ureteric bud morphogenesis (ISO)

cellular response to gonadotropin stimulus (ISO)

central nervous system development (ISO)

DNA-templated transcription (ISO)

epithelial cell differentiation (ISO)

inner ear morphogenesis (ISO)

kidney development (ISO)

kidney epithelium development (ISO)

mesenchymal to epithelial transition involved in metanephros morphogenesis (ISO)

mesonephric tubule development (ISO)

mesonephros development (ISO,ISS)

metanephric comma-shaped body morphogenesis (ISO)

metanephric distal convoluted tubule development (ISO,ISS)

metanephric epithelium development (ISO)

metanephric nephron tubule formation (ISO,ISS)

metanephric S-shaped body morphogenesis (ISO)

metanephros development (ISO)

negative regulation of apoptotic process involved in metanephric collecting duct development (ISO,ISS)

negative regulation of apoptotic process involved in metanephric nephron tubule development (ISO,ISS)

negative regulation of cardiac muscle cell apoptotic process (ISO)

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis (ISO,ISS)

negative regulation of mesenchymal cell apoptotic process involved in metanephros development (ISO,ISS)

nervous system development (IBA)

otic vesicle development (ISO)

positive regulation of branching involved in ureteric bud morphogenesis (ISO,ISS)

positive regulation of DNA-templated transcription (ISO,ISS)

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (ISO,ISS)

positive regulation of metanephric DCT cell differentiation (ISO,ISS)

positive regulation of thyroid hormone generation (ISO,ISS)

positive regulation of transcription by RNA polymerase II (IDA,ISO)

pronephric field specification (ISO,ISS)

pronephros development (ISO,ISS)

regulation of apoptotic process (ISO,ISS)

regulation of DNA-templated transcription (IEA,IMP)

regulation of metanephric nephron tubule epithelial cell differentiation (ISO,ISS)

regulation of thyroid-stimulating hormone secretion (ISO,ISS)

regulation of transcription by RNA polymerase II (IBA)

S-shaped body morphogenesis (ISO)

sensory organ development (IBA)

sulfur compound metabolic process (IEP)

thyroid gland development (ISO,ISS)

urogenital system development (ISO,ISS)

ventricular septum development (ISO)

Cellular Component

nucleoplasm (IDA,ISO)

nucleus (IEA,ISO)

Molecular Function

DNA binding (IDA,IEA,ISO,ISS)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA)

DNA-binding transcription factor activity (ISO,ISS)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (IPI,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA,ISO,ISS)

sequence-specific DNA binding (IDA)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

thyroid cancer pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8.	Cao X, etal., Biochem Biophys Res Commun 2002 Sep 20;297(2):288-93.
2.	Glutathionylation of two cysteine residues in paired domain regulates DNA binding activity of Pax-8.	Cao X, etal., J Biol Chem. 2005 Jul 8;280(27):25901-6. Epub 2005 May 11.
3.	The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.	Di Palma T, etal., J Biol Chem. 2003 Jan 31;278(5):3395-402. Epub 2002 Nov 18.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1.	Kang HC, etal., Endocrinology 2001 Jan;142(1):267-75.
7.	PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis.	Macchia PE, etal., Nat Genet. 1998 May;19(1):83-6.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8.	Nitsch R, etal., Biochem J. 2004 Feb 1;377(Pt 3):553-60.
11.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17.	TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.	Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.
18.	Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.	Zannini M, etal., Mol Cell Biol. 1992 Sep;12(9):4230-41.

Additional References at PubMed

PMID:1337742	PMID:1723950	PMID:7856737	PMID:8413205	PMID:8861958	PMID:9388203	PMID:9590297	PMID:11773436	PMID:12435636	PMID:12586753	PMID:14623893	PMID:15356023
PMID:15489334	PMID:15494458	PMID:15961562	PMID:16319112	PMID:16627577	PMID:16641100	PMID:17047028	PMID:17314325	PMID:19010321	PMID:19282367	PMID:20727173	PMID:21317881
PMID:21966443	PMID:22453009	PMID:22531031	PMID:23868062	PMID:25270402	PMID:26030152	PMID:27780871	PMID:34012023	PMID:34726504

Genomics

Comparative Map Data

Pax8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	27,584,000 - 27,641,094 (-)	NCBI		GRCr8
mRatBN7.2	3	7,185,721 - 7,242,363 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	7,185,723 - 7,242,363 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	10,289,591 - 10,345,823 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	18,875,838 - 18,932,068 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,065,649 - 17,121,886 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	1,527,316 - 1,586,019 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	1,527,279 - 1,584,946 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	1,520,144 - 1,576,052 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	2,671,478 - 2,726,801 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	2,672,153 - 2,726,345 (-)	NCBI
Celera	3	2,022,899 - 2,078,650 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

PAX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	113,215,997 - 113,278,921 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	113,215,997 - 113,278,921 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	113,973,574 - 114,036,498 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	113,690,045 - 113,752,968 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	113,691,170 - 113,752,728	NCBI
Celera	2	107,358,161 - 107,421,066 (-)	NCBI		Celera
Cytogenetic Map	2	q14.1	NCBI
HuRef	2	106,427,614 - 106,522,962 (-)	NCBI		HuRef
CHM1_1	2	113,977,965 - 114,040,915 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	113,642,573 - 113,705,473 (-)	NCBI		T2T-CHM13v2.0

Pax8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	24,310,563 - 24,365,611 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	24,310,572 - 24,365,611 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	24,420,551 - 24,475,599 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	24,420,560 - 24,475,599 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	24,276,080 - 24,331,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	24,242,569 - 24,297,575 (-)	NCBI		MGSCv36	mm8
Celera	2	24,140,049 - 24,195,191 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	16.43	NCBI

Pax8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	1,016,289 - 1,073,796 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	1,016,226 - 1,072,643 (+)	NCBI	ChiLan1.0	ChiLan1.0

PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	14,933,395 - 14,971,937 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	14,936,160 - 14,974,705 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	88,845,877 - 88,905,266 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	114,162,110 - 114,222,865 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	114,162,110 - 114,222,865 (-)	Ensembl	panpan1.1		panPan2

PAX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	37,307,130 - 37,331,729 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	37,306,033 - 37,363,178 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	37,077,650 - 37,133,660 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	38,084,443 - 38,141,710 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	38,085,541 - 38,141,710 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	37,220,866 - 37,276,852 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	37,277,373 - 37,333,166 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	37,490,112 - 37,546,218 (-)	NCBI		UU_Cfam_GSD_1.0

Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	82,629,178 - 82,682,663 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936783	1,523,661 - 1,576,568 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936783	1,523,658 - 1,553,464 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	16,236,074 - 16,299,650 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	16,233,378 - 16,297,365 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666080	3,382,976 - 3,450,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pax8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	13,300,606 - 13,357,903 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	13,291,880 - 13,358,066 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pax8
148 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	85
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000031058
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat

Markers in Region

D11Bir2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	7,207,455 - 7,207,593 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	243,621,084 - 243,621,222 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	264,508,928 - 264,509,065	NCBI	Rnor6.0
Rnor_6.0	3	1,549,052 - 1,549,189	NCBI	Rnor6.0
Rnor_5.0	3	1,541,880 - 1,542,017	UniSTS	Rnor5.0
Rnor_5.0	1	271,951,604 - 271,951,741	UniSTS	Rnor5.0
RGSC_v3.4	1	249,808,393 - 249,808,530	UniSTS	RGSC3.4
RGSC_v3.4	3	2,693,184 - 2,693,321	UniSTS	RGSC3.4
Celera	3	2,044,635 - 2,044,772	UniSTS
Celera	1	239,432,502 - 239,432,639	UniSTS
Cytogenetic Map	3	p13	UniSTS
Cytogenetic Map	1	q54	UniSTS

Pax8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	7,207,541 - 7,209,050 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	1,549,138 - 1,550,646	NCBI	Rnor6.0
Rnor_5.0	3	1,541,966 - 1,543,474	UniSTS	Rnor5.0
Celera	3	2,044,721 - 2,046,229	UniSTS
Cytogenetic Map	3	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	5	32	98	87	89	58	25	58	6	189	72	81	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X94246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031058 ⟹ ENSRNOP00000033966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	7,185,723 - 7,242,363 (-)	Ensembl
Rnor_6.0 Ensembl	3	1,527,279 - 1,584,946 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086447 ⟹ ENSRNOP00000070564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	7,185,723 - 7,209,358 (-)	Ensembl
Rnor_6.0 Ensembl	3	1,527,992 - 1,549,189 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096826 ⟹ ENSRNOP00000078325

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	7,188,065 - 7,242,363 (-)	Ensembl

RefSeq Acc Id:

NM_031141 ⟹ NP_112403

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	27,584,000 - 27,640,631 (-)	NCBI
mRatBN7.2	3	7,185,721 - 7,242,363 (-)	NCBI
Rnor_6.0	3	1,527,316 - 1,584,925 (-)	NCBI
Rnor_5.0	3	1,520,144 - 1,576,052 (-)	NCBI
RGSC_v3.4	3	2,671,478 - 2,726,801 (-)	RGD
Celera	3	2,022,899 - 2,078,650 (-)	RGD

Sequence:

show sequence

CTTCAGAAGAAGAAACGCCTGGGCCCTGGGCACCCTCGGGGGCAGACCCAGGCAGAAAGGGCCT
GAGGCCAGCCGGCTAGGGCAGCGGCGTGGCAGCTGGAGCTGCCAGGACCTGCGTAAGAGAGCTG
CGAGTGTTCCGCAGCTGTGAGCGACTCCCCAGCGGCGATGCCTCACAACTCGATCAGATCCGGC
CACGGAGGGCTGAATCAGTTAGGAGGGGCTTTTGTGAATGGCAGGCCTCTGCCAGAAGTTGTCC
GGCAACGCATTGTGGACTTGGCCCACCAGGGAGTGAGACCCTGTGATATCTCTCGCCAGCTTCG
TGTCAGCCATGGCTGTGTAAGCAAGATCCTTGGCAGGTACTACGAGACTGGCAGCATCCGGCCT
GGAGTGATAGGGGGCTCCAAGCCCAAGGTGGCCACCCCCAAGGTGGTGGAGAAGATAGGGGACT
ACAAGCGGCAGAACCCTACCATGTTTGCTTGGGAGATCCGGGACCGGCTCTTGGCAGAAGGCGT
TTGTGACAATGACACTGTGCCCAGTGTCAGCTCCATCAACAGAATCATCCGGACCAAAGTGCAG
CAGCCATTCAACCTCCCCATGGACAGCTGCGTGGCCACCAAATCTCTGAGCCCAGGACACACAC
TGATCCCCAGCTCAGCTGTCACACCCCCAGAGTCACCCCAGTCGGATTCCTTGGGCTCTACCTA
CTCTATCAACGGGCTCCTAGGAATTGCTCAGCCTGGCAGTGACAACAAGAGAAAGATGGATGAT
AGTGACCAGGACAGTTGTCGACTGAGCATCGATTCCCAGAGCAGCAGTAGTGGTCCTCGAAAGC
ATCTTCGTACAGACACCTTCGGGCAGCACCACCTCGAGCCGCTCGAGTGCCCGTTTGAGCGGCA
GCATTACCCGGAGGCCTATGCCTCCCCCAGCCACACCAAAGGCGAGCAGGGGCTATACCCACTG
CCCTTACTCAACAGTACCCTGGATGACGGAAAGGCCACCCTGACACCTTCCAATACACCTCTGG
GACGCAACCTCTCAACTCACCAGACCTACCCTGTGGTGGCAGATCCTCATTCACCCTACGCCAT
AAAGCAGGAAACCCCAGAGCTCTCCAGTTCTAGCTCCACCCCTTCCTCTTTATCTAGCTCCGCC
TTTTTGGATCTGCAGCAAGTCGGCTCTGGGGGCCCAGCAGGTGCCTCGGTCCCACCCTTCAATG
CCTTTTCCCATGCTGCCTCCGTGTATGGGCAGTTCACGGGCCAGGCCCTCCTCTCAGGGCGAGA
GATGGTGGGGCCCACGCTGCCTGGATACCCACCCCACATCCCCACCAGTGGACAGGGCAGCTAT
GCCTCTTCCGCTATTGCAGGCATGGTGGCAGGAAGTGAGTATTCTGGCAATGCCTACAGCCACA
CCCCGTACGCCTCCTACAGTGAGGCCTGGCGCTTCCCCAACTCCAGCCTGCTGAGTTCCCCATA
TTATTACAGCTCTACAACAAGGCCAAGCGCACCGCCCACCTCTGCCACGGCCTTTGACCATCTG
TAGTTGTCATGGGGACAGTGGGAACAACCAGGCAACAGGAGGACTTGGCCTGAGACGGGCCCCA
GAGAGTCACACAAAGGAATCTTTATTTATTACATGAAAAATAACCACAATTCCAGCATTGCCGC
TCACTCCCTGTGTGGTCAATTAAATGAACCATGAAAGTCAGGATGACCTTGGGGAAGGCCAAAC
TGTCCTCCAAGAGTCATTTCGTGAGTGACAGGAGTTCCAGGAACCAAGAACCATCCATTTCAAA
AGAGTCACGGAGGAGAAATGGACCAAGGCTGGTACCCACCAAGAGAAAGAAACAGGATTTGCAA
AGAACTTAGAGGGTGTACAGGGCCACCTGTGTGGTCTTCATCACTACAACTCCAGCAATTATGG
ACAGTAAGCAAGTCCTTCTGGCCTAGAGTCATGGCCTAGGGCCAAGGCTCTACTTATCAGTTAT
CCTGGGAGTTACCACCTCTACCACCTGATGGGCACTTCTCTGGGGATTCAGCTGACCTCCCACT
TCCAGTTGTTATGAGCCTACAAACACCCCCTAGCCTCTCAACTAGTGGGCTACCCCTTTGGCAG
CAATGAACCTGTCCCCTGGAAAATTCAGTGAGCACAGGAAGACACAATAGATGGGACTGGCCAT
GTCCTCTTCTCAACAGCCCTGCCAACTCAAGTGTGCTTTCTGCAGCTCCAGCCCTCACGAGTCA
CTGAAGAGACCCCGAGGCCAGCAACAAGATTCCCTCTCTGGCTCCCCAGCTCTTTCCCCCACAC
AACCTTACTGTAAATACCGTAAATGAAGCTCTGTTTCGGTCAAGCTTCCCTCTTTCCATCCCCC
AGACCTTGGCTTCTAAAATGTCTCCCTACTATGTTGGGCTTTTCTCCTTGATTTTTTTTTTAAA
AAAGACAACCCATCATTACCATATGACTCAATAAACCATTACTCTTGGTCTCAGAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063284639 ⟹ XP_063140709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	27,584,000 - 27,641,094 (-)	NCBI

RefSeq Acc Id:

XM_063284640 ⟹ XP_063140710

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	27,584,000 - 27,607,637 (-)	NCBI

RefSeq Acc Id:

XM_063284641 ⟹ XP_063140711

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	27,584,000 - 27,607,095 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416443	(Get FASTA)	NCBI Sequence Viewer
	NP_112403	(Get FASTA)	NCBI Sequence Viewer
	XP_063140709	(Get FASTA)	NCBI Sequence Viewer
	XP_063140710	(Get FASTA)	NCBI Sequence Viewer
	XP_063140711	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81779	(Get FASTA)	NCBI Sequence Viewer
	CAA63930	(Get FASTA)	NCBI Sequence Viewer
	EDL93660	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033966.6
	ENSRNOP00000070564.2
	ENSRNOP00000078325.1
	ENSRNOP00055000611
	ENSRNOP00060044428
	ENSRNOP00065031404
GenBank Protein	P51974	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112403 ⟸ NM_031141

- UniProtKB:

Q66HM8 (UniProtKB/Swiss-Prot), P51974 (UniProtKB/Swiss-Prot), A6JSY7 (UniProtKB/TrEMBL), A0A0G2JY90 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGR
YYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI
NRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPG
SDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDTFGQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSSS
TPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLPGYPPH
IPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYASYSEAWRFPNSSLLSSPYYYSSTTRPSAPP
TSATAFDHL

hide sequence

Ensembl Acc Id:

ENSRNOP00000033966 ⟸ ENSRNOT00000031058

Ensembl Acc Id:

ENSRNOP00000070564 ⟸ ENSRNOT00000086447

Ensembl Acc Id:

ENSRNOP00000078325 ⟸ ENSRNOT00000096826

RefSeq Acc Id:	XP_063140709 ⟸ XM_063284639
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063140710 ⟸ XM_063284640
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063140711 ⟸ XM_063284641
- Peptide Label:	isoform X2

Protein Domains

Paired

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51974-F1-model_v2	AlphaFold	P51974	1-457	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691850

Promoter ID:

EPDNEW_R2375

Type:

single initiation site

Name:

Pax8_1

Description:

paired box 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	1,584,933 - 1,584,993	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620434	AgrOrtholog
BioCyc Gene	G2FUF-50505	BioCyc
Ensembl Genes	ENSRNOG00000026203	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055000468	UniProtKB/Swiss-Prot
	ENSRNOG00060030736	UniProtKB/Swiss-Prot
	ENSRNOG00065022625	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000031058.7	UniProtKB/Swiss-Prot
	ENSRNOT00000086447.2	UniProtKB/TrEMBL
	ENSRNOT00000096826.1	UniProtKB/TrEMBL
	ENSRNOT00055000797	UniProtKB/Swiss-Prot
	ENSRNOT00060053481	UniProtKB/Swiss-Prot
	ENSRNOT00065038711	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7127710	IMAGE-MGC_LOAD
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAIRED_DNA-bd_dom	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	Paired_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pax2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAX_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81819	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93376	IMAGE-MGC_LOAD
NCBI Gene	81819	ENTREZGENE
PANTHER	PAIRED BOX PROTEIN PAX-8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45636	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pax2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pax8	PhenoGen
PRINTS	PAIREDBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PAIRED_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAIRED_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026203	RatGTEx
	ENSRNOG00055000468	RatGTEx
	ENSRNOG00060030736	RatGTEx
	ENSRNOG00065022625	RatGTEx
SMART	PAX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JY90	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZKP4_RAT	UniProtKB/TrEMBL
	A6JSY7	ENTREZGENE, UniProtKB/TrEMBL
	P51974	ENTREZGENE, UniProtKB/Swiss-Prot
	Q66HM8	ENTREZGENE
UniProt Secondary	Q66HM8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-30	Pax8	paired box 8	Pax8	paired box gene 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Pax8	paired box gene 8		Pax-8 protein	Name updated	625702	APPROVED
2002-08-07	Pax8	Pax-8 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_mutations_overexpression	oversuprression abolishes Tgfb1 mediated suppression of Tg gene expression in thyrocytes	628521
gene_physical_interaction	binds to promoter region of Tg at the Pax8-binding element and forms protein-DNA complex	628521
gene_process	thyroid-specific transcription factor important for thyroglobulin (Tg) gene regulation by Tgfb1	628521
gene_regulation	DNA binding activity is inhibited by oxidation and facilitated by reduction	727430
gene_regulation	Cys45 and Cys57 are critical residues for mediating redox regulation of transcriptional transactivation activity	727430
gene_regulation	protein-DNA complex formation suppressed by Tgfb1 and mRNA and protein levels decreased by Tgfb1	628521

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)