Pax8 (paired box 8) - Rat Genome Database

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Gene: Pax8 (paired box 8) Rattus norvegicus
Analyze
Symbol: Pax8
Name: paired box 8
RGD ID: 620434
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8); PARTICIPATES IN thyroid cancer pathway; INTERACTS WITH (S)-nicotine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93376; paired box gene 8; paired box protein Pax-8; Pax-8 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,185,721 - 7,242,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,289,591 - 10,345,823 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0318,875,838 - 18,932,068 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,065,649 - 17,121,886 (-)NCBIRnor_WKY
Rnor_6.031,527,316 - 1,586,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,520,144 - 1,576,052 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,671,478 - 2,726,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,672,153 - 2,726,345 (-)NCBI
Celera32,022,899 - 2,078,650 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure development  (IBA)
branching involved in ureteric bud morphogenesis  (ISO)
cell differentiation  (ISO)
cellular response to gonadotropin stimulus  (ISO)
central nervous system development  (ISO)
DNA-templated transcription  (IEA,ISO)
epithelial cell differentiation  (ISO)
inner ear morphogenesis  (ISO)
kidney development  (ISO)
kidney epithelium development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO,ISS)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric distal convoluted tubule development  (ISO,ISS)
metanephric epithelium development  (ISO)
metanephric nephron tubule formation  (ISO,ISS)
metanephric S-shaped body morphogenesis  (ISO)
metanephros development  (ISO)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO,ISS)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO,ISS)
otic vesicle development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
positive regulation of metanephric DCT cell differentiation  (ISO,ISS)
positive regulation of thyroid hormone generation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
pronephric field specification  (ISO,ISS)
pronephros development  (ISO,ISS)
regulation of apoptotic process  (ISO,ISS)
regulation of DNA-templated transcription  (IEA,IMP)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO,ISS)
regulation of thyroid-stimulating hormone secretion  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
S-shaped body morphogenesis  (ISO)
sulfur compound metabolic process  (IEP)
thyroid gland development  (ISO,ISS)
urogenital system development  (ISO,ISS)
ventricular septum development  (ISO)

Cellular Component
nucleoplasm  (IDA,ISO)
nucleus  (IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8. Cao X, etal., Biochem Biophys Res Commun 2002 Sep 20;297(2):288-93.
2. Glutathionylation of two cysteine residues in paired domain regulates DNA binding activity of Pax-8. Cao X, etal., J Biol Chem. 2005 Jul 8;280(27):25901-6. Epub 2005 May 11.
3. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. Di Palma T, etal., J Biol Chem. 2003 Jan 31;278(5):3395-402. Epub 2002 Nov 18.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1. Kang HC, etal., Endocrinology 2001 Jan;142(1):267-75.
7. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Macchia PE, etal., Nat Genet. 1998 May;19(1):83-6.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8. Nitsch R, etal., Biochem J. 2004 Feb 1;377(Pt 3):553-60.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.
18. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Zannini M, etal., Mol Cell Biol. 1992 Sep;12(9):4230-41.
Additional References at PubMed
PMID:1337742   PMID:1723950   PMID:7856737   PMID:8413205   PMID:8861958   PMID:9388203   PMID:9590297   PMID:11773436   PMID:12435636   PMID:12586753   PMID:14623893   PMID:15356023  
PMID:15489334   PMID:15494458   PMID:15961562   PMID:16319112   PMID:16627577   PMID:16641100   PMID:17047028   PMID:17314325   PMID:19010321   PMID:19282367   PMID:20727173   PMID:21317881  
PMID:21966443   PMID:22453009   PMID:22531031   PMID:23868062   PMID:25270402   PMID:26030152   PMID:27780871   PMID:34012023   PMID:34726504  


Genomics

Comparative Map Data
Pax8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,185,721 - 7,242,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,289,591 - 10,345,823 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0318,875,838 - 18,932,068 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,065,649 - 17,121,886 (-)NCBIRnor_WKY
Rnor_6.031,527,316 - 1,586,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,520,144 - 1,576,052 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,671,478 - 2,726,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,672,153 - 2,726,345 (-)NCBI
Celera32,022,899 - 2,078,650 (-)NCBICelera
Cytogenetic Map3p13NCBI
PAX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,215,997 - 113,278,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2113,215,997 - 113,278,921 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,973,574 - 114,036,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,690,045 - 113,752,968 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,691,170 - 113,752,728NCBI
Celera2107,358,161 - 107,421,066 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,427,614 - 106,522,962 (-)NCBIHuRef
CHM1_12113,977,965 - 114,040,915 (-)NCBICHM1_1
T2T-CHM13v2.02113,642,573 - 113,705,473 (-)NCBIT2T-CHM13v2.0
Pax8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,310,563 - 24,365,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,310,572 - 24,365,611 (-)EnsemblGRCm39 Ensembl
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBIMGSCv36mm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
Pax8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,016,289 - 1,073,796 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,016,226 - 1,072,643 (+)NCBIChiLan1.0ChiLan1.0
PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,162,110 - 114,222,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PAX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,307,130 - 37,331,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,306,033 - 37,363,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,077,650 - 37,133,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,084,443 - 38,141,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,085,541 - 38,141,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,220,866 - 37,276,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,277,373 - 37,333,166 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,490,112 - 37,546,218 (-)NCBIUU_Cfam_GSD_1.0
Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,629,178 - 82,682,663 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,523,661 - 1,576,568 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367831,523,658 - 1,553,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,236,074 - 16,299,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,382,976 - 3,450,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,300,606 - 13,357,903 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474913,291,880 - 13,358,066 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pax8
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:85
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000031058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
D11Bir2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,207,455 - 7,207,593 (+)MAPPERmRatBN7.2
mRatBN7.21243,621,084 - 243,621,222 (+)MAPPERmRatBN7.2
Rnor_6.01264,508,928 - 264,509,065NCBIRnor6.0
Rnor_6.031,549,052 - 1,549,189NCBIRnor6.0
Rnor_5.031,541,880 - 1,542,017UniSTSRnor5.0
Rnor_5.01271,951,604 - 271,951,741UniSTSRnor5.0
RGSC_v3.41249,808,393 - 249,808,530UniSTSRGSC3.4
RGSC_v3.432,693,184 - 2,693,321UniSTSRGSC3.4
Celera32,044,635 - 2,044,772UniSTS
Celera1239,432,502 - 239,432,639UniSTS
Cytogenetic Map3p13UniSTS
Cytogenetic Map1q54UniSTS
Pax8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,207,541 - 7,209,050 (+)MAPPERmRatBN7.2
Rnor_6.031,549,138 - 1,550,646NCBIRnor6.0
Rnor_5.031,541,966 - 1,543,474UniSTSRnor5.0
Celera32,044,721 - 2,046,229UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 22
Low 3 16 8 19 8 37 13 6
Below cutoff 26 37 32 32 5 5 29 6 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031058   ⟹   ENSRNOP00000033966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)Ensembl
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086447   ⟹   ENSRNOP00000070564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,185,723 - 7,209,358 (-)Ensembl
Rnor_6.0 Ensembl31,527,992 - 1,549,189 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096826   ⟹   ENSRNOP00000078325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,188,065 - 7,242,363 (-)Ensembl
RefSeq Acc Id: NM_031141   ⟹   NP_112403
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.237,185,721 - 7,242,363 (-)NCBI
Rnor_6.031,527,316 - 1,584,925 (-)NCBI
Rnor_5.031,520,144 - 1,576,052 (-)NCBI
RGSC_v3.432,671,478 - 2,726,801 (-)RGD
Celera32,022,899 - 2,078,650 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112403 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81779 (Get FASTA)   NCBI Sequence Viewer  
  CAA63930 (Get FASTA)   NCBI Sequence Viewer  
  EDL93660 (Get FASTA)   NCBI Sequence Viewer  
  P51974 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112403   ⟸   NM_031141
- UniProtKB: Q66HM8 (UniProtKB/Swiss-Prot),   P51974 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033966   ⟸   ENSRNOT00000031058
RefSeq Acc Id: ENSRNOP00000070564   ⟸   ENSRNOT00000086447
RefSeq Acc Id: ENSRNOP00000078325   ⟸   ENSRNOT00000096826
Protein Domains
Paired

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51974-F1-model_v2 AlphaFold P51974 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691850
Promoter ID:EPDNEW_R2375
Type:single initiation site
Name:Pax8_1
Description:paired box 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.031,584,933 - 1,584,993EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620434 AgrOrtholog
BioCyc Gene G2FUF-50505 BioCyc
Ensembl Genes ENSRNOG00000026203 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033966 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070564.2 UniProtKB/TrEMBL
  ENSRNOP00000078325.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031058 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086447.2 UniProtKB/TrEMBL
  ENSRNOT00000096826.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127710 IMAGE-MGC_LOAD
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_DNA-bd_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Paired_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pax2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81819 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93376 IMAGE-MGC_LOAD
NCBI Gene 81819 ENTREZGENE
PANTHER PTHR45636 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pax2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pax8 PhenoGen
PRINTS PAIREDBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JY90_RAT UniProtKB/TrEMBL
  A0A8I5ZKP4_RAT UniProtKB/TrEMBL
  P51974 ENTREZGENE, UniProtKB/Swiss-Prot
  Q66HM8 ENTREZGENE
UniProt Secondary Q66HM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Pax8  paired box 8  Pax8  paired box gene 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pax8  paired box gene 8    Pax-8 protein  Name updated 625702 APPROVED
2002-08-07 Pax8  Pax-8 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression oversuprression abolishes Tgfb1 mediated suppression of Tg gene expression in thyrocytes 628521
gene_physical_interaction binds to promoter region of Tg at the Pax8-binding element and forms protein-DNA complex 628521
gene_process thyroid-specific transcription factor important for thyroglobulin (Tg) gene regulation by Tgfb1 628521
gene_regulation DNA binding activity is inhibited by oxidation and facilitated by reduction 727430
gene_regulation Cys45 and Cys57 are critical residues for mediating redox regulation of transcriptional transactivation activity 727430
gene_regulation protein-DNA complex formation suppressed by Tgfb1 and mRNA and protein levels decreased by Tgfb1 628521