Fbxo33 (F-box protein 33) - Rat Genome Database

Name: Fbxo33
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fbxo33 (F-box protein 33) Rattus norvegicus

Analyze

Symbol:

Fbxo33

Name:

F-box protein 33

RGD ID:

1307543

Description:

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to localize to SCF ubiquitin ligase complex. Orthologous to human FBXO33 (F-box protein 33); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; methamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

F-box only protein 33; LOC314157

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBXO33 (F-box protein 33)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Fbxo33 (F-box protein 33)	HGNC	EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fbxo33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FBXO33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBXO33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbxo33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBXO33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	FBXO33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbxo33 (F-box protein 33)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FBXO33 (F-box protein 33)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Fbxo33 (F-box protein 33)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG4911	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	76,900,619 - 76,934,232 (-)	NCBI
Rnor_6.0 Ensembl	6	80,302,303 - 80,334,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	6	80,302,291 - 80,334,536 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	89,828,077 - 89,860,407 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	79,902,508 - 79,934,591 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	79,905,965 - 80,032,484 (-)	NCBI
Celera	6	75,655,646 - 75,687,363 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

clothianidin (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

ethanol (ISO)

fluoranthene (ISO)

lead diacetate (ISO)

methamphetamine (EXP)

oxaliplatin (EXP)

p-toluidine (EXP)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chloride (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

sunitinib (ISO)

topotecan (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

SCF ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

References

References - curated


1.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Fbxo33
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	76,900,619 - 76,934,232 (-)	NCBI
Rnor_6.0 Ensembl	6	80,302,303 - 80,334,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	6	80,302,291 - 80,334,536 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	89,828,077 - 89,860,407 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	79,902,508 - 79,934,591 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	6	79,905,965 - 80,032,484 (-)	NCBI
Celera	6	75,655,646 - 75,687,363 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

FBXO33
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	14	39,397,669 - 39,432,500 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	14	39,396,373 - 39,432,500 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	14	39,865,577 - 39,901,704 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	38,936,710 - 38,971,371 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	14	38,936,710 - 38,971,371	NCBI
Celera	14	19,731,269 - 19,768,589 (-)	NCBI
Cytogenetic Map	14	q21.1	NCBI
HuRef	14	19,979,341 - 20,016,798 (-)	NCBI		HuRef
CHM1_1	14	39,864,175 - 39,900,294 (-)	NCBI		CHM1_1

Fbxo33
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	59,247,441 - 59,268,747 (-)	NCBI	GRCm39		mm39
GRCm38	12	59,200,655 - 59,221,961 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	59,200,655 - 59,219,725 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	60,301,642 - 60,320,470 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	60,118,668 - 60,123,701 (-)	NCBI			mm8
Celera	12	60,360,719 - 60,379,552 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI

Fbxo33
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	21,930,071 - 21,951,068 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	21,929,863 - 21,952,812 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBXO33
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	14	38,524,595 - 38,558,579 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	38,526,437 - 38,558,626 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	14	20,170,332 - 20,205,181 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

FBXO33
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	8	17,462,937 - 17,528,249 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	8	17,495,795 - 17,528,389 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Fbxo33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936494	12,930,659 - 12,969,264 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBXO33
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	169,877,192 - 169,915,602 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	169,877,189 - 169,915,856 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	188,588,681 - 188,627,424 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBXO33
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	16,174,116 - 16,206,955 (-)	NCBI
ChlSab1.1 Ensembl	24	16,175,882 - 16,207,155 (-)	Ensembl

Fbxo33
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624813	8,791,774 - 8,812,870 (-)	NCBI

Position Markers

D6Rat98

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	80,324,849 - 80,325,057	NCBI	Rnor6.0
Rnor_5.0	6	89,850,635 - 89,850,843	UniSTS	Rnor5.0
RGSC_v3.4	6	79,924,547 - 79,924,756	RGD	RGSC3.4
RGSC_v3.4	6	79,924,548 - 79,924,756	UniSTS	RGSC3.4
RGSC_v3.1	6	79,928,004 - 79,928,212	RGD
Celera	6	75,677,690 - 75,677,898	UniSTS
RH 3.4 Map	6	546.1	UniSTS
RH 3.4 Map	6	546.1	RGD
RH 2.0 Map	6	768.9	RGD
SHRSP x BN Map	6	51.1399	RGD
FHH x ACI Map	6	60.2299	RGD
Cytogenetic Map	6	q23	UniSTS

AI642135

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	80,302,440 - 80,302,545	NCBI	Rnor6.0
Rnor_5.0	6	89,828,226 - 89,828,331	UniSTS	Rnor5.0
RGSC_v3.4	6	79,902,652 - 79,902,757	UniSTS	RGSC3.4
Celera	6	75,655,790 - 75,655,895	UniSTS
Cytogenetic Map	6	q23	UniSTS

RH135434

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	80,302,351 - 80,302,533	NCBI	Rnor6.0
Rnor_5.0	6	89,828,137 - 89,828,319	UniSTS	Rnor5.0
RGSC_v3.4	6	79,902,563 - 79,902,745	UniSTS	RGSC3.4
Celera	6	75,655,701 - 75,655,883	UniSTS
RH 3.4 Map	6	546.69	UniSTS
Cytogenetic Map	6	q23	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	2537030	111715717	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	7009971	115379601	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	22042854	84763421	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	22042854	84763421	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34367436	80490628	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	36260288	84763275	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	38106308	83106308	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	41679046	86679046	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	41679046	86679046	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	41679046	86679046	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	48432758	108268790	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	59803065	94001333	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	60606431	108154445	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	60606431	108154445	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	62263348	107263348	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	66129520	111129520	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	68781170	147991367	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	68781170	147991367	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	71206251	116206251	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	75449871	120449871	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	75623277	120276465	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	75623277	120623277	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	75623277	136143011	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	75623277	136426962	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	75623393	84763275	Rat
1581550	Pur8	Proteinuria QTL 8			total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	75623393	136142742	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	75623393	136142742	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	76902247	114203334	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	643
Count of miRNA genes:	292
Interacting mature miRNAs:	359
Transcripts:	ENSRNOT00000059316
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	6	29	16	19	16			63	31	41	11
Low		37	28	25		25	8	11	11	4			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000059316 ⟹ ENSRNOP00000056078

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	80,302,303 - 80,334,522 (-)	Ensembl

RefSeq Acc Id:

NM_001108023 ⟹ NP_001101493

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	76,900,624 - 76,932,337 (-)	NCBI
Rnor_6.0	6	80,302,296 - 80,334,522 (-)	NCBI
Rnor_5.0	6	89,828,077 - 89,860,407 (-)	NCBI
RGSC_v3.4	6	79,902,508 - 79,934,591 (-)	RGD
Celera	6	75,655,646 - 75,687,363 (-)	RGD

Sequence:

show sequence

GTCAGTGCCGCAGCCCCGACCGCCGGGAGCGCGAACCCGAGCCGGGGCCGCCCGGGTGGTGCGG
TGGCGGCGGCGGCAGCGGCTGCGGCTGCGGCAGCTGCGCCGGCTGCGGGGGCTGCTGCGAGGAC
TGCGCGGGCGGTCGGGGACGAGCGGCCGGCGGCGGAGCCGGATGGCTCTGTGCGGGCAGGCGGC
CGGCGCCGCGTCGCTGCCCAGCGAACTCATCGTGCACATCTTCTCCTTTCTGCCGGCGCCCGAC
CGGCTGCGGGCCTCGGCCTCCTGCTCGCACTGGCGGGAGTGCCTCTTCTACCCAGCCCTGTGGC
CCCAGCTCCGCATCTGCCTCCGCGTCTCGCCAGCGGAGCAGCCGCGGCTCGAGTTTCTCATGCG
CAAGTGCGGCTGGTTCGTACGGGAGCTACGGGCCCTGCAACTCTCCTCCCGCTGGCTAGAAGTG
CTGCGCATCTACTTGGAGCTGGTGTTGTGCGTGCTGCTCAGCATCCGGAACAACAGGAACCTCC
AGAAGTTTAGTCTTTTTGGAGATATAAGTGTCGTTCAGCAGCAAGGAAGTCTGTCCAGCACATA
CCTCAGCAGAGTAGACCCTGACGGCAAGAAGATTAAGCAAATTCAGCAGCTGTTTGAAGAAATA
CTGAGCAATAGTAGGCAACTAAAATGGCTGTCCTGTGGGTTTATGCTGGAAATAGTAACCCCAT
CATCACTGTCGTCTCTGTCTAACTCCATTGCCAACACCATGGAACACCTGAGTTTACTGGACAA
CAACATTCCTGGTAACAGCACGCTCATCACCGCAGTCGAACTAGAGCGCTTTGTAAATCTGCGC
TCACTTGCCCTGGATTTCTGTGACTTTACAGCTGAGATGGCGAGAGTCCTGACCGACAGCAACC
ATGTGCCTTTGCAGCGACTGTCTCTTCTGGTCCACAATGCTTCAGTGATGCTCAAGTCATTAGA
CAACATGCCAAACGATGAGCACTGGAAGGCCCTGTCACGAAAGAGCTCCAGCCTCCGGGTCTAT
CTAATGGCTTTTGATGTTAAAAGTGAAGACATGCTAAAGATTCTGAAACCCAGTATACCACTTG
AGAGGGTTCACTTTGACAGCTACGTCACTTGTGTCTCAGGGGCTATTGTTGATCTTATATCCAG
GCAGTATGACAAGTTCCTCACCCATTTTATATTGATGAATGATATGATTGATACGTCTGGTTTT
CCGGATCTTAGTGACAACCGAAATGAAGATCCATTGGTTTTATTGGCATGGCGGTGCACAAAGC
TCACTCTTTTGGCAATTCATGGTTACACCGTGTGGGCACACAACCTCATTGCCATTGCTCGTCT
TCGTGGCTCTGACCTAAAAGTGCTTGAAGTCACCGAAGAAAGCATTGATTTTGACCAAGGTGAA
CTAGCCGACCAGGATGTGGATCCCGTACATAACCTTCTTGAGCAGGTATCCCTGGGCCTTGGTC
AGTCTTGGCACGCAGTCTTGGACATCGAATCACTCAGTGTCTTCACTGAACCAAATCGTCATTT
TTACAGAGAGATGCAAAGCTTCAGCGAAGACATTTAGCTTTTTTAAAATGTATAATTCCTGTGG
CTACATATGCAAGTAGGGTCCCATTATGTTTTTTTCATTAGTGGAAACTAATCCTTTTGTGCTG
TGTTTAATCAGTATTAGCTTTATAGAATTATAAATGTATATTCTACTTCTTGATCAAAGAACGT
AGTCGGGTATTGGTTTTAGAAGTTCAAAGTGACACTGTATAGGGCTTTCACGGTTAATGGGATT
GTTAGCAAATCTTAAGGACATACAGCCAATGATTATCTGAGGTTACTGGCTAACTGTTTTTCAC
TGAGTTACTCTGCCTTTTTGACATTTTTATTCTTTGTTTGTCAGAATCCAGAGCTCAGGAGCCA
AATATTTTTATACGTATATATATATATATATAAATATCCATAAGCCTGGTGGATTTGTATGCAA
TGCACTGCATCTATGTATTCTGATAGCATCTCATTGATTTTTGTTTGAAATAGAAAGAAAGATA
GTATCCCAAATGAGTTATCTTTAACAGAAAGCTGAGTTTAACTTTTATTACCTATATAATAATT
GATATTGCCAATTACCATTCTGAATTTCATATAGTATAAGTTAGACATTGCTTAATCCCCTTTT
AAATGTATTTACATAGACATGAACACTCAAATTGCTGGATTTTTTAAATATATCTGACATAATT
TTTTTCATCTGTTACATTCAAGTTAGCTTGTTTAGCCCAGATTTCAGAATAGTAAAGGAGGAAA
GGAACCGCATTCCAGGGAAACCTCTGAGGCCAAGTCAGAGTCCAGAACTGTAAACGCACAGGCC
TGCAAGCCAACATTAGTCGTGAAATCCCTAACACGTCACTGGATTCTCTCTGTCAGCGCAAGTG
TCAGCTGCCAAAGAATAGACTTACATGAAGAAGTGCCCACATGCTGGCAGGGGCTGGCCGGCTC
CGGCCAGCAGACACTGCTAGATTGTAATATTTAAGGTCGAGTTTCGACCTGTGGTACACAGCTG
TGCTGTGCTCAGTCAGCAACCTCAGAACTCTGAAAAAAACATAAAAAAGAAAAAAAAAGAAAAA
AAACATGCACCTGTTTCACTGTGAATAGTGAATGTAAAGGAAAGAAAGGAAAACCAAAAGCTTG
TTCCATCACAGGTATGAGCTGCTATGATTCATGAAGAACATTCCATGGAGTATGTTTTAAAACC
TTGTTATATCTGAGAGGCTTTAAAAGCCAACTTAACTGTTTCAGGGCAACCGCGGTACAGACGT
GGTCTCTGTGAGACTTCCACCTGACCCAAGTTTTAAGTGGTACGAATGTTGTGCATTTAATGTT
AAGGACAGTCTGCAATAATAAGTAAGTAGCCAGCGTGGGTGCCCAGCAGTGCTGAGACCTGGCT
GCTCTATTGTACGCTTTGGAAACACAATTTATGCAACAGATGTCCAGATATGATTCTATTTATG
GAAAAAGTTTATATGTTTTACAAATGGTTTTACCATCTTATATTAAATGACCTTTTGACAGGTG
TGCACTGTTTTGTCTCCAGTGAGCACATACCATGCGGATTTTATATGTACATCAGTAGTGTGAA
TCCACTGGCACAGTGTGTGTAAATGCCAGATGTGGTGAGATTTTATCTTGTATATGTGATCAGA
TAAAATAACTCCTGACAGAAACTGTAAGGAAACCAGCTGAATGTTTGACCTGATGACTGATGTT
GTATGGTTTATGTTAAATGTATATTCTTTTAATCAATGAATAAAGCATTAAAAAAT

hide sequence

RefSeq Acc Id:

XM_006240119 ⟹ XP_006240181

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	76,901,282 - 76,932,493 (-)	NCBI
Rnor_6.0	6	80,302,291 - 80,334,536 (-)	NCBI
Rnor_5.0	6	89,828,077 - 89,860,407 (-)	NCBI

Sequence:

show sequence

ATGTTGTTGTTCTTGTCAGTGCCGCAGCCCCGACCGCCGGGAGCGCGAACCCGAGCCGGGGCCG
CCCGGGTGGTGCGGTGGCGGCGGCGGCAGCGGCTGCGGCTGCGGCAGCTGCGCCGGCTGCGGGG
GCTGCTGCGAGGACTGCGCGGGCGGTCGGGGACGAGCGGCCGGCGGCGGAGCCGGATGGCTCTG
TGCGGGCAGGCGGCCGGCGCCGCGTCGCTGCCCAGCGAACTCATCGTGCACATCTTCTCCTTTC
TGCCGGCGCCCGACCGGCTGCGGGCCTCGGCCTCCTGCTCGCACTGGCGGGAGTGCCTCTTCTA
CCCAGCCCTGTGGCCCCAGCTCCGCATCTGCCTCCGCGTCTCGCCAGCGGAGCAGCCGCGGCTC
GAGTTTCTCATGCGCAAGTGCGGCTGGTTCGTACGGGAGCTACGGGTTGAGTTCGCCGCGGAGA
ATTATCTGAGCGGAGGCGGCGGCCCGGGCGACGGTGGCGGAAGCGGCGGGGGCACCGACACGGG
CAACGGAGGGGAAGAAAGTGAGGCCCTGCAACTCTCCTCCCGCTGGCTAGAAGTGCTGCGCATC
TACTTGGAGCTGGTGTTGTGCGTGCTGCTCAGCATCCGGAACAACAGGAACCTCCAGAAGTTTA
GTCTTTTTGGAGATATAAGTGTCGTTCAGCAGCAAGGAAGTCTGTCCAGCACATACCTCAGCAG
AGTAGACCCTGACGGCAAGAAGATTAAGCAAATTCAGCAGCTGTTTGAAGAAATACTGAGCAAT
AGTAGGCAACTAAAATGGCTGTCCTGTGGGTTTATGCTGGAAATAGTAACCCCATCATCACTGT
CGTCTCTGTCTAACTCCATTGCCAACACCATGGAACACCTGAGTTTACTGGACAACAACATTCC
TGGTAACAGCACGCTCATCACCGCAGTCGAACTAGAGCGCTTTGTAAATCTGCGCTCACTTGCC
CTGGATTTCTGTGACTTTACAGCTGAGATGGCGAGAGTCCTGACCGACAGCAACCATGTGCCTT
TGCAGCGACTGTCTCTTCTGGTCCACAATGCTTCAGTGATGCTCAAGTCATTAGACAACATGCC
AAACGATGAGCACTGGAAGGCCCTGTCACGAAAGAGCTCCAGCCTCCGGGTCTATCTAATGGCT
TTTGATGTTAAAAGTGAAGACATGCTAAAGATTCTGAAACCCAGTATACCACTTGAGAGGGTTC
ACTTTGACAGCTACGTCACTTGTGTCTCAGGGGCTATTGTTGATCTTATATCCAGGCAGTATGA
CAAGTTCCTCACCCATTTTATATTGATGAATGATATGATTGATACGTCTGGTTTTCCGGATCTT
AGTGACAACCGAAATGAAGATCCATTGGTTTTATTGGCATGGCGGTGCACAAAGCTCACTCTTT
TGGCAATTCATGGTTACACCGTGTGGGCACACAACCTCATTGCCATTGCTCGTCTTCGTGGCTC
TGACCTAAAAGTGCTTGAAGTCACCGAAGAAAGCATTGATTTTGACCAAGGTGAACTAGCCGAC
CAGGATGTGGATCCCGTACATAACCTTCTTGAGCAGGTATCCCTGGGCCTTGGTCAGTCTTGGC
ACGCAGTCTTGGACATCGAATCACTCAGTGTCTTCACTGAACCAAATCGTCATTTTTACAGAGA
GATGCAAAGCTTCAGCGAAGACATTTAGCTTTTTTAAAATGTATAATTCCTGTGGCTACATATG
CAAGTAGGGTCCCATTATGTTTTTTTCATTAGTGGAAACTAATCCTTTTGTGCTGTGTTTAATC
AGTATTAGCTTTATAGAATTATAAATGTATATTCTACTTCTTGATCAAAGAACGTAGTCGGGTA
TTGGTTTTAGAAGTTCAAAGTGACACTGTATAGGGCTTTCACGGTTAATGGGATTGTTAGCAAA
TCTTAAGGACATACAGCCAATGATTATCTGAGGTTACTGGCTAACTGTTTTTCACTGAGTTACT
CTGCCTTTTTGACATTTTTATTCTTTGTTTGTCAGAATCCAGAGCTCAGGAGCCAAATATTTTT
ATACGTATATATATATATATATAAATATCCATAAGCCTGGTGGATTTGTATGCAATGCACTGCA
TCTATGTATTCTGATAGCATCTCATTGATTTTTGTTTGAAATAGAAAGAAAGATAGTATCCCAA
ATGAGTTATCTTTAACAGAAAGCTGAGTTTAACTTTTATTACCTATATAATAATTGATATTGCC
AATTACCATTCTGAATTTCATATAGTATAAGTTAGACATTGCTTAATCCCCTTTTAAATGTATT
TACATAGACATGAACACTCAAATTGCTGGATTTTTTAAATATATCTGACATAATTTTTTTCATC
TGTTACATTCAAGTTAGCTTGTTTAGCCCAGATTTCAGAATAGTAAAGGAGGAAAGGAACCGCA
TTCCAGGGAAACCTCTGAGGCCAAGTCAGAGTCCAGAACTGTAAACGCACAGGCCTGCAAGCCA
ACATTAGTCGTGAAATCCCTAACACGTCACTGGATTCTCTCTGTCAGCGCAAGTGTCAGCTGCC
AAAGAATAGACTTACATGAAGAAGTGCCCACATGCTGGCAGGGGCTGGCCGGCTCCGGCCAGCA
GACACTGCTAGATTGTAATATTTAAGGTCGAGTTTCGACCTGTGGTACACAGCTGTGCTGTGCT
CAGTCAGCAACCTCAGAACTCTGAAAAAAACATAAAAAAGAAAAAAAAAGAAAAAAAACATGCA
CCTGTTTCACTGTGAATAGTGAATGTAAAGGAAAGAAAGGAAAACCAAAAGCTTGTTCCATCAC
AGGTATGAGCTGCTATGATTCATGAAGAACATTCCATGGAGTATGTTTTAAAACCTTGTTATAT
CTGAGAGGCTTTAAAAGCCAACTTAACTGTTTCAGGGCAACCGCGGTACAGACGTGGTCTCTGT
GAGACTTCCACCTGACCCAAGTTTTAAGTGGTACGAATGTTGTGCATTTAATGTTAAGGACAGT
CTGCAATAATAAGTAAGTAGCCAGCGTGGGTGCCCAGCAGTGCTGAGACCTGGCTGCTCTATTG
TACGCTTTGGAAACACAATTTATGCAACAGATGTCCAGATATGATTCTATTTATGGAAAAAGTT
TATATGTTTTACAAATGGTTTTACCATCTTATATTAAATGACCTTTTGACAGGTGTGCACTGTT
TTGTCTCCAGTGAGCACATACCATGCGGATTTTATATGTACATCAGTAGTGTGAATCCACTGGC
ACAGTGTGTGTAAATGCCAGATGTGGTGAGATTTTATCTTGTATATGTGATCAGATAAAATAAC
TCCTGACAGAAACTGTAAGGAAACCAGCTGAATGTTTGACCTGATGACTGATGTTGTATGGTTT
ATGTTAAATGTATATTCTTTTAATCAATGAATAAAGCATTAAAAAATGGGCA

hide sequence

RefSeq Acc Id:

XM_039112237 ⟹ XP_038968165

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	76,900,619 - 76,934,232 (-)	NCBI

RefSeq Acc Id:

XM_039112238 ⟹ XP_038968166

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	76,900,619 - 76,932,493 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101493	(Get FASTA)	NCBI Sequence Viewer
	XP_006240181	(Get FASTA)	NCBI Sequence Viewer
	XP_038968165	(Get FASTA)	NCBI Sequence Viewer
	XP_038968166	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68929	(Get FASTA)	NCBI Sequence Viewer
	EDM03471	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001101493 ⟸ NM_001108023

- UniProtKB:

D3ZVL5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQ
PRLEFLMRKCGWFVRELRALQLSSRWLEVLRIYLELVLCVLLSIRNNRNLQKFSLFGDISVVQQ
QGSLSSTYLSRVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPSSLSSLSNSIANTM
EHLSLLDNNIPGNSTLITAVELERFVNLRSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNA
SVMLKSLDNMPNDEHWKALSRKSSSLRVYLMAFDVKSEDMLKILKPSIPLERVHFDSYVTCVSG
AIVDLISRQYDKFLTHFILMNDMIDTSGFPDLSDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAH
NLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLLEQVSLGLGQSWHAVLDIESLSV
FTEPNRHFYREMQSFSEDI

hide sequence

RefSeq Acc Id:

XP_006240181 ⟸ XM_006240119

- Peptide Label:

isoform X1

- Sequence:

show sequence

MLLFLSVPQPRPPGARTRAGAARVVRWRRRQRLRLRQLRRLRGLLRGLRGRSGTSGRRRSRMAL
CGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRL
EFLMRKCGWFVRELRVEFAAENYLSGGGGPGDGGGSGGGTDTGNGGEESEALQLSSRWLEVLRI
YLELVLCVLLSIRNNRNLQKFSLFGDISVVQQQGSLSSTYLSRVDPDGKKIKQIQQLFEEILSN
SRQLKWLSCGFMLEIVTPSSLSSLSNSIANTMEHLSLLDNNIPGNSTLITAVELERFVNLRSLA
LDFCDFTAEMARVLTDSNHVPLQRLSLLVHNASVMLKSLDNMPNDEHWKALSRKSSSLRVYLMA
FDVKSEDMLKILKPSIPLERVHFDSYVTCVSGAIVDLISRQYDKFLTHFILMNDMIDTSGFPDL
SDNRNEDPLVLLAWRCTKLTLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELAD
QDVDPVHNLLEQVSLGLGQSWHAVLDIESLSVFTEPNRHFYREMQSFSEDI

hide sequence

RefSeq Acc Id:

ENSRNOP00000056078 ⟸ ENSRNOT00000059316

RefSeq Acc Id:	XP_038968165 ⟸ XM_039112237
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038968166 ⟸ XM_039112238
- Peptide Label:	isoform X3

Protein Domains

F-box

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694619

Promoter ID:

EPDNEW_R5143

Type:

initiation region

Name:

Fbxo33_1

Description:

F-box protein 33

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	80,334,540 - 80,334,600	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
6	79904441	79904442	G	T	snv	SS/JrHsdMcwi (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307543	AgrOrtholog
Ensembl Genes	ENSRNOG00000005285	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000056078	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059316	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	F-box_dom_cyclin-like	UniProtKB/TrEMBL
	F-box_dom_like	UniProtKB/TrEMBL
	FBXO33	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
KEGG Report	rno:314157	UniProtKB/TrEMBL
NCBI Gene	314157	ENTREZGENE
PANTHER	PTHR20933	UniProtKB/TrEMBL
Pfam	F-box-like	UniProtKB/TrEMBL
PhenoGen	Fbxo33	PhenoGen
PROSITE	FBOX	UniProtKB/TrEMBL
SMART	FBOX	UniProtKB/TrEMBL
Superfamily-SCOP	F-box_dom_Skp2-like	UniProtKB/TrEMBL
UniProt	B5DF53_RAT	UniProtKB/TrEMBL
	D3ZVL5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Fbxo33	F-box protein 33	Fbxo33_predicted	F-box only protein 33 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Fbxo33_predicted	F-box only protein 33 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)