Adgrg6 (adhesion G protein-coupled receptor G6) - Rat Genome Database
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Gene: Adgrg6 (adhesion G protein-coupled receptor G6) Rattus norvegicus
Analyze
Symbol: Adgrg6
Name: adhesion G protein-coupled receptor G6
RGD ID: 1308551
Description: Predicted to have G protein-coupled receptor activity and laminin binding activity. Predicted to be involved in several processes, including cAMP-mediated signaling; heart trabecula formation; and myelination in peripheral nervous system. Predicted to localize to cell surface; cytoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: adhesion G-protein coupled receptor G6; G protein-coupled receptor 126; G-protein coupled receptor 126; Gpr126; hypothetical protein LOC681235; LOC308376; LOC681235
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.218,812,889 - 8,954,239 (-)NCBI
Rnor_6.0 Ensembl18,593,075 - 8,751,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.018,593,342 - 8,751,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0110,212,403 - 10,369,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419,290,306 - 9,402,175 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119,290,940 - 9,495,056 (-)NCBI
Celera17,291,590 - 7,431,077 (-)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:15189448   PMID:15225624   PMID:24082093   PMID:24227709   PMID:25695270   PMID:26004201   PMID:27501152   PMID:30193173  


Genomics

Comparative Map Data
Adgrg6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.218,812,889 - 8,954,239 (-)NCBI
Rnor_6.0 Ensembl18,593,075 - 8,751,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.018,593,342 - 8,751,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0110,212,403 - 10,369,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419,290,306 - 9,402,175 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119,290,940 - 9,495,056 (-)NCBI
Celera17,291,590 - 7,431,077 (-)NCBICelera
Cytogenetic Map1p13NCBI
ADGRG6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6142,301,854 - 142,446,266 (+)EnsemblGRCh38hg38GRCh38
GRCh386142,302,007 - 142,446,261 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376142,623,144 - 142,767,398 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366142,664,759 - 142,809,078 (+)NCBINCBI36hg18NCBI36
Build 346142,664,758 - 142,808,343NCBI
Celera6143,363,551 - 143,507,919 (+)NCBI
Cytogenetic Map6q24.2NCBI
HuRef6140,189,101 - 140,333,652 (+)NCBIHuRef
CHM1_16142,885,437 - 143,030,142 (+)NCBICHM1_1
Adgrg6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391014,278,327 - 14,421,467 (-)NCBIGRCm39mm39
GRCm39 Ensembl1014,278,327 - 14,421,403 (-)Ensembl
GRCm381014,402,583 - 14,545,723 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1014,402,583 - 14,545,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371014,122,391 - 14,264,842 (-)NCBIGRCm37mm9NCBIm37
MGSCv361014,092,783 - 14,235,234 (-)NCBImm8
Celera1014,303,952 - 14,442,752 (-)NCBICelera
Cytogenetic Map10A2NCBI
Adgrg6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543617,805,068 - 17,931,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543617,804,548 - 17,931,667 (-)NCBIChiLan1.0ChiLan1.0
ADGRG6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16144,142,374 - 144,283,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6144,142,374 - 144,283,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06140,069,168 - 140,211,011 (+)NCBIMhudiblu_PPA_v0panPan3
ADGRG6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl133,969,268 - 34,104,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1133,967,783 - 34,106,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adgrg6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366253,552,611 - 3,688,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRG6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,662,020 - 22,801,864 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,662,009 - 22,802,166 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,289,954 - 25,409,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRG6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11330,810,167 - 30,951,082 (-)NCBI
ChlSab1.1 Ensembl1330,809,634 - 30,950,767 (-)Ensembl
Adgrg6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475311,676,967 - 11,807,444 (-)NCBI

Position Markers
RH47174  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.018,610,069 - 8,610,202NCBIRnor6.0
Rnor_5.0110,229,130 - 10,229,263UniSTSRnor5.0
RGSC_v3.419,305,060 - 9,305,193UniSTSRGSC3.4
Celera17,308,314 - 7,308,447UniSTS
Cytogenetic Map1p13UniSTS
RH133430  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.018,595,565 - 8,595,754NCBIRnor6.0
Rnor_5.0110,214,626 - 10,214,815UniSTSRnor5.0
RGSC_v3.419,290,556 - 9,290,745UniSTSRGSC3.4
Celera17,293,813 - 7,294,002UniSTS
Cytogenetic Map1p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124368159Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128468970Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1134993530Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1134993530Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1134993530Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1383915911314658Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:112
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000030511
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 11 4 4 4 11
Low 3 23 57 41 8 41 8 8 70 31 32 8
Below cutoff 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030511   ⟹   ENSRNOP00000029263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl18,593,075 - 8,751,198 (-)Ensembl
RefSeq Acc Id: XM_001071417   ⟹   XP_001071417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera17,291,590 - 7,431,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006222822   ⟹   XP_006222884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera17,293,992 - 7,431,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227647   ⟹   XP_006227709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.218,815,500 - 8,954,238 (-)NCBI
Rnor_6.018,595,744 - 8,751,539 (-)NCBI
Rnor_5.0110,212,403 - 10,369,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588135   ⟹   XP_017443624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera17,294,251 - 7,431,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588138   ⟹   XP_017443627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera17,294,290 - 7,431,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589821   ⟹   XP_017445310
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.218,815,503 - 8,954,239 (-)NCBI
Rnor_6.018,596,003 - 8,751,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589822   ⟹   XP_017445311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.218,815,542 - 8,954,239 (-)NCBI
Rnor_6.018,596,042 - 8,751,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098598   ⟹   XP_038954526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.218,815,294 - 8,860,299 (-)NCBI
RefSeq Acc Id: XM_218313   ⟹   XP_218313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.218,812,889 - 8,954,238 (-)NCBI
Rnor_6.018,593,342 - 8,751,539 (-)NCBI
Rnor_5.0110,212,403 - 10,369,135 (-)NCBI
RGSC_v3.419,290,306 - 9,402,175 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_006227709 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445310 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445311 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954526 (Get FASTA)   NCBI Sequence Viewer  
  XP_218313 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001071417   ⟸   XM_001071417
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_218313   ⟸   XM_218313
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006222884   ⟸   XM_006222822
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006227709   ⟸   XM_006227647
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017443624   ⟸   XM_017588135
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017443627   ⟸   XM_017588138
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017445310   ⟸   XM_017589821
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017445311   ⟸   XM_017589822
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JST1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029263   ⟸   ENSRNOT00000030511
RefSeq Acc Id: XP_038954526   ⟸   XM_039098598
- Peptide Label: isoform X5
Protein Domains
CUB   G_PROTEIN_RECEP_F2_4   GPS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689506
Promoter ID:EPDNEW_R24
Type:initiation region
Name:Adgrg6_1
Description:adhesion G protein-coupled receptor G6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018,751,211 - 8,751,271EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 10229261 10229262 C T snv LH/MavRrrc (KNAW), ZFDM (KyushuU), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), Crl:SD (UDEL), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), LL/MavRrrc (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 8610200 8610201 C T snv SBH/Ygl (MCW), WKY/NHsd (RGD), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS, F344/NRrrc (MCW), M520/N (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW), FHL/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), FHH/EurMcwi (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SHR/NHsd (RGD), SHRSP/Gcrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WKY/NCrl (RGD), WKY/Gcrc (RGD), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308551 AgrOrtholog
Ensembl Genes ENSRNOG00000011411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029263 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030511 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
  Pentaxin UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
NCBI Gene 308376 ENTREZGENE
Pfam 7tm_2 UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  Pentaxin UniProtKB/TrEMBL
PhenoGen Adgrg6 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  PTX_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  PTX UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
UniProt A0A0G2JST1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Adgrg6  adhesion G protein-coupled receptor G6  LOC681235  hypothetical protein LOC681235  Data Merged 737654 PROVISIONAL
2015-03-16 Adgrg6  adhesion G protein-coupled receptor G6  Gpr126  G protein-coupled receptor 126  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gpr126  G protein-coupled receptor 126   Gpr126_predicted  G protein-coupled receptor 126 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC681235  hypothetical protein LOC681235      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Gpr126_predicted  G protein-coupled receptor 126 (predicted)      Symbol and Name status set to approved 70820 APPROVED