Tgfbi (transforming growth factor, beta induced) - Rat Genome Database

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Gene: Tgfbi (transforming growth factor, beta induced) Rattus norvegicus
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Symbol: Tgfbi
Name: transforming growth factor, beta induced
RGD ID: 620017
Description: Predicted to enable several functions, including collagen binding activity; extracellular matrix binding activity; and identical protein binding activity. Involved in chondrocyte differentiation. Located in basement membrane. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Big-h3; BIGH3; transforming growth factor, beta induced, 68 kDa; transforming growth factor-beta-induced protein ig-h3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,960,885 - 7,990,234 (-)NCBIGRCr8
mRatBN7.2177,955,603 - 7,984,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,973,969 - 8,002,492 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,505,209 - 9,534,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,970,355 - 7,998,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,400,123 - 8,429,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,576,347 - 10,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,904,882 - 13,935,110 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,907,546 - 13,912,997 (-)NCBI
Celera178,049,686 - 8,078,886 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
TgfbiRatcorneal dystrophy  ISORGD:13514201599387granular dystrophy Groenouw type I, OMIM:121900, Thiel-Behnke corneal dystrophy, OMIM:602082, lattice corneal dystrophy type I more ...RGD 
TgfbiRatDiabetic Nephropathies  IEP 1304421 RGD 
TgfbiRatkidney disease  IEP 1599389chronic cyclosporin A-induced nephropathyRGD 
TgfbiRatTubulointerstitial Fibrosis  IEP 1304308mRNA, protein:increased expression:kidneyRGD 
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Original Reference(s)
TgfbiRatcorneal dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: Corneal Dystrophy, Dominant | ClinVar Annotator: match by term: Corneal more ...ClinVarPMID:10832717|PMID:11004271|PMID:11024425|PMID:11923233|PMID:12400061|PMID:15177960|PMID:16652336|PMID:16670477|PMID:16809844|PMID:19303004|PMID:19337156|PMID:21462384|PMID:21617751|PMID:21744490|PMID:23884333|PMID:24406863|PMID:24940934|PMID:25284770|PMID:25525159|PMID:25741868|PMID:25932442|PMID:26748743|PMID:26961680|PMID:28492532|PMID:9497262
TgfbiRatepithelial basement membrane dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: Epithelial basement membrane dystrophyClinVarPMID:16652336|PMID:19337156|PMID:25525159|PMID:28492532
TgfbiRatepithelial-stromal TGFBI dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: Epithelial-stromal TGFBI dystrophy | ClinVar Annotator: match by term: TGFBI-related more ...ClinVarPMID:10798644|PMID:11923233|PMID:23559853|PMID:25741868|PMID:28492532|PMID:9054935|PMID:9463327|PMID:9559741
TgfbiRatfamilial adenomatous polyposis 1  ISORGD:13514208554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004|PMID:18487285|PMID:19279422|PMID:19409520|PMID:20685668|PMID:21643010|PMID:28492532
TgfbiRatgenetic disease  ISORGD:13514208554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
TgfbiRatgranular corneal dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: Granular corneal dystrophyClinVar 
TgfbiRatgranular corneal dystrophy 1  ISORGD:13514208554872ClinVar Annotator: match by term: Groenouw corneal dystrophy type IClinVarPMID:11923233|PMID:1264234|PMID:21135107|PMID:21264234|PMID:22355247|PMID:23559853|PMID:25741868|PMID:28492532|PMID:9054935|PMID:9727509
TgfbiRatgranular corneal dystrophy 2  ISORGD:13514208554872ClinVar Annotator: match by term: Avellino corneal dystrophy | ClinVar Annotator: match by term: Granular more ...ClinVarPMID:10798644|PMID:11923233|PMID:15059726|PMID:16606891|PMID:23559853|PMID:25741868|PMID:26197481|PMID:28492532|PMID:34097874|PMID:9054935|PMID:9780098|PMID:9930165
TgfbiRatHereditary Neoplastic Syndromes  ISORGD:13514208554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004|PMID:18487285|PMID:19279422|PMID:19409520|PMID:20685668|PMID:21643010|PMID:28492532
TgfbiRatLattice Corneal Dystrophy Type 1  ISORGD:13514208554872ClinVar Annotator: match by term: Lattice corneal dystrophy Type IClinVarPMID:10798644|PMID:11923233|PMID:1264234|PMID:15059726|PMID:21135107|PMID:21264234|PMID:22355247|PMID:23559853|PMID:25741868|PMID:26197481|PMID:28492532|PMID:34097874|PMID:9054935|PMID:9463327|PMID:9559741|PMID:9727509
TgfbiRatLattice Corneal Dystrophy, Type IIIA  ISORGD:13514208554872ClinVar Annotator: match by term: Corneal dystrophy, lattice type 3AClinVarPMID:10832717|PMID:11004271|PMID:11024425|PMID:11923233|PMID:12400061|PMID:1264234|PMID:15790870|PMID:16809844|PMID:19337156|PMID:21135107|PMID:21264234|PMID:21462384|PMID:22355247|PMID:23559853|PMID:23884333|PMID:25741868|PMID:26748743|PMID:28492532|PMID:9054935|PMID:9497262|PMID:9727509
TgfbiRatNeurodevelopmental Disorders  ISORGD:13514208554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
TgfbiRatReis-Bucklers corneal dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: GRANULAR CORNEAL DYSTROPHY, TYPE III | ClinVar Annotator: match by more ...ClinVarPMID:10660331|PMID:10798644|PMID:11146721|PMID:11923233|PMID:15885785|PMID:16606891|PMID:23559853|PMID:25741868|PMID:28492532|PMID:9780098|PMID:9930165
TgfbiRatThiel-Behnke corneal dystrophy  ISORGD:13514208554872ClinVar Annotator: match by term: Thiel-Behnke corneal dystrophyClinVarPMID:11923233|PMID:21135107|PMID:22355247|PMID:25741868|PMID:28492532|PMID:9054935|PMID:9780098
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Original Reference(s)
TgfbiRatDiabetic Nephropathies  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTDPMID:18682491
TgfbiRatepithelial basement membrane dystrophy  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatgranular corneal dystrophy 1  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatgranular corneal dystrophy 2  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatLattice Corneal Dystrophy Type 1  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatLattice Corneal Dystrophy, Type IIIA  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatReis-Bucklers corneal dystrophy  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
TgfbiRatSepsis  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTDPMID:27887929
TgfbiRatSpontaneous Abortions  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
TgfbiRatThiel-Behnke corneal dystrophy  ISORGD:135142011554173CTD Direct Evidence: marker/mechanismCTD 
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TgfbiRatcorneal dystrophy  ISSRGD:155328513592920 MouseDO 
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Original Reference(s)
TgfbiRatepithelial basement membrane dystrophy  ISORGD:13514207240710 OMIM 
TgfbiRatgranular corneal dystrophy 1  ISORGD:13514207240710 OMIM 
TgfbiRatgranular corneal dystrophy 2  ISORGD:13514207240710 OMIM 
TgfbiRatLattice Corneal Dystrophy Type 1  ISORGD:13514207240710 OMIM 
TgfbiRatLattice Corneal Dystrophy, Type IIIA  ISORGD:13514207240710 OMIM 
TgfbiRatReis-Bucklers corneal dystrophy  ISORGD:13514207240710 OMIM 
TgfbiRatThiel-Behnke corneal dystrophy  ISORGD:13514207240710 OMIM 

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Original Reference(s)
TgfbiRat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:13514206480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TGFBI mRNACTDPMID:22079256
TgfbiRat1,1-dichloroethene increases expressionISORGD:15532856480464vinylidene chloride results in increased expression of TGFBI mRNACTDPMID:26682919
TgfbiRat1,2-dimethylhydrazine multiple interactionsISORGD:15532856480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TGFBI mRNACTDPMID:22206623
TgfbiRat17alpha-ethynylestradiol multiple interactionsISORGD:15532856480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNACTDPMID:17942748
TgfbiRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of TGFBI mRNACTDPMID:16174780
TgfbiRat17beta-estradiol multiple interactionsISORGD:13514206480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNA; [Estradiol co-treated with TGFB1 more ...CTDPMID:19619570|PMID:30165855
TgfbiRat17beta-estradiol increases expressionISORGD:15532856480464Estradiol results in increased expression of TGFBI mRNACTDPMID:39298647
TgfbiRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of TGFBI mRNACTDPMID:32145629
TgfbiRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TGFBI mRNACTDPMID:32741896
TgfbiRat17beta-estradiol increases expressionISORGD:13514206480464Estradiol results in increased expression of TGFBI mRNACTDPMID:19619570
TgfbiRat17beta-estradiol decreases expressionISORGD:15532856480464Estradiol results in decreased expression of TGFBI mRNACTDPMID:15289156
TgfbiRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TGFBI mRNACTDPMID:32741896
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13514206480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNACTDPMID:19619570
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of TGFBI mRNACTDPMID:34747641
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:15532856480464Tetrachlorodibenzodioxin results in decreased expression of TGFBI mRNACTDPMID:33956508
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13514206480464Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNACTDPMID:19619570|PMID:20106945|PMID:21632981|PMID:22262711
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TGFBI mRNACTDPMID:21215274
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNACTDPMID:15644576|PMID:33387578
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:15532856480464Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNACTDPMID:19933214
TgfbiRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:15532856480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNACTDPMID:17942748

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Biological Process
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Original Reference(s)
TgfbiRatangiogenesis involved_inISORGD:13514201624291 PMID:11866539RGDPMID:11866539
TgfbiRatangiogenesis involved_inIEAUniProtKB:Q15582|ensembl:ENSP000004163301600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatcell adhesion involved_inIBAFB:FBgn0285925|MGI:1926321|MGI:99959|PANTHER:PTN000855676|UniProtKB:Q150631600115GO_REF:0000033GO_CentralGO_REF:0000033
TgfbiRatcell adhesion acts_upstream_of_or_withinIEAUniProtKB:P82198|ensembl:ENSMUSP000000377191600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatcell adhesion acts_upstream_of_or_withinISORGD:15532851624291 PMID:12963107RGDPMID:12963107
TgfbiRatcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
TgfbiRatchondrocyte differentiation  IEP 1599388 RGD 
TgfbiRatextracellular matrix organization acts_upstream_of_or_withinIEAUniProtKB:P82198|ensembl:ENSMUSP000000377191600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular matrix organization acts_upstream_of_or_withinISORGD:15532851624291 PMID:18757743RGDPMID:18757743
TgfbiRatextracellular matrix organization involved_inIBAMGI:1926321|MGI:99959|PANTHER:PTN0008556761600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
TgfbiRatbasement membrane  IDA 1304421 RGD 
TgfbiRatextracellular matrix located_inISORGD:15532851624291 PMID:12963107RGDPMID:12963107
TgfbiRatextracellular matrix located_inIEAUniProtKB:P82198|ensembl:ENSMUSP000000377191600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular matrix is_active_inIBAMGI:1926321|MGI:99959|PANTHER:PTN000855676|RGD:620017|UniProtKB:Q150631600115GO_REF:0000033GO_CentralGO_REF:0000033
TgfbiRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
TgfbiRatextracellular space located_inISORGD:13514201624291 PMID:19478074RGDPMID:19478074
TgfbiRatextracellular space located_inIEAUniProtKB:P82198|ensembl:ENSMUSP000000377191600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular space located_inIEAUniProtKB:Q15582|ensembl:ENSP000004163301600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular space located_inISORGD:15532851624291 PMID:12838408RGDPMID:12838408
TgfbiRatextracellular space is_active_inIBAMGI:99959|PANTHER:PTN000096378|RGD:1305285|UniProtKB:Q155821600115GO_REF:0000033GO_CentralGO_REF:0000033
TgfbiRattrans-Golgi network located_inISORGD:13514201624291 PMID:19478074RGDPMID:19478074
TgfbiRattrans-Golgi network located_inIEAUniProtKB:Q15582|ensembl:ENSP000004163301600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  
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Original Reference(s)
TgfbiRatcell adhesion molecule binding enablesIBAFB:FBgn0285925|PANTHER:PTN0008556761600115GO_REF:0000033GO_CentralGO_REF:0000033
TgfbiRatcollagen binding enablesISORGD:13514201624291UniProtKB:A8TX70 PMID:19478074RGDPMID:19478074
TgfbiRatcollagen binding enablesIEAUniProtKB:Q15582|ensembl:ENSP000004163301600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular matrix binding enablesIEAUniProtKB:P82198|ensembl:ENSMUSP000000377191600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatextracellular matrix binding enablesISORGD:15532851624291 PMID:18757743RGDPMID:18757743
TgfbiRatidentical protein binding enablesISORGD:13514201624291UniProtKB:Q15582 PMID:31197037RGDPMID:31197037
TgfbiRatidentical protein binding enablesIEAUniProtKB:Q15582|ensembl:ENSP000004163301600115GO_REF:0000107EnsemblGO_REF:0000107
TgfbiRatprotein binding enablesISORGD:13514201624291UniProtKB:A0A0G2K692|UniProtKB:P05106|UniProtKB:P05107|UniProtKB:P06756|UniProtKB:P25815|UniProtKB:Q15063|UniProtKB:Q8IZU0 PMID:18083624, PMID:19478074, PMID:25416956, PMID:25853243, PMID:32296183RGDPMID:18083624|PMID:19478074|PMID:25416956|PMID:25853243|PMID:32296183


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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose. Lee SH, etal., Kidney Int 2003 Sep;64(3):1012-21.
4. Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy. Li C, etal., Am J Nephrol. 2005 Nov-Dec;25(6):611-20. Epub 2005 Nov 22.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. Munier FL, etal., Nat Genet. 1997 Mar;15(3):247-51.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta. Ohno S, etal., Connect Tissue Res. 2005;46(4-5):227-34.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Expression of transforming growth factor-beta-inducible gene-h3 in normal and cyclosporine-treated rat kidney. Sun BK, etal., J Lab Clin Med 2004 Mar;143(3):175-83.
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PMID:8889548   PMID:11866539   PMID:12838408   PMID:12963107   PMID:18249103   PMID:18757743   PMID:19023196   PMID:19199708   PMID:19478074   PMID:20551380   PMID:21362503   PMID:23979707  
PMID:24006456   PMID:25740786   PMID:27068509   PMID:27559042   PMID:32312943  



Tgfbi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,960,885 - 7,990,234 (-)NCBIGRCr8
mRatBN7.2177,955,603 - 7,984,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,973,969 - 8,002,492 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,505,209 - 9,534,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,970,355 - 7,998,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,400,123 - 8,429,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,576,347 - 10,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,904,882 - 13,935,110 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,907,546 - 13,912,997 (-)NCBI
Celera178,049,686 - 8,078,886 (-)NCBICelera
Cytogenetic Map17p14NCBI
TGFBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,028,988 - 136,063,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,028,988 - 136,063,818 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,364,677 - 135,399,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,392,597 - 135,427,406 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,392,596 - 135,427,406NCBI
Celera5131,489,316 - 131,524,237 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,553,034 - 130,587,955 (+)NCBIHuRef
CHM1_15134,797,217 - 134,832,140 (+)NCBICHM1_1
T2T-CHM13v2.05136,551,486 - 136,586,315 (+)NCBIT2T-CHM13v2.0
Tgfbi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,757,399 - 56,787,172 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,757,336 - 56,787,375 (+)EnsemblGRCm39 Ensembl
GRCm381356,609,586 - 56,639,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,609,523 - 56,639,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,710,964 - 56,740,700 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,619,225 - 56,648,961 (+)NCBIMGSCv36mm8
Celera1357,674,398 - 57,704,061 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.09NCBI
Tgfbi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,093,050 - 31,125,398 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,093,450 - 31,124,715 (+)NCBIChiLan1.0ChiLan1.0
TGFBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,295,568 - 131,350,946 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,405,032 - 129,490,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,420,403 - 131,455,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,560,046 - 137,594,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,559,321 - 137,596,392 (+)Ensemblpanpan1.1panPan2
TGFBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,932,038 - 23,971,983 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,938,453 - 23,971,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,686,607 - 22,719,238 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,755,795 - 24,788,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,755,189 - 24,788,074 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,442,552 - 23,475,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,309,379 - 23,341,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,958,407 - 23,991,029 (+)NCBIUU_Cfam_GSD_1.0
Tgfbi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,103,129 - 124,136,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,127,795 - 3,162,242 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,128,007 - 3,161,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,191,807 - 138,225,366 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,191,793 - 138,225,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,856,237 - 143,880,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,774,387 - 38,808,624 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,774,473 - 38,808,649 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603439,100,477 - 39,134,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473311,038,043 - 11,071,175 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473311,038,041 - 11,070,559 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Tgfbi
241 total Variants

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:82
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000016390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat

1 to 10 of 21 rows
D17Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8177,985,243 - 7,985,461 (+)Marker Load Pipeline
mRatBN7.2177,979,968 - 7,980,186 (+)MAPPERmRatBN7.2
Rnor_6.0178,424,467 - 8,424,684NCBIRnor6.0
Rnor_5.01710,600,735 - 10,600,952UniSTSRnor5.0
RGSC_v3.41713,930,241 - 13,930,458UniSTSRGSC3.4
RGSC_v3.41713,930,240 - 13,930,458RGDRGSC3.4
RGSC_v3.11713,930,241 - 13,930,458RGD
Celera178,074,017 - 8,074,234UniSTS
RH 3.4 Map1774.0RGD
RH 3.4 Map1774.0UniSTS
RH 2.0 Map1748.0RGD
SHRSP x BN Map176.81RGD
FHH x ACI Map174.4999RGD
Cytogenetic Map17p14UniSTS
D17Wox2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8177,984,899 - 7,985,004 (+)Marker Load Pipeline
mRatBN7.2177,979,624 - 7,979,729 (+)MAPPERmRatBN7.2
Rnor_6.0178,424,123 - 8,424,227NCBIRnor6.0
Rnor_5.01710,600,391 - 10,600,495UniSTSRnor5.0
RGSC_v3.41713,929,896 - 13,930,001RGDRGSC3.4
RGSC_v3.41713,929,897 - 13,930,001UniSTSRGSC3.4
RGSC_v3.11713,929,896 - 13,930,001RGD
Celera178,073,673 - 8,073,777UniSTS
RH 3.4 Map1775.3RGD
RH 3.4 Map1775.3UniSTS
RH 2.0 Map1748.1RGD
Cytogenetic Map17p14UniSTS
RH127317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,955,659 - 7,955,869 (+)MAPPERmRatBN7.2
Rnor_6.0178,400,180 - 8,400,389NCBIRnor6.0
Rnor_5.01710,576,404 - 10,576,613UniSTSRnor5.0
RGSC_v3.41713,904,939 - 13,905,148UniSTSRGSC3.4
Celera178,049,743 - 8,049,952UniSTS
RH 3.4 Map1774.6UniSTS
Cytogenetic Map17p14UniSTS
RH129409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,955,616 - 7,955,826 (+)MAPPERmRatBN7.2
Rnor_6.0178,400,137 - 8,400,346NCBIRnor6.0
Rnor_5.01710,576,361 - 10,576,570UniSTSRnor5.0
RGSC_v3.41713,904,896 - 13,905,105UniSTSRGSC3.4
Celera178,049,700 - 8,049,909UniSTS
RH 3.4 Map1773.6UniSTS
Cytogenetic Map17p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016390   ⟹   ENSRNOP00000016389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,604 - 7,984,873 (-)Ensembl
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108364   ⟹   ENSRNOP00000081900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,603 - 7,982,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112669   ⟹   ENSRNOP00000094843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)Ensembl
RefSeq Acc Id: NM_053802   ⟹   NP_446254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,960,885 - 7,990,113 (-)NCBI
mRatBN7.2177,955,603 - 7,984,838 (-)NCBI
Rnor_6.0178,400,123 - 8,429,338 (-)NCBI
Rnor_5.01710,576,347 - 10,605,606 (-)NCBI
RGSC_v3.41713,904,882 - 13,935,110 (-)RGD
Celera178,049,686 - 8,078,886 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095289   ⟹   XP_038951217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,960,885 - 7,990,234 (-)NCBI
mRatBN7.2177,955,603 - 7,984,903 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_446254 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951217 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG23357 (Get FASTA)   NCBI Sequence Viewer  
  EDL93931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016389
  ENSRNOP00000016389.7
  ENSRNOP00000081900
  ENSRNOP00000081900.1
  ENSRNOP00000094843.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_446254   ⟸   NM_053802
- Peptide Label: precursor
- UniProtKB: D4A8G5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016389   ⟸   ENSRNOT00000016390
RefSeq Acc Id: XP_038951217   ⟸   XM_039095289
- Peptide Label: isoform X1
- UniProtKB: D4A8G5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094843   ⟸   ENSRNOT00000112669
Ensembl Acc Id: ENSRNOP00000081900   ⟸   ENSRNOT00000108364
EMI   FAS1

Name Modeler Protein Id AA Range Protein Structure
AF-D4A8G5-F1-model_v2 AlphaFold D4A8G5 1-685 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700286
Promoter ID:EPDNEW_R10809
Type:initiation region
Name:Tgfbi_1
Description:transforming growth factor, beta induced
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,429,373 - 8,429,433EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10277 BioCyc
Ensembl Genes ENSRNOG00000012216 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016390 ENTREZGENE
  ENSRNOT00000016390.8 UniProtKB/TrEMBL
  ENSRNOT00000108364 ENTREZGENE
  ENSRNOT00000108364.1 UniProtKB/TrEMBL
  ENSRNOT00000112669.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.180.10 UniProtKB/TrEMBL
InterPro Adhesion/Biosynth-related UniProtKB/TrEMBL
  EMI_domain UniProtKB/TrEMBL
  FAS1_dom_sf UniProtKB/TrEMBL
  FAS1_domain UniProtKB/TrEMBL
  TGFb-ind_bIGH3/osteoblast_fac2 UniProtKB/TrEMBL
NCBI Gene 116487 ENTREZGENE
PANTHER PERIOSTIN-RELATED UniProtKB/TrEMBL
  PTHR10900:SF82 UniProtKB/TrEMBL
Pfam Fasciclin UniProtKB/TrEMBL
PhenoGen Tgfbi PhenoGen
PIRSF BIGH3_OSF2 UniProtKB/TrEMBL
PROSITE EMI UniProtKB/TrEMBL
  FAS1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012216 RatGTEx
SMART FAS1 UniProtKB/TrEMBL
Superfamily-SCOP BIgH3_FAS1 UniProtKB/TrEMBL
UniProt A0A8I5ZSM4_RAT UniProtKB/TrEMBL
  A0A8I6AMY6_RAT UniProtKB/TrEMBL
  A6KAM3_RAT UniProtKB/TrEMBL
  D4A8G5 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Tgfbi  transforming growth factor, beta induced    transforming growth factor, beta induced, 68 kDa  Name updated 1299863 APPROVED
2002-08-07 Tgfbi  transforming growth factor, beta induced, 68 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL