Tgfbi (transforming growth factor, beta induced) - Rat Genome Database

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Gene: Tgfbi (transforming growth factor, beta induced) Rattus norvegicus
Analyze
Symbol: Tgfbi
Name: transforming growth factor, beta induced
RGD ID: 620017
Description: Predicted to enable several functions, including collagen binding activity; extracellular matrix binding activity; and identical protein binding activity. Involved in chondrocyte differentiation. Located in basement membrane. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Big-h3; BIGH3; transforming growth factor, beta induced, 68 kDa; transforming growth factor-beta-induced protein ig-h3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,960,885 - 7,990,234 (-)NCBIGRCr8
mRatBN7.2177,955,603 - 7,984,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,973,969 - 8,002,492 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,505,209 - 9,534,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,970,355 - 7,998,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,400,123 - 8,429,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,576,347 - 10,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,904,882 - 13,935,110 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,907,546 - 13,912,997 (-)NCBI
Celera178,049,686 - 8,078,886 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
azoxystrobin  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clothianidin  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dabrafenib  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
eplerenone  (EXP)
epoxiconazole  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
graphene oxide  (ISO)
GW 4064  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
irinotecan  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose. Lee SH, etal., Kidney Int 2003 Sep;64(3):1012-21.
4. Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy. Li C, etal., Am J Nephrol. 2005 Nov-Dec;25(6):611-20. Epub 2005 Nov 22.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. Munier FL, etal., Nat Genet. 1997 Mar;15(3):247-51.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta. Ohno S, etal., Connect Tissue Res. 2005;46(4-5):227-34.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Expression of transforming growth factor-beta-inducible gene-h3 in normal and cyclosporine-treated rat kidney. Sun BK, etal., J Lab Clin Med 2004 Mar;143(3):175-83.
Additional References at PubMed
PMID:8889548   PMID:11866539   PMID:12838408   PMID:12963107   PMID:18249103   PMID:18757743   PMID:19023196   PMID:19199708   PMID:19478074   PMID:20551380   PMID:21362503   PMID:23979707  
PMID:24006456   PMID:25740786   PMID:27068509   PMID:27559042   PMID:32312943  


Genomics

Comparative Map Data
Tgfbi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,960,885 - 7,990,234 (-)NCBIGRCr8
mRatBN7.2177,955,603 - 7,984,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,973,969 - 8,002,492 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,505,209 - 9,534,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,970,355 - 7,998,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,400,123 - 8,429,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,576,347 - 10,605,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,904,882 - 13,935,110 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,907,546 - 13,912,997 (-)NCBI
Celera178,049,686 - 8,078,886 (-)NCBICelera
Cytogenetic Map17p14NCBI
TGFBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,028,988 - 136,063,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,028,988 - 136,063,818 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,364,677 - 135,399,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,392,597 - 135,427,406 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,392,596 - 135,427,406NCBI
Celera5131,489,316 - 131,524,237 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,553,034 - 130,587,955 (+)NCBIHuRef
CHM1_15134,797,217 - 134,832,140 (+)NCBICHM1_1
T2T-CHM13v2.05136,551,486 - 136,586,315 (+)NCBIT2T-CHM13v2.0
Tgfbi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,757,399 - 56,787,172 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,757,336 - 56,787,375 (+)EnsemblGRCm39 Ensembl
GRCm381356,609,586 - 56,639,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,609,523 - 56,639,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,710,964 - 56,740,700 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,619,225 - 56,648,961 (+)NCBIMGSCv36mm8
Celera1357,674,398 - 57,704,061 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.09NCBI
Tgfbi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,093,050 - 31,125,398 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,093,450 - 31,124,715 (+)NCBIChiLan1.0ChiLan1.0
TGFBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,295,568 - 131,350,946 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,405,032 - 129,490,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,420,403 - 131,455,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,560,046 - 137,594,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,559,321 - 137,596,392 (+)Ensemblpanpan1.1panPan2
TGFBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,932,038 - 23,971,983 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,938,453 - 23,971,607 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,686,607 - 22,719,238 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,755,795 - 24,788,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,755,189 - 24,788,074 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,442,552 - 23,475,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,309,379 - 23,341,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,958,407 - 23,991,029 (+)NCBIUU_Cfam_GSD_1.0
Tgfbi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,103,129 - 124,136,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,127,795 - 3,162,242 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,128,007 - 3,161,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,191,807 - 138,225,366 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,191,793 - 138,225,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,856,237 - 143,880,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,774,387 - 38,808,624 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,774,473 - 38,808,649 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603439,100,477 - 39,134,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473311,038,043 - 11,071,175 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473311,038,041 - 11,070,559 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbi
241 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:82
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000016390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
D17Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,979,968 - 7,980,186 (+)MAPPERmRatBN7.2
Rnor_6.0178,424,467 - 8,424,684NCBIRnor6.0
Rnor_5.01710,600,735 - 10,600,952UniSTSRnor5.0
RGSC_v3.41713,930,241 - 13,930,458UniSTSRGSC3.4
RGSC_v3.41713,930,240 - 13,930,458RGDRGSC3.4
RGSC_v3.11713,930,241 - 13,930,458RGD
Celera178,074,017 - 8,074,234UniSTS
RH 3.4 Map1774.0RGD
RH 3.4 Map1774.0UniSTS
RH 2.0 Map1748.0RGD
SHRSP x BN Map176.81RGD
FHH x ACI Map174.4999RGD
Cytogenetic Map17p14UniSTS
D17Wox2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,979,624 - 7,979,729 (+)MAPPERmRatBN7.2
Rnor_6.0178,424,123 - 8,424,227NCBIRnor6.0
Rnor_5.01710,600,391 - 10,600,495UniSTSRnor5.0
RGSC_v3.41713,929,897 - 13,930,001UniSTSRGSC3.4
RGSC_v3.41713,929,896 - 13,930,001RGDRGSC3.4
RGSC_v3.11713,929,896 - 13,930,001RGD
Celera178,073,673 - 8,073,777UniSTS
RH 3.4 Map1775.3UniSTS
RH 3.4 Map1775.3RGD
RH 2.0 Map1748.1RGD
Cytogenetic Map17p14UniSTS
RH127317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,955,659 - 7,955,869 (+)MAPPERmRatBN7.2
Rnor_6.0178,400,180 - 8,400,389NCBIRnor6.0
Rnor_5.01710,576,404 - 10,576,613UniSTSRnor5.0
RGSC_v3.41713,904,939 - 13,905,148UniSTSRGSC3.4
Celera178,049,743 - 8,049,952UniSTS
RH 3.4 Map1774.6UniSTS
Cytogenetic Map17p14UniSTS
RH129409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,955,616 - 7,955,826 (+)MAPPERmRatBN7.2
Rnor_6.0178,400,137 - 8,400,346NCBIRnor6.0
Rnor_5.01710,576,361 - 10,576,570UniSTSRnor5.0
RGSC_v3.41713,904,896 - 13,905,105UniSTSRGSC3.4
Celera178,049,700 - 8,049,909UniSTS
RH 3.4 Map1773.6UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 141 194 147 69 147 36 45 41 115 111 57 24
Low 33 207 34
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000016390   ⟹   ENSRNOP00000016389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,604 - 7,984,873 (-)Ensembl
Rnor_6.0 Ensembl178,400,146 - 8,429,338 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108364   ⟹   ENSRNOP00000081900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,603 - 7,982,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112669   ⟹   ENSRNOP00000094843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,955,603 - 7,985,240 (-)Ensembl
RefSeq Acc Id: NM_053802   ⟹   NP_446254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,960,885 - 7,990,113 (-)NCBI
mRatBN7.2177,955,603 - 7,984,838 (-)NCBI
Rnor_6.0178,400,123 - 8,429,338 (-)NCBI
Rnor_5.01710,576,347 - 10,605,606 (-)NCBI
RGSC_v3.41713,904,882 - 13,935,110 (-)RGD
Celera178,049,686 - 8,078,886 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095289   ⟹   XP_038951217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,960,885 - 7,990,234 (-)NCBI
mRatBN7.2177,955,603 - 7,984,903 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446254 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951217 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG23357 (Get FASTA)   NCBI Sequence Viewer  
  EDL93931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016389.7
  ENSRNOP00000081900.1
  ENSRNOP00000094843.1
RefSeq Acc Id: NP_446254   ⟸   NM_053802
- Peptide Label: precursor
- UniProtKB: D4A8G5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016389   ⟸   ENSRNOT00000016390
RefSeq Acc Id: XP_038951217   ⟸   XM_039095289
- Peptide Label: isoform X1
- UniProtKB: D4A8G5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094843   ⟸   ENSRNOT00000112669
Ensembl Acc Id: ENSRNOP00000081900   ⟸   ENSRNOT00000108364
Protein Domains
EMI   FAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8G5-F1-model_v2 AlphaFold D4A8G5 1-685 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700286
Promoter ID:EPDNEW_R10809
Type:initiation region
Name:Tgfbi_1
Description:transforming growth factor, beta induced
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,429,373 - 8,429,433EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620017 AgrOrtholog
BioCyc Gene G2FUF-10277 BioCyc
Ensembl Genes ENSRNOG00000012216 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016390.8 UniProtKB/TrEMBL
  ENSRNOT00000108364.1 UniProtKB/TrEMBL
  ENSRNOT00000112669.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.180.10 UniProtKB/TrEMBL
InterPro Adhesion/Biosynth-related UniProtKB/TrEMBL
  EMI_domain UniProtKB/TrEMBL
  FAS1_dom_sf UniProtKB/TrEMBL
  FAS1_domain UniProtKB/TrEMBL
  TGFb-ind_bIGH3/osteoblast_fac2 UniProtKB/TrEMBL
NCBI Gene 116487 ENTREZGENE
PANTHER PERIOSTIN-RELATED UniProtKB/TrEMBL
  PTHR10900:SF82 UniProtKB/TrEMBL
Pfam Fasciclin UniProtKB/TrEMBL
PhenoGen Tgfbi PhenoGen
PIRSF BIGH3_OSF2 UniProtKB/TrEMBL
PROSITE EMI UniProtKB/TrEMBL
  FAS1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012216 RatGTEx
SMART FAS1 UniProtKB/TrEMBL
Superfamily-SCOP BIgH3_FAS1 UniProtKB/TrEMBL
UniProt A0A8I5ZSM4_RAT UniProtKB/TrEMBL
  A0A8I6AMY6_RAT UniProtKB/TrEMBL
  A6KAM3_RAT UniProtKB/TrEMBL
  D4A8G5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Tgfbi  transforming growth factor, beta induced    transforming growth factor, beta induced, 68 kDa  Name updated 1299863 APPROVED
2002-08-07 Tgfbi  transforming growth factor, beta induced, 68 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL