Chrna2 (cholinergic receptor nicotinic alpha 2 subunit) - Rat Genome Database

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Gene: Chrna2 (cholinergic receptor nicotinic alpha 2 subunit) Rattus norvegicus
Analyze
Symbol: Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
RGD ID: 621533
Description: Enables acetylcholine-gated monoatomic cation-selective channel activity; heterocyclic compound binding activity; and quaternary ammonium group binding activity. Involved in cellular response to nicotine; modulation of inhibitory postsynaptic potential; and response to acetylcholine. Located in neuron projection cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4 and benign familial infantile seizures 6. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1,1-dimethyl-4-phenylpiperazinium iodide; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ACHR; cholinergic receptor, nicotinic, alpha 2; cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2; nicotinic acetylcholine receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,342,317 - 40,358,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,209,601 - 42,225,892 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,359,798 - 43,376,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,802,620 - 41,818,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,808,897 - 42,825,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,768,230 - 48,785,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,570,809 - 45,587,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,586,588 - 45,602,871 (+)NCBI
Celera1540,015,644 - 40,031,870 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acetylcholine  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
crotyl alcohol  (ISO)
cytisine  (EXP,ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dihydro-beta-erythroidine  (EXP)
diquat  (ISO)
epibatidine  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (ISO)
glucose  (ISO)
glyphosate  (EXP)
isobutanol  (ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nicotine  (EXP,ISO)
paracetamol  (EXP)
pentan-1-ol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
purine-6-thiol  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butanol  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP,ISO)
tubocurarine  (EXP)
valproic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits. Jia Y, etal., Eur J Neurosci. 2009 Apr;29(8):1588-603. doi: 10.1111/j.1460-9568.2009.06706.x.
5. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus. Son JH and Winzer-Serhan UH, J Chem Neuroanat. 2006 Dec;32(2-4):179-90. doi: 10.1016/j.jchemneu.2006.09.001. Epub 2006 Oct 12.
13. Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor. Wada K, etal., Science 1988 Apr 15;240(4850):330-4.
14. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
Additional References at PubMed
PMID:8906617   PMID:15026122   PMID:21884692  


Genomics

Comparative Map Data
Chrna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,342,317 - 40,358,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,209,601 - 42,225,892 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,359,798 - 43,376,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,802,620 - 41,818,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,808,897 - 42,825,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,768,230 - 48,785,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,570,809 - 45,587,091 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,586,588 - 45,602,871 (+)NCBI
Celera1540,015,644 - 40,031,870 (+)NCBICelera
Cytogenetic Map15p12NCBI
CHRNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,459,756 - 27,479,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,459,756 - 27,479,883 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,317,273 - 27,336,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,373,195 - 27,392,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,374,181 - 27,392,675NCBI
Celera826,277,396 - 26,296,925 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,862,340 - 25,881,872 (-)NCBIHuRef
CHM1_1827,519,147 - 27,538,678 (-)NCBICHM1_1
T2T-CHM13v2.0827,737,110 - 27,756,814 (-)NCBIT2T-CHM13v2.0
Chrna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,370,685 - 66,390,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,372,488 - 66,390,397 (+)EnsemblGRCm39 Ensembl
GRCm381466,133,236 - 66,152,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,135,039 - 66,152,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,759,797 - 66,771,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,095,070 - 65,107,058 (+)NCBIMGSCv36mm8
Celera1463,889,359 - 63,901,395 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Chrna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,970,398 - 49,989,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,970,398 - 49,989,095 (-)NCBIChiLan1.0ChiLan1.0
CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1821,704,317 - 21,723,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,932,846 - 23,952,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensemblpanpan1.1panPan2
CHRNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,117,384 - 30,137,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,117,239 - 30,135,599 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,711,637 - 30,723,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,316,301 - 30,326,148 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,307,340 - 30,325,726 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,245,712 - 30,257,580 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,126,596 - 30,137,323 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,292,990 - 30,304,860 (+)NCBIUU_Cfam_GSD_1.0
Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,251,532 - 8,258,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675327,501 - 334,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675327,501 - 334,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,195,228 - 11,207,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,374,481 - 12,388,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,571,958 - 25,591,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,571,863 - 25,591,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,552,356 - 16,572,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,182,951 - 22,200,063 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,182,468 - 22,200,076 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrna2
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:91
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000023475
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
D15Wox3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,353,977 - 40,354,096 (+)MAPPERmRatBN7.2
Rnor_6.01542,820,558 - 42,820,674NCBIRnor6.0
Rnor_5.01548,773,415 - 48,773,531UniSTSRnor5.0
RGSC_v3.41545,582,469 - 45,582,586RGDRGSC3.4
RGSC_v3.41545,582,470 - 45,582,586UniSTSRGSC3.4
RGSC_v3.11545,598,249 - 45,598,366RGD
Celera1540,027,310 - 40,027,432UniSTS
RH 2.0 Map15296.8RGD
Cytogenetic Map15p12UniSTS
Chrna2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,356,876 - 40,357,168 (+)MAPPERmRatBN7.2
Rnor_6.01542,823,455 - 42,823,746NCBIRnor6.0
Rnor_5.01548,770,343 - 48,770,634UniSTSRnor5.0
RGSC_v3.41545,585,367 - 45,585,658UniSTSRGSC3.4
Celera1540,030,146 - 40,030,437UniSTS
Cytogenetic Map15p12UniSTS
UniSTS:496005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,356,280 - 40,356,378 (+)MAPPERmRatBN7.2
Rnor_6.01542,822,859 - 42,822,956NCBIRnor6.0
Rnor_5.01548,771,133 - 48,771,230UniSTSRnor5.0
RGSC_v3.41545,584,771 - 45,584,868UniSTSRGSC3.4
Celera1540,029,550 - 40,029,647UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2
Low 2 2 20 12 19 12 37 23 2 8
Below cutoff 1 17 27 19 19 5 5 19 4 9 3 5

Sequence


RefSeq Acc Id: ENSRNOT00000023475   ⟹   ENSRNOP00000023475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)Ensembl
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)Ensembl
RefSeq Acc Id: NM_133420   ⟹   NP_596911
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,342,317 - 40,358,601 (+)NCBI
Rnor_6.01542,808,897 - 42,825,179 (+)NCBI
Rnor_5.01548,768,230 - 48,785,192 (-)NCBI
RGSC_v3.41545,570,809 - 45,587,091 (+)RGD
Celera1540,015,644 - 40,031,870 (+)RGD
Sequence:
RefSeq Acc Id: NP_596911   ⟸   NM_133420
- Peptide Label: precursor
- UniProtKB: O08952 (UniProtKB/Swiss-Prot),   Q53YK3 (UniProtKB/Swiss-Prot),   P12389 (UniProtKB/Swiss-Prot),   A6K6M0 (UniProtKB/TrEMBL),   A6K6L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023475   ⟸   ENSRNOT00000023475
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12389-F1-model_v2 AlphaFold P12389 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621533 AgrOrtholog
BioCyc Gene G2FUF-13331 BioCyc
Ensembl Genes ENSRNOG00000017424 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006718 UniProtKB/Swiss-Prot
  ENSRNOG00060010857 UniProtKB/Swiss-Prot
  ENSRNOG00065017636 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023475 ENTREZGENE
  ENSRNOT00000023475.3 UniProtKB/Swiss-Prot
  ENSRNOT00055010976 UniProtKB/Swiss-Prot
  ENSRNOT00060018389 UniProtKB/Swiss-Prot
  ENSRNOT00065029502 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter-gated ion-channel transmembrane domain UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 170945 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTRANSMITTER GATED ION CHANNEL UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA2 RGD
PhenoGen Chrna2 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017424 RatGTEx
  ENSRNOG00055006718 RatGTEx
  ENSRNOG00060010857 RatGTEx
  ENSRNOG00065017636 RatGTEx
Superfamily-SCOP Neurotransmitter-gated ion-channel transmembrane pore UniProtKB/TrEMBL
  Nicotinic receptor ligand binding domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A6K6L9 ENTREZGENE, UniProtKB/TrEMBL
  A6K6M0 ENTREZGENE, UniProtKB/TrEMBL
  ACHA2_RAT UniProtKB/Swiss-Prot
  O08952 ENTREZGENE
  P12389 ENTREZGENE
  Q53YK3 ENTREZGENE
UniProt Secondary O08952 UniProtKB/Swiss-Prot
  Q53YK3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrna2  cholinergic receptor nicotinic alpha 2 subunit  Chrna2  cholinergic receptor, nicotinic, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Chrna2  cholinergic receptor, nicotinic, alpha 2  Chrna2  cholinergic receptor, nicotinic, alpha 2 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chrna2  cholinergic receptor, nicotinic, alpha 2 (neuronal)  Chrna2  cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Chrna2  cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Chrna2  cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)      Symbol and Name status set to provisional 70820 PROVISIONAL